Nuzul WAHYUNING Diyah

Nuzul WAHYUNING Diyah
Airlangga University | UNAIR · Faculty of Pharmacy

Doctor of Pharmacy

About

14
Publications
2,440
Reads
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51
Citations
Citations since 2017
9 Research Items
50 Citations
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015
Introduction
Current research interests: drug design & bioactivity testing on antibacterial agents, anti-inflammatory, antiplatelet. The other works: bioactivity testing on anti-diabetes, glycemic index, physicochemical and thermodynamic parameters.

Publications

Publications (14)
Conference Paper
Full-text available
ID: OP013 1 OBJECTIVE • Investigate the potency of benzenesulfonyl-azacyclic urea derivatives as antiviral for treating COVID-19 through in silico molecular docking against the main protease (M pro) of SARS-CoV-2 • Predict the absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles of the potential compounds. 2 BACKGROUND
Article
Objectives: This study was purposed to design gossypetin derivatives which have higher activity than the parent compound found in Hibiscus sabdariffa and to find the most potent compound as the antibacterial agent. Methods: Twenty-five gossypetin derivatives were designed by conjugation the molecular structure of gossypetin with acyl group from...
Article
Full-text available
Wonorejo village in Batu city is known as a vegetable and fruit producing area. Another popular product of Batu mostly is fresh dairy milk and only a small amount of processed products while the cow milk collected in KUD Batu has reached 16-17 tons per day. The problem was that the target community had no experiences in processing cow milk using pr...
Article
Agar diffusion and turbidimetry were commonly used to evaluation of antibacterial activity of honey. However, there is no report about which one of these two methods is better. This study attempts to validate the agar diffusion method and turbidimetry used for growth inhibitory assay of ceiba honey against Bacillus subtilis ATCC 6633 based on valid...
Article
Full-text available
p>Ferulic acid (FA) has been reported to have antiplatelet activity through indirectly inhibiting P2Y12 receptor. In order to increase the activity of FA, by improving its lipophilicity, so that it is easier to enter the cell, synthesis methyl ferulate was conducted through Fisher esterification. Ultrasonic waves were utilized as source of energy e...
Article
Full-text available
Objectives: This study was designed to verify the antiangiogenic activity of ferulic acid (FA) and its potency to inhibit cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expression in the chorioallantoic membrane (CAM) model. Moreover, we verified its mechanism of action by docking the molecule on COX-2, tyrosine kinase, and...
Article
Full-text available
P2Y12 is a platelet receptor that is involved in ADP signal transduction and is an attractive target for antithrombotic drugs. The side effects of antithrombotic drugs are not pleasant for the patient, so research into the development of new antithrombotic agents is still necessary. Evaluation of absorption, distribution, metabolism, elimination, a...
Article
Pendahuluan: Berbagai penelitian menunjukkan bahwa diet makanan ber-Indeks Glikemik (IG) rendah mampu menurunkan resistensi insulin pada penderita Diabetes Mellitus. Masalah utama dalam diet pangan IG rendah adalah ketersediaan bahan pangan dengan IG rendah sementara makanan pokok sebagian besar penduduk Indonesia adalah nasi, yang tergolong pangan...
Article
Full-text available
We have designed and synthesized N,N'-carbonylbis(N-ethylbenzamide) to find new urea derivative with antitumor activity. The compound was synthesized from reaction of N,N'-diethylurea and benzoyl chloride in tetrahydrofuran. The designed molecule was docked into binding site of p38 MAP Kinase (pdb. 3HEG) to predict its binding affinity. The antitu...
Article
Full-text available
Objective: To find new antitumor agents a serie of ring-substituted N,N'-Dibenzoyl-N,N'-Diethylureas (3a-d) were designed and synthesized. The study was conducted to synthesize N,N'-Dibenzoyl-N,N'-Diethylureas and examine their antitumor activity against human breast carcinoma cell line (MCF-7). Methods: The compounds were synthesized from reaction...

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Projects

Project (1)