Ofer Moses

Tel Aviv University | TAU · Department of Periodontology

Uncontrolled diabetes is characterized by aberrant inflammatory reactions and increased collagenolysis. We have reported that it accelerates the degradation of implanted collagen membranes (CM), thus compromising their function in regenerative procedures. In recent years, a group of physiological anti-inflammatory agents called specialized pro-reso...

Objectives We previously showed that accelerated degradation of collagen membranes (CMs) in diabetic rats is associated with increased infiltration of macrophages and blood vessels. Since pre-implantation immersion of CMs in cross-linked high molecular weight hyaluronic acid (CLHA) delays membrane degradation, we evaluated here its effect on the nu...

The aim of this histomorphometric study was to compare the outcome of sinus floor augmentation procedures using bovine bone mineral and a xenograft enriched with gelatin and a polymer. In 20 patients a single sinus floor elevation procedure with a lateral window approach was performed. In half of the patients, sinuses were grafted with a deproteini...

Stress concentrated at an implant’s neck may affect bone-to-implant contact (BIC). The objective of this study was to evaluate four different implant neck designs using two different drilling protocols on the BIC. Methods: Ninety-six implants were inserted in 12 minipigs calvarium. Implants neck designs evaluated were: type 1–6 coronal flutes (CFs)...

Background: Peri-implant marginal bone loss is influenced by the interaction between tissues and the implant-abutment complex. The implant-abutment connection geometry is considered to be one of the factors that most affects peri-implant bone remodelling. Purpose: The primary purpose was to compare the clinical and radiographical differences betwee...

This in-vitro study assessed the effect of an underdrilling implant placement protocol on the insertion torque, implant surface temperature and surface roughness (Sa) topography of the cervical microthreads of implants. Three groups of 25 implants (3.75 mm × 10 mm) were placed in osteotomies prepared in an artificial bone disc with final diameters...

This in vitro preliminary study investigated the attachment of Fusobacterium nucleatum and Porphyromonas gingivalis on titanium alloy healing abutments, which differed in their surface macro-morphology: one was groove-marked while the other was completely smooth. Altogether, twenty implant-healing abutments, ten of each macro-morphology, were evalu...

Objective Diabetes increases the incidence/severity of periodontal diseases by inducing a chronic inflammation, driven by accumulation of AGEs (advanced glycation end products). We tested whether glycated human serum albumin (G-HSA, a form of AGE), representing a diabetic state, augments the pro-inflammatory response of human gingival fibroblasts (...

Background: Membrane durability is critical for regenerative procedures. We reported previously that type 1-like diabetes in rats accelerates the degradation of collagen membranes and we tested here whether this is associated with increased local production of inflammatory molecules as part of a diabetes-induced chronic inflammation around and wit...

Free connective tissue grafts, barrier membranes, pedicle flaps, soft tissue allografts, and xenografts have been described for root coverage and augmenting the zone of attached gingiva. The present report evaluated a modified tunnel surgical procedure for root coverage of mandibular anterior teeth where a connective tissue graft was combined with...

Aim To examine the in vitro biokinetics of hyaluronic acid (HA) from a collagen membrane (CM) and to evaluate the in vivo effect of immersion of the CM in HA solution on its degradation in streptozotocin (STZ)‐induced diabetes conditions in a rat calvaria subcutaneous model. Background CM degradation is accelerated in uncontrolled diabetic rats. I...

Endodontic–periodontal lesions occur as a combination of an endodontic infection and periodontal disease in a single tooth. As an endodontic–periodontal lesion is a complex condition, establishing an accurate diagnosis and prognosis of the involved teeth is crucial while treatment planning. Modern endodontic and periodontal treatment modalities can...

Periodontal-endodontic lesions are the combination of pulp involvement and periodontal disease in the same tooth. Diagnosis may become difficult; however, a differential etiological consideration is indispensable for appropriate treatment.

Objective: The aim of this study was to evaluate the influence of the location and length of root pieces on buccal peri-implant bone width and socket preservation in socket shield technique. Material and methods: Forty-eight dental implants (24 narrow and 24 regular platform internal hex implants) were placed in six dogs. The clinical crowns of...

Increased collagenolytic activity, characteristic of uncontrolled diabetes, may compromise collagen membrane (CM) survival. Tetracycline (TTC) possesses anti-collagenolytic properties and delays CM degradation in healthy animals. This study evaluated the degradation of TTC-immersed and non-immersed CMs in diabetic, compared with normoglycemic rats....

Objective: To use a modified direct contact test (DCT) to evaluate the bacterial growth on 3 commercially available implants. Materials and methods: Streptococcus salivarius growth was tested on 1 machined surface and 2 commercial rough surface implants. Seven implants from each group were fixed to the cover of a 96-well microtiter plate. Bacter...

The purpose of this work is to evaluate changes in temperature of one-piece titanium implant surface during the setting of acrylic resin temporary crowns and to correlate thermal changes to implant diameter. Thirty-Three one-piece implants (ARRP, Alpha-Biotec) were divided into 3 groups according to diameter size (G1=3 mm, G2=3.3 mm, G3=3.6 mm). Im...

Objectives The objective of this study is to histologically and radiologically compare a sintered and a non-sintered bovine bone substitute material in sinus augmentation procedures. Materials and methods Thirty-three patients were included in the clinically controlled randomized multicentre study resulting in a total of 44 treated sinuses. After l...

IntroductionDental implant insertion for oral rehabilitation is a worldwide procedure for healthy and medically compromised patients. The impact of systemic disease risks on the outcome of implant therapy is unclear, since there are few if any published randomized controlled trials (RCTs). Objective The objective of this study is to investigate the...

Objectives The objective of this study is to compare bone-to-implant contact (BIC) between implants inserted at high torque due to under-drilling of the crestal bone to those inserted at low torque due to over-drilling of the crestal bone. Materials and methods Forty implants with diameters of 3.75 mm (group A) or 3.55 mm (group B) were inserted in...

Objectives Increased collagenolytic activity in diabetes may compromise collagen membrane (CM) survival. Tetracycline (TTC) possesses anti-collagenolytic properties and delays CM degradation. This study evaluated macrophage and capillary infiltration within CMs in diabetic rats. Materials and methods Diabetes was induced in 20 Wistar rats by strept...

Objectives The present study evaluated the degradation of collagen matrix (CM) immersed in tetracycline (TTC) or phosphate-buffered saline (PBS) in diabetic and normoglycemic rats. Materials and methods Diabetes was induced in 15 rats by systemic streptozotocin (STZ) (experimental); 15 healthy rats served as controls. One day before implantation 60...

Figure SB. Following full‐thickness flaps raised and repositioned on each side of the incision, resorbable sutures were performed to replace the soft tissues.

Figure S4. Study group 5 days after surgery.

Figure S3. Study group. 12 days after surgery.

Figure S5. Study group. 12 days after surgery.

Figure SA. Mid‐crestal incision on the maxillary alveolar ridge in the existing edentulous area between the 1st molar and the incisors.

Figure SC. PerioPatch® or placebo patch was placed on the incision line immediately following surgery and replaced every 12 h for the following 3 days.

Figure S1. Epithelial healing in the negative control group 12 days after surgery.

Figure S2. Study group. 5 days after surgery.

Table S1. Antibodies applied in this study.

AimThe present study evaluated the effects of a topical herbal patch (PerioPatch®) for gingival wound healing in a rat model.Materials and MethodsA mid-crestal incision was performed on each side of the edentulous anterior maxilla in 48, six-month-old, Wistar rats. Full thickness flaps were raised, repositioned and sutured. Four experimental groups...

Epidemiologic and clinical studies have indicated that diabetes is a risk factor for periodontal disease progression and healing. The aim of the present study was to evaluate short-term healing after enamel matrix derivative (EMD) application in combined supra/infrabony periodontal defects in diabetic rats. Thirty male Wistar rats were initially di...

Bone formation is reduced in animals and humans with type 1 diabetes, leading to lower bone mass and inferior osseous healing. Since bone formation greatly depends on the recruitment of osteoblasts from their bone marrow precursors, we tested whether experimental type 1 diabetes in rats diminishes the number of bone marrow osteoprogenitors. Diabete...

Objective: To test whether the degradation of collagen membranes implanted in rats and their infiltration by macrophages and capillaries into will be enhanced by diabetes and attenuated by their immersion in a tetracycline (TTC) solution prior to implantation. Method: Diabetes was induced in 35 rats with streptozotocin, while 35 served as normogl...

Objective: uncontrolled diabetes may increase collagenolytic activity, which may influence the survival of collagen matrix implanted in diabetic animals. Tetracycline (TTC) possesses anti-collagenolytic properties and thus slows down the degradation of collagen membranes in healthy and diabetic animals. This study compared the degradation of TTC-im...

Background: Increased collagenolytic activity, characteristic of uncontrolled diabetes, may compromise collagen membrane (CM) survival. Tetracycline (TCN) possesses anticollagenolytic properties and delays CM degradation in healthy animals. This study evaluates the degradation of TCN--immersed and -non-immersed CMs in rats with diabetes compared t...

The aim of this 10 year retrospective study was to evaluate the crestal bone loss around immediate implant placed in tricalcium phosphate (TCP) grafted extraction sockets Data were collected from files of 58 patients (33 females, 25 males, average age 54.78 years) undergoing immediate implant placement into fresh extraction socket with or without t...

Objectives: Evaluation of heat generation in 1-piece implants according to 3 variables: preparation time, bur type, and preparation environment. Materials and methods: Study implants were 1-piece designs with the same endosseous dimensions and surface microtexture, but with abutment sections that were either conical in shape, which required clin...

The crestal core elevation (CCE) technique is reportedly a less invasive procedure than the lateral window elevation technique. We retrospectively evaluated long-term outcomes of CCE procedures over an 11-year time period. Core preparations were made after extractions of 57 upper molars in 45 patients. Extraction sites were drilled with a calibrate...

Restoration of the edentulous alveolar ridge with dental implants often requires the ridge width to be augmented in order to allow its placement. Technique of splitting the alveolar ridge aimed to enlarge its horizontal dimension is achieved by using different osseous surgical tools to allow simultaneous or staged placement of dental implants. Trea...

This study was a retrospective assessment of reentry sinus augmentation compared with sinus augmentation performed for the first time. There were 38 subjects who required sinus augmentation. The study group (17 patients, 21 sinuses) included subjects following failure of a previous sinus augmentation procedure that required reentry augmentation. Th...

Peripheral giant cell granuloma (PGCG) is a reactive hyperplastic lesion involving the gingiva or alveolar mucosa consisting of proliferating endothelial cells, a rich capillary bed, chronic inflammatory cells, fibroblasts, and giant cells. After complete clinical removal of PGCG recurrence occurs in about 10% of cases, and may result in an estheti...

Elevated levels of prostaglandins such as PGE(2) in inflamed gingiva play a significant role in the tissue destruction caused by periodontitis, partly by targeting local fibroblasts. Only very few studies have shown that PGE(2) inhibits the proliferation of a gingival fibroblast (GF) cell line, and we expanded this research by using primary human G...

Objective: The aim of this study was to evaluate histologically the bio-degradation of two layers of Bio-Gide((R)) (BG) membrane, as compared with that of a single layer. Material and methods: Two circular calvarial bony defects, 5 mm in diameter, were made in 24 Wistar rats. BG membrane, labeled with biotin, was cut into 5-mm-diameter disks, an...

Premature collagen membrane degradation may compromise the outcome of osseous regenerative procedures. Tetracyclines (TTCs) inhibit the catalytic activities of human metalloproteinases. Preprocedural immersion of collagen membranes in TTC and systemic administration of TTC may be possible alternatives to reduce the biodegradation of native collagen...