O. I. Lipskikh

Tomsk Polytechnic University · Department of Physical and Analytical Chemistry

This study presents the synthesis of new fluorosulfate derivatives of 1,4-naphthoquinone by the SuFEx reaction. Anticancer properties of obtained compounds were studied on PC-3 (prostate adenocarcinoma), SKOV-3 (ovarian cancer), MCF-7 (breast cancer), and Jurkat cell lines. All the studied compounds showed higher cytotoxic effects than Cisplatin. T...

One of the main directions in the development of modern electroanalytical chemistry is the development of new effective methods for research and analysis of biological objects, particularly, human blood serum. The creation of new electrochemical sensors is a promising approach, which has determined several main directions in applied voltammetry in...

Voltammetric determination of Tartrazine (Tz) and Brilliant Blue FCF (BB) in their mixture using novel type of carbon black-polyethylene composite electrode (CBPCE) with renewable surface modified by carbon ink (CI) was developed. Electrochemical properties of the tested dyes were investigated in 0.1 mol L–1 Britton-Robinson (BR) buffer by cyclic v...

Glutathione (GSH) is one of the most important thiol-containing antioxidants involved into various biochemical processes in the human body. Glutathione determination in biological fluids (saliva, urine, serum) and pharmaceutical preparations is rather important for clinical practice. Various analytical methods — spectrophotometry, fluorimetry, high...

Synthetic azo dyes are currently used for food coloring more frequently than natural ones and the field of their application is very wide. However, many of them can have detrimental effects on living systems and thus the azo dyes content control in food is very important. Voltammetric azo dyes determination offers many advantages, e.g. high sensiti...

A voltammetric study of the electrochemical behavior of red food azo dye Carmoisine on a glassy carbon electrode (GCE) is performed. The influence of various factors on the cathode signal of the dye is shown: pH and values of accumulation time and potential sweep rate. The operating conditions of Carmoisine identification in model media are selecte...

A possibility of using voltammetry for the direct determination of yellow synthetic food dye Tartrazine, included in the list of substances regulated in food, is demonstrated. The electrochemical behavior of the dye is studied by direct current voltammetry using a glassy carbon electrode. It is shown that the signal of Tartrazine electrochemical re...

The antioxidant properties of catalase and superoxide dismutase (SOD) have been studied by voltammetry. The effect of pH on the antioxidant properties of catalase and SOD has been evaluated. It is established that the antioxidant activity of both enzymes is maximum at pH 6.86. Mechanisms of the interaction of enzymes with reactive oxygen species ar...