Oksana Yanshyna

• PhD
• Postdoctoral fellow at Weizmann Institute of Science

The architecture of self-assembled host molecules can profoundly affect the properties of the encapsulated guests. For example, a rigid cage with small windows can efficiently protect its contents from the environment; in contrast, tube-shaped, flexible hosts with large openings and an easily accessible cavity are ideally suited for catalysis. Here...

Confining molecules within well-defined nanosized spaces can profoundly alter their physicochemical characteristics. For example, the controlled aggregation of chromophores into discrete oligomers has been shown to tune their optical properties whereas encapsulation of reactive species within molecular hosts can increase their stability. The resazu...

We show that the optical properties of indigo carmine can be modulated by encapsulation within a coordination cage.

Sustainable energy storage devices are required in view of the current demand for environmentally friendly technology. We fabricated a fully recyclable electrochemical doublelayer supercapacitor (EDLC), based on multiwall carbon nanotube (MWCNT) electrodes, organic nanocrystalline (ONC) dielectric membrane, and aqueous electrolyte. The entire EDLC...

Reaction of chloroximes bearing protected amino group and active methylene nitriles under basic conditions is described. It is shown that functionalized 5‐aminoisoxazoles are obtained in 37‐78% yields. The method has a broad substrate scope, which includes acetonitriles with CN, CO₂Me, SO₂Me groups or heterocyclic substituents at the α‐position. Mo...

Invited for the cover of this issue is the group of Pavel K. Mykhailiuk at the Taras Shevchenko National University of Kyiv and Enamine Ltd. The image depicts spirocyclic pyrrolidine—a novel building block for drug discovery. Read the full text of the article at 10.1002/chem.201702362.

The cover picture shows novel building blocks for drug discovery—spirocyclic pyrrolidine. The synthesis starts from common four-, five-, six- and seven-membered-ring ketones and includes only two chemical steps. The key transformation is the reaction between electron-deficient exocyclic alkenes and in situ generated N-benzyl azomethine ylide. The h...

Novel spirocyclic pyrrolidines were synthesized in two steps from common 3- to 7-membered (hetero)alicyclic ketones. The key transformation was the reaction between electron-deficient exocyclic alkenes with in situ generated N-benzyl azomethine ylide. The method was used to synthesize the central diamine core of the known antibacterial agents - Sit...