Olapeju Aiyelaagbe

Olapeju Aiyelaagbe
University of Ibadan · Department of Chemistry

Ph.D Chemistry, Ib.

About

92
Publications
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1,977
Citations
Citations since 2017
30 Research Items
1058 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Introduction
Olapeju Aiyelaagbe currently works at the Department of Chemistry, University of Ibadan. She is a Professor of Organic Chemistry/Natural products. Her research area is isolation and characterisation of bioactive compounds from African medicinal plants. She is also the current coordinator of the Biocide Research group in the University, working on sourcing safe biocides for the protection of various fruits and vegetables.

Publications

Publications (92)
Article
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Xylopia aethiopica is a plant used ethnomedicinally for the treatment of several infections in Nigeria. This study was carried out to isolate the active compound(s) in Xylopia aethiopica and evaluate their anti-measles virus activity. The Dichloromethane (DCM) fraction of Xylopia aethiopica was fractionated using chromatographic techniques, which l...
Article
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The leaves and bark of Ficus sagittifolia have been used as a cure for stomach and pulmonary disorders, respectively. The bark is edible and is taken against colic. From the leaves of F. sagittifolia, a steroidal glycoside named Stigmast-5,22-diene-3-O-β-D-glucopyranoside 1 and three isoflavonoids named 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-ch...
Article
Helminth infections remain a major constraint to livestock productivity in the tropical and subtropical areas across the world, especially in the areas where extensive grazing is practiced. The development of resistance to anthelmintic drugs, scarcity and high cost of purchase especially to farmers of low income in developing countries led to the n...
Article
A survey was carried out on ethnoveterinary practices used by Fulani agropastoralists for maintaining the health and treating of livestock diseases in Ido agrarian community of Oyo State, Nigeria. Information was collected from fifty cattle herders using interview method with the help of Hausa interpreter and with the aid of questionnaires. The dat...
Article
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Tapinanthus bangwensis is a parasitic woody shrub traditionally employed to cure various ailments in Nigeria including leprosy, rickets, rheumatism, cough, skin and respiratory diseases. The crude organic extracts of T. bangwensis were subjected to bioassays - cytotoxicity antibacterial and antidiabetic. The cytotoxicity assay was carried out using...
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Background Chewing sticks are commonly used as oral hygiene tool in Africa and reactive oxygen species have been linked to the cause of degenerative diseases because of their ability to induce oxidative damage to biological molecules. Plants have been a long source of dietary antioxidants as most plants have been found to exhibit excellent antioxid...
Article
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Background: Cancer is one of the leading causes of global mortality and recently, it has been established that there is a link between periodontal disease and various types of cancer. In Nigeria, chewing sticks are used especially in the rural areas to maintain oral hygiene and to prevent periodontal disease. Mezoneuron benthamianum is a plant that...
Article
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The search for new natural antioxidants has grown tremendously over the years because reactive oxygen species (ROS) production and oxidative stress have been linked to a large number of human degenerative diseases, such as cancer, cardiovascular diseases and diabetes. Tapinanthus bangwensis, a parasitic plant commonly known as mistletoe is employed...
Article
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Phytochemical investigation of the ethyl acetate extract of the root of Mezoneuron benthamianum, a shrub commonly used as chewing stick in the southwest of Nigeria, led to the isolation of three compounds characterised as trans-resveratrol, piceatannol and gallic acid by the use of spectroscopic techniques. The anticaries activity of the polyphenol...
Article
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Tomato cultivation in Nigeria and around the world is seriously threatened by disease infection. Soilless cultivation and gene engineering are modern innovations used worldwide to ensure production of quality disease-free vegetables; yet annual crop loss still persists. In 2011, a commercial vegetable farm in Apẹtẹ, Ibadan, Nigeria was totally rava...
Article
Gakolanone (3',5'-digeranyl-2',4',6',3-tetrahydroxybenzophenone; 1), a novel benzophenone derivative was isolated from the hexane extract of Garcinia kola Heckel stem-bark along with three known 3-8'' linked biflavonoids: 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8''-biflavanone (2); 3'',4',5,5'',5''',7,7''-heptahydroxy-4-methoxy-3,8''-biflavanone (3)...
Article
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Chewing sticks are commonly used as oral hygiene tool in Nigeria to prevent different types of oral disease including periodontal disease and dental caries. A link has recently been established between periodontal disease and various types of cancers, including lung and breast cancer. The crude extracts of four Nigerian chewing sticks (Fagara zanth...
Article
Chloroform extract from the leaves of Turraea vogelii Hook f. ex Benth demonstrated cytotoxic activity against a chronic myelogenous leukemia cell, K-562 with IC50 of 14.27 μg/mL, while chloroform, ethyl acetate and methanol extracts from the stem of the plant inhibited K-562 cells growth with IC50 of 19.50, 24.10 and 85.40 μg/mL respectively. Bioa...
Article
Isolated from the n-hexane soluble fraction of the chloroform extract of Syzygium guineense stem bark were two friedelane-type isoprenoids, friedelan-3-one (1) and a novel derivative 12-hydroxy-27-normethylfriedelan-3-one (2). Mass, NMR (1- and 2-D), and FTIR spectroscopic techniques were used for structural elucidation. GC-MS analysis of the lipoi...
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Correction to: https://doi.org/10.1007/s00044-017-2033-4 © 2017 Springer Science+Business Media, LLC, part of Springer Nature
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This study was to investigate the constituents of stem extracts of Alafia barteri and evaluate its antiproliferative activity in order to support its ethnomedicinal application. Chromatographic isolation procedure was used to separate the constituents from n-hexane, ethyl acetate, and methanol extracts of Alafia barteri stem and testing against thr...
Article
A new oleanane derivative, 3β-acetyloleana-5,12-dien-2,23-diol (1), and a new lupane compound, lup-11,20(29)-dien-3 β,28-diol (2), together with eight known compounds, oleana-5,12-dien-3β-yl acetate (3), lup-5,20(29)-dien-3 β -yl acetate (4), 18-methylethylnonadecan-19-oic-9-enoate (6), octadecane (5), cis-pentadec-7-enoic acid (7), cis-tetradec-7,...
Article
N-hexane and methanol extracts of Asystasia buettneri Lindau aerial parts exhibited antiproliferative activity on leukaemia blood carcinoma, K-562. Hexadecane (1), 1,3-propan-2-ol (9Z,12′Z,15″Z)-bis(doeicos-9,12,15-trienoate) (2), hydrocarbon, 2,3,3,10,23-pentamethyl tetraeicos-10,13,16-trien-1-ol (3), hexadecanoic acid (4) and taraxerol (5) were i...
Article
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Plant derived isoprenoids commonly called terpenoids, are not only useful as chemosytemic markers but are increasingly attracting attention in the development of newer drugs for the treatment of multi-drug resistant tuberculosis. Anti-tuberculosis activity guided solvent fractionation and chromatographic separation of the chloroform extract of S. g...
Presentation
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The presentation was based on a research carried out to determine the nematicidal activity of Tagetes inorder to ascertian its possible use in crop protection.
Article
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Phytochemical investigation of the hexane extract of the roots of Mezoneuron benthamianum (Baill.) led to the isolation of two Cassane diterpenoids, taepeenin A and nortaepeenin A. Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, IR and MS) and by comparison with the spectroscopic data reported in the lit...
Article
Prostate cancer is one of the most common cancers in men. Diosgenin and related compounds are potential cytotoxic agents. Twelve diverse analogues of long chain fatty acid/ester of diosgenin-7-ketoxime have been prepared. Six of the analogues exhibited significant anticancer activity against a panel of human cancer cell lines with IC50 ranging from...
Article
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Background Plant extracts were evaluated on poultry bacteria known to be threatening public health. This is to develop better bio-therapeutic agents from plant origin. Methods Bacteria were isolated from water, feed, crop, gizzard and faeces of layer chicken. Isolates of interest (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa an...
Article
Ethyl acetate extract of Smilax korthalsii A.D.C. leaves exhibited antiproliferative activity on leukaemia carcinoma K562, hepatic liver cancer cells WRL and colorectal carcinoma with IC50 of 125.20, 46.10 and 160.00 μM respectively. Isolation of the bioactive ethyl acetate extract of Smilax korthalsii A.D.C. leaves gave eight compounds; 3β-hydroxy...
Article
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Phytochemical analyses as well as antimicrobial and antioxidant activities of the extracts of C. sumatrensis aerial parts were investigated in this study. METHODS: The aerial parts of C. sumatrensis were air dried, weighed and exhaustively extracted with hexane, ethyl acetate and methanol successively. The crude extracts were screened for metabolit...
Article
Methanol extract of Alafia barteri leaves showed cytotoxic activity on leukaemia carcinoma K562, and hepatic liver cancer cells WRL (IC50 values 193.1 and 225.0 μM respectively). Isolation of the extract gave ursane triterpenoid, 28-acety-urs-5,20-dien-2β,3β,24α-triol, 1, together with undecanol, 2, stigmasterol, 3 and octadecanoic acid, 4. The str...
Article
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Ethnopharmacological significance: Nigerian herbalists possess indigenous ethnomedicinal recipes for the management of tuberculosis and related ailments. A collaborative preliminary modern scientific evaluation of the efficacy of some Nigerian ethnomedicines used by traditional medicine practitioners (TMPs) in the management of tuberculosis and re...
Article
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This study investigates the phytofungicidal potentials of aqueous extracts of Mangifera indica and Jatropha curcas on the Fusarium pathogens of millet seedlings in southwestern Nigeria. Aqueous extracts of M. indica and J. curcas prepared at 0.15, 0.30 and 0.45 mg/ml concentration levels were evaluated in-vitro using standard methods, while the in-...
Article
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Phytochemical investigation of the root extract of Terminalia glaucescens afforded three known compounds, ellagic acid 1, arjungenin 2, hypatic acid 3 and and a new triterpenoid named glaucescic acid, 2a,3a,6a,23-tetrahydroxyolean-12-en-28-oic acid 4. The structure and relative configuration of this new compound was elucidated on the basis of spect...
Article
The chemical composition of the essential oil from the leaves and the flowers of Albizia lebbeck (L.) growing in Nigeria were studied using GC and GC-MS. The leaves oil contains 24 compounds which constituted about 91.2 % of the oil and was dominated by aromatic hydrocarbons (35.9 %), oxygenated monoterpenes (32.3 %), n-hydrocarbons (13.7 %), alkan...
Article
α-and β-ionones and seven ionone derivatives were synthesized from the base catalyzed condensation of citral (obtained from lemon grass Cymbopogon citratus essential oil) with eight different ketones. The pseudo-ionones obtained were acid cyclized to the respective ionone derivatives which were purified by vacuum liquid chromatography(VLC). The pur...
Article
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In-vitro antibacterial and antifungal activities of methanol extracts of Desmodium adscendens (Sw.) DC root and Bombax buonopozense P. Beauv. leaves against some bacterial and fungal isolates implicated in oro-dental, urogenital and other opportunistic infections were investigated using standard microbiological methods. The extracts of D. adscenden...
Article
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Rabbits showed varied preferences in the order of their consumption of these four plants as meal: Syndrella nodiflora > Hyptis suaveolens > Aspillia africana > Chromolaena odorata. Chemical compositions with differences in levels of nutrients, palatability and odour may be responsible for the preferences observed. This study was targeted at examini...
Article
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Enzymes are proteins evolved by the cells of living organisms. Their specific function is to catalyse chemical reactions. Enzymes increase the rate at which reactions approach equilibrium. Enzymes have found wide and diverse applications in different disciplines and fields of human endeavours. Enzymes play critical role in the metabolic activities...
Article
Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical c...
Article
The present study seeks to evaluate the medicinal relevance of the Coffea brivipes extracts against some clinically identified strains of Mycobacterium tuberculosis, using standard methods of microbial sensitivity test and phytochemical analysis. The whole plant samples of Coffea brivipes were extracted with absolute ethanol. The ethanol extract of...
Article
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Essential oils have been important substances since early times. The review of its extraction methods and applications were treated in this study. These include hydrodistillation, hydrodiffusion, effleurage, steam distillation, cold pressing, solvent extraction, microwave assisted process and carbondioxide extraction. Its applications both the medi...
Article
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The hexane, ethylacetate and methanol extracts obtained from the whole plant of Asystasia gangetica were evaluated invitro to determine inhibition of human pathogenic microorganisms made up of six bacteria and six fungi. The crude extracts inhibited the growth of twelve test organisms to different degrees. All the bacteria strains were sensitive to...
Article
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Extracts from Jatropha curcas, a plant used in African traditional medicine for various diseases, were tested for cytotoxic activity. The root extracts strongly reduced cell growth of tumor cells in vitro, a result consistent with the knowledge of the application of these plant extracts in traditional medicine, especially to cure/ameliorate cancer....
Article
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Antioxidants are essential and important for plants and animals' sustenance. They are substances that protect cells from the damage caused by unstable molecules known as free radicals. The sources and origin of antioxidants which include fruits and vegetables, meats, poultry and fish were treated in this study. The types of antioxidants such as asc...
Article
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The chemical composition of the essential oil from the whole plant of Acalypha segetalis Muell. Arg. was analyzed by GC and GC/MS. Nineteen volatile constituents were identified. The main compounds were alpha-pinene (8.5%), neophytadiene, isomer II (14.7%) and neophytadiene, isomer III (33.6%). Toxicity and larvicidal assays revealed that the plant...
Article
The antimicrobial activities of two Nigerian medicinal plant commonly used as chewing sticks Zanthoxylum xanthoxyloides and Pseudocedrela kotschyi antimicrobial activities were investigated against 7clinical strains of Streptococcus mutans, Staphylococcus aureus ATCC 29213, Candida albicans, Candida tropicalis and Candida krusei ATCC 6825. The anti...
Article
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The uses of Brysocarpus coccineus stem in traditional African medicine have led to the antibacterial and antifungal activities of the hexane, ethylacetate and methanol stem extracts of the plant evaluation using six pathogenic bacteria and six fungi. The extracts inhibited the 12 test organisms to different degrees. Hexane, ethylacetate and methano...
Article
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The chemical composition of the essential oils obtained from fresh leaves and stems of Momordica charantia were analysed by GC and GC/MS. A total of fifteen and eleven compounds representing 61.20% and 79.60% of the leaf and stem essential oils of M. charantia were analysed, respectively. The major constituents in the leaf oil were heneicosane (21....
Article
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The antimicrobial activities of two Nigerian medicinal plant commonly used as chewing sticks Zanthoxylum xanthoxyloides and Pseudocedrela kotschyi antimicrobial activities were investigated against 7clinical strains of Streptococcus mutans, Staphylococcus aureus ATCC 29213, Candida albicans, Candida tropicalis and Candida krusei ATCC 6825. The anti...
Article
The stem and root barks of Quassia undulata were exhaustively extracted with methanol to give the methanolic extracts: MeQuS and MeQuR, respectively. The chloroform extracts were obtained and fractionated on an open column of silica gel by gradient elution with chloroform and chloroform–methanol mixtures. Purification of fractions afforded the isol...
Article
Jatropha multifida L. (Euphorbiaceae) is a multipurpose shrub commonly planted as an ornamental but often exploited as a medicinal plant in many parts of Africa. Many Jatropha plants have toxic and irritant properties and are used in folklore medicines to cure various diseases in Africa, Asia and Latin America [1]. As part of a continuing investiga...
Article
Abstract  Hexane, petroleum ether, chloroform, ethyl acetate, methanol and water extracts of Clausena anisata[(Willd.) Hook F. Ex Benth] leaves and roots were evaluated against Helicoverpa armigera (Hübner) for antifeedant activities. Antifeedant activity was confirmed, and was found to be higher in root extracts than those of the leaf. Chloroform...
Article
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The use of medicinal plants as raw materials in the production of new drugs is ever increasing because of their potentials in combating the problem of drug resistance in micro-organisms. Demand for medicinal plants is increasing in both developing and developed countries. Research on medicinal plants is one of the leading areas of research globally...
Article
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Chromatographic analysis of the defatted dichloromethane extract of the leaves of Heteropyxis natalensis afforded the isolation of (E)-1-(2',4'-dihydroxy, 5'-methoxy, 3'-methylphenyl)-3-phenylprop-2-en-1-one (R1 = Me; R2 = OH; R3 = OMe; R4 = H) a chalcone. The structure of this compound was established by its spectroscopic data-1D, 2D-NMR, EIMS and...
Article
In the present study, we have examined the effects of an ethyl acetate extract of Melaleuca bracteata on gastric acid secretion and indomethacin-induced ulceration. The plant is popularly known for its ornamental use in South Africa. Gastric acid secretion was studied using modified method of continuous acid secretion while gastric ulcers were prod...
Article
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A new aliphatic acid named japodic acid (1) with a gem-dimethyl cyclopropane ring has been isolated from the roots of Jatropha podagrica. Its structure was established by 1D and 2D NMR and mass spectrometric data. Two other known compounds, erythrinasinate (2) and fraxidin (3) were also isolated from this plant for the first time. Japodic acid show...
Article
Trichilia heudelotii (Th) (Meliaceae) is common in the western part of Nigeria and is commonly used in traditional medicine for the treatment of many microbial infections ranging from gastrointestinal infections to gonorrhoea. The preliminary phytochemical screening revealed the presence of tannins, saponins, alkaloids, cardenolides and anthraquino...
Article
Jatropha curcas and Jatropha multifida are ornamental, medicinal plants belonging to the family Euphorbiaceae. Many Jatropha plants have toxic and irritant properties and are used in folklore medicines to cure various infections in Africa, Asia and Latin America [1]. As part of a continuing investigation of the biological activity of Jatropha speci...
Article
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There are two major steps in the synthesis of pleasant fragrant α- and β- campholene nitriles from camphor. The first is the reaction of hydroxylamine with camphor to give the camphoroxime, which rearranges in the presence of acid during the second step to give eitherα- or β- or both αβ- campholene nitriles. The nature of the acid determines the ty...
Article
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This study was carried out to investigate the antimicrobial activity of the plant against different microorganisms especially those responsible for sexually transmitted infections which is becoming endemic in Africa. Hexane, ethyl acetate and methanol extracts of the plant and chromatographic fractions were screened against seven pathogenic organis...
Article
Japodagrin (1) and japodagrone (2), two macrocylic diterpenoids possessing lathyrane and jatrophane skeletons, respectively, have been isolated from the root of Jatropha podagrica Hook. Four other diterpenoids (3-6) were also isolated from this plant. The structures of these compounds were elucidated on the basis of NMR and HRMS analysis, and by sp...