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Olatunji Sunday yinka

Olatunji Sunday yinka
Adventist School of Medicine of East Central Africa, Adventist University of Central Africa

BSc, MSc, Ph.D.

About

60
Publications
25,452
Reads
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102
Citations
Additional affiliations
December 2014 - present
Babcock University
Position
  • Lecturer
Description
  • NEUROTOXICOLOGY, EPILEPSY AND APPLIED MORPHOLOGY

Publications

Publications (60)
Poster
Full-text available
Background: Epileptogenesis mechanisms is critical for understanding epilepsy and developing therapeutic strategies for epilepsy management. Hippocampal-mediated functions and structure were investigated in a lithium-chloride pilocarpine rat model during the acute, latent, and chronic phases of epiloptogenesis. Methodology: Forty-eight male Wistar...
Article
Full-text available
Background Anatomy education in this context refers to the training of anatomists particularly in the university or college setting with an emphasis on equipping them with skills to be biomedical researchers and scientists, educators, and providers of applied or allied health services. There has been a recurring call to carefully evaluate and scrut...
Article
Full-text available
Background : The stimulant, empathogenic, euphoric, and hallucinogenic properties of 3,4-methylenedioxymethamphetamine (MDMA), also known as 'Ecstasy,' make it a popular drug among teenagers. These effects are thought to be caused by significant increases in dopamine, serotonin, and glutamate neurotransmission. However, little is known about Garcin...
Article
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Background The study was done to establish the neurotoxic effect of intracerebroventricular streptozotocin (ICV STZ)-induced brain insulin resistance, and also considered Zingiber officinale (Z. officinale) mechanism of action in ameliorating behavioural, molecular and histopathological changes associated with ICV STZ-induced brain insulin resistan...
Article
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Abstarct Background 3,4-methylenedioxymethamphetamine (MDMA) is a psychoactive drug that teenagers and young adults habitually abuse for pleasurable sensations and can cause neurological disorders. Aim: This research focuses on investigating the attenuating potential of Ginkgo biloba (G. biloba) aqueous extract, following MDMA-induced neurodegener...
Article
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Chronic stress if not manage properly results to major depression disorder which has profound impact on individual's life quality and deeply related to suicide death worldwide. This serious mental disorder is closely linked to the hippocampus due to it functionality in the regulation of cortisol production. Abelmoschus Esculentus (A. Esculentus) po...
Article
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Background Early signs of neurodegenerative events of Alzheimer’s disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl3), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its neurogenesis, thereby causing cognitive and memory impairment. Buchholzia...
Article
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Introduction: Technological devices have become a very important part of our everyday life. These electronic devices create an artificial electromagnetic field (EMF) and emit radiofrequency radiations (RFR) which have been reported to have deleterious effects on various tissues in living organisms. Fish oil is a rich source of the n-3 (also known a...
Article
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Background: Garcinia kola (GK) has been experimentally tested for its potential usefulness against oxidative stress-related disorders in a number of body tissues, as well as a number of pathogenic and parasitic diseases. Studies investigating GK extracts' usefulness in combating nervous tissue toxicity, neuroinflammatory disorders, and neuronal deg...
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Background: 3, 4-methylenedioxymethamphetamine (MDMA) causes neurological disorders. Garcinia kola (GK) has neuroprotective property. We investigated the neuroprotective roles of GK on MDMA-induced cerebellar damage. Method: Sixty male Wistar rats (120 - 160g), 5 months old were grouped into six (n =10). Rats were fed with normal chow and water ad...
Article
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Recent findings show conflicting evidences of both beneficial and deleterious effects of inducible nitric oxide synthase (iNOS). Ascorbic acid (ACA) is a source of antioxidant. This study seeks to examine the role of iNOS in acetaminophen (APAP)-induced liver damage following treatment with ACA. Twenty (20) female rats (150-200g) were used for the...
Article
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This study investigated the effects of Parkia clappertoniana (PC) on the hippocampal structure and functions in Lithium Chloride-Pilocarpine-induced Epilepsy in Wistar rat Model. A total of 36 adult male Wistar rats were used for this study and divided into groups A to F, group A (Control), B (200mg/kg of PC), C (127mg/kg of Lithium chloride + 30mg...
Article
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Background: Alarming population increase with fewer resources in this century is undisputable especially in under-developed countries. Hence, the need for efficient and affordable birth control which majority don’t have access to, unfortunately. Aim: This study investigated the paradoxical anti-fertility effect of amlodipine in Wistar rats with a v...
Article
Full-text available
Plastination is a modern method of preservation of biological specimens, including human cadavers. This study elucidated how temperature might affect plastination, noting that there is sparse scientific literature on this technique, especially from Africa. It is also relevant to the feasibility of adapting and adopting the technique as a feasible a...
Poster
Full-text available
Comparative Study of Forced Impregnation Temperatures Variation on the outcome of Brain Plastination. SONA 2019 Abstract
Poster
Full-text available
Caffeine nicotine and MDMA effects on retinal morphology and rhodopsin expression suggest potential functional consequences. SONA POSTER
Article
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Transcranial direct current stimulation (tDCS) is capable of modulating brain activity significantly and it has emerged as a promising treatment for schizophrenia and pain, and also to inhibit cravings. However, there is a rapid increase on the use of this neuro-stimulation method to enhance cognitive ability in healthy people. The present study in...
Article
Human overexposure to nickel (Ni) emanating from the increasing application of Ni compounds in modern technology is a major public health concern. Nickel has been shown to be teratogenic, immunotoxic, genotoxic and carcinogenic. The current knowledge on Ni neurotoxicity is still relatively limited. We have previously demonstrated that Ni treatment...
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Several conditions such as chemotherapy and toxins can interfere with spermatogenesis and reduce sperm quality and production. In the case where natural antioxidant response cannot manage oxidative stress and free radical overload, oxidative damage occurs and this begins the genesis of many diseases of which diabetes is one of them. This has awaken...
Article
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Abstract: Heavy metal poisoning is often as a result of prolonged occupational or domestic exposure to toxic metals and it is difficult to treat it immediately as the effects manifest over time. The use of herbal medicines and phytonutrients continues to expand rapidly across the world with many people now resorting to these products for treatment...
Article
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Caffeine is ingested in form of its natural sources that chiefly include coffee and tea; it is also a major additive to soda or soft drinks as well as a number of medical drugs. Its wide range of availability and legal status in many countries make it available for consumption with little or no restrictions. Caffeine in a psychoactive agent with po...
Article
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Cognition, memory and behavioural changes associated with the use of psychoactive substances are typically modelled in murine models. This study involved a modelling the use of caffeine and cannabis to provide information potential effects on learning and behavioural aberrations in users [humans]. The natures of memory retention and anxiety levels...
Article
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Caffeine is popularly consumed and it is a legal psychoactive substance. The effects on testicular structure remains largely unknown. This research was aimed at investigating the effects of caffeine on the testis structure and function. The study was done using 40 Male Wistar rats. The rats were randomly divided into 5 groups. Group A was the contr...
Article
Full-text available
It is important to study possible relationships between retinopathy and visual cortex integrity. The human retina is a very delicate component of the human eye. Due to the retina's vital role in visual perception, damage to it can cause permanent blindness. Conditions such as retinopathy can compromise the integrity of its vascularity thereby preve...
Article
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Retinopathy is a major problem of vision. It could lead to loss of vision. It is simply the degeneration of the retina. This can be as a result of assault or trauma to the eye or its retina. It can also be as a result of complications of health including diabetes. A totally damaged retina is an indication of total loss of visual perception, which a...
Article
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Cannabis preparations have been reported to have potential positive effects on retinal health and potential to ameliorate retinopathy or help in protecting the retina. This fact suggests that cannabis can improve vision health. A major component of cannabis that has been found to have such protective effects is cannabinoid. Cannabinoids have been d...
Article
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Background: Caffeine and cannabis are globally consumed and abused psychoactive substances. While caffeine is legally used in various forms, including in tea and coffee as beverages, it is also consumed in soda and energy drinks as additives. Cannabis, on the other hand, is considered illegal in most countries; albeit, it is being consumed globall...
Article
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Caffeine is commonly consumed in an effort to enhance speed in performance and wakefulness. However, little is known about the deleterious effects it can produce on the brain, this study aimed at determining the extents of effects and damage that can be caused by excessive consumption of caffeine on the cerebral cortex of mice models with a view to...
Article
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Caffeine and cannabis are two of the world most popularly consumed psychoactive substances. While caffeine is consumed with little or no regulation and restrictions in moist of the countries of the world; cannabis safety of consumption has been queried severally and as such, it is labeled an illegal drug in many countries. It is important to apprec...
Article
Full-text available
The present study investigated the effects of Ginkgo biloba extract (GBE) in attenuating cadmium-induced hepatotoxicity. A total of 24 adult Wistar rats with an average weight of 145g were used for this study. The rats were randomly divided into groups of four: groups A (control), B (Cd at 50mg/kg BW), C (Cd at 50mg/kg BW and GBE at 100mg/kg BW) an...
Article
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This study was aimed at investigating the cytoprotective activities of Curcuma longa (Turmeric) on the histological structure of the testes in diabetic male rats. Turmeric is commonly called the golden spice, is used as a spice in cooking and also has a long history of medicinal use, dating back nearly 4000 years to the Vedic culture in India. Its...
Article
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A number of literatures have reported that caffeine could have negative effects on mental health and brain structures and chemistry. There are also reported positive effects of caffeine, such as improvement in memory, especially for those who consume caffeine from its natural sources. Sixty male juvenile Wistar rats were grouped into six (6) groups...
Article
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Rohypnol and alcohol abuse is often reported among young people. Rohypnol is often abused voluntarily to erase memory of indulgence. It is also used in perpetuating crime such as in rape cases when the perpetrator administers certain doses of rohypnol to make the victim lose the memory of such event. Interestingly, young people often abuse alcohol...
Article
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ABSTRACT Hippocampal structural and functional integrity; and its neurogenesis are crucial to memory and associated neurological functions. Caffeine ingestion or exposure is postulated to have significant influence on the hippocampus, especially at puberty which is a critical stage in postnatal neurological development. To this end, this investigat...
Article
Full-text available
Solanum macrocarpon is a plant with edible fruit and its potentials as a medicinal herb have also been investigated. Its leaf extract had been suggested to have effects that could ameliorate myocardial infarction. In the current investigation, S. macrocarpon leaf aqueous extract effects on the brain tissue was observed when it is being used to amel...
Article
Full-text available
Solanum macrocarpon is a plant with edible fruit and its potentials as a medicinal herb have also been investigated. Its leaf extract had been suggested to have effects that could ameliorate myocardial infarction. In the current investigation, S. macrocarpon leaf aqueous extract effects on the brain tissue was observed when it is being used to amel...
Article
Full-text available
Caffeine is a neurostimulant that is globally consumed with little or no restrictions by various groups of people. Though concerns have been raised over the possible effects of caffeine exposure during intrauterine life or pregnancy; there are not enough empirical evidences to establish the specific potential effects of caffeine exposure on the dev...
Article
Full-text available
Abstract: Renal failure is a growing concern in the modern society and the increasing rate of exposure to toxic substances has contributed a lot to renal diseases. As a result of this, there is a great need for agents that can serve as nephroprotective. The present study assessed some parameters of renal function on the ameliorative properties of G...
Article
Full-text available
Caffeine is a neurostimulant that is globally consumed with little or no restrictions by various groups of people. Though concerns have been raised over the possible effects of caffeine exposure during intrauterine life or pregnancy; there are not enough empirical evidences to establish the specific potential effects of caffeine exposure on the dev...
Article
Full-text available
One of the clinical significance of the sella turcica is the empty sella syndrome which is the condition of a shrunken or flattened pituitary gland; hence a familiarity with the sella turcica anatomy and radiological appearance is of great importance. The present study investigated the normal dimensions of the sella turcica and the relationship wit...
Article
Full-text available
One of the clinical significance of the sella turcica is the empty sella syndrome which is the condition of a shrunken or flattened pituitary gland; hence a familiarity with the sella turcica anatomy and radiological appearance is of great importance. The present study investigated the normal dimensions of the sella turcica and the relationship wit...
Article
Full-text available
ABSTRACT Objective: This study investigated the effects of Vitex doniana leaf extract on testicular torsion of Wistar rats with a view to determining its effects on sperm motility, sperm count and serum testosterone level. Methods: Thirty adult male Wistar rats weighing 120 - 160 g, obtained from the Animal House of the College of Health Sciences,...
Article
Full-text available
Objective: The general objective of this study was to evaluate the prevalence of dysmenorrhea and its effects on the quality of life among females of different age groups in a community. Methods: The study involves the random selection of 450 subjects with the use of a cross sectional survey among three (3) different age groups of 13-20 years, 21-3...
Article
Full-text available
The comparative effect of Caffeine (1,3,7-Trimethylpurine-2,6 Dione) and cannabis (tetrahydrocannabinol) on the Retina and Optic nerve in rats were studied after 21 days of oral administration on 72 Wistar albino rats of both sexes, weight between 200.29-203.49g. They were divided into six groups of six rats each of both sexes. Group A, the control...