Ofer Jacobowitz

Ofer Jacobowitz
Hofstra Northwell School of Medicine

MD PhD FAASM FAAOA

About

52
Publications
4,760
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,152
Citations
Additional affiliations
January 2013 - present
Icahn School of Medicine at Mount Sinai
Position
  • Professor (Assistant)
January 2011 - present
ENT and Allergy Associates
Position
  • Targeted Hypoglossal Neurostimulation for OSA
Description
  • Investigator and scientific contributor for trial of implantable neurostimulation device for therapy of obstructive sleep apnea (imthera medical THN2 and THN3 trials)
August 2004 - August 2013
Columbia University
Position
  • Professor (Assistant)
Education
July 1997 - May 2001
Mount Sinai Hospital
Field of study
  • Otolaryngology, Head and Neck Surgery Residency
July 1996 - June 1997
Mount Sinai Hospital
Field of study
  • General Surgery Internship
July 1988 - May 1996
Icahn School of Medicine at Mount Sinai
Field of study
  • Medicine (Medical Scientist Training Program)

Publications

Publications (52)
Article
Introduction THN3 was the first reported parallel-arm, randomized controlled trial of hypoglossal nerve stimulation (HGNS), wherein targeted HGNS (THN) was shown to be safe and efficacious at ameliorating sleep disordered breathing in selected patients with moderate to severe OSA and BMI≤35kg/m2 without screening with drug-induced sleep endoscopy....
Article
Introduction With few exceptions, clinical trials of hypoglossal nerve stimulation (HGNS) for obstructive sleep apnea (OSA) are single-arm, open-label studies sometimes followed by short-term, unblinded, randomized withdrawal. By contrast, the THN3 study was a parallel-arm, randomized, controlled trial (RCT) of targeted HGNS (THN) in moderate to se...
Article
Full-text available
Obstructive sleep apnea (OSA) affects nearly 1 billion people worldwide, including approximately 35 million US residents. OSA has detrimental cardiovascular and neurocognitive consequences. Positive airway pressure corrects sleep disordered breathing but is not always tolerated or used sufficiently. Oral appliances and surgery provide alternatives...
Article
Full-text available
Kuo YH, Liu TJ, Chiu FH, et al. Nat Sci Sleep. 2021;13:2087–2099. The authors have advised that the funding statement on page 2098 is incorrect. The text “This study was supported by a grant from Shin Kong Wu- Ho-Su memorial Hospital (2018SKHADR018)” should read “This study was supported by a grant from Shin Kong Wu-Ho-Su memorial Hospital (2019SKH...
Article
Full-text available
Purpose No study to date has described the overall landscape of sleep disorders management and training in otolaryngology departments of different countries. The aim of our study was to investigate and compare settings, diagnostic and therapeutic approaches and training programmes. Methods An international online survey was developed with the coll...
Article
Full-text available
Background: In intermittent negative airway pressure (iNAP) therapy, soft tissues are reshaped into a forward-resting position, thus reducing airway obstruction during sleep. This study investigated the effect of iNAP therapy that was administered during drug-induced sleep endoscopy with target-controlled infusion (TCI-DISE) in patients with obstr...
Article
Guidelines for the evaluation and management of sleep disorders from national societies provide recommendations that may be regionally appropriate but may not always be practical or relevant in other parts of the world. A task force of experts from the World Sleep Society's (WSS) International Sleep Medicine Guidelines Committee and Sleep and Breat...
Article
Hypoglossal nerve stimulation (HGNS) has evolved as a novel and effective therapy for patients with moderate-to-severe obstructive sleep apnea. Despite positive published outcomes of HGNS, there exist uncertainties regarding proper patient selection, surgical technique, and the reporting of outcomes and individual factors that impact therapy effect...
Article
Full-text available
Introduction: The findings of drug-induced sleep endoscopy (DISE) are not always correlated with the outcome of upper airway surgery for obstructive sleep apnea (OSA), and whether multilevel surgery is truly required in treating multilevel obstruction identified in preoperative DISE remains an issue. We attempted to compare DISE findings before an...
Article
Full-text available
Background Insufficiency of the nasal valve is increasingly being recognized as a cause of nasal airway obstruction. The condition is associated with many symptoms, including nasal congestion, sleep disturbance, snoring, and an overall decline in quality of life (QoL). An in‐office, minimally invasive radiofrequency treatment of the nasal valve has...
Article
None: The AASM Payer Policy Review Committee (PPRC) launched an initiative to assess the alignment between clinical practice guidelines (CPGs) and private payer medical policies. This article summarizes the importance of the initiative, details the scorecard development process, including an analysis of policy scores and subsequent revisions, and...
Article
Full-text available
Citation: Jacobowitz O, Woodson BT. A new metric for precision medicine: PAP and hypoglossal neurostimulation. J Clin Sleep Med. 2019;15(8):1079-1080.
Article
Full-text available
Objectives To assess the safety and effectiveness of in‐office bipolar radiofrequency treatment of nasal valve obstruction Study Design Prospective, nonrandomized, multicenter case series Methods Adult patients with a Nasal Obstruction Symptom Evaluation scale (NOSE) score ≥60 were selected. Patients were clinically diagnosed with dynamic or stat...
Article
Objective To evaluate the association between findings of blinded reviews of preoperative drug‐induced sleep endoscopy (DISE) examinations using the VOTE Classification and obstructive sleep apnea (OSA) surgical outcomes in a large multicenter, international cohort. Methods Retrospective, multi‐center cohort study of adults without tonsillar hyper...
Article
Full-text available
Study objectives: Although drug-induced sleep endoscopy (DISE) is an accepted method to localize upper airway obstruction, it is not known whether allsites identified by DISE must be treated to achieve sufficient apnea-hypopnea index (AHI) improvement. The aim of this study was to compare outcomes forunilevel (upper) versus multilevel DISE collaps...
Chapter
Oral appliances that advance the mandible are widely used as alternatives to positive airway pressure (PAP) devices or as primary therapy for obstructive sleep apnea (OSA) in adults. Although PAP is more efficacious at lowering the polysomnographic indices of OSA, the clinical effectiveness of PAP and oral appliances is similar, and patients are mo...
Article
Full-text available
Introduction Targeted Hypoglossal Neurostimulation (THN) is a novel treatment for OSA that aims to stimulate selective tongue muscles using a 6-contact cuff, placed around the hypoglossal nerve trunk. Selective stimulation and cycling between contacts is used to minimize risk of neuromuscular fatigue. From earlier safety and feasibility trials, pre...
Article
Objectives/hypothesis: This feasibility study was designed to show the preliminary safety and efficacy of targeted hypoglossal neurostimulation (THN), and to identify baseline predictors of successful therapy. Study design: Open-label, prospective, multicenter, single-arm cohort study, conducted at seven centers in the U.S.A. and Europe. Method...
Article
Full-text available
Obstructive sleep apnea (OSA) is a prevalent disorder associated with a multitude of adverse outcomes when left untreated. There is significant heterogeneity in the evaluation and management of OSA resulting in variation in cost and outcomes. Thus, the goal for developing these measures was to have a way to evaluate the outcomes and reliability of...
Article
Full-text available
Objectives Determine safety and effectiveness of targeted hypoglossal neurostimulation sleep therapy system for obstructive sleep apnea (OSA). Titration with multi-contact electrode and multi-channel pulse generator (IPG) allows stimulation of multiple areas of the proximal hypoglossal nerve permitting identification of optimal tongue position in e...
Article
Program Description Obstructive sleep apnea (OSA) significantly affects sleep, daytime function, quality of life, public safety, and cardiovascular risk. Although positive pressure remains the primary treatment, suboptimal adherence rates necessitate alternative treatment strategies. Hypoglossal nerve stimulation is a new and emerging treatment opt...
Article
Program Description With increased demand of patients seeking treatment for obstructive sleep apnea/hypopnea syndrome (OSAHS), diagnosis of OSAHS will become an increasingly significant component of every ENT practice. Surgical treatment will remain an option for selected patients Explain options for attended and unattended polysomnography. Review...
Article
Introduction: Obstructive sleep apnea (OSA) is a chronic condition that affects millions adults. The effective standard treatment is positive airway pressure (PAP). However, approximately half of the patients that are prescribed PAP are unable or unwilling to comply with this therapy. Untreated OSA ultimately leads to very serious comorbidities. An...
Article
Positive airway pressure can be effective for OSA treatment but is not effectively used by many patients. Surgical reconstruction of the airway is appropriate for patients who are not otherwise effectively treated or as first-line treatment for patients with focal airway lesions. For surgical planning, examination schemes of the awake patient, as w...
Article
Full-text available
In defining a strategy and vision for the field of sleep medicine for the future, a concerted effort has been made over the past year to determine trends likely to impact sleep medicine practitioners and their ability to care for patients with sleep disorders. Emerging changes in the healthcare system will undoubtedly have a large, but unfortunatel...
Article
The environment in which otolaryngologists coexist with device and drug development has become increasingly complex. There are broad implications for both the academic and the private practitioner, with neither group being more or less insulated than the other. From the medical, ethical, and resource-oriented standpoints, otolaryngologists must con...
Article
To assess the effect of concurrent uvulopalatopharyngoplasty (UPPP) and hypopharyngeal procedures in obstructive sleep apnea (OSA) patients with diffuse airway narrowing. Forty-eight patients were treated surgically by a single surgeon in private practice over 2 years. Symptoms, Epworth score, and polysomnographic outcome were assessed preoperative...
Article
To demonstrate a causal relationship between bone dust and the development of headache after retrosigmoid removal of acoustic neuromas. The study design was both retrospective (group I) and prospective (groups 2 and 3). Tertiary Care Referral Center/Outpatient Data Collection. Eighty-four consecutive patients underwent surgery at the Mount Sinai Me...
Article
Full-text available
Regulation of basal activities of adenylyl cyclase (AC) 2 and 6, expressed in Sf9 cells by infection with recombinant baculovirus, was studied. An antipeptide antibody that recognizes AC2 and AC6 with equal sensitivity was used to establish that equivalent levels were expressed. Basal activities of AC2 and AC6 were compared at varying concentration...
Article
Full-text available
Adenylyl cyclase 2 was expressed in Sf9 cells by recombinant baculovirus infection. Phorbol 12-myristate 13-acetate (PMA) treatment of cells expressing adenylyl cyclase 2 (AC2) increased basal activity. This increase was blocked by staurosporine, a protein kinase C inhibitor. PMA treatment increased Vmax without affecting Km. Greatest increase in b...
Article
Six Gs-stimulated adenylyl cyclases have been cloned. Two additional forms have been identified as partial cDNAs. These adenylyl cyclases have distinct functional properties and are differentially regulated by protein kinases. The adenylyl cyclases have distinct patterns of distribution in peripheral tissues and various brain regions. The unique fu...
Article
Full-text available
Regulation of adenylyl cyclases by protein kinase C was studied. Types 1-6 were transiently expressed in 293 cells. The cells were treated with 4 beta-phorbol 12-myristate 13-acetate (PMA), and adenylyl cyclase activity was measured. PMA treatment of untransfected or vector-transfected cells resulted in a 35% (mean) increase in basal and forskolin-...
Article
Full-text available
Regulation of adenylyl cyclases by protein kinase C was studied. Types 1-6 were transiently expressed in 293 cells. The cells were treated with 4 beta-phorbol 12-myristate 13-acetate (PMA), and adenylyl cyclase activity was measured. PMA treatment of untransfected or vector-transfected cells resulted in a 35% (mean) increase in basal and forskolin-...
Article
Treatment of chick hepatocytes with glucagon results in homologous and heterologous desensitization of the receptor-stimulated adenylyl cyclase. The loci of postreceptor heterologous desensitization was studied. The addition of excess purified GS to glucagon-desensitized hepatocyte membranes did not fully restore fluoride stimulation of adenylyl cy...
Chapter
Adenylyl cyclase (EC 4.6.1.1) converts MgATP into 3′,5′-cyclic AMP (cAMP) and pyrophosphate. Since the initial characterization of the enzyme by Sutherland and coworkers in 1962 adenylyl cyclase activities have been identified in organisms ranging from bacteria to man. The structure and regulation of these adenylyl cyclase enzymes as well as the re...

Network

Cited By

Projects

Projects (3)
Project
FDA trial conducted using Aerin Medical's Vivaer device to remodel the nasal valve using radiofrequency in 1 session in the office setting. A 6 month study was performed assessing outcome using the NOSE questionnaire and results submitted to the FDA. Additional long term follow up observation is ongoing.
Project
Standards are published documents that establish specifications and procedures designed to maximize the reliability of the materials, products, methods, and/or services people use every day. Standards address a range of issues, including but not limited to various protocols to help maximize product functionality and compatibility, facilitate interoperability and support consumer safety and public health. It is only through the use of standards that the requirements of interconnectivity and interoperability can be assured. It is only through the application of standards that the credibility of new products and new markets can be verified. In summary standards fuel the development and implementation of technologies that influence and transform the way we live, work and communicate.