Ojochenemi E. Yakubu

Ojochenemi E. Yakubu
Federal University Wukari · Department of Biochemistry

B.Sc. KSU. M.Sc. ABU. Ph.D Nig.
Deciphering mechanism of action for newly purified active agents.

About

95
Publications
31,726
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307
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Introduction
Ojochenemi Yakubu currently works in the Department of Biochemistry, Federal University Wukari. Their current project is 'Bioassay-guided fractionation, Purification of active ingredients and Determination antioxidant, hepatoprotective and antidiabetic activities of of some indigenous medicinal plants'.
Additional affiliations
October 2017 - present
Federal University Wukari
Position
  • Professor (Associate)
Description
  • Involved in Teaching Research and community Service.
Education
September 2011 - November 2014
University of Nigeria Nsukka
Field of study
  • Pharmacological Biochemistry

Publications

Publications (95)
Article
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Proteins are the basis of cellular and physiological functioning in living organisms, and the physical and chemical properties of proteins dictate their activities and functions. The primary sequence of a protein is a main determinant of protein folding and final conformation as well as biochemical activity, stability, and half-life. Post-translati...
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Yakubu OE, Abu MS, Akighir J, Onuche JI, Arabi A. 2021. Comparative determination of total antioxidant effects of ethanol extract of Phyllanthus amarus leaves. Biofarmasi J Nat Prod Biochem 19: xxxx. Some medicinal and therapeutic potency have been reported of Phyllanthus in traditional settings. Hence, the current study evaluated the total antioxi...
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Abu MS, Yakubu OE, Onuche JI, Okpe O. 2022. Lipid profiles, hematological parameters and histopathological analysis of CCl4-intoxicated wistar albino rats treated with n-butanol extract of Ficus glumosa leaves. Cell Biol Dev 6: 6-12. This research critically assessed the effect of n-butanol fraction of methanol extract of Ficus glumosa Delile leave...
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Yakubu OE, Bando DC, Zephaniah M, Umaru IJ, Abu MS. 2021. Kidney function status of Wistar rat treated with ethanolic extract of Phyllanthus amarus leaves owing to diethylnitrosamine intoxication. Asian J Trop Biotechnol 19: 6-9. The kidney plays a central role in detoxification and excretion of harmful metabolites and therefore is susceptible to t...
Article
Yakubu OE, Abu MS, Akighir J, Onuche JI, Arabi A. 2021. Comparative determination of total antioxidant effects of ethanol extract of Phyllanthus amarus leaves. Asian J Nat Prod Biochem 19: 81-85. Some medicinal and therapeutic potency have been reported of Phyllanthus in traditional settings. Hence, the current study evaluated the total antioxidant...
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This work compared the nutritional and phytochemical compositions, antioxidant capacities of fermented castor oil and soursop seeds. The seeds of castor oil and soursop were fermented traditionally and standard methods were applied for the determination of the phytochemical, proximate, vitamins, minerals and in vitro antioxidant activity. The phyto...
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Forensic toxicology is a field of science that deals with the detection, identification and isolation of drugs, chemicals and other xenobiotics in the biological specimens as well as interpreting the results for medical and other legal investigations. This field encompasses toxicologists and other experts in disciplines such as biochemistry, pharma...
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Background The fruits of Xylopia aethiopica and seeds and leaves of Piper guineense are commonly used as spices. Due to their wide use in nutrition and traditional medicine, there is need to examine the biochemical and histological effects of ethanolic extracts of fruits of Xylopia aethiopica and seeds and leaves of Piper guineense on liver and kid...
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p class="abstract"> Background: Induction of toxicity using nitrosamines provides a reliable animal model for the study of oxidative damage to lipids, cellular membranes, proteins and DNA. In the present report, the effects of partially purified fractions of Senna occidentalis leaves on diethylnitrosamine intoxicated rats were studied. Methods: Fra...
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Medicinal plants have been the mainstay of traditional herbal medicine. Their medicinal properties are due to the presence of phytochemicals which exert pharmacological effects on the body. In this study, phytochemicals from partially purified fractions of ethanolic extract of Senna occidentalis leaf were comparatively determined using GC-MS. Fract...
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Liver plays crucial roles in transforming and clearing toxic chemical substances ingested into the body and thus needs to be investigated for wide spectrum of protective and ameliorative therapeutic agents that are readily available and affordable. In this study, ameliorative effects of fractionated crude methanol extract of Ficus glumosa leaves ag...
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Abstract Liver plays crucial roles in transforming and clearing toxic chemical substances ingested into the body and thus needs to be investigated for wide spectrum of protective and ameliorative therapeutic agents that are readily available and affordable. In this study, ameliorative effects of fractionated crude methanol extract of Ficus glumosa...
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ABSTRACT Background: There is paucity of experimental evidence on the complementary use of standard anti-diabetic drugs with herbal formulations. Materials and Methods: In this study, extracts of Annona muricata (AME) and Tapinanthus globiferus (TGE) were administered with metformin to diabetic rats in order to study the potential complementary eff...
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Lipsticks and lip-glosses are common beautifying cosmetics used by young and matured ladies for the purpose of appearing attractive. The unfortunate incidence however is that while so many doubt its toxicological effects, it has carcinogenic effect that develops over a long period of time. The objective of this work is to, evaluate the hazard quoti...
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Background: Ficus glumosa parts have been previously used as food and in folklore medicine in several African countries. It therefore necessitated this study to scientifically substantiate the active ingredients that may be responsi�ble for the efficacy of the plant and to know whether or not the consumption poses any deleterious effect on the c...
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Background: Ficus glumosa parts have been previously used as food and in folklore medicine in several African countries. It therefore necessitated this study to scientifically substantiate the active ingredients that may be responsible for the efficacy of the plant and to know whether or not the consumption poses any deleterious effect on the cells...
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Background and Objective The use of medicinal plants in industrialized societies for extraction and development of many drugs and other chemotherapeutics and traditionally for herbal remedies has increased in recent times. Plant–based medicine is essential in health care services with about 80% global population relying on it because of its cheap s...
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Aflatoxins are mostly toxic secondary fungal metabolites which are derived from some certain strains of fungi such as species of Aspergillus, specifically Aspergillus flavus, Aspergillus parasiticus and they are quickly absorbed by blood cells in the human body if consumed in any aflatoxin contaminated food. It can also lead to serious threats to b...
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This study considered the use of crude cellulase sourced locally to improve the yield of fat extracted from shea kernels. The enzyme was produced by submerged fermentation using Aspergillus fumigatus with palm frond as carbon source. Shea fat was extracted with the aid of crude enzyme (cellulase) and compared with fat extracted from shea kernels tr...
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Abstract Background and objective: Rats were first used for experimental purposes in the mid-18th century. The availability of these rats and their survival rate for experimental purposes has been a major challenge throughout most research institutes and universities across Nigeria. Materials and methods: Twenty albino rats were separated in twos (...
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The study evaluated the proximate composition and amino acid contents of selected legumes and Hura crepitans seed in Wukari,Taraba State, Nigeria. The Sand box seeds were collected from its tree in Wukari town, while black eyed pea and red kidney beans were purchased from Wukari market. The samples were processed into powder for proximate compositi...
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This study aimed at instituting the standard values of CD4 and CD8 total counts among apparently healthy pregnant women in Wukari, Nigeria. Sixty (60) apparently healthy pregnant women age group of 18-40 years and thirty (30) non-pregnant women (control) age 18-40 were used as participants in the study. The pregnant individuals were divided into th...
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This study investigated the nutritional composition and pesticide residue levels in cereal grains sold in Wukari market, Taraba State, Nigeria. Standard methods of AOAC were used for the nutrient analysis of the samples (wheat, sorghum, millet and maize). The organophosphate pesticide residue analysis was based on QuEchERs (Quick, easy, cheap, effe...
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Aims and objectives: The aim of this study is to look at the influence of different concentrations from the different solvent extracts of Barringtonia asiatica on selected pathogens. Material and Methods: Barringtonia asiatica extracts were evaluated for their functional potential antimicrobial properties. The leaves of the plant were extracted wit...
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Ringworm is a global infection that is treated using various antifungal agent including plant extracts. A survey was carried out among one hundred and twenty (120) pupils (eighty (80) males and forty (40) females) in schools in Wukari to determine the traditional treatment of ringworm infection among children using chickweed (Stellaria citrifolia)...
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Background and Objective: Environmental pollution is occurring on a vast and unprecedented scale around the globe, with mining activities been implicated. The study quantified the levels of heavy metals in soil and water samples from Mambilla artisanal mining site and its environs, to ascertain their levels compared to standard acceptable levels in...
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Hornstedtia scyphifera var belongs to ginger family, they are most of time used as spices for cooking, preservatives in food industry and colouring agents. It provides health-promoting effects to cutile certain diseases and ailment such as stomach-ache, Catarrh, asthma, diarrhoea, cold and cough, digestive disorder and rheumatism. In this study, we...
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It has been shown that heat stress can also increase adrenal gland weight and reduces pituitary, testis and seminal vesicle weights in rats and consequently decreased spermatozoa count and cause male infertility [5,6]. Arancibia et al. [7]. Found a decrease in prenatal healthy follicles and appearance of a new population of follicles after 2 weeks...
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Bush burning is the removal of the natural vegetation cover that protects the soil surface through the use of fire. This exposes the land to the effect of wind, water erosion and ultraviolet radiation. Bush burning has detrimental effect to the environment, health and the economy. It involves the production of air pollution such as carbon monoxide,...
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Effects of ethanolic extracts of leaf, seed and fruit of Datura metel on kidney function of male albino rats was investigated in this study. The result showed a non-significant (p > 0.05) increase of urea concentration in groups 2 and 3 administered low (300 mg/kg bw) and high (600 mg/kg bw) dose of leaf extract respectively and a non-significant (...
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Mosquitoes particularly anopheles are the main vectors for the malaria parasites that causes malaria fever diseases which is the highest killer of human beings in the tropics. There has been exploration of various methods over the centuries to control mosquito borne diseases. Larvicidal activities of essential oil extracted from country onion (Afro...
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Background and Objective: Piper guineense seeds and leaves are among the plant parts commonly used as spices and also in herbal medicine for the treatment and management of different conditions. The proximate, mineral and phytochemical composition of Piper guineense seeds and leaves were evaluated in this study. Materials and Methods: Piper guineen...
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Aim: Chemical composition of Xylopia aethiopica fruits was evaluated in this study. Materials and Methods: Xylopia aethiopica fruits were purchased as commonly sold at the new market in Wukari, Taraba State, Nigeria. The fruits were sorted for healthy parts, air-dried, and pulverized using manual blender. The AOAC method and AAS were used for proxi...
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Senna occidentalis has been reported to have certain medicinal properties in traditional settings. Extraction was carried out using absolute ethanol and elution was done with the following solvent; beginning from chloroform, ethyl acetate, methanol and finally water. The in vitro antioxidant activity, total flavonoid and total phenolic contents of...
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Background and objective: This study investigated the nutritional and phytochemical composition, antioxidant characteristics of Adansonia. digitata (baobab) leaves as well as fractionation of its ethanolic extract using column chromatography. Materials and methods: Baobab leaves were collected from wukari, dried under shade and analyzed for proxima...
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Herbal therapies have been used to manage liver diseases resulting from hepatotoxicity and hyperglycemia. The study investigated the hepatoprotective and gluco-stabilizing abilities of ethanol extracts of stem bark of Flacourtia indica in albino Wistar rats. Thirty-one rats of mixed sex, weighing 165-285g were used and divided into five groups of A...
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Eighteen (18) male albino rats were used to determine the glycemic indices of flour and starch component of two varieties, each, of maize and millet grains. The flour was obtained by milling the grains while the starch components were extracted from the grains using the method of Signh and Sadh (2009). Steeping, grinding, sieving and several rounds...
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The effect of toothpastes on oral microflora was investigated in order to identify the presence of different cultivating microorganisms which cause dental infections and their susceptibility to different types and concentrations of toothpastes. The investigation was carried out using seven (7) different types of toothpastes marked TP001, TP002 TP00...
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Dennettia tripetala belongs to the family Annonaceae. The aqueous and n-Hexane extract were screened for the presence of phenols, flavonoids and vitamin C and the 2,2-diphenyl-picrlhydrazyl (DPPH) radical scavenging activities of the extracts were also determined. Twenty five Wistar rats of either sex, weighing 130-140g, were used for this study. T...
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This study was designed to determine the spermatogenic and haematological effects of aqueous and ethanolic stem bark extracts of Hymenocardia acida on Aluminium chloride-induced toxicity in male wistar rats. Thirty male albino Wistar rats were used and toxicity was induced using 100 mg/kg body weight (bw) AlCl3. The rats were distributed into six g...
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This study was designed to determine the spermatogenic and haematological effects of aqueous and ethanolic stem bark extracts of Hymenocardia acida on Aluminium chloride-induced toxicity in male wistar rats. Thirty male albino Wistar rats were used and toxicity was induced using 100 mg/kg body weight (bw) AlCl3. The rats were distributed into six g...
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In the current study, the biochemical changes in haematological and liver function parameters in Intoxicated Male Albino Rats treated with Hymenocardia acida leaves ethanolic extract on AlCl3-toxicity was investigated. Twenty albino rats assigned to four groups of five each were used. Exactly 100 mg/kg bw of the plant extract was administered to gr...
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The present study was designed to study the fermentation process and to scientifically evaluate its phytochemical components. Fermentation was carried out using traditional method. Exactly 160 g of the seeds were soaked in water, washed, and cooked for 2 h, after which they were washed, sieved and parboiled for 20 min, the seeds sieved, cotyledon p...
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The present study was designed to evaluate the effects of Senna occidentalis in alloxan-induced diabetic and its complications in Wistar rats. Thirty male Wistar rats with body weight ranging from 180-250 g were selected for the study. Diabetes was induced by single intraperitoneal dose of alloxan injection (150 mg/ kg body weight). Treatment was c...