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O. A. Smolyanskaya

O. A. Smolyanskaya
ITMO University | SPbNRU ITMO · Department of Photonics and Optical Information Technology

PhD Optics

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55
Publications
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486
Citations
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April 2007 - March 2016
National Research University ITMO
Position
  • Professor (Assistant)

Publications

Publications (55)
Chapter
The potential of terahertz (THz) technology is beyond doubt, with water being a key endogenous marker of pathological processes in tissue in the THz medical diagnosis. The content and state (free or bound) of tissue water can reflect biochemical changes in normal tissues, as well as the presence and severity of pathological changes. At the same tim...
Article
Full-text available
Terahertz phase retrieval is a promising technique able to assess the complex diffracted wave properties through an iterative processing algorithm. In this Letter, we demonstrate the implementation of this technique in reflection geometry with a continuous wave acquisition system working at 0.287 THz. To ensure a high signal-to-noise ratio in the m...
Article
Full-text available
Creation of the biological tissue phantoms especially breast tissue cancer in the terahertz frequency range is an actual problem of medical physics. This paper suggests using soy protein as one of the main component of breast tissue phantom instead of gelatin, as it’s water-and fat-holding substance, “quasi-bioidentical” to animal proteins and thei...
Article
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia accompanied by the disruption of carbohydrate, lipid, and proteins metabolism and development of long-term microvascular, macrovascular, and neuropathic changes. This review presents the results of spectroscopic studies on the glycation of tissues and cell proteins in...
Conference Paper
Using the THz-PTDH method we have created the theoretical model and experimental set up for phase imaging of breast tissue sample and designed the image reconstruction procedure suitable for a cancer diagnostics.
Conference Paper
Full-text available
We have developed a method of the terahertz (THz) solid immersion microscopy for the reflection-mode imaging of soft biological tissues. It relies on the use of the solid immersion lens (SIL), which employs the electromagnetic wave focusing into the evanescent-fi�eld volume (i.e. at a small distance behind the medium possessing high refractive inde...
Article
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The optical clearing method has been widely used for different spectral ranges where it provides tissue transparency. In this work, we observed the enhanced penetration of the terahertz waves inside biological samples (skin, kidney, and cornea) treated with glycerol solutions inducing changes of optical and dielectric properties. It was supported b...
Article
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In the course of in vitro studies of blood of laboratory animals with progressing Ehrlich carcinoma, we have revealed the change of the blood plasma optical properties in the THz range, which can be used for developing the express diagnostics of the presence of oncological diseases. An applied software package is elaborated that allows the phantoms...
Article
New methods have been developed for noninvasive monitoring of pathological processes in a living organism by means of terahertz spectroscopy and visualization using contrast agents based on magnetic nanoparticles. The nanoparticles must possess good magnetic characteristics, must be nontoxic and stable against aggregation, and must exhibit chemical...
Conference Paper
Permittivity tensor of an ensemble of equal double stranded DNA molecules in the terahertz frequency range was qualitatively analyzed within the self-consistent phonon approximation. The model showed the dependence of the tensor components on such parameters as DNA length and helix period. The corresponding DNA absorption spectra were calculated. I...
Article
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This paper is devoted to studying of optical properties of whole blood and blood plasma in SHR mice grafted Ehrlich's carcinoma and mice with chronic inflammation at the terahertz frequency range. Additionally physiological saline solution suspension of ascites Ehrlich's carcinoma cells was explored.
Article
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The study revealed the most promising candidates for phantoms mimicking different biological tissues in the terahertz frequency range. Closest to biological tissues in terms of the refractive index appeared to be gelatin-based gels; in terms of the absorption coefficient they were agar-based gels. Gelatin is more stable in time, but requires specia...
Conference Paper
Full-text available
Optical measurements of FemOn-SiO2 dispersed in KBr and pure KBr pressed tablets were carried out at sub-THz and IR ranges. Obtained spectra were compared with the pure iron oxide IR-spectrum, KBr and silica wide-range spectra. Changes in sub-THz spectra of refractive index and absorption coefficient caused by the addition of FemOn-SiO2 were observ...
Article
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The optical properties of normal fibroblasts and fibroblasts cultured with cancer cells were studied in the frequency range of 0.2 - 1.0 THz. The results show the possibility to distinguish healthy cells from corrupted ones using their optical parameters.
Conference Paper
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We revealed that after exposure of scarified cornea of rabbits to low-intensity pulsed terahertz radiation 0.1 to 1.8 THz a positive effect on epithelization triggered within the first hours was higher compared to non-irradiated cornea. However, while elevating power of terahertz radiation up to 60.8 nW it resulted in retarding epithelialization pr...
Conference Paper
Full-text available
Characterization of absorption lines of the degraded deoxyribonucleic acid (DNA) in the range of 0.1 – 1 THz measured by terahertz pulsed and continuous spectroscopy. DNA intramolecular vibrations, vibrations of the hydrogen bonds between two strands of DNA and vibrations responsible for the changes in molecular conformation of DNA when dissolved i...
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We have studied the mechanisms underlying the effect of pulsed broadband terahertz radiation on the growth of neurites of sensory ganglia using a comparative analysis of measured reflection spectra of ganglion neurites (in the frequency range 0.1 – 2.0 THz) and spectra obtained by numerical simulation with CST Microwave Studio. The observed changes...
Conference Paper
Full-text available
We propose a new method of cancer diagnostics based on identification of characteristic cancer spectral lines in the frequency range of 0.1–2 THz. Using terahertz spectral database of normal and pathological human tissues we could monitor the slightest changes caused by the appearance of cancer at the early stages.
Conference Paper
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The dispersion of penetration depth of terahertz radiation in various human pathological tissues were obtained and analyzed for development of subcutaneous diseases diagnostics in terahertz frequency range.
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The effect of low-intensity broadband pulsed THz radiation in the range from 0.05 to 1.2 THz, with power from 0.25 to 11.6 µW, on the growth of neurites of spinal ganglia of (10–12)-day chick embryos has been investigated. An analysis of the 3-min irradiation with powers in this range has demonstrated both stimulating and suppressive effects of THz...
Article
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The scattering anisotropy factors of splenocytes, thymocytes, and several leukemia cellular lines have been measured. It is shown that the scattering anisotropy factors of leukemia cellular lines exceed several times those of normal cells.
Conference Paper
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We have shown the prospect of development of a contactless diagnostics method for pathological skin and cornea in the terahertz frequency range. We observed stimulation of the nerve cells growth by low-intensity terahertz radiation. There is a possibility that specific terahertz radiation parameters would allow expectation of acceleration of skin a...
Conference Paper
Full-text available
The question about the fundamental justification of the possibility of using terahertz (THz) radiation to influence biological systems, particularly the nervous system, is still open. Our research was devoted to the impact of broadband pulsed THz radiation in the frequency range of 0.05 to 1.20 THz on the neurite growth. We found that the changes i...
Article
In order to ensure safety in the use of terahertz radiation for medical problems, impact assessment of broadband terahertz radiation in the frequency range of 0.05-1.7 THz was made to investigate functional activity of tumor cells in vitro. According to the results of flow cytometry we can speculate that pulsed terahertz radiation with a power dens...
Article
According to the literary data, terahertz radiation has some effects on different blood cells. Our study focuses on the determining the level of some cell surface antigens of lymphocytes when exposed to broadband terahertz range of 0.05-1.70 THz. These data indicate that terahertz radiation with power density of 9.55, 0.63 and 0.03mW/cm2 for 1 minu...
Article
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The spectral characteristics of the human cornea in vitro were analyzed in this work. Correct identification of the reflection spectra peaks allows using the terahertz radiation as the new diagnostics method of eye diseases.
Conference Paper
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Knowledge of the biological effects induced by THz radiation can have a crucial impact in future developments in fields of medicine, biology or chemistry. The lack of THz radiation sources with sufficient power as well as the missing knowledge of the specifics of their use led to the fact that the impact of microwave radiation on different organism...
Article
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In order to determine the limits of the biologically safe maximum allowable levels of pulsed terahertz (THz) radiation, a prototype of apparatus has been developed for the irradiation of cell cultures immersed in a liquid medium with broad-band THz radiation in the 0.05-1.2 THz frequency range. The action of THz radiation on the functional activity...
Article
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It was revealed correlation between the optical density of the lens's nucleus in terahertz range with its density, determined according to the L. Buratti classification. Consolidation of the lens fibers caused by senile cataract, increases the reflectivity of the lens in the THz range. The temporal structure of reflected THz signals allows to deter...
Article
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Application of terahertz radiation for the creation of medical equipment and solving of biological problems has become widely spread. From this point of view, the influence of THz radiation on the nerve fibers is of primary concern. In addition, several studies indicated both stimulating and depressive effects on nerve cells. However, the mechanism...
Article
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We study the destructive action of femtosecond pulses (200 fs) on the human cataractous crystalline lens and the transmission of the cataractous lens in the terahertz spectral range of electromagnetic oscillations (0.2–1 THz) in relation to the density of the nucleus of the lens.
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This paper presents the results of studies of how broad-band terahertz radiation of the range 0.1-2THz affects individual biological systems. Samples of biological tissue have different extinction coefficients, which differ in healthy and pathological tissues. The transmittance of tissue samples for pulsed terahertz radiation depends on their thick...
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This article discusses questions of how the pulse width of a femtosecond fiber laser, its spectrum, and the envelope of its spectrum vary when the pulse passes through single-mode and multimode quartz optical fibers about 1m long.
Article
In the present paper research results of broadband THz radiation influence in a range 0.1÷2 THz on some biological tissues are presented. Theoretical modeling of THz radiation propagation through the fat sample is performed. Experimental absorption spectra of samples of vegetable oil, nail tissue, skin tissue and blood are obtained. Spectra of thes...
Article
Full-text available
In the present paper research results of broadband THz radiation influence in a range 0.1 divided by 2 THz on some biological tissues are presented. Theoretical modeling of THz radiation propagation through the fat sample is performed. Experimental absorption spectra of samples of vegetable oil, nail tissue, skin tissue and blood are obtained. Spec...
Article
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The study of thermoinduced changes of optical properties of adipose tissue is very actual problem. We made the optical model of thermo-sensitive heterophase medium (adipose tissue). Here the elementary adipose cell will consist of a cube which basic volume will contain a adipose ball, everything else- water. The adipose ball will contain liquid and...
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The intensity of the collimated and diffusely scattered components of a light flux transmitted through a layer of adipose tissue at various temperatures has been investigated. It is shown that, when the tissue is heated from 5 to 50 °C, a sharp degradation in the scattering properties of adipose tissue occurs in the temperature range 25-30 °C. The...
Article
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One of the most attractive perspectives for modern medicine is to solve a problem of a superfluous weight. Method of solving the problem by means of a light source initiates to study optical characteristics of fatty tissue in details. This paper studies temperature dynamic of IR, NIR and visible spectrum of fatty tissue. It refers to temperature, s...
Article
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The problem of a superfluous weight is extremely exciting for a modern cosmetology. The solution of the problem by application of light sources is quite difficult if no optical characteristic of a fat tissue is known. This paper studies a temperature dynamics of full, collimated and diffuse and scattering flows of non-coherent polychromatic light c...
Article
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The goal of the present paper is to find a connection between time-point of fat tissue removal out of a human organism, rotation angle of polarization plane and optical transmission as well. The authors determined experimentally that in vitro fat tissue rotates polarization plane of linearly polarized light at temperature of 24 °C. At that as left-...

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Project (1)
Project
1. Research of optical properties of blood plasma on mice and human with carcinoma in frequency range of 0.1 - 1.0 THz. 2. Impact of terahertz radiation on the epithelialization rate of scarified cornea. 3. Gyrotropy and absorption of DNA and amylose at THz frequencies. 4. Fabrication and characterization of biotissue-mimicking phantoms in the THz frequency range.