Nynke Smidt

Nynke Smidt
University of Groningen | RUG · Department of Epidemiology

PhD

About

202
Publications
30,296
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Introduction
My mission is to investigate the determinants that shape our health behavior over the life course. Health behavior has a major impact on our health and life expectancy. The determinants of health behavior are complex and multifaceted, including individual, social and environmental factors. This makes change of health behavior difficult. Therefore, prevention of unhealthy behavior and maintaining of healthy behavior are important. To investigate the development of health behavior over the life course and to identify susceptible periods of health behavior change, large population based cohort studies are needed.

Publications

Publications (202)
Article
Full-text available
Background: Evidence on the association between the presence of fast-food outlets and Body Mass Index (BMI) is inconsistent. Furthermore, mechanisms underlying the fast-food outlet presence-BMI association are understudied. We investigated the association between the number of fast-food outlets being present and objectively measured BMI. Moreover,...
Article
Background: Our aim was to investigate sex differences in the associations between socioeconomic position (SEP) and metabolic syndrome (MetS) development, and to what extent these associations are mediated by health literacy and self-management skills. Methods: A subsample (n = 88,384, 59.5% female) of the adult Lifelines Cohort Study was used....
Article
Background Major depressive disorder (MDD) onset varies by socioeconomic position (SEP), this could be explained by lifestyle factors, but little is known about this pathway. Our study aims to disentangle the interplay between SEP measures (i.e., education, income and occupational prestige) and MDD onset and to examine to what extent these associat...
Article
Full-text available
Purpose To investigate the structural validity, internal consistency, measurement invariance, and construct validity of the Dutch PROMIS-29 v2.1 profile, including seven physical (e.g., pain, physical function), mental (e.g., depression, anxiety), and social (e.g., role functioning) domains of health, in a Dutch general population sample including...
Article
We examined whether childhood abuse is related to body mass index (BMI) in young adults and whether this relationship is mediated by depression and anxiety. Data are from the Dutch longitudinal cohort study TRAILS (n females = 836, n males = 719). At wave 4, childhood sexual, physical and verbal abuse, and lifetime major depressive disorder (MDD) a...
Article
Full-text available
Background: Metabolic syndrome (MetS) development strongly varies based on individuals' socioeconomic position (SEP), but to date, no studies have assessed the mediating role of perceived stress from long-term difficulties (chronic stress) in this association. The aim of this study is to examine the mediating role of chronic stress in the associat...
Article
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Background The COVID-19 pandemic and the subsequent lockdown have a strong impact on health and health behaviours, such as alcohol consumption. Although there is some evidence of an overall decline in alcohol consumption during the lockdown, studies also show an increase in risky drinking patterns, e.g. solitary drinking, and differences between su...
Article
Full-text available
Background Fatigability is an important marker of functional decline in community dwelling older people, yet its relationship with functional decline after hospitalization is unclear. The objectives of this study were to identify trajectories of fatigability and mobility over time and to examine the association between demographic and clinical char...
Article
Full-text available
The aim of the current study is to investigate which major life events are associated with transitions into and out of volunteering over the life course and, especially, why these associations exist. Social Production Function theory is used to derive hypotheses, which are tested using longitudinal data (adult subsample) from Lifelines. Association...
Article
Unhealthy food environments may contribute to an elevated Body Mass Index (BMI), which is a chronic disease risk factor. We examined the association between residential fast-food outlet exposure, in terms of proximity and density, and BMI in the Dutch adult general population. Additionally, we investigated to what extent this association was modifi...
Article
Full-text available
Objective Individuals with a parental family history (PFH) of dementia have an increased risk to develop dementia, regardless of genetic risks. The aim of this study is to investigate the association between a PFH of dementia and currently known modifiable risk factors for dementia among middle-aged individuals using propensity score matching (PSM)...
Article
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Background Although the incidence of metabolic syndrome (MetS) strongly varies based on individuals’ socioeconomic position (SEP), as yet no studies have examined the SEP-MetS remission relationship. Our aim is to longitudinally assess the associations between SEP measures education, income and occupational prestige, and MetS remission, and whether...
Article
Full-text available
Background There is growing interest for interventions aiming at preventing frailty progression or even to reverse frailty in older people, yet it is still unclear which frailty instrument is most appropriate for measuring change scores over time to determine the effectiveness of interventions. The aim of this prospective cohort study was to determ...
Article
Background: People with chronic obstructive pulmonary disease (COPD) show considerable variation in symptoms, limitations, and well-being; this often complicates medical care. A multi-disciplinary and multi-component programme that addresses different elements of care could improve quality of life (QoL) and exercise tolerance, while reducing the n...
Article
Full-text available
Background Individuals with a parental family history of dementia have an increased risk of developing dementia because they share their genes as well as their psychosocial behaviour. Due to this increased risk and their experience with dementia, they may be particularly eager to receive information regarding dementia risk reduction (DRR). This stu...
Article
Full-text available
Unemployment is expected to influence alcohol consumption, but studies show mixed results, partly because most studies concentrate on current employment status. However, unemployment could be particularly consequential if it is part of a trajectory of employment precariousness. Moreover, the association between unemployment and alcohol consumption...
Article
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Background Positive health beliefs and attitudes towards dementia and dementia risk reduction may encourage adopting a healthy behaviour. Therefore, we aimed to investigate the knowledge, health beliefs and attitudes towards dementia and dementia risk reduction among the Dutch general population and its association with the intention to change heal...
Article
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Background: The Ruff Figural Fluency Test (RFFT) is a valid but time-consuming and labour-intensive cognitive paper-and-pencil test. A digital RFFT was developed that can be conducted independently using an iPad and Apple Pencil and RFFT scores are computed automatically. We investigated the validity and reliability of this digital RFFT. Methods:...
Article
Background The incidence of metabolic syndrome (MetS) strongly varies by socioeconomic position (SEP), but little is known about the mediating role of health behaviours in this association. This study examines the associations between the SEP measures, education, income and occupational prestige, and incident MetS and whether the associations are m...
Preprint
Full-text available
Background Individuals with a parental family history of dementia have an increased risk of developing dementia because they share their genes as well as their psychosocial behaviour. Due to this increased risk and their experience with dementia, they may be particularly eager to receive information regarding dementia risk reduction (DRR). This stu...
Article
As no curative treatments for dementia are yet available, prevention is a key element to counteract the dementia epidemic. Our aim is to investigate the uptake and effectiveness of a tailor‐made online‐lifestyle‐program for dementia‐risk‐reduction targeting risk and protective factors for dementia among middle‐aged descendants of people with recent...
Article
The Ruff Figural Fluency Test (RFFT) is a valid pencil‐and‐paper test for evaluating cognitive functioning in the general population. The assessment of the pencil‐and‐paper‐RFFT is time‐consuming and requires training of raters. We developed a digital‐RFFT which can be filled in by people independently on an Ipad, after which RFFT patterns are auto...
Article
Approximately one third of the dementia cases are attributed to modifiable risk factors, including physical inactivity, unhealthy diet, excessive alcohol use and smoking (Livingston et al., 2017). Positive health beliefs and attitudes towards dementia (risk reduction) may encourage adopting a healthy lifestyle. We aimed to investigate the associati...
Article
Since treatment options for curing dementia are unavailable to date, prevention of dementia is the key in decreasing the burden of dementia for patients, their families, and caregivers, as well as societies as a whole. Around one third of all dementia cases worldwide is estimated to be attributable to nine modifiable risk factors (Livingston et al....
Article
Individuals with a parental family history (PFH) of dementia have an increased risk to develop dementia, as they do not only share their genes but also their psychosocial behavior (Borenstein et al., 2016). This study will explore the knowledge, beliefs and attitudes towards dementia‐risk‐assessment and dementia‐risk‐reduction by changing health be...
Article
Individuals with a positive parental family history (PFH) of dementia have an increased risk to develop dementia in the future. It is unclear whether this risk is caused by genetic factors or by modifiable‐risk‐factors for dementia, as parents and their children often share their psychosocial behavior. The aim of this study is to investigate the as...
Article
Full-text available
Introduction Descendants of patients with dementia have a higher risk to develop dementia. This study aims to investigate the uptake and effectiveness of an online tailor-made lifestyle programme for dementia risk reduction (DRR) among middle-aged descendants of people with recently diagnosed late-onset dementia. Methods and analysis Demin is a cl...
Article
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Background: cognitive impairment is highly prevalent among older patients attending the Emergency Department (ED) and is associated with adverse outcomes. Methods: we conducted a systematic review and meta-analysis to evaluate the diagnostic accuracy of cognitive screening instruments to rule out cognitive impairment in older patients in the ED....
Article
Introduction Metabolic syndrome (MetS) incidence strongly varies by socioeconomic status (SES). Each SES measure comprises different resources of an individual, including cultural, economic and social resources. To date, no studies have examined the SES - MetS remission relationship. Understanding the role of each SES measure for MetS remission cou...
Article
Introduction The incidence of metabolic syndrome (MetS) strongly varies by socioeconomic status (SES). Health behaviors could be one of the mechanisms explaining the SES-MetS relationship, but little is known about their mediating role. This study aims to longitudinally asses the association between SES measures, education, income and occupational...
Article
Background: The effectiveness of surgical interventions for cervical degenerative disorders has been investigated in multiple systematic reviews. Differences in study population (e.g., patients with myelopathy and/or radiculopathy) were often neglected. Therefore, the objective of this study was to investigate the effectiveness of surgical interve...
Article
Full-text available
Background: This study aimed to translate and validate the Motivation to Change Lifestyle and Health Behaviours for Dementia Risk Reduction (MCLHB-DRR) scale in the Dutch general population. Methods: A random sample of Dutch residents aged between 30 and 80 years old were invited to complete an online questionnaire including the translated MCLHB...
Article
Full-text available
Background: The original Pittsburgh Fatigability Scale (PFS) was developed to assess perceived fatigability in older adults. The objective of this study was to translate the PFS into Dutch and investigate its validity and reliability among hospitalized older adults aged ≥70 years. Methods: The PFS was translated into Dutch and pretested for comp...
Preprint
Full-text available
BACKGROUND: This study aims to translate and validate the Motivation to Change Lifestyle and Health Behaviours for Dementia Risk Reduction (MCLHB-DRR) scale in the Dutch general population. METHODS: A random sample of Dutch residents aged between 30 and 80 years old were invited to complete an online questionnaire including the translated MCLHB-DRR...
Preprint
BACKGROUND: This study aims to translate and validate the Motivation to Change Lifestyle and Health Behaviours for Dementia Risk Reduction (MCLHB-DRR) scale in the Dutch general population. METHODS: A random sample of Dutch residents aged between 30 and 80 years old were invited to complete an online questionnaire including the translated MCLHB-DRR...
Preprint
BACKGROUND: This study aimed to translate and validate the Motivation to Change Lifestyle and Health Behaviours for Dementia Risk Reduction (MCLHB-DRR) scale in the Dutch general population.METHODS: A random sample of Dutch residents aged between 30 and 80 years old were invited to complete an online questionnaire including the translated MCLHB-DRR...
Preprint
Full-text available
BACKGROUND: This study aimed to translate and validate the Motivation to Change Lifestyle and Health Behaviours for Dementia Risk Reduction (MCLHB-DRR) scale in the Dutch general population. METHODS: A random sample of Dutch residents aged between 30 and 80 years old were invited to complete an online questionnaire including the translated MCLHB-DR...
Article
Full-text available
Objectives Poor self-rated health (SRH) is a strong predictor of premature mortality in older adults. Trajectories of poor SRH are associated with multimorbidity and unhealthy behaviours. Whether trajectories of SRH are associated with deviating physiological markers is unclear. This study identified trajectories of SRH and investigated the associa...
Article
Full-text available
Evidence on the association between physical activity (PA) and adiposity in young children is inconclusive. A systematic review and meta-analyses were conducted to examine associations between accelerometer-derived PA and varying adiposity outcomes in preschool children. Searches were conducted in Embase, MEDLINE and Web of Science to identify stud...
Article
Full-text available
Currently, no valid scales exist to compare volunteer motivations between volunteers and non-volunteers. We aimed to adapt the Dutch version of the Volunteer Functions Inventory (VFI) in order to make it applicable for the comparison of volunteer motivations between Dutch older volunteers and non-volunteers. The Dutch version of the VFI was include...
Article
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Background Elevated Body Mass Index (BMI) is a key risk factor for numerous non-communicable diseases, such as cardiovascular diseases, cancer, diabetes type II and dementia. Previous studies showed associations between fast-food outlet exposure and BMI, but contained methodological shortcomings. Particularly within the Netherlands, evidence is sca...
Article
Full-text available
Improvement of volunteering rates in the Netherlands is important because increased productivity among older adults would contribute to societal sustainability in the light of population aging. Therefore, a better understanding of volunteer motivations of Dutch older adults is needed. The Volunteer Functions Inventory (VFI) for assessing volunteer...
Article
Full-text available
Study question: Is there an association between maternal occupational exposure to solvents, pesticides and metals as assessed by expert-based assessment and congenital anomalies in the offspring? Summary answer: There is an association between maternal occupational exposure to solvents and congenital anomalies in the offspring, including neural...