Olalekan Stephen Ojerinde

• B.Sc (Ind.Chemistry), M.Sc (Pharmaceutical Chemistry)
• Lecturer at University of Jos

Herbal medicines remain a major birthplace of lead compounds for drug discovery and development. Adenodolichos paniculatus Hua & Hutch (Fabaceae) is a plant whose root bark was claimed to be used against diabetes mellitus and cancer in traditional medicine. This study aimed to isolate antiproliferative compounds from root barks of Adenodolichos pan...

Adenodolichos paniculatus Hua & Hutch (Fabaceae) is a plant whose roots are traditionally employed for the treatment of non-communicable diseases such as diabetes and cancer. The powdered root bark of Adenodolichos paniculatus were extracted with dichloromethane followed by 70% methanol to afford dichloromethane (DCM) and hydromethanolic (HME) extr...

Plectranthus esculentus N.E.Br. (family Lamiaceae) also known as Livingstone potato (vat or rizga in Nigeria), is a dicotyledonous perennial shrub growing up to 2 m tall. While it is cultivated mainly for its edible tubers, the plant is potentially valuable as phytomedicine. Three varieties (vat-long’at, vat-riyom and vat-bebot) are well known amon...

The aim of this study was to investigate the antimicrobial, antioxidant and antiproliferative activities of leaves of Senna siamea. A sequential solvent extraction procedure was used in extracting powdered Senna leaves, starting with hexane, ethylacetate, ethanol and distilled water, respectively. Dry extracts obtained were tested at various concen...

The incidence and prevalence of cancer has been on the rise in recent years and this has been linked to environmental factors, adoption of westernized lifestyle and aging populations. This situation is further complicated by the inadequacies of currently used anticancer agents such as toxicity and resistance which has prompted the search for new an...

Carissa edulis Vahl (Apocynaceae) is a plant whose leaves, roots and fruits are traditionally employed for the treatment of malaria, microbial infections, headache, cough, fever and ulcer among many others. Fresh fruits of Carissa edulis were crushed and extracted with 70 % methanol for 72 hours to obtain MeOH extract. Proximate analysis as well as...

Three varieties of Plectranthus esculentus (Livingstone potato) are grown for their edible tubers by Berom people of Nigeria. Phytochemical, antimicrobial and antioxidant screening; with quantification of total phenols and flavonoids were carried out on hexane, ethyl acetate, methanol and aqueous extracts of leaves and tubers of each variety. Resul...

Boswellia dalzielii is the West African species of the frankincense producing genus (B. carterii, B. frereana and B. serrata are the more popular congeners). Its ethnobotanical uses include the treatment of rheumatism, venereal diseases and gastro-intestinal disorders, among others.Scientific investigations were carried out to evaluate the biologic...

Boswellia dalzielii is the West African species of the frankincense producing genus (B. carterii, B. frereana and B. serrata are the more popular congeners). Its ethnobotanical uses include the treatment of rheumatism, venereal diseases and gastro-intestinal disorders, among others.Scientific investigations were carried out to evaluate the biologic...

This work aims to evaluate the total phenolic and flavonoid contents, and antioxidant and Antiproliferative activities of the stem bark of Boswellia dalzielii. Hundred gram (100 g) of methanolic extract was re-dissolved in 70% methanol and partitioned exhaustively with different solvent hexane and ethyl acetate in a separating funnel; and this meth...

Detarium microcarpum commonly known as ''sweet detar'' has been used for centuries in Nigerian traditional system of medicine for the treatment of diabetes. The present study deals with the scientific evaluation of the in-vitro alpha amylase, alpha glucosidase and the antioxidant potential of various leaf extracts of the plant by examining the free...

The objective of the study was to further examine the medicinal value of Boswellia dalzielii plant by evaluating the antifungal activity and carrying out phytochemical screening of methanolic extract, hexane, ethyl acetate, aqueous fractions and the sub-fractions of the stem bark of the plant. Standard methods were used for the evaluation of phytoc...

Free radicals damage is responsible for the development many chronic health problems. 3 analogues of L-arginine were synthesized and their structures were confirmed with FTIR, 1H and 13C NMR. Molecular properties and bioactivity prediction of the synthesized compounds was carried out with molinspirationsoftware. The antioxidant activity of the synt...

The prevalence of Type 2 diabetes mellitus is on the rise and treatment failure is common. New agents that have superior profile in diabetic treatment are therefore needed. This present study investigates the aqueous and ethanolic extracts of the fruiting bodies of the basidiomycetes Lyophyllum connatum and Tuber melanosporum for antioxidant and hy...

Kanwa and Shem are food additives and also local dietary salts which are commonly used in Nigeria for various purposes both in rural and urban communities. Kanwa and Shem were subjected to acute toxicological studies using the modified Lorke method while the elemental, qualitative analysis and pH were determined by employing standard methods. The F...

Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus the disease constitutes a major health concern. Presently, it is an incurable metabolic disorder which affects about 2.8% of the global population. This study, investigate the antidiabetic effect of methanolic leaf extract of Crossopteryx febrifuga in alloxan in...

Tea which is one of the most widely consumed beverages after water, contains diverse polyphenols such as flavonoids and other catechins. These polyphenols confer anti-oxidant properties on tea with the capacity to slow down or prevent oxidation of other molecules. Ten instant tea brands were tested for purity and anti-oxidant properties. Qualitativ...

Most fungi occur in nature and utilize simple sources of carbohydrates and nitrogen for growth. Sabouraud's dextrose agar has been an ideal medium for primary isolation of fungi from clinical specimens, but for specimens from nonsterile sites or heavily contaminated ones, it has been necessary to include inhibitory substances such as antibiotics li...

Boswellia dalzielii is the West African species of the frankincense producing genus ( B. carterii, B. frereana and B. serrata are the more popular congeners). Its ethnobotanical uses include the treatment of rheumatism, venereal diseases and gastro-intestinal disorders, swellings/ growths on the skin, among other things. The anti-inflammatory, anti...