
Odile Feys- MD, PhD
- Université Libre de Bruxelles
Odile Feys
- MD, PhD
- Université Libre de Bruxelles
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37
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Publications (37)
This review explores the role of the thalamus in focal epilepsy, focusing on insights gained from stereoelectroencephalography (SEEG). The thalamus has recently regained attention as a crucial player in seizure dynamics. Thalamic SEEG recordings can be used to assess certain aspects of the thalamus’s role in human focal epilepsy, in particular the...
Cryogenic magnetoencephalography (MEG) has a lower yield in temporal lobe epilepsy (TLE) than in extratemporal lobe epilepsy. The advent of optically pumped magnetometers (OPMs) might change this situation thanks to on‐scalp MEG. This study aims to investigate the detection/localization accuracy of interictal epileptiform discharges (IEDs) using on...
Objective
Intracranial single‐pulse electrical stimulation (SPES) can elicit cortico‐cortical evoked potentials. Their investigation with intracranial EEG is biased by the limited number and selected location of electrodes, which could be circumvented by simultaneous non‐invasive whole‐scalp recording. This study aimed at investigating the ability...
In recent years, new technologies have been developed to study epilepsy, in particular optically pumped magnetometers. In this editorial, I review some recent work on on-scalp magnetoencephalography in epilepsy and ponder the question: is it science fiction or reality? I specifically develop two aspects of my point of view on advances and challenge...
The fetus in the third trimester of gestation has already the remarkable capacity to process external sensory information in utero. So far, investigations of fetal brain responses to sensory information have mostly relied on cryogenic magnetoencephalography (MEG), which is suitable to record fetal brain activity and is not much affected by layers o...
Characterizing the early development of the human brain is critical from both fundamental and clinical perspectives. However, existing neuroimaging techniques are either not well suited to infants or have limited spatial or temporal resolution. The advent of optically pumped magnetometers (OPMs) has revolutionized magnetoencephalography (MEG) by en...
Magnetoencephalography (MEG) allows the non-invasive detection of interictal epileptiform discharges (IEDs). Clinical MEG analysis in epileptic patients traditionally relies on the visual identification of IEDs, which is time consuming and partially subjective. Automatic, data-driven detection methods exist but show limited performance. Still, the...
Magnetoencephalography (MEG) allows the non-invasive detection of interictal epileptiform discharges (IEDs). Clinical MEG analysis in epileptic patients traditionally relies on the visual identification of IEDs, which is time consuming and partially subjective. Automatic, data-driven detection methods exist but show limited performance. Still, the...
Cryogenic magnetoencephalography (MEG) has a lower yield in temporal lobe epilepsy (TLE) than in extra-TLE (ETLE). The advent of optically pumped magnetometers (OPMs) might change this thanks to on-scalp MEG, which allows sensors to be placed closer to the brain and the design of bespoke sensor arrays to target specific brain regions. This study ai...
Introduction
Cortico‐cortical evoked potentials (CCEPs) were described as reproducible during trains of single‐pulse electrical stimulations (SPES). Still, few studies described a variability of CCEPs that was higher within the epileptogenic zone (EZ). This study aimed at characterizing the relationship of CCEP variability with the occurrence of in...
Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; however, the field has been revolutionised in recent years by the introduction of optically-pumped magne...
Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; however, the field has been revolutionised in recent years by the introduction of optically-pumped-magne...
Background
Epileptic seizures are an established comorbidity of Alzheimer’s disease (AD). Subclinical epileptiform activity (SEA) as detected by 24-h electroencephalography (EEG) or magneto-encephalography (MEG) has been reported in temporal regions of clinically diagnosed AD patients. Although epileptic activity in AD probably arises in the mesial...
Background
Plasma melatonin levels drop in elderly, which might become more pronounced in Alzheimer’s disease (AD) as compared to controls.(1) Melatonin can serve as a potential biomarker for AD, given the inverse correlation between cerebrospinal fluid (CSF) melatonin levels and severity of neuropathology (Braak stages).(2) Due to suggested antiep...
Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the application of tri-axial OPMs [⁸⁷Rb (Rb-OPM) and ⁴He gas (He-OPM)] for the detection of interictal epileptiform di...
Characterizing the early development of the human brain is critical from both fundamental and clinical perspectives. However, existing neuroimaging techniques are either not well suited to infants or have limited spatial or temporal resolution. The recent advent of optically pumped magnetometers (OPMs) has revolutionized magnetoencephalography (MEG...
The validation of on-scalp magnetoencephalography based on optically pumped magnetometers (OPM-MEG) for clinical applications requires the assessment of the spatial concordance between reconstructed neural sources and intracranial data recorded simultaneously.
We here report unprecedented data from an epileptic woman suffering from refractory focal...
Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the interest of tri-axial OPMs (87Rb (Rb-OPM) and 4He gas (He-OPM)) for the detection of interictal epileptiform disch...
The analysis of clinical magnetoencephalography (MEG) in patients with epilepsy traditionally relies on the visual identification of interictal epileptiform discharges (IEDs), which is time consuming and dependent on (subjective) human criteria. Data-driven approaches enabling both spatial and temporal localization of epileptic spikes would represe...
Magnetoencephalography (MEG) is a neurophysiological technique based on the detection of brain magnetic fields. Whole‐head MEG systems typically house a few hundred sensors requiring cryogenic cooling in a rigid one‐size‐fits‐all (commonly adult‐sized) helmet to keep a thermal insulation space. This leads to an increased brain‐to‐sensor distance in...
Due to heterogenous seizure semiology and poor contribution of scalp electroencephalography (EEG) signals, insular epilepsy requires use of the appropriate diagnostic tools for its diagnosis and characterization. The deep location of the insula also presents surgical challenges. The aim of this article is to review the current diagnostic and therap...
Background: Magnetoencephalography (MEG) is an established method used to detect and localize focal interictal epileptiform discharges (IEDs). Current MEG systems house hundreds of cryogenic sensors in a rigid, one-size-fits-all helmet, which results in several limitations, particularly in children. Purpose: To determine if on-scalp MEG based on op...
Magnetoencephalography (MEG) is an established method to investigate epilepsy. Current MEG systems house hundreds of cryogenic sensors in a rigid, one-size-fits-all helmet, which results in several limitations, particularly in children. On-scalp MEG based on optically-pumped magnetometers (OPMs) may alleviate these limitations.
We report on five ch...
Purpose
To evaluate the yield of Functional Connectivity (FC) in addition to low-density ictal Electrical Source Imaging (ESI) in extratemporal lobe epilepsy (ETLE), using an automated algorithm for analysis.
Method
Long-term EEG monitoring of consecutive ETLE patients who underwent surgery was reviewed by epileptologists, and seizure onsets chara...