Ömer Koz

Ömer Koz
Bursa Teknik Üniversitesi · Chemistry Department

Prof. Dr.

About

21
Publications
1,887
Reads
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183
Citations
Introduction
Ömer Koz currently works at the Chemistry Department, Bursa Technical University. Ömer does research in Natural Product chemistry and Organic Synthesis. Their current project is 'Design and Synthesis of New Organic Molecules for the Treatment of Alzheimer's Disease.'
Additional affiliations
September 2009 - March 2010
University of Pennsylvania
Position
  • Professor
February 2005 - May 2005
Università degli Studi di Salerno
Position
  • Visiting Researcher
September 1997 - June 2012
Ege University
Position
  • Dr.

Publications

Publications (21)
Article
The incidence of cancer has exhibited an increasing trend in recent years because of many reasons such as environmental and nutritional factors. There is a great need for the development of new and natural molecules with lower side effects in the therapy of cancer. It was aimed to evaluate the antiproliferative effect of semi-purified triterpene gl...
Article
Full-text available
Astragalus species are widely distributed in Turkey. There are 445 species in the Flora of Turkey. Plenty of species of Astragalus are used in traditional medicine in many countries such as European Countries, Turkey, China, India etc. They are used for treatment of diabetes, nephritis, leukaemia, and uterine cancer. In addition, they are used as a...
Article
Full-text available
In vitro cytotoxic, antioxidant, and antimicrobial activities along with total phenolic and flavonoid contents of methanol, hexane, dichloromethane, butanol, and aqueous extracts and chemical composition and fatty acids of n-hexane extract from endemic Hedysarum aucheri were determined. The fatty acid content of the n-hexane extract was determined...
Article
A simple method via the base-catalyzed Michael addition of nitroalkanes to 2-iminochromenes was developed, which leads to the production of highly functionalized 2-amino-3-nitrile-4
Article
A series of medicinally important title compounds are synthesized using enantioselective conjugate addition of nitromethane to iminochromenes.
Article
A series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu (II) catalytic system and moderate to good enantioselectivities (62-88%) and yields (66-96%) were obtained.
Article
The methanol extract of Astragalus plumosus var. krugianus Chamb. & Matthews afforded sixteen cycloartane glycosides among which krugianoside A, never reported before. All compounds were evaluated for their cytotoxic activity in human skin fibroblast WS1 cells. For compounds exhibiting no significant effect on WS1 viability, the antioxidant potenti...
Article
A series of phenolic and saponin type natural products such as quercetin, rutin, catechin, epicatechin, silymarin, trojanoside H, astragaloside IV, astragaloside VIII and astrasieversianin X, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). We here report inhibitory effects of these compo...
Article
The genus Astragalus belonging to the Leguminosae family is widely distributed throughout the temperate regions of the world. In the flora of Turkey, this genus is represented by 445 species [1,2]. The roots of Astragalus are used in traditional medicine as an antiperspirant, diuretic and tonic drug. It has also been used in the treatment of diabet...
Article
Four triterpene saponins, agrostemmosides A-D were isolated from the methanol extract of Agrostemma gracilis. The structures of the compounds were determined as 3-O-beta-D-xylopyranosyloleanolic acid 28-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->6)]-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester, 3-O-alpha-L-rhamnopyranos...
Article
A novel triterpene glycoside, undulatoside (1), which is characterised as 3-O-(beta-D-glucopyranosyl)-29-O-(beta-D-glucopyranosyl)-2alpha,23-dihydroxyolean-12-en-28-oic acid, was isolated from Anchusa undulata subsp. hybrida and its structure was deduced by spectral data. In addition to undulatoside, seven known triterpene glycoside and a flavonoid...
Article
Two flavonoid glycosides (compounds 1 and 3) of which one is reported for the first time and a methylinositol (compound 2) were isolated from the aerial parts of Ebenus haussknechtii (Leguminosae). The structures were established as quercetin-7-O-[alpha-L-rhamnopyranosyl(1 --> 6)-beta-D-galactopyranoside] (1), morin-3-O-[4-[5-(4-hydroxyphenyl)penta...
Article
Full-text available
UV/VIS spectral characteristics of three new biologically active natural products, isolated from Turkish lichens, have been investigated in solvents of various polarity and proton donating ability. The effect of the solvent on spectral characteristics has been estimated. Quantum chemical calculations with the optimization of molecular geometry were...
Article
Full-text available
Two subspecies of mistletoe (Viscum album L. ssp. album and ssp. abietis) growing on lime and pine trees, respectively, were investigated for the monosaccharides and polyols by GC-MS spectrometry. Arabinose, xylose, glucose, galactose, mannose, xylitol and inositol were determined in methanol extracts following the acidic hydrolysis. Sugar contents...
Article
Three natural products were isolated from three dierent Turkish lichens. Microbiological investiga- tions were also examined of these lichens. Compound 1 is known as 2-hydroxy-4-methoxy-3,6-dimethyl benzoic acid, and is isolated from Pseudevernia furfuracea for the rst time. Compounds 2 and 3 are de- tected as new compounds and called, 3-acetyl-4-a...

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