Nurul Izzaty Hassan

Universiti Kebangsaan Malaysia | ukm · Department of Chemical Sciences

The current study aims to provide a roadmap for future research by analyzing the research structures and trends in scholarly publications related to the status of zinc in public health. Only journal articles published between 1978 and 2022 are included in the refined bibliographical outputs retrieved from the Web of Science (WoS) database. The firs...

8-carboxamidoquinoline derivatives were gradually investigated as zinc's label in resolving weak water solubility, poor membrane permeability, and difficulty measuring free Zn2+ ion in cells quantitatively. The potential of 2-oxo-2-(quinolin-8-ylamino)acid (OQAA) as zinc's label was prepared and characterized spectroscopically. Theoretical and expe...

Diplazium esculentum is an edible fern commonly consumed by the local community in Malaysia either as food or medicine. Isolation work on the ethyl acetate extract of the stem of D. esculentum resulted in the purification of two steroids, subsequently identified as stigmasterol (compound 1) and ergosterol-5,8-endoperoxide (compound 2). Upon further...

Individuals with cerebral palsy (CP) frequently present with multiple feeding problems, which may require food texture modification to ensure safe feeding. This review aims to explore the challenges individuals with CP and their caregiver’s face and recommend modified food textures to ensure safety and improve the quality of life and nutritional st...

Malaria poses a severe public health risk and a significant economic burden in disease-endemic countries. One of the most severe issues in malaria control is the development of drug resistance in malaria parasites. The standard treatment for malaria is artemisinin-combination therapy (ACT). Nevertheless, the Plasmodium parasite's extensive resistan...

Kemunculan strain parasit yang rintang terhadap hampir semua ubatan antimalaria telah mendorong para saintis mengkaji penggantian mekanisme tindakan alternatif yang lebih berkesan. Keberkesanan rawatan semasa antimalaria adalah terhad dari segi bio ketersediaan ubat yang rendah, ketoksikan ubat yang tinggi dan kadar keterlarutan dalam air yang rend...

The current study aims to provide a roadmap for future research by analyzing the research structures and trends in scholarly publications related to the status of zinc in public health. Only journal articles published between 1978 and 2022 are included in the refined bibliographical outputs retrieved from the Web of Science (WoS) database. The firs...

The progress in C‐N bond construction is significant in synthetic and biological chemistry. Cross‐dehydrogenative couplings of C‐H and N‐H motifs serve as a unique class of the most atom‐economical and straightforward strategies for constructing C‐N bonds. Herein, we enclosed the most updated methodologies developed in the assembly of C‐N bonds via...

Malaria remains one of the most lethal endemic diseases, and the treatment used today to treat malaria is artemisinin-based combination therapy. However, access to this treatment is minimal and has a huge impact on low-income countries due to the high cost of therapy. The evaluation of antimalarial activity for metal complexes based on tetraaza mac...

The occurrence of a technological disaster could be due to different causes, one of which is chemicals. The major accidents triggered by chemicals, such as the Seveso incident in 1976, the Bhopal incident in 1984, and the recent Beirut explosion in 2020, have had severe impacts on people and the environment. Many countries have established their re...

Widespread resistance of Plasmodium falciparum to current artemisinin-based combination therapies necessitate the discovery of new medicines. Pharmacophoric hybridization has become an alternative for drug resistance that lowers the risk of drug-drug adverse interactions. In this study, we synthesized a new series of hybrids by covalently linking t...

Malaria infection is a severe infectious disease caused by plasmodium parasites and should be treated as emergency medicine. Until now, no vaccine has been commercialized to prevent malaria. Six nickel(II) and zinc(II) metal porphyrin compounds based on free meso porphyrin base 5,15-diphenylporphrin (2), 5,15-dihexylporphyrin (3), and 5,10,15,20-te...

Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the Zingiber zerumbet ginger plant, has exhibited anti-allodynic and antihyperalgesic effects in a neuropathic pain animal model, amongst other pharmacological properties. This study was conducted to further elucidate the...

Early bacterial infection (BI) identification in resource-limiting Emergency Departments (ED) is challenging, especially in low- and middle-income counties (LMIC). Misdiagnosis predisposes to antibiotic overuse and propagates antimicrobial resistance. This study evaluates new emerging biomarkers, secretory phospholipase A2 group IIA (sPLA2-IIA) and...

Early bacterial infection (BI) identification in resource-limiting Emergency Departments (ED) is challenging especially in low- and middle-income counties (LMIC). Misdiagnosis predisposes to antibiotic overuse and propagates antimicrobial resistance. This study evaluates new emerging biomarkers, secretory phospholipase A2 group IIA (sPLA2-IIA), and...

Background: Sufficient intake of macronutrients and micronutrients are essential for child growth. Many children with autism spectrum disorder (ASD) however are reported to be picky eaters which may lead to malnourishment. As diet and behaviour are importantly interconnected, this study aims to determine the level of knowledge on nutrition among pa...

Mass-spectrometry-based and X-ray fluorescence-based techniques have allowed the study of the distribution of Zn2+ ions at extracellular and intracellular levels over the past few years. However, there are some issues during purification steps, sample preparation, suitability for quantification, and the instruments’ availability. Therefore, work on...

Plasmodium falciparum is the most virulent species of human malaria. Widespread resistance by Plasmodium parasites to quinolone based antimalarials and decreased efficacy of artemisinin-based combination therapy necessitates the discovery of new drugs. Malaria parasite enzyme in glycolytic pathway, Plasmodium falciparum lactate dehydrogenase (PfLDH...

An all-solid-state potentiometric electrode system for aluminium ion determination was developed with a new aluminium ion sensor as the working electrode based on a new ionophore for aluminium ion, 1,1′-[(methylazanediyl)bis(ethane-2,1-diyl)]bis[3-(naphthalen-1-yl)thiourea] (ACH). The reference electrode was a potassium ion sensor, which acts as a...

Aminoalkylated chalcone compounds (4a-4c) have been designed using Quantitative Structure-Activity Relationship (QSAR) analysis, synthesized and evaluated for their in vitro antimalarial activity. The best QSAR model obtained was log IC50 = 705.132 (qC7) - 65.573 (qC3) - 24.845 (qC4) - 4.634 (qC13) - 220.479 and statistical analysis showed R2 of 0....

Aromatic (ar)-turmerone is one of the aromatic constituents abundant in turmeric essential oil from Curcuma longa. Ar-turmerone exhibited anti-inflammatory properties. So far, antiplasmodial data for ar-turmerone is still not reported. The data showed the in vitro antiplasmodial effect of ar-turmerone against Plasmodium falciparum 3D7 (chloroquine-...

Abundant of preparatory works have recognized that fluorescent sensors based on 8-aminoquinoline are popular tools to detect Zn2+ ions in environmental and biological applications. Along with these studies, researchers started to introduce a variety of carboxamido group into an 8-aminoquinoline molecule in forming 8-amidoquinoline derivatives. Ther...

Autism spectrum disorder (ASD) is a complex neurodevelopmental disability that is frequently associated with food refusal, limited food repertoire and high-frequency single food intake mainly among children with ASD. Provision of nutrition can be very challenging due to the fact of these behavioural problems, either for the parents or special educa...

Inhibition of acetylcholinesterase (AChE) enzyme is a known procedure to treat severe Alzheimer's disease through increasing the acetylcholine level in the brain and thus slowing down the progression of Alzheimer's symptoms. The approved medications are only considered as palliative and addressed some reported deficiencies. Therefore, the demand fo...

The Child Safety Car Alert System by Arduino is an integrated device that sends alerts to the driver if a child is left unintendedly in the car. The system is developed using the Arduino board which incorporates the integration between sensors and GSM module. This system uses pressure and motion sensors to detect the presence of a child located at...

A toxicity electrochemical DNA biosensor has been constructed for the detection of carcinogens using 24 base guanine DNA rich single stranded DNA, and methylene blue (MB) as the electroactive indicator. This amine terminated ssDNA was immobilized onto silica nanospheres and deposited on gold nanoparticle modified carbon-paste screen printed electro...

A series of self-healing bio-based polyurethanes (SHPU) was synthesized by embedding coumarin derivatives into bio-based polyurethanes. The self-healing process of SHPU was activated by low energy UV light. UV-vis spectroscopy exhibited disappearance of a band at 340 nm. This band is corresponding to the photo-cycload-dition of 6,7-dihydroxycoumari...

A copper ion sensor based on a new bis-thiourea compound N¹,N³-bis[[3,5-bis(trifluoromethyl)phenyl]carbamothioyl] isophthalamide (or TPC) as neutral carrier was investigated. The immobilization of the TPC into poly(n-butyl acrylate) (pBA) membrane via drop casting and the sensor was characterized by potentiometry. The sensor fabricated from TPC onl...

Borylated porphyrin is one of building blocks in coupling reactions to obtain the multiporphyrin containing two, three or more subunits of porphyrins. In this study, one of borylated porphyrin derivatives, 5-(4,4,5,5 – tetramethyl – 1,3,2 – dioxoborolane) -10,20 – diphenylporphyrin (B-DPP) was synthesized through four steps of reactions. The buildi...

An efficient and a green route to synthesize phthalide-fused indoline, 3-[(5-chloro-1,3,3-trimethylindolin-2-ylidene)methyl] isobenzofuran-1(3H)-one (3) has been developed by the coupling reaction of 5-chloro-2-methylene-1,3,3-trimethylindoline, 1 and 2-formylbenzoic acid, 2 under solvent-free domestic microwave irradiation. The compound was produc...

The building blocks for synthesis of light harvesting antenna which are 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)-10,20-diphenylporphyrin, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)-10,20-dihexylporphyrin and 5,10,15,20-tetra-(bromophenyl)porphyrin were synthesized. Borylated porphyrin was synthesized by Suzuki coupling reaction between A2BC bro...

An efficient and green method of synthesizing phthalide-fused indoline, 3-[(1,3,3-trimethylindolin-2-ylidene)methyl]isobenzofuran-1(3H)-one (3) has been developed by the coupling reaction of 1,3,3-trimethyl-2-methyleneindoline, 1 and phthalaldehydic acid, 2 under solvent-free domestic microwave irradiation. The compound was produced with an excelle...

A new thiourea derivative, N¹,N³-bis[[3,5-bis(trifluoromethyl)phenyl]carbamothioyl]isophthalamide (TPC), as a potential copper ionophore was investigated. TPC was immobilized via drop casting method into poly(n-butyl acrylate) pBA membrane and the sensor was characterized by potentiometric method. The sensor fabricated based on TPC showed a Nernsti...

A new thiourea compound, 2,2-oxybis(ethyl)-4-(1-naphthyl)-3-thiourea 3 has been synthesized and characterized by using FTIR, 1H-NMR, 13C-NMR, and MS spectroscopy. The binding properties of with various cations were also carried out using ‘naked eye’, UV-vis and 1H-NMR titration experiments. This compound exhibited effective binding for Hg2+ in the...

A tri-enzyme system consisting of choline kinase/choline oxidase/horseradish peroxidase was used in the rapid and specific determination of the biomarker for bacterial sepsis infection, secretory phospholipase Group 2-IIA (sPLA2-IIA). These enzymes were individually immobilized onto the acrylic microspheres via succinimide groups for the preparatio...

Selenocompounds have been widely synthesized for their potential in pharmacology. Ebselen, a selenazole oxide, is a glutathione peroxidase mimic which is known to possess high antioxidant activity. Four derivatives of 3-(2-amino-1,3-selenazol-4-yl)-2H-chromen-2-ones were synthesized by reacting 3-(2-bromoacetyl)-chromen-2-one derivatives with selen...

The 3-substituted phthalides (3a–3d) were synthesized by coupling reaction of methylenindoline derivatives (1) with 2-formylbenzoic acid derivatives (2), under solvent-free microwave irradiation. The reaction rate enhancement resulted from irradiation has proven to be higher and more efficient compared to the conventional method with an excellent y...

Four new thiourea derivatives namely 1-(2-aminophenyl)-3-(naphthlene-1-yl)thiourea, 3a, N-(2-aminophenyl)-N-(1-naphthalenyl)thiourea, 3a’, 1-(3-aminophenyl)-3-(naphthalene-1-yl)thiourea, 3b, and 1,4-phenylene-bis[3-(α-naphthyl)thiourea], 3c have been synthesized by the reaction of 1-naphthyl isothiocyanate, 1a with 1,2-phenylenediamine, 2a, 1,3- ph...

Two pyridine-2,6-dicarboxylates each containing butynyl and pentynyl at position 2 and 6 were synthesized by esterification of 2,6-pyridinedicarbonyl dichloride with N-alkyne alcohol. All compounds were characterized by using nuclear magnetic resonance spectroscopy (NMR), infrared spectroscopy (IR) and mass spectrometry (MS) techniques. Crystallogr...

Kimia merupakan salah satu cabang ilmu sains yang telah lama dipelopori oleh ilmuwan Islam. Walau bagaimanapun, sekularisme telah menjadikan sains terpinggir dari Islam, apatah lagi merapatkan hubungan di antara manusia dan Pencipta. Seminar Sains Tauhidik telah diadakan untuk menghebahkan pengetahuan dan penemuan oleh penyelidik dari latar belakan...

C15H15N3O3Se, triclinic, P1̅ (no. 2), a = 9.5686(7) Å, b = 12.3795(9) Å, c = 14.7854(11) Å, α = 93.844(2)°, β = 106.344(2)°, γ = 110.816(2)°, V = 1543.4(2) ų, Z = 4, Rgt(F) = 0.0489, wRref(F²) = 0.1066, T = 300 K.

The development of environmentally friendly methodologies for pericyclic reactions such as Diels Alder reaction is astonishing. Nevertheless, this is still scarce for the rest of pericyclic reactions. In this work, diastereosiomeric cycloadducts were formed via 1,3-dipolar cycloaddition between N-4-Tert-Benzylidene nitrone and maleimide in imidazol...

A new route to the synthesis of maleimide is described. 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid maleimide (1) and 2-(4-(2,5-Dioxo-2,5-dihydro- 1H-pyrrol-1-yl)phenyl)ethanoic acid maleimide (2) have been synthesized by the reaction of maleic anhydride with glycine and 4-aminophenyl acetic aicd. Maleimide (1) was synthesized by convention...

New mono-thiourea derivative, 1-(3-aminophenyl)-3-(naphthalen-1-yl)thiourea (3) has been synthesized from the reaction of 1-naphthyl isothiocyanate (1) and 1,3-phenylenediamine (2) using conventional method. The percentage yield of compound 3 was 82%. The compound 3 was characterized using FT-Infrared (FT-IR), ¹H and ¹C Nuclear Magnetic Resonance (...

A tetradentate ligand with four donor atoms OONN and its platinum metal complex were synthesized. Bis(phenoxy)bipyridine ligand was prepared by Suzuki coupling reaction between 6,6’-dibromo-2,2’-bipyridyl and 2-hydroxyphenylboronic acid with the presence of palladium (II) acetate. The formation of platinum complex was done by introducing the ligand...

Thioureas play an important role in medicinal chemistry and agricultures due to their biological activity such as antibacterial, antifungal, antiviral, herbicides, rodenticides,phenoloxidase enzymatic inhibitors, anti-HIV and anti-tumor agents. In this study, five substituted bis-thioureas have been synthesized. The isophataloyl chloride and 2,6-py...

Being abundant in many tropical part of the world, Dioscorea sp. as food is limited due to its toxicity. However polysaccharides derive from these tubers could be important for other applications. Here we developed a Highly Luminescent Carbon Nanodots (C-dots) via acid hydrolysis of Gadong starch (GS). The hydrolysis rate of GS increased from 49% t...

Within a small interconnected reaction network, orthogonal recognition processes drive the assembly and replication of a [2]rotaxane. Rotaxane formation is governed by a central, hydrogen bonding-mediated binding equilibrium between a macrocycle and a linear component, which associate to give a reactive pseudorotaxane. Both the pseudorotaxane and t...

The tetradentate ligand with four donor atoms OONN was synthesized. Bis(phenoxy)bipyridine ligand was prepared by Suzuki coupling reaction between 6,6’-dibromo-2,2’-bipyridyl and 2-hydroxyphenylboronic acid with presence of palladium (II) acetate. Bis(phenoxy)bipyridine ligand was also synthesized by demethylating of 6,6’-bis(2-methoxyphenyl)-2,2’-...

Palm-based polyurethane (pPU) with varying lithium salt (LiClO4) content was synthesized. Higher loading percentage of LiClO4 in the pPU led to the inhibition of prepolymerization process from taking place. Hydrogen bonded C=O was detected in the FTIR spectrum indicating the hydrogen bonding between the urethane bonds. Ordered complexed C=O was obs...

Synthesis of imine compounds usually results in moderate yield due its reversibility characteristic and prone to hydrolysis. Hence, to increase the formation of imine compound, self-replicating catalyst was introduced. The self-replicating catalyst is the imine product itself. The first imine compound, 4-{[4-(3,5-Dimethyl-phenylcarbamoyl)-benzylide...

A Diels-Alder reaction between anthracene and 1- p-tolyl-2,5-dione was conducted in imidazolium-based ionic liquids. Imidazolium cation was utilised with counter anions, [BF 4] and [PF6], as the solvents to carry out the desired Diels-Alder reaction. In this work, the diene and dienophile were introduced into the ionic liquids for 72 hours at room...

A novel symmetrical macrocycle has been synthesised via oxidative homocoupling of bisalkyne, diprop-2-ynyl pyridine-2,6-dicarboxylate mediated by copper (I) iodide (CuI) and 4-dimethylaminopyridine (DMAP). The precursor compound was synthesised from 2,6-pyridine dicarbonyl dichloride and propargyl alcohol in the presence of triethylamine. The react...

The complete title molecule, C23H19N3O2, is generated by a twofold axis passing through the central ring. The two oxymethyl-benzo-nitrile arms are attached at the meta positions of the central pyridine ring. The dihedral angle between the pyridine ring and benzene ring of both arms is 84.55 (6)° while the benzene rings make a dihedral angle of 46.0...

Novel bio-based polymer electrolyte was synthesized with LiClO4 as the main source of charge carrier. Initially, polyurethane-LiClO4 polymer electrolytes were synthesized via prepolymerization method with different NCO/OH ratios and labelled them as PU1, PU2, PU3 and PU4. Fourier transform infrared (FTIR) analysis indicates the co- ordination be...

Spiropyran is particularly interesting compound that can be used for the development of information recording systems, optical switching and metalchelating agents. This based photo-conversion design has dramatically changed its physical and chemical properties allowing such exploration to take place. In this study, a colorimetric - spiropyran (A) b...