Nyamongo Bw'Onkoba

Nyamongo Bw'Onkoba
University of North Carolina at Chapel Hill | UNC · Microbiology & ImmunologyChildren's Research Institute

BSc. (MLS), MSC., PhD
Pediatric HIV vaccine; SHIV/SIV/HIV immunology; B-cells; NHPs; Transcriptomics; Big data.

About

28
Publications
11,781
Reads
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162
Citations
Citations since 2016
22 Research Items
146 Citations
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Introduction
My research interests are in host-parasite interactions, parasite biology, preclinical vaccine trials and drug screening, Vaccinology, malaria DNA vaccine, zoonotic diseases, natural products for malaria treatment and animal models for translational research. Population health, Ecohealth, disease surveillance and monitoring and epidemiology.
Additional affiliations
July 2013 - January 2022
University of KwaZulu-Natal
Position
  • Ad hoc Lecturer
Description
  • Providing tutorials and experimental assistance to undergaduate students in biology and parasitology.
June 2013 - July 2016
Mount Kenya University
Position
  • Adjunct faculty in Medical Laboratory Sciences
Description
  • Lecturing in chemical pathology, haematology, blood transfusions sciences to Masters students in Medical Laboratory sciences.
January 2013 - April 2013
Jomo Kenyatta University of Agriculture and Technology
Position
  • Lecturer
Description
  • Lecturing Microbial physiology to BSc. in medical microbiology students
Education
July 2013 - April 2016
University of KwaZulu-Natal
Field of study
  • Doctor of Philisophy in Medicine (Public Health Medicine)
September 2010 - August 2012
University of Nairobi
Field of study
  • Master of Science in Applied Parasitology
September 2000 - December 2005
Maseno University
Field of study
  • Bachelor of Science in Medical Laboratory Science

Publications

Publications (28)
Article
Full-text available
Background. Naturally acquired immunity to malaria develops over several years and can be compromised by concomitant infections. This study explored the influence of chronic schistosomiasis on clinical outcome and immunity to repeated malaria infection. Methods. Two groups of baboons (n=8 each), were infected with Schistosoma mansoni cercariae to e...
Article
Full-text available
Aim: This study sought to evaluate Pronto dry rapid urease® diagnostic test and compare its performance with culture. Study Design: Cross-sectional study. Place and Duration: From September 2017 to July 2018, across-sectional study was conducted at the Aga Khan University Hospital. Methodology: Patients attending endoscopy unit at the hospital were...
Article
Full-text available
Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species efficacy of Plasmodium falciparum serine repeat antigen 5 polypeptide co-expressed with epitopes of Bacille-Calmette Guerin (BCG),...
Article
Full-text available
In developing countries, malaria remains a major global public health concern whose laboratory diagnosis is paramount in its control. The present study sought to determine malaria laboratory diagnostic capacity in the Kisii Level 5 Hospital, Kenya by assessing staff capacity and competency. This was a cross-sectional, descriptive study conducted by...
Article
In sub-Saharan Africa, parasitic diseases including neglected tropical diseases (NTDs), account for the largest portion of its disease burden. This is due to lack of effective drugs and reduced funding of disease management and control making traditional medicine (TM) the better option. However, TM has a paucity of information on its efficacy and s...
Article
Full-text available
Background Salmonella has significant public health implications causing food borne and zoonotic diseases in humans. Treatment of infections due to Salmonella is becoming difficult due to emergence of drug resistant strains. There is therefore need to characterize the circulating non-typhoidal Salmonella (NTS) serovars in domestic animals and anima...
Article
Full-text available
The rapid increase and subsequent management of Typhoid fever in Kenya has been complicated by the emergence and rise of antimicrobial resistance to the Salmonella Typhi pathogen. This situation is yet to be addressed due to the paucity of information regarding the circulating strains and their antimicrobial resistance profiles. This study was henc...
Article
Full-text available
Background: The chewing of khat leaves (Catha edulis Forsk) is widely practiced in East Africa and parts of the Middle East, where it forms a deep-rooted social and cultural function. Consumption of Khat is common among men but recently it has extended to women. Biochemical and toxicological effects of Khat on pregnancy and fetal development in low...
Article
Full-text available
Tissue-dwelling helminths are known to induce intestinal and systemic inflammation accompanied with host compensatory mechanisms to counter balance nutritional and metabolic deficiencies. The metabolic and immune responses of the host depend on parasite species and tissues affected by the parasite. This study investigated metabolic and immuno-infla...
Article
Full-text available
Background: Community-acquired haematogenous Staphylococcus aureus pneumonia is a rare infection, though it can be acquired nosocomially. Currently, antibiotics used against S. aureus pneumonia have shown reduced efficacy. Thus, there is need for an alternative therapy against multidrug-resistant S. aureus (MDRSA) strains in the community. Objecti...
Article
Full-text available
In sub-Saharan Africa, use of bacteriophages against infections caused by multi-drug resistant bacteria is controversial. This study explored the efficacy of environmental obtained bacteriophages against multidrug-resistant Staphylococcus aureus. Mice were randomly assigned into bacterial infection, phage-infection and naïve control groups. Mice in...
Article
Full-text available
Introduction: The use of bacteriophages as an alternative treatment method against multidrug-resistant bacteria has not been explored in Kenya. This study sought to determine the efficacy of environmentally obtained lytic bacteriophage against multidrug-resistant Staphylococcus aureus (MDRSA) bacterium in mice. Methodology: Staphylococcus aureus...
Article
Full-text available
Background: There is limited data on the resistance mechanisms of Diarrhoeagenic Escherichia coli (DEC) from our centre which prompted us to perform this study to determine the antimi-crobial resistance pattern. Methods & Materials: DNA extracted from confirmed DEC strains (48) isolated between November 2014 to March 2015 from 120 diarrhoeal stool...
Article
Full-text available
Malaria and schistosomiasis co-infections are common and chronic schistosomiasis has been implicated in affecting the severity of acute malaria. But whether it enhances or attenuates malaria has been controversal due lack of appropriately controlled human studies and relevant animals models. To examine this interaction, we conducted a randomized co...
Article
Full-text available
Malaria leads in global rates of mortality and morbidity majorly borne by children aged below five years and primigravida women in developing countries. According to WHO, the cases of malaria infections in 2014 declined, despite cases of parasite resistance to available anti-malarial drugs and anopheline mosquitoes resistant to insecticides being r...
Article
Full-text available
Placental malaria (PM) causes adverse pregnancy outcomes in the mother and her foetus. It is difficult to study PM directly in humans due to ethical challenges. This study set out to bridge this gap by determining the outcome of PM in non-immune baboons in order to develop a non-human primate model for the disease. Ten pregnant baboons were acquire...
Article
Full-text available
Human zoonosis threatens public health disease surveillance, management, control and eventual elimination. Nowadays, people and pets share private and public utilities oblivious of the potential risk of zoonotic pathogen transmissions. Toxocariasis is one of the most prevalent zoonotic helminthic infections that are transmitted by cats and dogs thr...
Article
Full-text available
Mechanisms and outcomes of host-parasite interactions during malaria co-infections with gastrointestinal helminths are reasonably understood. In contrast, very little is known about such mechanisms in cases of malaria co-infections with tissue-dwelling parasites. This is lack of knowledge is exacerbated by misdiagnosis, lack of pathognomonic clinic...
Article
To improve diagnostic tools, immunotherapies and vaccine development for trichinellosis surveillance and control there is a need to understand the host immune responses induced during infection with Trichinella zimbabwensis, a tissue-dwelling nematode. In this study, we sought to determine immune responses induced in mice during T. zimbabwensis inf...
Article
Full-text available
Although there is currently no vaccine against leishmaniasis in routine use anywhere in the world, cases of self cure in cutaneous leishmaniasis, accompanied by solid immunity to reinfection, make vaccine development a feasible control method. Immunity against visceral leishmaniasis is mediated by IFN-γ-inducing parasite specific CD4+ and CD8+ T ce...

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