Odile Chambin

Odile Chambin
University of Burgundy | UB · Unité Mixte de Recherche Procédés Alimentaires et Microbiologiques (PAM)

About

82
Publications
24,245
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3,762
Citations
Citations since 2017
12 Research Items
2281 Citations
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400

Publications

Publications (82)
Article
This work aims to synthesize polygalacturonate-based magnetic iron oxide nanoparticles (INP-polyGalA). The synthesis consists of the diffusion of both Fe²⁺ and Fe³⁺ at a molar ratio of 1:2 through polyGalA solution followed by the addition of an alkaline solution. To form individual nanoparticle materials, the polyGalA concentration needs to be bel...
Article
A phytochemical study of Cordyline fruticosa “Fairchild red” (Asparagaceae) from Vietnam, led to the isolation of fourteen steroidal glycosides, including twelve previously undescribed along with two known ones. Ten compounds were obtained by successive solid/liquid chromatographic methods from an aqueous-ethanolic extract of the roots, and four fr...
Chapter
Pectin as a natural biopolymer is extensively used for pharmaceutical and biomedical applications, essentially due to its gelling properties that could be influenced by pectin sources and extraction methods. This chapter focuses on an overview of pectin drug delivery systems classified by their administration routes. Oral drug delivery systems have...
Article
Hydrocolloid-based films containing natural phenolic antioxidants (gallic and trans-cinnamic acids at 5% w/wt of polymers) embedded in a gelatin/chitosan matrix were designed as sustainable active packaging. This work deals with characterizing the release mechanisms of the phenolic acids from the films immersed into food simulants (sugar or polyol...
Article
Anaerobic commensal gut bacteria are among the most promising future treatments for many diseases. Because of their sensitivity to oxygen and to the harsh conditions of the gut, few studies on formulations that deliver bacteria in a viable and functional form to the intestine have been done. The aim of this study was to develop a reliable and easy-...
Article
Pectin from mango peel (MP) was extracted and studied by analytical and physicochemical methods in comparison to low methoxyl pectin (LMP). The results revealed that MP contained 68% galacturonic acid, and its degree of esterification determined by titration and ¹H NMR were 76% and 79%, respectively. For water sorption kinetics, LMP exhibited highe...
Article
Seven oleanane-type glycosides were extracted and isolated by various chromatographic methods from the roots of Weigela x “Bristol Ruby” (1–7), six previously undescribed (1–6) and a known one (7). Their structures were assigned by spectroscopic analysis mainly 2D NMR and mass spectrometry (ESIMS). Selected triterpenoid glycosides (1–3,6,7) display...
Article
Polysaccharide-based hydrogels were prepared by the diffusion of divalent cations (X²⁺) into the polygalacturonate (polyGal) solution through a dialysis membrane. The diffusion of four divalent cations (Mg²⁺, Ca²⁺, Zn²⁺ and Ba²⁺) was investigated. The polyGal gel growth was studied as a function of the initial cation concentration by both viscoelas...
Article
Faecalibacterium prausnitzii was previously recognized for its intestinal anti-inflammatory activities and it has been shown less abundant in patients with chronic intestinal diseases. However, the main problems encountered in the use of this interesting anaerobic microorganism are firstly its high sensitivity to the oxygen and secondly, its abilit...
Article
Résumé La pharmacovigilance repose sur le signalement des effets indésirables, le recueil des données, la prise de mesures correctives ou préventives, voire la réalisation d’études complémentaires. Le pharmacien d’officine doit jouer un rôle de premier ordre, concourant à réduire les risques liés à l’utilisation des médicaments. Il doit se position...
Article
Full-text available
This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor; propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20–40% w/w) on mechanical and thermal properties of LMP films a...
Article
Three polyuronates: amidated low methoxyl pectin (ALMP), low methoxyl pectin (LMP) and polygalacturonic acid (PGA) were used to encapsulate rutin in pellets, and they were characterized by different techniques (macroscopic properties, calcium and rutin release). The ability of the three polyuronates to bind calcium ions and the viscoelastic propert...
Patent
The invention concerns a method for preparing a double emulsion of a fat-soluble and hydrophobic active ingredient, which comprises the following steps: • ◦(a) Providing an aqueous solution of at least one whey protein; ◦(b) Providing an aqueous solution of at least one anionic polysaccharide; ◦(c) Subjecting the whey protein(s) to a denaturation t...
Article
This work dealt with the study of the release kinetics of quercetin incorporated into chitosan-gelatin edible films after electron beam irradiation. The aim was to determine the influence of irradiation dose (at 40 and 60kGy) on the retention of quercetin in the films, their release in a hydroalcoholic medium (30% ethanol v/v) at 25°C. Irradiation...
Article
In this work, we have investigated the interactions between polygalacturonate (polyGal) and four divalent cations (M(2+)= Ba(2+), Ca(2+), Mg(2+), Zn(2+)) that differ in size and affinity for water. Our results evidence that M(2+)-polyGal interactions are intimately linked to the affinity of M(2+) for water. Mg(2+) interacts so strongly with water t...
Article
Chitosan and fish gelatin were used to formulate active biobased films containing an antioxidant (coumarin). After drying, the films were irradiated at 40 and 60 kGy using an electron beam accelerator. The effect of irradiation on the film properties as well as the coumarin release mechanism were investigated and compared with the control. Electron...
Article
Résumé Jeûner pendant le ramadan expose les personnes diabétiques à des risques tels que des hypoglycémies pouvant aller jusqu’au malaise, voire au coma. Durant cette période, le pharmacien d’officine joue un rôle de relais en tant que premier acteur en contact avec les patients auxquels il doit prodiguer des conseils diététiques et thérapeutiques.
Article
This work deals with the study of the release kinetics of antioxidants (ferulic acid and tyrosol) incorporated into chitosan-gelatin edible films after irradiation processes. The aim was to determine the influence of electron beam irradiation (at 60 kGy) on the retention of antioxidants in the film, their release in water (pH=7) at 25 °C, in relati...
Article
Full-text available
This study investigated the scavenging activity of rutin encapsulated in non-amidated low methoxyl pectin beads in various formulations with or without sorbitol and/or sodium bicarbonate (NaHCO3). The beads were made and the releases of rutin from various bead formulations were investigated. Also, the DPPH radical scavenging activity of all bead fo...
Article
Full-text available
In this paper, we compare the interactions between low methoxy pectin (LMP) and either Ca2+ or Zn2+ in semi-dilute solutions. Intrinsic viscosity and turbidity measurements reveal that pectin-calcium solutions are more viscous, but yet less turbid, than pectin-zinc ones. To get a molecular understanding on the origin of this rather unexpected behav...
Article
A young woman aged 24 comes to the pharmacy for a monthly renewal of her prescription for the medication she is taking for psoriasis which has been developing for the past 15 months. The pharmacist must take the opportunity to explain how to manage this symptomatic treatment and notably the precautions to take with regard to its application, as wel...
Article
A young girl of 19 comes to the pharmacy with her monthly repeat prescription for a treatment for papulopustular acne.
Data
Full-text available
The aim of this work is to develop novel organic–inorganic hybrid beads for colonic drug delivery. For this purpose, calcium pectinate beads with theophylline are prepared by a cross-linking reaction between amidated low-methoxyl pectin and calcium ions. The beads are then covered with silica, starting from tetraethyoxysilane (TEOS), by a sol–gel p...
Article
Curcumin is a polyphenolic compound with diverse effects interesting to develop health benefit products but its formulation in functional foods or in food supplement is hampered by its poor water solubility and susceptibility to alkaline conditions, light, oxidation and heat. Encapsulation of curcumin could be a mean to overcome these difficulties....
Patent
L'invention concerne un procédé de préparation d'une émulsion double d'un principe actif hydrophobe et liposoluble, qui comprend les étapes suivantes: (a) On dispose d'une solution aqueuse d'au moins une protéine de lactosérum; (b) On dispose d'une solution aqueuse d'au moins un polysaccharide anionique; (c) On soumet la ou les protéines du lactosé...
Article
The aim of this work was to apply flow cytometry in order to assess and compare the viability of freeze-dried entrapped bacteria with an usual technique by quantification by plate count techniques. It also aimed at studying the effect of various cryoprotectants on the viability of an entrapped Bifidobacterium bifidum subjected to freeze-drying to c...
Article
The aim of this work is to develop novel organic-inorganic hybrid beads for colonic drug delivery. For this purpose, calcium pectinate beads with theophylline are prepared by a cross-linking reaction between amidated low-methoxyl pectin and calcium ions. Then beads are covered with silica starting from tetraethyoxysilane (TEOS) by a sol-gel process...
Article
Engineering the interface of oil-in-water emulsion droplets with biopolymers that modify its permeability could provide a novel technique to improve flavour retention in dry powders. The objective of this study was to determine if volatile compounds were more retained in dry emulsions stabilized by pea protein isolate (PPI)/pectin complex than that...
Article
The drug delivery systems that are the object of this article take the form of a hydrophilic matrix (collagen or crosslinked collagen) containing a drug. These devices can be used as The model active agents, were chosen from the range of local anaesthetics (lidocaine hydrochloride), anti-inflammatory (diclofenac sodium salt) and antioxydant (caffei...
Article
The drug delivery systems that are the object of this article take the form of a polymer matrix made of silicone containing a drug. These devices can be used as patches for local dermal applications releasing the drug in a controlled manner. The model active agent, lidocaine hydrochloride was chosen from the range of local anesthetics. When the dru...
Article
This work analyses the release of n-hexanal and d-limonene from edible films, previously encapsulated in the iota-carrageenan matrix (with and without lipid). Both volatile compounds have different physico-chemical properties. The effect of temperature (25 °C and 37 °C) and dissolution medium (water and 0.9% NaCl) on the release and retention of ar...
Article
Oil-in-water emulsions can be considered as an important delivery system for lipophilic food molecules. In this study, pea protein isolate (PPI) was studied for its emulsifying capacity at various pH values and pH7 was selected to prepare emulsions for the production of dry microcapsules. Emulsions stabilized by PPI just enough to cover oil droplet...
Article
Zinc-pectinate beads are interesting drug carriers for oral delivery. In order to investigate their in vitro and in vivo release behaviour, ionotropic gelation was used to entrap theophylline into calcium- or zinc-pectinate beads. Beads were investigated in vitro for their particle properties, especially the release kinetic in different media, and...
Article
The aim of this study was to investigate drug release from calcium and zinc pectinate beads and to understand the impact of medium electrolytes during drug transfer. A potential drug carrier for colonic drug delivery (rutin) was prepared with calcium and zinc pectinate beads and was tested in three different simulated intestinal fluids (pH 7.3) wit...
Article
In this study, development of pea (Pisum sativum) protein stabilised dry and reconstituted emulsions is presented. Dry emulsions were prepared by spray-drying liquid emulsions in a laboratory spray-dryer. The effect of drying on the physical stability of oil-in-water emulsions containing pea protein-coated and pea protein/pectin-coated oil droplets...
Article
The effect of the addition of high methoxyl pectin on the stability of pea protein isolate emulsions was investigated. Except for low pectin concentrations at acidic pHs where bridging flocculation occurred the addition of pectin improved emulsion stability to pH changes and depletion flocculation induced by maltodextrin addition. The mechanism of...
Article
Calcium and zinc pectinate gels were prepared using a method which allowed calcium or zinc to diffuse from the cross-linking solution through a dialysis membrane to form a gel with amidated low-methoxyl pectin. The gel thus obtained was then dried, and the film structure was studied using FTIR spectroscopy as a function of the cation content (0%, 5...
Article
This work presents equilibrium and dynamic aspects for the adsorption at the oil–water interface of pea (Pisum sativum L.) protein isolate (PPI). Dynamic interfacial tension, γ, and surface viscoelasticity modulus, ε, were determined using pendant-drop method. Adsorption kinetics studies revealed that pea proteins adsorb faster at pH 7.0 than at ac...
Conference Paper
Conventional oil-in-water emulsions could be considered as an important delivery system of lipophilic molecules because of their relative ease of preparation and low cost. Emulsification is one of the key steps in the preparation of microencapsulated components by spray-drying. The emulsion must be stable over a certain period of time prior to spra...
Article
To overcome low oral bioavailability of poorly water-soluble drugs, self-emulsifying drug delivery systems (SEDDS) have been noted as a promising strategy. However, incorporation of drugs into SEDDS composed of Gelucire44/14 could induce interactions not yet well understood. The aim of this study was to investigate the influence of drug polarity up...
Article
Spray-drying process has been used for decades to encapsulate food ingredients such as flavors, lipids, and carotenoids. During this drying process, the evaporation of solvent, that is most often water, is rapid and the entrapment of the interest compound occurs quasi-instantaneously. This required property imposes a strict screening of the encapsu...
Poster
Full-text available
To investigate the effect of relative humidity upon the surface structure of Gelucire® 44/14 by Atomic Force Microscopy
Poster
Full-text available
To evaluate the possibility to obtain a solid SEDDS containing Gelucire® 44/14 and adsorbents (Aerosil®200 or Aeroperl®300) by spray-congealing methods.
Article
In this study, pectinate gel beads were produced by ionotropic gelation method with different solutions of cross-linking agents and ketoprofen was entrapped as model drug. The influence of these formulation parameters was investigated upon bead properties and upon their performance to target the colon. Zinc pectinate beads obtained with 10% of coun...
Article
For colonic delivery, pectin beads obtained by ionotropic gelation method have been already reported as an interesting approach. This study investigated the influence of the cross-linking agent (calcium or zinc) and the type of shell capsule used (classical or enteric capsules) on pectin beads properties and on their performance to target the colon...
Article
Lipid excipients are usually used for the development of sustained-release formulations. When used in relatively high quantities, Precirol ATO 5 imparts sustained-release properties to solid oral dosage forms, by forming a lipid matrix. To control or adjust the drug release kinetics from such lipid matrix however, one must often resort to complemen...
Poster
Full-text available
The aim of this study was to investigate the influence of two hydrophilic polymers, Poloxamers 188 & 407 on the dissolution performance and stability of Precirol ATO 5 lipid-matrices obtained by capsule molding.
Article
Nowadays, oral dosage forms with controlled release kinetics have known an increasing interest. The polymer coating of drug-loaded particles is one of the most common methods used for controlling drug delivery. Such multilayered particles could be either filled into capsules or compressed into tablets for their oral administration. However, many st...
Article
This paper focuses on the interest of a multifunctional lipid excipient from the lauroyl macrogolglycerides, i.e., Gelucire 44/14. This compound, characterized by a drop point of 44 degrees C and a HLB (Hydrophilic Lipophilic Balance) of 14, is made of a specific mixture, leading to particular properties. Gelucire 44/14 forms a fine emulsion in con...
Article
Self Emulsifying Drug Delivery Systems and dry emulsions are innovative lipid formulations. Their main interest is to increase the bioavailability of lipophilic active substances, while increasing their stability on a physicochemical and microbiological level. The main difference is the manufacturing process: Self Emulsifying Systems are formulated...
Article
Recently, self-emulsifying drug delivery systems (SEDDS) have been developed as a method to deliver lipophilic drugs. Gelucire 44/14 is an excipient, from the lauroyl macrogolglycerides family, producing a fine oil-in-water emulsion when introduced into an aqueous phase under gentle agitation as SEDDS, improving thereby solubility of poorly water-s...
Article
Recently, self-emulsifying drug delivery systems (SEDDS) have been developed as a method to deliver lipophilic drugs. Gelucire® 44/14 is an excipient, from the lauroyl macrogolglycerides family, producing a fine oil-in-water emulsion when introduced into an aqueous phase under gentle agitation as SEDDS, improving thereby solubility of poorly water-...
Article
As a matter of fact, in vitro dissolution is well known to be the method of choice for the pharmaceutical industry to develop effective medicines. However, many experiments must be performed all along a new product life and they represent an overcharge of work for researchers. The purpose of this paper was to assess the relevance of new parameters...
Article
The behaviour of a pharmaceutical form, called dry adsorbed emulsion (DAE), containing a sparingly soluble drug (i.e. theophylline) was studied for dissolution drug release kinetic, in relation with DAE structure characterisation. In vitro dissolution testings were performed under different experimental conditions (medium at pH 1.2 and 7.4, medium...
Article
A recent solid pharmaceutical form called "Dry Adsorbed Emulsion" (DAE) was characterized in morphological and structural fields. A DAE is an intricate system initiated by a water-in-oil emulsion including the active drug (i.e., theophylline). Each emulsion phase is adsorbed on pulverulent adsorbents with a suitable polarity (silica) to obtain a fr...
Article
This study evaluates the influence of moisture content on the packing performances of a new grade of microcrystalline cellulose (MCC) (Avicel PH-302) either by classical method or by an unconventional compression technique (constant volume reduction of powder bed). An increase in moisture content decreases the apparent density of the powder bed, re...
Article
The percutaneous absorption of caffeine from two vehicles, an emulsion and an acetone solution, was quantified by in vivo techniques in humans. A surface recovery technique over a 6-h application and a stripping method after a 30-min application were performed on the volar aspect of the forearm on 12 volunteers. Caffeine was assessed by HPLC. Two p...

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