Oana Patricia Zaharia

Oana Patricia Zaharia
German Diabetes Center | DDZ · Institute for Clinical Diabetology

MD

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67
Publications
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407
Citations
Introduction
Dr. Oana Patricia Zaharia currently works as a clinical scientist at the Institute for Clinical Diabetology, German Diabetes Center in Düsseldorf.

Publications

Publications (67)
Article
Background: Cluster analyses have proposed different diabetes phenotypes using age, BMI, glycaemia, homoeostasis model estimates, and islet autoantibodies. We tested whether comprehensive phenotyping validates and further characterises these clusters at diagnosis and whether relevant diabetes-related complications differ among these clusters, duri...
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Full-text available
Aims Restrictive exclusion criteria from different study populations may limit the generalizability of the observations. By comparing two differently designed German cohorts, we assessed the prevalence of cardiovascular risk factors and diabetes-related complications in recent-onset adult type 1 diabetes. Methods This study evaluated 1511 persons...
Conference Paper
Background: The neurofilament light chain (NFL) is a polypeptide abundant in neuronal axons, reflecting ongoing neuroaxonal degeneration when detected in the blood. However, no previous study has explored NFL as a potential biomarker for diabetic sensorimotor polyneuropathy (DSPN) , a neurodegenerative disease of the peripheral nervous system commo...
Conference Paper
Insulin resistance and nonalcoholic fatty liver disease (NAFLD) frequently associate with type 2 diabetes (T2D) and cardiovascular disease and worsen their prognosis. We hypothesized that people with recent myocardial infarction (MI) have lower left ventricular ejection fraction (EF) and higher degree of insulin resistance (IR) , hepatocellular lip...
Article
Background and aims: It is unclear whether socioeconomic status (SES) is associated with glycaemic control in people with recently diagnosed diabetes. The aim was to investigate whether SES is related to haemoglobin A1c (HbA1c) during the first year after diagnosis in people with type 1 and type 2 diabetes and if metabolic, quality of care or ment...
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Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile dysfunction among the five novel subgroups of recent-onset diabetes and...
Article
Carriers heterozygous for the D124N (c.370, GAC>AAC in exon 4) variant of GCK not only exhibit reduced insulin-secretion, but also impaired adipose insulin sensitivity, which may shift fatty acids towards the liver. This could contribute to increased hepatic lipid-accumulation and alterations of liver energy metabolism resulting in dysglycemia. Cli...
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Full-text available
Context Physical inactivity promotes insulin resistance and increases the risk of diabetes and cardiovascular disease. Recently introduced clustering based on simple clinical measures identified diabetes subgroups (clusters) with different risks of diabetes-related comorbidities and complications. Objective This study aims to determine differences...
Article
Patienten mit Diabetes weisen eine breite Palette von Stoffwechselmerkmalen auf, die die Klassifizierung in Cluster basierend auf Autoimmunität, Alter, Body-Mass-Index (BMI), Betazellfunktion und Insulinsensitivität als primäre Diabetes-ätiologische Parameter ermöglichen. Die Cluster weisen ein unterschiedliches Risikomuster für Diabetes-Komplikati...
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Purpose Recent trials demonstrated remission of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) following formula diet-induced weight loss. To improve the outreach for populations in need, many mobile health apps targeting weight loss have been developed with limited scientific evaluation of these apps. The present feasibility study i...
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The rs540467 SNP in the NDUFB6 gene, encoding a mitochondrial complex I subunit, has been shown to modulate adaptations to exercise training. Interaction effects with diabetes mellitus remain unclear. We assessed associations of habitual physical activity (PA) levels with metabolic variables and examined a possible modifying effect of the rs540467...
Article
Frequencies of circulating immune cells are altered in type 1 and type 2 diabetes compared with healthy individuals and associate with insulin sensitivity, glycemic control and lipid levels. This study aimed to determine whether specific immune cell types are associated with novel diabetes subgroups. We analyzed automated white blood cell counts (n...
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Background: Application of mixed meal tolerance tests (MMTT) to measure beta-cell function in long-term studies is limited by modification of the commercial products occurring over time. This study assessed the intra-individual reliability of MMTTs and compared the effects of liquid meals differing in macronutrient composition on the estimation of...
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Context In addition to unfavourable effects on insulin sensitivity, elevated plasma branched-chain amino acids (BCAA) stimulate insulin secretion, which in the long-term could impair pancreatic β-cell function. Objective To investigate cross-sectional and prospective associations between circulating BCAA and postprandial β-cell function in recentl...
Article
A novel clustering approach identified five subgroups of diabetes with distinct progression trajectories of complications. We hypothesized that these subgroups differ in multiple biomarkers of inflammation. Serum levels of 74 biomarkers of inflammation were measured in 414 individuals with recent adult-onset diabetes from the German Diabetes Study...
Article
Full-text available
Context Type 2 diabetes associates with greater risk for musculoskeletal disorders, yet its impact on joint function remains unclear. Objective We hypothesized that patients with type 2 diabetes and osteoarthritis would exhibit musculoskeletal impairment, which would associate with insulin resistance and distinct microRNA profiles. Design, Partic...
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Blood flow restriction resistance training (BFRT) employs partial vascular occlusion of exercising muscles via inflation cuffs. Compared with high-load resistance training, mechanical load is markedly reduced with BFRT, but induces similar gains in muscle mass and strength. BFRT is thus an effective training strategy for people with physical limita...
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Full-text available
Introduction Non-alcoholic fatty liver disease (NAFLD) associates with abnormal mitochondrial capacity. While oxidative capacity can be increased in steatosis, hepatic adenosine triphosphate (ATP) descreases in long-standing diabetes. However, longitudinal studies of diabetes-related NAFLD and its relationship to hepatic energy metabolism are lacki...
Article
Context: While inflammation has been associated with kidney function in long-standing diabetes, its possible association in newly-diagnosed diabetes is unknown. Objective: To investigate cross-sectional and prospective associations between biomarkers of inflammation and kidney function in recent-onset diabetes. Methods: The study included indi...
Article
Diabetes mellitus is a heterogeneous disease with different clinical pictures and risks of comorbidities and complications. Previous classifications have been limited—aside from gestational diabetes and specific forms of known cause—to the description of type 1 and type 2 diabetes. Using simple variables, it is possible to subdivide these diabetes...
Article
Zusammenfassung Diabetes mellitus ist eine heterogene Erkrankung, die in der Ausprägung der Klinik und dem Risiko für die Entwicklung von Komplikationen variiert. Bisherige Klassifikationen beschränken sich jedoch weitestgehend auf die 2 Hauptformen des Diabetes (Typ-1- und Typ-2-Diabetes), was der Komplexität der Erkrankung nur bedingt gerecht wir...
Article
Objective: The rs738409(G) single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain-containing 3 (PNPLA3) gene associates with increased risk and progression of nonalcoholic fatty liver disease (NAFLD). As the recently described severe insulin-resistant diabetes (SIRD) cluster specifically relates to NAFLD, this study examined...
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Full-text available
BACKGROUND While saturated fat intake leads to insulin resistance and nonalcoholic fatty liver, Mediterranean-like diets enriched in monounsaturated fatty acids (MUFA) may have beneficial effects. This study examined effects of MUFA on tissue-specific insulin sensitivity and energy metabolism.METHODSA randomized placebo-controlled cross-over study...
Article
Context Vitamin B12 and folate deficiency are not only linked to hematological, neurological and cardiovascular diseases, but also associate with insulin resistance. Metformin can decrease vitamin B12 and folate concentrations. Objective To examine (i) effects of short-term metformin treatment on serum holotranscobalamin (holoTC) and folate and (i...
Article
Impaired baroreflex sensitivity (BRS) predicts cardiovascular mortality and is prevalent in long-term diabetes. We determined spontaneous BRS in recent-onset diabetes patients and its temporal sequence over 5 years by recording beat-to-beat blood pressure and R-R intervals over 10 minutes. Four time domain and four frequency domain BRS indices were...
Article
Full-text available
Context/objective: Impaired adipose tissue (AT) function might induce recent-onset type 2 diabetes (T2D). Understanding AT energy metabolism could yield novel targets for the treatment of T2D. Design/patients: Recently diagnosed male T2D patients and healthy humans (controls, CON) of similar abdominal subcutaneous AT (SAT)-thickness, fat mass an...
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Background Epidemiological studies have shown that increased circulating branched-chain amino acids (BCAAs) are associated with insulin resistance and type 2 diabetes (T2D). This may result from altered energy metabolism or dietary habits. Objective We hypothesized that a lower intake of BCAAs improves tissue-specific insulin sensitivity. Methods...
Conference Paper
Abstract Increased levels of branched-chain amino acids (BCAA) associate with insulin resistance and type 2 diabetes (T2D), which could result from dietary habits, gut microbiome composition or direct effects on cellular energy metabolism. We hypothesized that reduced dietary intake of BCAA improves whole body insulin sensitivity and hyperinsulinem...
Article
Zusammenfassung Der Versuch einer neuen Diabetesklassifikation, welche neben den klassischen Merkmalen auch den Krankheitsverlauf und das Risiko für die Entwicklung von Folgeerkrankungen miteinbezieht, ermöglicht möglicherweise eine differenzierte Einteilung der Erkrankung. Dies könnte dazu beitragen, Behandlungen zu individualisieren und Personen...
Article
Background Diabetes mellitus is a heterogeneous disease characterized by a variety of different metabolic features that may have an indispensable prognostic value for the patient’s disease course. This finding raises questions about the traditional taxonomy of type 1 and type 2 diabetes and allows new approaches to associate diabetes patients with...
Article
Full-text available
Context and objective: Among patients diagnosed with type 2 diabetes, autoimmune diabetes often remains undetected. Metabolic features of these patients are insufficiently characterized at present. Design, setting and patients: This study compared age- and sex-matched adult (41-62 years) humans with recent-onset diabetes: patients positive for a...

Questions

Question (1)
Question
I am looking for large prospective observational studies for patients with diabetes. No interventions. Just longitudinal assessment. Thank you!

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Projects

Project (1)
Project
To elucidate the effects of dietary BCAA restriction on insulin resistance in patients with type 2 diabetes