Oğuzhan Doğanlar

Oğuzhan Doğanlar
Trakya University · Department of Medical Biology

About

95
Publications
9,857
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627
Citations
Citations since 2016
54 Research Items
541 Citations
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140

Publications

Publications (95)
Article
Study design: This is a retrospective cohort study. Purpose: This study aimed to clarify the role of crosstalk between discoidin domain receptors (DDRs) and matrix metalloproteinases (MMPs) in the ligamentum flavum (LF) fibrosis obtained from patients with degenerative lumbar canal stenosis (DLCS). Overview of literature: The DDRs, DDR1 and DD...
Article
Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide, particularly in developed countries. Recently, microRNAs (miRs) have become popular research area to develop new treatment options of AMD. However, interaction between hsa-miR-184 and AMD remain largely unexplored. In this study, sub-lethal levels of Deforox...
Article
Full-text available
Abstract—There is increasing awareness that efficient and regular mitochondrial dynamics improvement cardiac function and affects the quality of life. Melatonin is a main pineal gland hormones and ameliorates mitochondrial dynamics in many cardiac disorders. For that purpose, we administrated melatonin to healthy rats all day long in order to inves...
Article
Full-text available
Increasing evidence supports the existence of cross-kingdom gene regulation. However, the therapeutic potential of stress-specific plant miRNAs and their role in UV-related pathologies in human tissue remain largely unexplored. The aim of this study was to investigate the therapeutic potential and mechanisms of action of stress-induced miRNA cockta...
Article
Micro-RNA (miRNA)-based regulation of hypoxia, angiogenesis and tumour growth provides promising targets for effective therapy in malignant glioblastoma multiforme (GBM). Accumulating evidence suggests a potential role of melatonin in miRNA expression in cancer cells. Despite these findings, the melatonin–miRNA interaction in GBM and the effect of...
Article
Galaxolide and tonalide are well-known polycyclic musks whose intensive use without limitations in numerous cleaning, hygiene, and personal care products has resulted in widespread direct human exposure via absorption, inhalation, and oral ingestion. Latest data shows that long-term, low-dose exposure to toxic chemicals can induce unpredictable har...
Article
Diabetic macular edema (DME) is a leading cause of blindness in diabetic retinopathy. Prolonged hyperglycemia plus hypoxia contributes to DME pathogenesis. Retinal pigmented epithelial cells comprise the outer blood-retinal barrier and are essential for maintaining physiological functioning of the retina. Melatonin acts as an antioxidant and regula...
Article
Full-text available
Currently, combination therapy is considered the most effective solution for a selective chemotherapeutic effect in the treatment of colon cancer. This study investigated the death of both colon cancer HT29 cells and healthy vascular smooth muscle TG-Ha-VSMC cells (VSMCs) induced by naringin combined with endoplasmic reticulum (ER) stress and NF-κB...
Article
High mechanical load of muscles may induce muscular apoptosis on the one hand and adaptation to exercise on the other. This study aimed to explore whether changes of circulatory levels of inflammation, apoptosis and heat shock proteins (HSPs) messenger RNA (mRNA) following single bout of high-intensity interval exercise (HIIE) differs between physi...
Article
Recent evidence indicates that chronic, low-dose exposure to mixtures of pesticides can cause adverse responses in a variety of cells, tissues and organs, although interactions between pesticides circulating in the blood and cancer cells remain largely unexplored. The aim of this study was to investigate the potential of a mixture of four pesticide...
Article
The aim of this study is to investigate the genotoxic effects of mixtures of five metals on zebrafish at two different concentrations; at the permissible maximum contamination levels in drinking water and irrigation waters. The drinking water limits are as follows: 300 µg/L for Aluminum (Al⁺³), 10 µg/L for Arsenic (As⁺³), 5 µg/L for Cadmium (Cd⁺²),...
Article
Full-text available
Objective This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods The fetal heart samples were obtained from melatonin administrated RUPP rats Results Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/...
Article
Full-text available
Objective: Glioblastoma multiforme (GBM) is the most aggressive for of brain tumor and treatment often fails due to the invasion of tumor cells into neighboring healthy brain tissues. Activation of the Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling pathway is essential for normal cellular function including angi...
Article
Full-text available
Reklam harcamalarının yıllık yarım trilyon doları aşması, reklam etkinliği konusunda yapılan çalışmaların önemini de artırmaktadır. Reklam etkinliği ile ilgili yapılan araştırmalar incelendiğinde kan dokusu ve genetik üzerine bir çalışmanın yapılmadığı görülmekte ve bu durum çalışmanın çıkış noktasını oluşturmaktadır. Söz konusu çalışmada reklam et...
Article
Full-text available
Çalışmamızda, Gala ve Sığırcı Gölleri için ekonomik açıdan önemli olan balık türleri (Carassius gibelio (Bloch, 1782), Carassius carassius (Linnaeus, 1758), Scardinius erythrophthalmus (Linnaeus, 1758), Cyprinus carpio Linnaeus, 1758, Sander lucioperca (Linnaeus, 1758), Perca fluviatilis Linnaeus, 1758) üzerinde kirliliğin etkileri araştırılmıştır....
Article
Full-text available
Prostate cancer (PCa) is the most common cancer in men worldwide. Midkine (MK) is overexpressed in PCa, as well as in tumor-initiating cells termed cancer stem cells (CSCs). Apigenin is a dietary flavone with considerable anti-tumor activities. In this study, we explored the possible therapeutic use of MK silencing, apigenin treatment, and a combin...
Article
Full-text available
Systemic chemotherapy-mediated cell toxicity is a major risk factor for cardiovascular disease and atherosclerosis. Life-threatening acute events of the FOLFIRI (irinotecan, folinic acid and 5-fluorouracil) regimen are mainly due to DNA damage induced by antimetabolite and topoisomerase inhibition effects. However, the role of human aortic smooth m...
Article
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In this study, the main aim was synthesis of dimeric compounds, which contain lithocholic acid and a triazole structure to investigate the selective cellular and molecular antiproliferative and proapoptotic potential of these products in healthy embryonic fibroblast (MEF), cervix cancer (HeLa), and breast cancer (MCF-7) cells. Four ester (5a–d) and...
Article
Objective: Although previous studies have reported the expression of JAK1, STAT3 and phosphorylated p-STAT3 in hypertrophied ligamentum flavum (LF), the role of the JAK/STAT signalling pathway in hypertrophied LF has not been fully elucidated. The aim of this study was to identify the important JAK/STAT gene expression patterns of the three main r...
Article
Aim: Generalized joint hypermobility (GJH) is a common feature of almost all Ehlers–Danlos syndrome (EDS) types; however, its genetic basis remains unclear. Therefore, it is crucial to distinguish the genetic basis of GJH from other connective tissue disorders, including the different subtypes of EDS. The aim of this study was to determine the bloo...
Article
Full-text available
Aim: The aim of this study was to investigate the possible mechanisms of ocular damage induced by pinealectomy (PNX) and preeclampsia (PE), and to determine the cellular and molecular effects of melatonin treatment on oxidative stress, DNA damage, molecular chaperone responses, induction of apoptosis and angiogenesis in the fetal eye of both PNX an...
Article
Aim: We aimed to determine the interaction between ruxolitinib, JAK/STAT signalling, and two angioMiRs to expose potential target molecules in the inhibition of glioblastoma invasion. Material and methods: The invasion properties of glioblastoma were analyzed using a cancer cell spheroid invasion assay. Following treatment of 195 nM ruxolitinib,...
Conference Paper
Full-text available
Reklam harcamalarının yıllık yarım trilyon doları aşması, reklam etkinliği konusunda yapılan çalışmaların önemini de artırmaktadır. Reklam etkinliği ile ilgili yapılan araştırmalar incelendiğinde kan dokusu ve genetik üzerine bir çalışmamanın yapılmadığı görülmekte ve bu durum çalışmanın çıkış noktasını oluşturmaktadır. Söz konusu çalışmada reklam...
Article
Full-text available
Although many studies related the toxic effects of pesticides on agricultural workers, little research has been done about agricultural area residents. The purpose of this work was to monitor the presence of pesticides, as well as their genotoxic and cytotoxic potential, in humans with blood samples collected from control and intensive agricultural...
Article
The aim of this study is to explain the possible mechanisms by which melatonin deficiency results in cardiovascular injury and to investigate the effects of melatonin administration on important signalling pathways and element equilibrium in the thoracic aorta (TA). For this purpose, we analysed the cellular and molecular effects of melatonin defic...
Article
Naringenin is a naturally occurring flavonoid and due to its broad spectrum of biological activities, including anti cancer properties has attracted scientific attention in recent years. To contribute to these studies, we synthesized some new (±)‐naringenin cyclic aminoethyl derivatives, analyzed the cytotoxic and anti‐proliferative properties of t...
Article
Combination therapies of cisplatin with 5-FU (PF) are an effective solution and have been widely used for the treatment of various categories of cancer. including anal, gastrointestinal and oral cancer, as well as head and neck tumours. The effects of combined PF treatment on vital intracellular signalling pathways in nontargeted cells remain uncle...
Article
Background The aim of the study was to evaluate whether the use of chemotherapy in combination with naringin, a dietary plant polyphenolic flavonoid, could enhance the therapeutic efficacy of paclitaxel treatment in human prostate cancer (PCa) cells. Materials and methods DU145, PC3, and LNCaP cells were treated with various concentrations of pacl...
Poster
Full-text available
Inhibition of Growth Factor Midkine by siRNA Enhances The Effects of Quercetin on CD133+/44+ Prostate Cancer Stem Cells
Article
Background Midkine (MDK) is a tumor-promoting factor that is often overexpressed in various human carcinomas, and the role of MDK has not yet been fully investigated in prostate cancer stem cells (PCSCs). Materials and Methods Prostate cancer CD133⁺ stem cells (PCSCs) were isolated from human castration-resistant PC3 cells. PCSCs were treated with...
Article
Aims: Cancer stem cells (CSCs) are involved in drug resistance, metastasis and recurrence of cancers. The efficacy of apigenin on cell survival, apoptosis, migration and stemness properties were analyzed in CSCs. Main methods: Prostate CSCs (CD44(+)) were isolated from human prostate cancer (PCa) PC3 cells using a magnetic-activated cell sorting...
Article
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease and may affect multiple organs and systems. Definite etiology and pathogenesis of disease is unknown. Apoptosis, defective clearance of apoptotic materials, uncontrolled DNA damage related to oxidative stress play important roles in the pathogenesis of SLE. Objectives In...
Article
Full-text available
Currently, the toxic effects and carcinogenic potential of individually treated arsenic (As) or cadmium (Cd) are well documented both in animal and human tissues. However, there are no data focusing on the genotoxicity of these heavy metals as a mixture at the very low concentrations of permissible limits for drinking water. In this study, we exami...
Article
In different cancer types, classical chemotherapy has several side effects due to the cytotoxic properties of the compounds and non-selective targeting of normal tissue. The aims of this study were to determine bioactive molecules and to investigate the genetic mechanisms of the anticancer properties of walnut special mixture, walnut milk (WM), as...
Article
This study aims to evaluate both genotoxic effect of Arsenic (As) and possible protective role of quercetin (Q) in Drosophila melanogaster Oregon R flies. Adult Drosophila flies were treated with with As (10, 50 and 100 ppb), quercetin (100 µm) and As+Q (10 ppb+100 µM Q, 50 ppb+100 µM Q and 100 ppb+ 100 µM Q) for 1 and 5 days. Relative expression l...
Poster
Full-text available
5-Fluorouracil (5-FU) is the most widely used antineoplastic and genotoxic standart chemotherapy agent which effects cell proliferation process. There are number of studies showed that natural bioactive compounds can prevent to non-targeting cells from chemotherapeutic agent induced toxicity Flavonoids such as Quercetin and Naringin have antioxidan...
Poster
Full-text available
244-serisinde araştırmayı amaçladık. Çalışmada 5-FU'nun IC50 değeri MTT testi ile 150 µM ve 48. saat olarak belirlendi. Hem T/G hem de HeLa hücrelerine 150 µM 5-FU, 100 µM quercetin ve naringin ayrı ayrı ve kombine olarak uygulandı. Uygulama süresinin sonunda hücrelerdeki DNA hasarı RAPD ile, bazı apoptotik (Bcl-2 ve Bax) ve antioksidan genlerin (s...
Article
In this study, we aimed to investigate the mutagenic and carcinogenic potential of a volatile organic compound (VOC) mixture with references to the response of D.melanogaster using selected antioxidant gene expressions, RAPD assay and base-pair change of ribosomal 18S, and the internal transcribed spacer, ITS2 rDNA gene sequences. For this purpose,...
Article
Full-text available
The effects of a mixture of seven pesticides were examined on the expression of antioxidant enzymes, Mn superoxide dismutase (Mn-SOD), catalase (CAT), glutathione synthetase (GS), and heat shock proteins (HSP) 26, 60, 70 and 83 in adult fruit flies (Drosophila melanogaster Oregon R). The flies were reared under controlled conditions on artificial d...
Article
The genotoxic effects of a mixture of 13 volatile organic compounds (VOCs) on total DNA profiles and the expression of heat shock proteins (HSPs) HSP26, HSP60, HSP70, and HSP83 in fruit fly tissues were examined. Drosophila melanogaster Oregon R(+), reared under controlled conditions on artificial diets, was treated with 13 VOCs commonly found in w...
Article
Full-text available
Eleven species of Epomphale Girault (Hymenoptera: Eulophidae: Ceranisinae), 4 from the menes species group and 7 from the auriventris species group, were obtained from several parts of the world. The species are: in the menes species group, E. menes (Walker), and E. filizinancae n. sp. from Turkey; E. africanensis n. sp. from Pretoria, South Africa...
Article
Full-text available
The palearctic species of Chrysolampinae DALLA TORRE 1898 (Hymenoptera: Perilampidae) are reviewed, and a key provided to identify species of Chrysolampus SPINOLA 1811. Descriptions and distributions of Chrysolampus thenae (WALKER 1848), C. splendidulus (SPINOLA 1808), C. rufitarsis (FÖRSTER 1859) and Brachyelatus viridis HOFFER & NOWICKY 1954 (the...
Article
Full-text available
Nine species of Urfacus Doğanlar (Hymenoptera: Eulophidae: Ceranisinae) were collected in Turkey: U. bozovaensis Doğanlar, 2003, and the new species, U. karacadagi, U. sekilinensis, U. adiyamanus, U. komurcukurus, U. sincanus, U. nizpus, U. karkamisus and U. atcanacus. Morphological characters of the species were studied, and by maximum parsimony a...
Article
Full-text available
Eight species of the cyanellus species group of genus Entedon Dalman (Hymenoptera: Eulophidae: Entedoninae) were collected in Turkey: E. cyanellus Dalman, E. biroi Erdös, E. parvicalcar Thomson, E. pallicrus Erdös, and the four new species, E. arabanensis n. sp., E. sarkislaensis n. sp., E. susuzensis n. sp., E. gumushanensis n. sp. Hypopygia of th...
Article
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Thrips parasitoid genera with reduced mandible of Eulophidae (Hymenoptera:Chalcidoidea) are reviewed, with providing Ceranisinae subfam.n. and comments on their systematic placement, and reasons for this placement are discussed. Three new genera, Sergueicus gen.n. by combining Ceranisus barsoomensis (TRIAPITSYN), Guelsenia gen.n., Gaziantepus gen.n...
Article
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The species of Entedon Dalman with complete frontal fork were studied. One species of the crassiscapus species group, E. crassiscapus Erdös, and 5 species of the cioni species group, E. cionobius Thomson, E. cioni Thomson, E. leucocnemus Erdös in Turkey and E. methion Walker, E. tibialis (Nees) in Germany, of genus Entedon Dalman (Hymenoptera: Eulo...
Article
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Palearctic species of Chrysomalla Forster 1859 (Hymenoptera: Perilampidae: Chrysolampinae) are reviewed, and a key provided to identify the species by inserting some new characters. Distributions and redescriptions of Chrysomalla stigmatica Boucek, 1972, and C. roseri Forster, 1859 were given. Three new species, Chrysomalla sekilica, C. nevsehirica...
Article
Full-text available
Five species of Ceranisus Walker, 1841 (Hymenoptera: Eulophidae: Entedoninae) were collected recently in Ukraine: C. pacuvius (Walker, 1841), C. menes (Walker, 1839), C. planitianus Erdös (a new record for Ukraine), and two new species C. ukrainensis sp. n. from Cherkas'ka (Kaniv National Reserve) and Khersonska (Black Sea Biosphere Reserve) oblast...
Article
Full-text available
Species of the Ceranisus thrips-attacking genus are difficult to distinguish morphologically. The phylogenetic relationships within the Ceranisus species were explored using nucleotide sequences of the 28S D2 expansion region of the rDNA gene. Bayesian, maximum likelihood, and parsimony inference methods were employed to construct the phylogenetic...