Okan Gulbahar

Okan Gulbahar
Ege University · Faculty of Medicine

MD
Allergos Alerji Klinigi

About

47
Publications
15,874
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Introduction
Okan Gulbahar currently works at the Faculty of Medicine, Ege University, and Allergos Allergy Clinic. Okan does research in Allergology and Clinical Immunology. Founder of Turkish Hereditary Angioedema Working Group. Founder of Hereditary Angioedema traveling school. Their current project is 'Hereditary Angioedema with normal C1 Inhibitor'.

Publications

Publications (47)
Article
Full-text available
Angioedema without wheals (urticaria) represents a heterogeneous group of clinically indistinguishable diseases of hereditary or acquired etiology. Hereditary angioedema (HAE) is a rare inherited condition leading to recurrent, sometimes life-threatening angioedema attacks in subcutaneous tissues, gastrointestinal and oropharyngeal mucosa dating ba...
Article
Full-text available
HAE is a rare hereditary disease that causes recurrent angioedema attacks. Attacks are often disturbing. However, it can sometimes cause death due to laryngeal edema. The disease is often not considered, and therefore the diagnosis of patients is often delayed. Although it was first described in the 19th century, pathogenesis was understood at the...
Book
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Bees are considered the most beneficial insect species for humanity among all insects. They allow plants, including fruits and vegetables, to reproduce through pollination. Although they play a crucial role in maintaining the natural cycle, most people are afraid of bees and try to stay away. There is a good reason for this: Bees sting. For most pe...
Article
Full-text available
Hereditary angioedema due to deficiency of the C1‐inhibitor (HAE‐C1INH; MIM#106100) is a rare autosomal disorder and affected individuals are generally heterozygous for dominant negative variants in the SERPING1 gene. Homozygosity for SERPING1 pathogenic variants was long considered to be embryonically lethal; however, five non‐related families wit...
Article
OBJECTIVE: Hereditary angioedema is a serious disease with unpredictable attacks. It has an impact on patients' health-related quality of life. This study aimed to assess the quality of life of the hereditary angioedema patients and to investigate the relationship between quality of life and demographic, clinical, laboratory, and psychiatric parame...
Article
Full-text available
Background: How genotype affects phenotype in hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) has not been totally clarified. In this study, we investigated the relationship between different types of mutations and various phenotypic characteristics. Methods: Clinical data from 81 patients from 47 families were recorded. Compleme...
Article
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Objective: Aim of the present study is to evaluate the effectiveness of Basic Communication and Coping with Difficult Situations Skills Training, which includes two different therapy techniques, on the burnout level and job satisfaction of hospital office staff. Method: Communication Skills Training was applied to hospital office staff (n=54). Psyc...
Article
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Background: It has been suggested that latex-specific IgE analysis may lead to false-positive results, especially in patients with pollen allergy. In the present study, the reasons underlying clinically irrelevant latex-specific IgE positivity were investigated. Methods: Thirty patients with latex allergy (group 1), 89 patients sensitised to aer...
Conference Paper
Full-text available
Comparing pathways of kinin formation in human whole blood: generating endogenous agonists of the bradykinin B2 and B1 receptors François Marceau1, Georges-É. Rivard2, Arnaud Bonnefoy2, Éric Wagner1 and Xavier Charest-Morin1 1CHU de Québec – Université Laval, Quebec City, QC, Canada G1V 4G2 2CHU Ste-Justine, Montréal, QC, Canada H3T 1C5 Backgrou...
Conference Paper
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Table of contents Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recogni...
Conference Paper
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Table of contents Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101) P92 16 years of experience with proton pump inhibitors (PPIs) Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez P93 Allergy evaluation of quinol...
Article
Full-text available
Objective: Hereditary angioedema (HAE) is a rare genetic disorder characterized by episodes of swelling in the skin, gastrointestinal tract and larynx. Laryngeal attacks can be fatal, especially in mis-/undiagnosed cases. In Turkey, the mean diagnostic delay of HAE is as long as 26 years. This study was conducted to assess Turkish doctors’ awarenes...
Article
CVID is characterized by hypogammaglobulinemia, recurrent respiratory and gastrointestinal bacterial infections. Good’s Syndrome(GS) is a thymoma-related immunodeficiency and characterized by hypogammaglobulinemia, decreased B cell and variable deficiencies in cell-mediated immunity. Case: A 47-year old male patient presented with a palpable anteri...
Article
No detailed information currently exists about the immune phenotypic profiles of peripheral blood stem cells (PBSCs) obtained by different mobilization regimens. The effects of these profiles on the outcome of transplantation are largely unknown. In this prospective study, the surface immune phenotypic features (CD11a, CD18, CD31, CD38, CD44, CD62e...
Poster
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About the impact of hereditary angioedema on patients´ daily life.
Poster
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How familiar are doctors in Turkey with hereditary angioedema?
Poster
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Subcutaneous immunotherapy with single or multiple allergens in monosensitised or polysensitised patients: clinical efficacy and the effects on health related quality of life.
Article
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In the Medical Faculty of Ege University, indoor airborne fungal concentrations and the types of fungi have been determined in the two parts and the intensive care unit where patients who are admitted to the Department of Internal diseases, Department of Endocrinology, Department of Hematology, Department of Immunology, Department of Nephrology, De...
Article
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It has previously been demonstrated that subcutaneous immunotherapy with allergoids positively affects clinical and immunological parameters even after 7 preseasonal injections. However, its effect on basophil activation remains unclear. We investigated the effect of preseasonal allergoid immunotherapy on basophils and concomitantly assessed its cl...
Article
Full-text available
The precision of the methods used to diagnose latex allergy is of great importance due to false-positive results. Neither the skin prick test (SPT) nor the latex-specific IgE assay has 100% diagnostic accuracy. We analysed the diagnostic value of latex-specific IgE by the first-ever concomitant use of the SPT and nasal provocation test (NPT). Twent...
Article
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ABS TRACT Ob jec ti ve: Ex po su re to in do or al ler gens du ring child ho od has be en as so ci a ted with an in cre a sed risk of sen si ti za ti on. The re is no da ta abo ut in do or al ler gen le vels in day-ca re cen ters in Tur key. We hypot he si zed that day-ca re cen ters (DC) wo uld be re le vant so ur ces of cat and mi te al-ler gens....
Article
Full-text available
No published data presently exist concerning hereditary angioedema (HAE) in Turkey. The aim of the study was to initiate a preliminary multicentric evaluation about HAE and to determine the genetic properties of Turkish patients. Based on records drawn from four medical centers we identified a total of 70 subjects, belonging to 60 unrelated familie...
Poster
Full-text available
About Hereditary Angioedema.
Article
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ZET Herediter anjiyoödem, fatal larinks ödemine ve gast-rointestinal sistem tıkanıklığına benzeyen bulgulara yol açabilen, tekrarlayıcı anjiyoödem ataklarıyla ka-rakterize, nadir görülen, otozomal dominant geçişli bir hastalıktır. Atakları sıklıkla travma, stres, hormonal tedaviler ve ACE inhibitörleri tetikler. Tanı, C4 ABSTRACT Hereditary angioed...
Article
Full-text available
Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia, defective antibody production, and recurrent upper and lower airway tract infections. To reveal the clinical heterogeneity of this condition, analyze the high frequency of respiratory and gastrointestinal complications despite satisfactory trough immunoglobulin (Ig)...
Article
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In this research, in order to determine mean fungus counts, indoor and outdoor air samples were taken in five elementary school buildings located in the city center of Seferihisar, Izmir (45 km from Izmir) within a 1-year period between March and April 2004, and between January and February 2005 representing similar climatic characteristics. Five s...
Article
Most studies regarding natural rubber latex (NRL) allergy have concentrated on the prevalence using skin prick test (SPT) and specific IgE assay. The objective of this study is to examine the target organ (skin, nasal mucosa) responses in patients with positive SPT to NRL using the nasal provocation test (NPT) and glove use test (GUT). Four thousan...
Article
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In order to prevent and control non-communicable diseases (NCDs), the 61st World Health Assembly has endorsed an NCD action plan (WHA resolution 61.14). A package for essential NCDs including chronic respiratory diseases (CRDs) has also been developed. The Global Alliance against Chronic Respiratory Diseases (GARD) is a new but rapidly developing v...
Article
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We report the case of a 28-year-old man who presented palatal itching and genaralized urticaria following ingestion of olive 3 years after being diagnosed with olive pollinosis. The patient did not have a history of food allergy or urticaria. The results of skin prick tests with aeroallergens including latex were positive for house dust mite and ol...
Article
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Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and a defect in antibody production. Herein we describe 3 patients diagnosed with CVID in whom vitamin D deficiency was detected in the absence of enteropathy. Biochemical and immunological analysis, serum osteocalcin, parathyroid hormone, 25-OH vitamin D, 1,25(OH)(2)...
Article
Full-text available
Pollens from the Cupressaceae family are considered important allergens in the Mediterranean area, though reports of the prevalence of allergic symptoms have ranged from 1.04% to 35.4%. Our aim was to detect the prevalence of cypress pollen sensitization and determine its clinical importance in patients with seasonal respiratory allergy. We used sk...
Article
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We report newly presenting systemic and local allergic reactions to egg in a 55-year-old woman. The patient did not have a history of egg allergy in childhood or occupational exposure to egg proteins; nor did she report any disease that is known to be related to food allergy. A skin prick test with commercial extracts, prick-to-prick test, CAP radi...
Article
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Background. – Subcutaneous allergen immunotherapy is considered as effective and safe in allergic patients. Although mild local cutaneous reactions occur frequently, the development of persistent nodules at the injection site is a rare event. We describe a case with unusual persistent nodular reactions at the sites of previous immunizations incorre...
Article
Arthritis is an important and sometimes life-threatening complication in patients with common variable immunodeficiency (CVID). To describe a patient with CVID and arthritis due to Chlamydia pneumoniae, which is usually regarded as a respiratory tract pathogen and has not previously been detected in the synovial fluid by cell culture technique. Rou...
Article
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More than 250 cases of allergic contact dermatitis due to propolis have been described. A few of these occurred in beekeepers. To describe a case of psoriasiform dermatitis caused by propolis in a beekeeper who thought that his lesions were related to honeybee stings. A 45-year-old beekeeper experienced hand dermatitis for the past 5 years. He beli...
Article
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Cockroach (CR) infestation is an important cause of sensitization in allergic individuals. We investigated the prevalence and the characteristics of sensitivity to CRs in patients with respiratory allergy in Izmir. Three hundred and fifty-four patients with allergic rhinitis and/or asthma responded to a questionnaire and were prick tested with CR e...
Article
Patients with allergic rhinitis and bronchial hyperresponsiveness (BHR) may be at higher risk of developing asthma. To investigate whether reactivity to aeroallergens in skin prick testing (SPT) and serum eosinophil cationic protein levels can be used to predict BHR in allergic rhinitis patients. Fifty-nine consecutive patients with allergic rhinit...
Article
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Allergic reactions to latex are common in patients with spina bifida. Its incidence varies between 28% and 67%. The aim of this study was to investigate the incidence of latex allergy and its risk factors in patients with spina bifida in Izmir, Turkey. Forty-six patients (24 male, mean age 10 years) were included in the study. A questionnaire was c...
Article
Recent studies suggest that autoimmune mechanisms may be involved in the etiology of chronic idiopathic urticaria (CIU). There is a higher prevalence of B12 deficiency in autoimmune diseases and possibly in gastric Helicobacter pylori (H. pylori) infection. The frequency of B12 deficiency in CIU is unknown. Our objective in this study was to determ...
Article
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Cats represent one of the most important sources of indoor allergens. The sensitization rate can reach up to 60% in western countries. Keeping cats indoors is uncommon in big cities in Turkey, but cats living in the streets are common. To investigate the prevalence of sensitization to cats in patients with respiratory allergy from Izmir, Turkey, an...
Article
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Extensive and severe hepatic centrilobular hemorrhagic necrosis is a common finding in hepatic vein obstruction and Budd-Chiari syndrome. Some drugs, including allopurinol, can also cause this histopathologic appearance but to our knowledge in this setting the lesions are not so massive. Here we report a case of a 41-year-old female who developed f...

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