Oktavia Indrati

• Islamic University of Indonesia

ABSTRAK Amoksisilin yang mengandung gugus fungsi betalaktam sering diberikan dalam bentuk serbuk/puyer yang diperoleh dengan menggerus tablet agar mudah ditelan oleh anak-anak. Perubahan bentuk tablet amoksisilin menjadi serbuk dan penyimpanan selama 10 hari dapat mempengaruhi stabilitas dan efektivitas obat. Tujuan dari penelitian ini adalah untuk...

Background: Pediatric patients frequently receive prescriptions for erythromycin due to its availability in chewable tablet form. Some conditions lead to the powdering of chewable tablets to enhance patient acceptability. Modifying the dosage form of chewable tablets into powder can change the drug's surface, affecting its physical stability and ef...

This study aimed to optimize the diclofenac sodium (DS)-loaded nanoemulsion (DSNE)s components, to characterize the optimum formula of DSNEs, including determining its skin penetration ability. DSNEs were optimized by the aqueous titration method to decide the optimum ratio of each component. The yielded diagram of pseudo-ternary phase was used on...

Introduction: Andrographolide is a compound that shows various pharmacological activities, which can be applied topically or orally. Nanoemulsion can improve drug solubility and stability, but has limitations for topical application. Incorporation of nanoemulsion into hydrogel can increase the viscosity of the system which can prolong the drug res...

Plantago major L. (Plantaginaceae) is widely used to treat various diseases. It is reported to have anti-microbial, anti-diabetic, anti-spasm, anti-inflammatory activity and wound healing properties. P. major contains biologically active compounds such as polysaccharides, flavonoids, iridoid glycosides, terpenoids, and alkaloids. 1 Despite several...

Objective: The purpose of this present study was to describe the employment of infrared (IR) spectroscopy and high-performance liquid chromatography with ultraviolet detection (HPLC-UV) method in determining the identity and purity of bulk material containing andrographolide.Methods: Attenuated total reflectance (ATR)-Fourier transform infrared (FT...

Melinjo seeds (Gnetum gnemon L.) have antioxidant properties one of which is from phenol compounds. However, there is no pharmaceutical dosage form of melinjo seeds especially effervescent tablet. The purpose of this research was to determine the best variation of citric-tartaric acid and PEG 6000 from effervescent tablet of melinjo seed extract....

Indonesia adalah negara tropis yang memiliki banyak tumbuhan, salah satu fungsinya bisa menjadi bahan pembuatan obat-obatan seperti pati dan umbi. Amilum dari umbi talas (Colocasia esculenta) berpotensi dikembangkan menjadi bahan tambahan obat tetapi peggunaannya masih terbatas. Tujuan dari penelitian ini yaitu mengkaji formulasi yang optimal dan m...

Starch is an economical excipient that is used in oral dosage form. It has poor compressibility and flowability. Pregelatinization and co-process as a physical modification technique have been conducted widely; nevertheless, the single modification shows a limitation. This study aims to assess and characterize the starch result of the modification...

Inflammation is a normal protective response for tissue injury by physical trauma, damaging chemicals or microbiologic substances. One of the plants that used empirically for inflammatory disease is Plantago major. Aim of this study was to formulate the ethanolic extract of P.major in microemulsion as a topical drug delivery system and determine it...

Lidah buaya (Aloe vera) mengandung komponen seperti acetylated mannans, polymannans, anthraquinone C-glycosides, anthrones, anthraquinones dan berbagai jenis lectins. Komponen dalam lidah buaya yang bermanfaat sebagai laksatif adalah anthraquinon glycoside. Salah satu sediaan farmasi yang menarik adalah tablet effervescent, dimana bentuk sediaan in...