Nurliana Abd Mutalib

London School of Business and Finance | LSBF · School of Health Sciences

Tapinoma sessile is the second most dominant ant pest in Malaysia. Synthetic pest repellent effectively protects against pest. However, there is a problem because the use of synthetic repellent has led to accumulation of residue and it is toxic to human. Plant based insect repellents are believed to be comparable or better alternatives to synthetic...

Christia vespertilionis locally known as ‘rerama’ has gained much attention as herbal preparation to treat various ailments and diseases although there is no conclusive evidence of its therapeutic values. Self-medication is commonly practiced by patients, underpinned by health believes that affect their adherence to medication regimens, and impacti...

Aims: This study aims to develop an efficient, and inexpensive transfection procedure using low cost polyethylenimine (PEI) as transfection reagent for overexpression of CYP2C9 in WRL 68 host cells. Introduction: Overexpression of CYP450 isozymes such as CYP2C9 has been a reliable approach in developing a high specificity in vitro tool for inhibiti...

The drawback of using hepatoma cell lines such as HepG2 instead of the “gold standard” primary hepatocytes in studying in vitro drug metabolism is that the phase I metabolism enzymes, cytochrome P450 (CYP450), are poorly expressed with lower activities. The accuracy of predicting drug metabolism and interactions could be jeopardized with these limi...

Background and Objectives The most common cause of severe foodborne salmonellosis is S. Typhimurium. Its interaction with intestinal epithelial cells is little known. Lactic acid bacteria (LAB) were recognized as a prominent probiotic gastrointestinal microbiota of humans and animals that confer health-promoting and protective effects. This study a...

Propolis is a sticky substance produced by stingless bees for construction and defence of their hive. It has notable anti-inflammatory, antioxidant, antibacterial, antifungal, anti-hyperglycemic, and wound healing effects. The present review summarised and examined the phytochemical properties, mode of action and current research prospects of Malay...

A growing body of literature has documented the adverse effects of bisphenol A (BPA) exposure on pregnancy and birth outcomes. Regardless, how gestational BPA exposure affects mother-newborn pairs in Malaysia is yet to be explored. Hence, this study aimed to investigate urinary BPA levels of pregnant women living in Klang Valley and their associati...

Testosterone is commonly used as a marker probe drug for CYP3A4 metabolic activity. Accurate measurement of its metabolite, 6β-hydroxytestosterone in cell culture media is very crucial. This study aimed to optimize solvent extraction method as well as to develop and validate HPLC analytical method for the quantification of 6β-hydroxytestosterone. T...

Background: In recent years, the potential role of probiotics has become prominent in the discoveries of neurotherapy against neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties and exert their effects via various mechanisms of actions. This review aimed to evaluat...

Four previously undescribed alkaloids, aspergillinine A-D, and four known diterpene pyrones were isolated from the potato dextrose agar (PDA) culture of Aspergillus sp. HAB10R12. The chemical structures of the isolated compounds were elucidated based on a detailed analysis of their NMR and MS data. The absolute configuration of the isolated compoun...

Many cancer patients are using complementary and alternative medicines (CAM) in combination with their conventional therapy, more than 72% of them do not inform their physician about CAM use. With the use of CAM in combination with conventional chemotherapeutics, there is an increasing risk for unwanted interactions. Chromolaena odorata locally kno...

Plant-beneficial microorganisms also known as endophytes colonize the inside healthy tissues of living plants and form mutualistic relationships with them. Endophytes are important components of the plant microbiome and give a variety of benefits to their hosts. Nam-Nam plant (Cynometra cauliflora), is an indigenous tree to Peninsular Malaysia with...

Drug-drug interactions (DDI) are the most common cases that occur in our healthcare in which are very alarming as it may lead to severe complications. Consumption of natural products concomitantly with conventional drugs or treatment using polypharmacy have become the norm that promoting the potential of pharmacokinetic or pharmacodynamic drug inte...

Clinacanthus nutans (Acanthaceae), locally known as Sabah snake grass, is popularly taken as prevention as well as treatment for cancer in Malaysia, despite lack of concrete clinical evidence. However, it is crucial to evaluate potential antagonistic, additive, or synergistic interactions that may result from the co-treatment of this plant in chemo...