Oleg MishchenkoЗГМУ · хир. стом
Oleg Mishchenko
Doctor of Medical Sciences
About
28
Publications
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128
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Publications
Publications (28)
In this study chitosan/alginate (Ch/Alg) composite scaffolds were prepared using a freeze-drying method and loaded with various concentrations of silver nanoparticles (AgNPs). Structural, chemichal composition as well as biocompatibility and antibacterial properties were studied focused to biomedical application. Formation of polyelectrolyte comple...
The biodegradable metals, including magnesium (Mg), are a convenient alternative to permanent metals but fast uncontrolled corrosion limited wide clinical application. Formation of a barrier coating on Mg alloys could be a successful strategy for the production of a stable external layer that prevents fast corrosion. Our research was aimed to devel...
Plasma Electrolytic Oxidation (PEO) is as a promising technique to modify metal surfaces by application of oxide ceramic coatings with appropriate physical, chemical and biological characteristics. Therefore, objective of this research was to find the simplest settings, yet able to produce relevant bioactive implant surfaces layers on Ti implants b...
Direct surface modification of dental implants based on zirconium (Zr), Ti–Zr alloys, and zirconia ceramics has been achieved by the irradiation of their surfaces with Ti:sapphire femtosecond laser. Fundamental (800 nm) and third (266 nm) harmonics of femtosecond laser have been used for the surface treatment. Laser treatment is one of the effectiv...
In a present paper, we demonstrate novel approach to form ceramic coatings with incorporated ZnO nanoparticles (NPs) on low modulus TiZrNb alloy with enhanced biocompatibility and antibacterial parameters. Plasma Electrolytic Oxidation (PEO) was used to integrate ZnO nanoparticles (average size 12–27 nm), mixed with Ca(H2PO2)2 aqueous solution into...
A method of thermal deposition that involves localized high peak temperatures at the electrode-electrolyte
interface was proposed for hydroxyapatite (HA) coatings deposition. Active surface layers were obtained by
HA incorporation from the aqueous electrolyte into the substrate surface due to the decrease of HA solubility
with increasing of substra...
High strength, excellent corrosion resistance, high biocompatibility, osseointegration ability, and low bacteria adhesion are critical properties of metal implants. Additionally, the implant surface plays a critical role as the cell and bacteria host, and the development of a simultaneously antibacterial and biocompatible implant is still a crucial...
In the present work, the generation of Laser Induced Periodic Surface Structures (LIPSS) by using femtosecond laser source is investigated in the surface texturing of Ti grade 5 dental implants. The proposed procedure permits a fast treatment of dental implants characterized by complex shape through the combined and synchronous use of a galvo scann...
The concept of mechanical biocompatibilities is considered an important factor for orthopedics and dental implants. The high Young modulus of traditional Ti-based alloys can lead to stress-shielding syndrome and late postoperative complications. The development of new Al- and V-free Ti alloys with a low elastic modulus is a critical task for implan...
Plasma electrolytic oxidation (PEO) can provide an ideal surface for osteogenic cell attachment and proliferation with further successful osteointegration. However, the same surface is attractive for bacteria due to similar mechanisms of adhesion in prokaryotic and eukaryotic cells. This issue requires the application of additional surface treatmen...
In the present work, the surface of Ti-6Al-7Nb samples was patterned with Laser Induced Periodic Surface Structures in order to improve biocompatibility, increase tissue ingrowth and decrease bacterial adhesion and inflammatory response for applications in dental and orthopedic implants. Polished and sandblasted disks 10 mm in diameter were treated...
In this paper, the effect of femtosecond laser nanotexturing of surfaces of Ti6Al4V and Zr implants on their biological compatibility is presented and discussed. Highly regular and homogeneous nanostructures with sub-micrometer period were imprinted on implant surfaces. Surfaces were morphologically and chemically investigated by SEM and XPS. HDFa...
The clinical success of dental implantation is associated with the phenomenon of osteointegration. Geometry and topography of the implant surface are critical for the short- and long-term success of an implantation. Modification of the surface of endosseous part of the implant with sandblasting was of special interest for our study. Taking into acc...
The clinical success of dental implantation is associated with the phenomenon of osteointegration. Geometry and topography of the implant surface are critical for the short-and long-term success of an implantation. Modification of the surface of endosseous part of the implant with sandblasting was of special interest for our study. Taking into acco...
Nowadays there is a need for new generation of biodegradable implants, which should be able to stimulate the healing responses of injured tissues at the molecular level. Magnesium alloys attract great attention as perspective bone implants due to their biocompatibility, physical properties and ability to degrade completely under physiological condi...
Osteoinegration is a main factor of successful implant ingrowth. It is depends on quality of bone, lack of initial stability, excessive loading, loosening or fracture of screw and fracture of implants. Other factors that can affect osteoinegration are implant composition and futures of implant surface. There are a lot of research that show better r...
The present work describes the elaboration of onteeth compression-distraction apparatus and the treatment method for mandible fractures within dentition using onteeth compression-distraction apparatus. The conclusions are made regarding advantage of onteeth compression-distraction apparatus over intermaxillary and wire fixation of the bone fragment...
Projects
Projects (5)
This project aimed to provide laser texturing of dental implant surface to increase biocompatibility
Osteoplant Research and Development otrzymał ze środków unijnych dofinansowanie do projektu pt. “Opracowanie technologii i uruchomienie produkcji innowacyjnych implantów stomatologicznych o zwiększonych właściwościach osteoinduktywnych.”
Rezultatem projektu będzie opracowanie technologii i uruchomienie produkcji innowacyjnych implantów stomatologicznych o zwiększonych właściwościach osteoinduktywnych. Innowacyjne implanty stomatologiczne będą cechowały się nową powierzchnią o odpowiedniej topografii i mikrostrukturze.
W ramach projektu zostanie stworzone stanowisko doświadczalne i wybudowana linia pilotażowa, przy pomocy których wytworzona zostanie demonstracyjna partia innowacyjnych implantów stomatologicznych. Implanty stomatologiczne zostaną poddane rygorystycznej ocenie, zgodnej z normą PN-EN ISO 10993, a także literaturowej ocenie klinicznej w celu uzyskania stosownego certyfikatu. Po zakończeniu projektu technologia produkcji implantów będzie wdrożona W Otseoplancie R&D, a innowacyjne implanty włączone do sprzedaży.
The project CanBioSe targeted to strengthen international and intersectoral collaboration, sharing new ideas and knowledge transfer from research to market and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cells detection. Interdisciplinary project research and innovation goals are targeted to develop a new portable tool for early stage cancer detection which can solve on of important health challenges in EU society. One dimensional (1D) polimer nanofibers will be deposited by electrospinning technique. Photonic nanomaterials, based on metal oxide based nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy will be used for recording of the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic system in order to minimize dimensions and simplify the use of the detection system.
