Odd V. Höglund

Odd V. Höglund
Swedish University of Agricultural Sciences | SLU · Department of Clinical Sciences

DVM, PhD

About

87
Publications
15,292
Reads
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651
Citations
Citations since 2016
52 Research Items
572 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
I've worked with the development and clinical tests of resorbable implants. The initial invention, based on the construction of a self-locking loop (the LigaTie®), is described in my PhD thesis, http://pub.epsilon.slu.se/8589/ , alongside methods for measurement of surgical stress. New surgical techniques are continuously being developed. Objective methods are needed for evidence based comparison and evaluation. In my research I have focused on intra-operative measurements of surgical stress.

Publications

Publications (87)
Article
Canine orchiectomy (COE) is one of the most commonly performed procedures in small animal veterinary surgery. The aim of this study was to assess veterinary students’ confidence in performing this surgery in relation to their previous surgical experience of the procedure. The hypothesis was that confidence to perform canine orchiectomies among rece...
Article
Full-text available
Background Canine tonsillectomy is performed due to acute or chronic tonsillitis, neoplasia, trauma or occasionally brachycephalic obstructive airway syndrome. Several tonsillectomy techniques are used but information about surgical complications is scarce. This retrospective study of patient records at the University Animal Hospital aimed to inves...
Preprint
Full-text available
Background: Canine tonsillectomy is performed due to acute or chronic tonsillitis, neoplasia, trauma or occasionally brachycephalic obstructive airway syndrome. Several tonsillectomy techniques are used but information about surgical complications is scarce. This retrospective study of patient records at the University Animal Hospital aimed to inve...
Article
Full-text available
Objective This study aimed to investigate the short-term effect of ovariohysterectomy on urine levels of serotonin and its relation to levels of cortisol, testosterone and progesterone in female dogs. Seven bitches were studied before surgical ovariohysterectomy and then once a week during 4 weeks. Spontaneously voided urine samples were collected...
Article
Full-text available
Objective Our aim was to analyse the chromogranin A-derived peptides vasostatin and catestatin in serum from wild boar ( Sus scrofa ) captured in a corral trap. Acute capture-related stress quickly leads to a release of adrenalin and noradrenalin, but these hormones have a short half-life in blood and are difficult to measure. Chromogranin A (CgA),...
Article
Full-text available
A resorbable 3D printed polydioxanone (PDO) device is manufactured to facilitate ligation of vascular tissue during surgery. The device must provide sufficient mechanical performance throughout the healing period. Therefore, degradation and mechanical performance of the device are investigated as a function of in vivo and in vitro aging. During agi...
Article
Full-text available
Cruciate ligament rupture (CLR) is a common orthopedic disorder in dogs. The study objectives were to evaluate incidence rate (IR), cause-specific mortality rate (CSMR) and risk factors for CLR in insured dogs. A single cohort study of dogs insured in Agria Pet Insurance in Sweden (2011–2016) was performed. Age at diagnosis, IR, CSMR and relative r...
Article
Objective To analyze the effect of surgical technique and other risk factors on severe postoperative complications in dogs with cranial cruciate ligament disease (CCLD). Materials and Methods A cohort study of 255 dogs (287 stifles) surgically treated for CCLD at two veterinary university hospitals (2011-2016) was performed. The electronic medical...
Article
Full-text available
Background: Stifle joint diseases (SJD) are common in dogs and include a variety of diagnoses. The objective of the study was to provide an overview of the epidemiology of SJD in insured dogs. Methods: An historical single cohort study of dogs insured in Agria Pet Insurance (2011-2016) in Sweden was performed. Incidence and relative risk (RR) of...
Article
Full-text available
Objective To test the feasibility of a resorbable self‐locking device for sealing of lung tissue in lung lobectomy in experimental dogs and dogs with pulmonary mass, and to study its resorption with CT. Study design Experimental study and clinical case series. Animals Five beagles in the experimental group; six canine patients with a pulmonary ma...
Article
Full-text available
Background: The protein chromogranin A (CgA) is stored and co-released with catecholamines from the stimulated adrenal glands. Increased plasma concentrations of CgA have been shown in people with heart disease. The aim of the study was to investigate whether plasma concentrations of the CgA-derived biologically active peptides catestatin and vaso...
Article
Full-text available
Background Dental disease is very common in dogs and veterinary professional dental cleaning and examination, together with daily dental home care, is the foundation for good dental health. To our knowledge, no previous study has investigated professional dental cleaning routines in small animal veterinary practice. A validated questionnaire survey...
Article
Full-text available
Periodontal disease is one of the most common diseases affecting dogs, with a reported prevalence of at least 80% in dogs over 3 years of age. However, there is a lack of studies regarding dog owners' assessment of their dog's dental health, and whether they perceive clinical signs often associated with periodontal disease, i.e., dental calculus, h...
Article
Full-text available
Objective To analyse the effect of treatment method and other risk factors on survival in dogs with cranial cruciate ligament disease (CCLD). Methods A historical cohort study of 333 dogs presenting with CCLD at two University Hospitals (2011-2016) was performed. Signalment, history, treatment and follow-up details were retrieved from medical reco...
Article
Full-text available
Background: Periodontal disease remains one of the dog's most common health issues, even though it is largely preventable by tooth brushing. Implementation of daily tooth brushing would not only improve animal welfare, but also reduce veterinary costs for the owner. There is a paucity of studies investigating attitudes, opinions and practices of d...
Presentation
A resorbable self-locking loop in case series
Article
Full-text available
A resorbable self-locking device (LigaTie) was developed to enable safe and easy surgical ligation of blood vessels. The aim of this study was to compare the long-term in vivo resorption of the device to a commercially available suture of equivalent material (Maxon) following ovarian pedicle ligation. After ovariohysterectomy follow-up ultrasound e...
Article
Full-text available
Background Dental disease is one of the most common health problems in dogs. However, no studies have investigated the attitudes, opinions and practices of dog owners, veterinarians and veterinary nurses regarding dental health and preventative dental home care in dogs. The objective of this study was therefore to develop and validate questionnaire...
Article
Objective To compare airway leak pressures after sealing peripheral lung biopsy sites with a resorbable ligation device (LigaTie) or thoracoabdominal (TA) staples. Study design Ex vivo study. Animals Four normal caprine cadavers. Methods Twelve lung lobes were harvested from 4 goats immediately after euthanasia. Each lobe was inflated to 20 cm H...
Data
File containing detailed survey construction. (DOCX)
Data
Correlation matrices of variables included in factor analyses. (XLSX)
Data
File containing translated questionnaire (English) to dog owners and translated questionnaire (English) to veterinary health practitioners. (PDF)
Data
File containing factor analysis estimates. (XLSX)
Data
File containing questionnaire items in Swedish, in English, short variable names, why some items are not included in the EFA, action on “”Don’t know” and action on missing value. (XLSX)
Article
Objective To compare the maximum pressure sustained by airways sealed with a resorbable ligation device (LigaTie) and with thoracoabdominal (TA) staples during thoracoscopic‐assisted hilar lung lobectomies. Study design In situ cadaveric study. Animals Ten feline cadavers. Methods Twenty lung lobectomies were performed with either a LigaTie or a...
Article
Catecholamines can be used to evaluate neuroendocrine tumors, stress, and potentially pain, but catecholamines degrade rapidly. Their metabolites normetanephrine (NME) and metanephrine (ME) have better stability in urine. In cats, urine sampling in a home environment would be beneficial to reduce effects of clinical stress and simplify sampling. We...
Patent
Full-text available
A medical device comprises an elongated, flexible band and a locking case. Multiple studs are arranged on the band. (Abbreviated).
Article
The aim of this pilot test was to test a new self-locking resorbable implant for hilum occlusion during a video-assisted thoracoscopic lung lobectomy in a surviving pig model. Once the thoracic cavity was assessed and structures identified, the right middle lobe and its respective hilum were exposed. The implant was introduced with a semiclosed loo...
Article
Objectives The use of physiological parameters such as respiratory rate and heart rate to assess pain has long been discussed. The aim of the study was to compare postoperative respiratory rate and heart rate in cats subjected to flank ovariohysterectomy treated with a preoperative non-steroidal anti-inflammatory drug (NSAID) or no NSAID, and deter...
Article
Full-text available
The neuroendocrine glycoprotein chromogranin A is a useful biomarker for stress in humans. Chromogranin A epitopes catestatin and vasostatin can be measured in dogs using radioimmunoassays. The objective of this study was to evaluate catestatin and vasostatin as canine stress biomarkers in a clinical setting. Blood and saliva were collected from 33...
Patent
Full-text available
A medical device for tissue ligation contains a band having perforations and rungs. A locking case is connected to the and and has a channel dimensioned for reception of the band. A locking member of the locking case is configured to interlock perforations and rungs in the band. The channel contains an arching portion into which the band at least p...
Article
Laparoscopic cholecystectomy is the standard of care in human medicine for gall bladder disease. Although infrequently reported in veterinary literature, laparoscopic cholecystectomy is an option for uncomplicated gall bladder disease in canine patients. Due to the risk of cystic duct ligature slippage or clip dislodgement, we wanted to explore the...
Article
Full-text available
Background Traumatic bone fractures cause moderate to severe pain, which needs to be minimized for optimal recovery and animal welfare, illustrating the need for reliable objective pain biomarkers for use in a clinical setting. The objectives of this study were to investigate catestatin (CST) and vasostatin (VS) concentrations as two new potential...
Article
Full-text available
Background Colorectal cancer is common in humans where treatment involves surgical removal of the cancerous part of the intestines. In the anastomosis procedure a purse-string suture may be time consuming to perform. The aim was to replace the purse-string suture, to develop and test a self-locking loop for temporary sealing of the lumen in colon a...
Patent
Full-text available
Article
Full-text available
Background: The neuroendocrine glycoprotein chromogranin A is a useful biomarker in humans for neuroendocrine tumors and stress. Chromogranin A can be measured in both blood and saliva. The objective of this study was to investigate concentrations of and correlation between the chromogranin A epitopes catestatin and vasostatin in healthy dogs accus...
Article
Full-text available
Background Surgery causes a stress response, a physiologic response to trauma. The intraoperative surgical stress response in dogs diagnosed with pyometra has not previously been described. The aim of this study was to investigate the intraoperative surgical stress response, assessed by blood pressure and heart rate measurements, in dogs diagnosed...
Article
Lack of confidence and self-efficacy are the main causes of negative emotions experienced by veterinary students when performing surgery. A surgical training model (STM) was developed to test the hypothesis that practical training on an STM before performing live surgery would enhance the students' confidence. In addition, low-cost and easily acces...
Article
Full-text available
Background The stress reaction induced by surgery and associated pain may be detrimental for patient recovery and should be minimized. The neuropeptide chromogranin A (CGA) has shown promise as a sensitive biomarker for stress in humans. Little is known about CGA and its derived peptides, catestatin (CST) and vasostatin (VS), in dogs undergoing sur...
Article
In veterinary clinical education, students perform surgery under guided supervision. This study aimed to determine if students' perception of how well they understood verbal guidance could be improved by using a laser pointer during feline castration. It was assumed that a teacher's use of a laser pointer could help students identify structures of...
Article
Full-text available
Background Ligation of the mesovarium in female dogs may be cumbersome with risk of complications and is associated with intense noxious stimuli. A resorbable implant, a self-locking loop designed for surgery, was developed as an alternative to traditional ligation. The study aimed to test the feasibility of ligating the canine ovarian pedicle with...
Article
Online light dosimetry with real-time feedback was applied for temoporfin-mediated interstitial photodynamic therapy (PDT) of dog prostate. The aim was to investigate the performance of online dosimetry by studying the correlation between light dose plans and the tissue response, i.e., extent of induced tissue necrosis and damage to surrounding org...
Conference Paper
Full-text available
Background: Pyometra often induces systemic inflammatory response syndrome (SIRS) and early diagnosis is crucial. Chromogranin A (CgA) is a neuroendocrine secretory protein that is co-released with catecholamines from the adrenal medulla and sympathetic nerve endings. A prognostic value of CgA has been shown in humans that are critically ill or tha...
Conference Paper
Full-text available
Introduction Chromogranin A (CgA) has been used as a valuable biomarker for psychological stress in humans [1, 2]. In dogs, plasma CgA has been shown to increase in response to acute stress caused by insulin-induced hypoglycemia [3]. CgA can be measured in both blood and saliva [1-3]. Recently, a radioimmunoassay for measuring the CgA-derived pepti...
Article
Full-text available
Objectives: Biomarkers representing sympathetic tone and the surgical stress response are measured to objectively evaluate surgical techniques and anaesthetic protocols. If a part of the intraoperative procedure is repeated on the contralateral organ, one animal may potentially serve as its own control and, if so, may minimize the problem of indiv...
Article
Full-text available
Background: Pyometra often induces systemic inflammatory response syndrome (SIRS) and early diagnosis is crucial for survival. Chromogranin A (CgA) is a neuroendocrine secretory protein that is co-released with catecholamines from the adrenal medulla and sympathetic nerve endings. A prognostic value of CgA has been found in humans that are critica...
Article
Full-text available
Background: Sepsis is a serious and potentially life-threatening condition and early diagnosis and appropriate treatment is crucial for survival. Pyometra is one of the most common diseases in intact female dogs. The disease often leads to sepsis (systemic inflammatory response syndrome, SIRS, caused by infection). Diagnostic markers for detecting...
Article
Full-text available
New surgical techniques are developed to enable a quicker, easier and safer surgery with reduced risk of complications and shortened time needed for recovery. A resorbable device, a self-locking loop, was designed for surgical ligation. The objective of this pilot study was to investigate the feasibility of ligating the spermatic cord with the devi...
Conference Paper
Background: Pyometra is potentially life-threatening and often leads to sepsis. Currently, there are no precise diagnostic markers for identifying dogs with sepsis. Serum amyloid A (SAA) is a major acute phase protein in dogs. The aim of the present study was to explore the value of SAA analysis as a possible marker for sepsis in dogs with pyometra...
Conference Paper
Full-text available
Based on the idea of a self-locking loop, an absorbable device for ligation of vessels and soft tissues was developed (LigaTie®). The aim of this study was to investigate the absorption and tissue reaction of the device when used for ligation of the spermatic cord in a male dog that was neutered. The device was made of a co-polymer of resorbable po...
Conference Paper
Introduction and aims. Pyometra is defined as a uterine inflammation with accumulation of pus in the uterus (1). The disease often induces systemic inflammatory response syndrome (SIRS) with organ dysfunction and death as possible consequences (2, 3). Early detection and proper treatment is therefore crucial. Currently, several biomarkers are used...
Article
Objective To investigate the physiologic reactions after removal of 1st ovary and whether this is repeated during removal of the 2nd ovary in elective ovariohysterectomy.Study DesignProspective study.AnimalsDogs (n = 10).Methods Dogs were premedicated with acepromazine, carprofen, and methadone and anesthetized with propofol and isoflurane. Blood p...
Conference Paper
Background: Sepsis, defined as presence of systemic inflammatory response syndrome (SIRS) initiated by infection, is associated with extensive morbidity and mortality. Early diagnosis and treatment of sepsis is crucial, but currently there is no rapid or precise diagnostic method available. Sepsis is present in the majority of dogs diagnosed with t...
Article
Full-text available
Background Methods for objective evaluation of stress in animals are important, but clinically difficult. An alternative method to study the sympathetic activity may be to investigate Chromogranin A (CGA), Chromogranin B (CGB) and Secretogranin II (SG2). The aim of this study was to investigate the cross-reactivity of CGA, CGB and SG2 between man,...
Conference Paper
Early diagnosis and appropriate treatment of pyometra is essential for a favorable outcome. The disease may have deadly consequences if sepsis develops. Sepsis, defined as systemic inflammatory response syndrome, SIRS, is caused by infection and is associated with increased morbidity and mortality rates in both veterinary and human medicine. Early...
Patent
Full-text available
Patent
Full-text available
A medical device comprises an elongated, flexible band equipped with ratchet members and connected to a device head having a channel dimensioned for reception of the band. A lock member is connected to the head and configured to interlock the ratchet members when the band is pulled through the channel to form a reverse-motion brake. A protrusion an...
Article
Full-text available
Pyometra, accumulation of pus in the uterus, is a bacterial infection which frequently initiates systemic inflammation. The disease may have lethal consequences when the systemic effects are severe or complications occur. Markers for identifying high-risk patients and predicting outcome are therefore in high demand. The objective of this study was...
Article
Full-text available
One of the most common diseases in intact bitches is pyometra- a potentially life-threatening disease associated with a variety of clinical and laboratory findings. The aims of the present study were to describe complications of the disease and to investigate clinically useful indicators associated with peritonitis and/or prolonged postoperative ho...
Conference Paper
Full-text available
In veterinary clinical education students perform surgery under guided supervision. It was hypothesized that oral guidance may be improved by use of a laser pointer in helping the students identify structures of importance. Results: A higher degree of contentment was found when the laser pointers were used (p<0.0001). The results suggest laser poin...