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Introduction
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Publications (66)
Remote ischemic preconditioning (RIPC) has been suggested to induce cardioprotection during cardiac surgery. Maintaining proper atrial function is imperative in preventing arrhythmia and thrombus formation. Mitochondria have been proposed as key targets in conveying RIPC mechanisms and effects. MicroRNA (miR) is emerging as an important regulator o...
Peak oxygen uptake (VO2peak) increases more after high intensity interval training compared to isocaloric moderate exercise in patients with coronary heart disease (CHD). We assessed the impact of exercise intensity during high intensity intervals on the increase in VO2peak.
We included 112 patients with coronary heart disease who had participated...
To provide a large reference material on aerobic fitness and exercise physiology data in a healthy population of Norwegian men and women aged 20-90 years.
Maximal and sub maximal levels of VO2, heart rate, oxygen pulse, and rating of perceived exertion (Borg scale: 6-20) were measured in 1929 men and 1881 women during treadmill running.
The highest...
Exercise performed at higher relative intensities has been found to elicit a greater increase in aerobic capacity and greater cardioprotective effects than exercise at moderate intensities. An inverse association has also been detected between the relative intensity of physical activity and the risk of developing coronary heart disease, independent...
Improving reduced skeletal muscle function is important for optimising exercise tolerance and quality of life in chronic obstructive pulmonary disease (COPD) patients. By applying high-intensity training to a small muscle group, we hypothesised a normalisation of muscle function.
Seven patients with COPD performed 6 weeks (3 days·week ⁻¹ ) of high-...
Aims: The aim of this study was to compare the effects of 5 years of supervised exercise training (ExComb), and the differential effects of subgroups of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), with control on the cardiovascular risk profile in older adults.
Methods and results: Older adults aged 7...
Objective:
To evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years).
Design:
Randomised controlled trial.
Setting:
General population of older adults in Trondheim, Norway.
Participants:
1567 of 6966 individuals born between 1936 and 194...
Objectives:
During open-heart surgery, the myocardium experiences ischaemia-reperfusion injury. A single bout of moderate, 30-min exercise induces preconditioning and protects the heart from ischaemia-reperfusion injury in rats, but this has never been investigated in humans. We aimed to investigate whether 1 bout of moderate exercise 24 h prior t...
Purpose:
Cardiorespiratory fitness (CRF) is regarded a clinical vital sign, and accurate reference values for all age groups are essential. Little data exist on CRF and cardiorespiratory function in older adults. The aim of this study was to provide normative values for CRF and cardiorespiratory function in older adults, including people with hist...
Background
Exercise of patients with intermittent claudication improves walking performance. Exercise does not usually increase blood flow, but seems to increase muscle mitochondrial enzyme activities. Although exercise is beneficial in most patients, it might be harmful in some. The mitochondrial response to exercise might therefore differ between...
Regular physical activity or exercise training are important actions to improve cardiorespiratory fitness and maintain health throughout life. There is solid evidence that exercise is an effective preventative strategy against at least 25 medical conditions, including cardiovascular disease, stroke, hypertension, colon and breast cancer, and type 2...
Background:
Symptoms of intermittent claudication (IC) are improved by exercise. The improvement might be secondary to increased blood perfusion or increased muscle mitochondrial capacity. Ischemia followed by reperfusion, also named preconditioning, is known to stimulate the mitochondria. We focused on a calf raise exercise inducing preconditioni...
Mitochondria are essential for energy production in the muscle cell and for this they are dependent upon a sufficient supply of oxygen by the circulation. Exercise training has shown to be a potent stimulus for physiological adaptations and mitochondria play a central role. Whether changes in mitochondrial respiration are seen after exercise in pat...
TREND statement checklist.
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Protocol as approved by Ethical committee.
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Introduction:
In this prospective randomized trial, we examined the effect of three popular exercise training modalities on maximal oxygen uptake (VO2max) in overweight and obese individuals. Additionally, we examined possible concomitant adaptations in endurance exercise performance (time to exhaustion (TTE)), citrate synthase (CS) activity, veno...
Objective
To investigate how a change in VO2max induced through 6 weeks of high intensity aerobic interval training affects daily total energy expenditure (TEE), active energy expenditure (AEE) and mitochondrial function in people not previously exposed to structured high intensity aerobic interval training (AIT).
Methods
Thirty healthy males (39±...
Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance in heart failure patients with preserved ejection fraction (HFpEF), however the underlying mechanisms remain unknown. We used an animal model to better understand potential molecular, mitochondrial, histological, and functional alterations induced by HFpEF in the...
Background. To discuss the cardiovascular and pulmonary physiology and common risk factors of an 80-year-old man with a world record maximal oxygen uptake of 50 mL·kg(-1)·min(-1). Methods.
Results. His maximal oxygen uptake of 3.31 L·min(-1), maximal heart rate of 175 beats·min(-1), and maximal oxygen pulse of 19 mL·beats(-1) are high. He is lean (...
Epidemiological studies suggest that exercise has a tremendous preventative effect on morbidity and premature death, but these findings need to be confirmed by randomised trials. Generation 100 is a randomised, controlled study where the primary aim is to evaluate the effects of 5 years of exercise training on mortality in an elderly population.
Al...
Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potential molecular, mitochondrial, histo...
Background:
Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to improve pathophysiology and de...
Several of the cellular alterations involved in atrial fibrillation (AF) may be linked to mitochondrial function and altered microRNA (miR) expression. A majority of studies on human myocardium involve right atrial (RA) tissue only. There are indications that AF may affect the two atria differentially. This study aimed to compare interatrial differ...
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a potential to cause serious complications. Mitochondria play central roles in cardiomyocyte function, and have been implicated in AF pathophysiology. MicroRNA (miR) are suggested to influence both mitochondrial function and the development of AF. Yet mitochondrial function and miR...
The training response of an intensified period of high-intensity exercise is not clear. Therefore, we compared the cardiovascular adaptations of completing 24 high-intensity aerobic interval training sessions carried out for either three or eight weeks, respectively.
Twenty-one healthy subjects (23.0±2.1 years, 10 females) completed 24 high-intensi...
To the Editor:
Exercise training in secondary prevention of cardiac disease is an established lifestyle strategy to improve cardiovascular risk factors and morbidity in cardiac patients. However, clinical data are surprisingly scarce. Therefore, the Norwegian group has to be congratulated for collecting a very large data set in this important cli...
Mammals have nine homologues of the Escherichia coli AlkB repair protein: Alkbh1–8, and the fat mass and obesity associated protein FTO. In this report, we describe the first
functional characterization of mouse Alkbh7. We show that the Alkbh7 protein is located in the mitochondrial matrix and that
an Alkbh7 deletion dramatically increases body wei...
High incidence and prevalence of chronic diseases, increasing obesity and inactivity as well as rising health expenditure represent a set of developments that cannot be considered sustainable, and will have dire long-term consequences given the increasing proportion of elderly people in our society. Based on a review of the experiences from previou...
Objective:
The aim of this study was to investigate the effects of moderate continuous training (MCT) and high intensity aerobic interval training (AIT) on systolic ventricular function and aerobic capacity in COPD patients.
Methods:
Seventeen patients with COPD (64 ± 8 years, 12 men) with FEV1 of 52.8 ± 11% of predicted, were randomly assigned...
Levosimendan is a novel inotropic agent claimed to improve myocardial contractility by a calcium-sensitizing effect. Our aim was to evaluate dose-dependent effects of levosimendan on left ventricular (LV) contractility and energetic properties in an acute, ischaemic heart failure porcine model.
Six pigs were used in an anaesthetized in vivo open-ch...
p>Høy forekomst av kroniske sykdommer og stigende helseutgifter representerer i lys av den kommende eldrebølgen
en stor samfunnsøkonomisk utfordring. Den negative helseutviklingen er i ferd med å bli et nasjonalt problem og må få konsekvenser for fremtidig norsk helsepolitikk. Fysisk inaktivitet er en livsstilsfaktor som er sterkt assosiert med lav...
Clustering of cardiovascular risk factors may lead to endothelial dysfunction. Physical exercise is an important factor in prevention and treatment of endothelial dysfunction. We wanted to determine the time course of adaptation to a single bout of exercise at either high or moderate intensity upon endothelial function both before and after a 16-we...
High incidence of chronic diseases and rising health expenditure represents in light of the increasing proportion of elderly in our society a development that cannot be considered sustainable in the long run. The negative health trend is becoming a national problem and should have consequences for future Norwegian health policy. Physical inactivity...
Maximal strength training with a focus on maximal mobilization of force in the concentric phase improves endurance performance that employs a large muscle mass. However, this has not been studied during work with a small muscle mass, which does not challenge convective oxygen supply. We therefore randomized 23 adult females with no arm-training his...
Individuals with the metabolic syndrome are 3 times more likely to die of heart disease than healthy counterparts. Exercise training reduces several of the symptoms of the syndrome, but the exercise intensity that yields the maximal beneficial adaptations is in dispute. We compared moderate and high exercise intensity with regard to variables assoc...
To study the effect of aerobic treadmill exercise training with different intensity on left ventricular (LV) function in patients with stable coronary artery disease, using Strain Rate- and Tissue Doppler Imaging.
Seventeen patients were randomly assigned to either moderate (50-60% of peak oxygen uptake (VO(2peak)) or high intensity exercise (80-90...
Exercise training reverses endothelial dysfunction, but the effect in young, healthy subjects is less clear. We determined the influence of maximal oxygen uptake (VO2max) and a single bout of high-intensity exercise on flow-mediated dilatation (FMD), brachial artery diameter, peak blood flow, nitric oxide (NO) bioavailability, and antioxidant statu...
Exercise training reduces the symptoms of chronic heart failure. Which exercise intensity yields maximal beneficial adaptations is controversial. Furthermore, the incidence of chronic heart failure increases with advanced age; it has been reported that 88% and 49% of patients with a first diagnosis of chronic heart failure are >65 and >80 years old...
Endothelial function is reduced by age, chronic heart failure, coronary artery disease, hypertension or type 2 diabetes, and it is shown that aerobic exercise may reverse this trend. The effect of a high aerobic training status on endothelial function in young, healthy subjects is however less clear. The present study was designed to determine whet...
Increased aerobic exercise capacity appears to reduce both all-cause mortality and cardiovascular disease mortality. Physical exercise to improve peak oxygen uptake (VO2peak) is thus strongly recommended, however evidence regarding the most efficient training intensity for patients with coronary artery disease (CAD) is still lacking. The purpose of...
