Oladoja Awofisayo

Objectives: Diabetes is increasingly recognized as a serious, worldwide public health concern. By early identifying those at risk to develop diabetes and if confirmed to be at pre-diabetes stage adequate care provided for them through lifestyle interventions or even hypoglycemic medications if necessary, thus delaying or preventing their progressio...

Objectives: The need for new antimalarials drugs and drug targets is pertinent due to the emergence of drug resistant strains of the parasites. Improper target selection has resulted in therapeutic failure. The genomic/post genomic era has made possible the deciphering of the 3D crystal structures of proteins and DNA which are drug targets and are...

Aim: To determine the effect of analogy and dimerization of bioactive compounds at the molecular level on the biological functions. Methodology: This work was carried out on a model set of bioactive compounds which consisted of resveratrol, piceatannol, isorhapontigenin, scirpusin A and scirpusin B, using computational methods which include target...

The aqueous extract of the dried root was investigated to determine its total yield, phytochemical constituents, acute toxicity, anti-inflammatory and anti-pyretic activities in groups of Wistar rats. The methanol crude extract and the n-hexane, dichloromethane, ethylacetate and butanol fraction of the stem bark of Nauclea latifolia were investigat...

The effect of ethanolic extracts of the leaf, seed and fruit of Telfairia occidentalis on oral glucose tolerance was determined. 500 mg/kg of the leaf, seed and fruit extracts were administered separately to a set of overnight fasted rats simultaneously with glucose solution (1 g/kg). Also, 500 mg/kg of the extracts were separately administered 45...

This study aimed at evaluating some quality control parameters to compare the quality, safety, and efficacy of nine brands of ofloxacin tablets available in the Nigerian market. The physicochemical parameters and assay of the nine brands of ofloxacin tablets were assessed through the evaluation of uniformity of tablet weight, friability, hardness,...

Purpose: A simple, reliable and rapid chemical identification system (RCIS) consisting of three colour reactions based on the functional groups in the molecule and two TLC methods was developed for preliminary detection of the 5–nitroimidazole drugs.Methods: Three members of this group of drugs (tablet form) available in the Nigerian market and lab...

The present work was undertaken to evaluate the effects of the aqueous and ethanolic leaf extracts of M. paradisiaca on some biomolecules in rats. Five groups of albino rats were respectively treated orally with 250 and 1000mg/kg of ethanolic extract, 250 and 1000 mg/kg of aqueous extract, and saline water daily for 28 days. Blood was collected on...

Various parts of Musa paradisiaca have been well established to possess medicinal value. The objective of this work was to determine the effect of the aqueous and ethanolic leaf extract of M. paradisiaca on the blood. Two hundred fifty and 1000mg/kg doses of ethanolic extract, 250 and 1000 mg/kg dose of aqueous extract, and saline water were given...

Purpose: The widespread use of non-steroidal anti-inflammatory drugs (NSAID) has meant that the adverse effects of these relatively safe drugs have become increasingly prevalent. This work examines the pattern of sale and use of NSAIDs as to call for caution in cases of misuse that may lead to renal, gastrointestinal and cardiac damage in users. Me...

The work involves the development of basic tests for sildenafil citrate (drug substance) and sildenafil citrate tablet (dosage form). The Basic Tests encompass physical observation, melting characteristics, colour and other test reactions for the drug substance and the dosage form. These tests are supplemented with thin layer chromatography. The te...