Özge Gizlenci

Özge Gizlenci
University of Cambridge | Cam · Babraham Institute

PhD student

About

10
Publications
1,013
Reads
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58
Citations
Citations since 2017
6 Research Items
58 Citations
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015
Additional affiliations
December 2016 - March 2017
Dana-Farber/Boston Children’s Hospital
Position
  • Graduate student
August 2016 - November 2016
Whitehead Institute for Biomedical Research
Position
  • Researcher
November 2015 - July 2016
German Cancer Research Center
Position
  • Student Research Assistant

Publications

Publications (10)
Preprint
Full-text available
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used label-free mass spectrometry to quantify the proteome of B cell subsets from the mouse spleen and map the differential expression of environmental sensing, transcript...
Article
Full-text available
The RNA‐binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) has been found to have roles in CD4 T cell activation, but its function in CD8 T cells remains untested. We show it is dispensable for the development of naïve mouse CD8 T cells, but is necessary for the optimal expansion and production of effector molecules by antigen‐specific...
Article
Full-text available
CD8+ T cell differentiation into effector cells is initiated early after antigen encounter by signals from the T cell antigen receptor and costimulatory molecules. The molecular mechanisms that establish the timing and rate of differentiation however are not defined. Here we show that the RNA binding proteins (RBP) ZFP36 and ZFP36L1 limit the rate...
Preprint
Full-text available
We show that the RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) is dispensable for the development of naive mouse CD8 T cells, but is necessary for the optimal expansion and production of effector molecules by antigen-specific CD8 T cells in vivo. PTBP1 has an essential role in regulating the early events following activation of...
Preprint
Full-text available
CD8 T cell differentiation into effector cells is initiated early after antigen encounter by signals from the T cell antigen receptor and costimulatory molecules. The molecular mechanisms that determine the timing and rate of differentiation however are not defined. Here we show that the RNA binding proteins (RBP) ZFP36 and ZFP36L1 limit the rate o...
Poster
Shwachman-Bodian-Diamond syndrome (SDS) is a bone marrow failure syndrome characterized by congenital abnormalities, progressive bone marrow failure and cancer predisposition. The most frequent hematopoietic abnormality is insufficient production of blood cells, which is associated with susceptibility to severe infections and the requirement for pl...
Article
An often-cited defining property of hematopoietic stem cells (HSCs) is their extensive or unlimited in vivo self-renewal capacity. We have recently described a novel mouse disease model forFanconi anemia, in which serial challenge with pro-inflammatory agonists that mimic infection, such aspolyinosinic:polycytidylic acid (pI:C), results in HSC attr...
Article
Full-text available
Background A total of 150 bread wheat genotypes representing 121 Indian and 29 Turkish origin were screened for nutrient concentrations and grain protein content. Elemental and grain protein composition were studied by Inductively Coupled Plasma-Atomic Emission Spectrophotometer and LECO analyser, respectively. The study was performed to determine...
Poster
Full-text available
Each proliferating cell in the body means a risk for cancer development. As lifespan increases, time to accumulate mutations increases and suppression of somatic cancer evolution becomes challenging. However, there is no apparent correlation between lifespan and cancer across species - a phenomenon termed ”Peto’s Paradox”. Diverse tumor suppressor...

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