Nurlan Brimkulov

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Verified

Nurlan verified their affiliation via an institutional email.

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• PhD, DSc
• Professor at Kyrgyz State Medical Academy

Occupational burnout (OB) among healthcare workers (HCWs) has significant implications for workforce sustainability and patient care. The COVID-19 pandemic exacerbated existing stressors, highlighting the urgent need to investigate burnout prevalence and associated factors among HCWs in Central Asia (CA). This study aimed to assess burnout levels,...

Objectives This study aimed to validate the Russian version of the Copenhagen Burnout Inventory (R-CBI) among nurses in Kazakhstan and Kyrgyzstan and explored factors contributing to burnout. Methods The original Copenhagen Burnout Inventory (CBI) was translated into the R-CBI using a rigorous forward-backward method and reviewed by experts. Betwe...

Based on an analytical review of information sources on the status and development of various aspects of primary health care (PHC) in the world and in selected countries, as well as international evidence-based recommendations in a series of reviews, to assess international experience and guidelines for the development of PHC in selected members of...

The article based on an analytical review of information sources on the status and development of various aspects of primary health care (PHC) in the world and in selected countries, as well as international evidencebased recommendations, to assess the prospects of using international experience and recommendations for the development of PHC in the...

Introduction Due to the specific work content, healthcare workers (HCWs) showed a high risk of mental health and well-being issues. And the COVID-19 pandemic has increased this effect. At the same time, the psychological well-being of HCWs from Central Asian countries remains poorly understood. In this study, we aimed to investigate the mental heal...

Respiratory disorders are among the most frequent conditions after COVID-19, along with increased fatigue, insomnia, depressive disorders, attention and memory disorders. The incidence of respiratory disorders after COVID-19 is on average 35%. The objective of the review is to study the characteristics and duration of functional respiratory disorde...

The formation of an evidence base for regulatory documents in the field of preliminary and periodic medical examinations is one of the urgent tasks of occupational health in the coming years. In the process of transition to a risk-based approach in occupational health, including in determining suitability for work, objective verification of risk is...

The aim of the study was to identify the relationship between bone mineral density disorders and chronic obstructive pulmonary disease among residents of Bishkek, Kyrgyz Republic, taking into account risk factors. Material and methods . 200 residents of lowland (mean age 56,9±1,7 years) were examined. Bone mineral density (BMD) was determined by du...

In occupational health, the management of patients with preliminary and periodic medical examinations for work in harmful conditions, for example, in high-altitude conditions, can be a difficult task. Bronchial asthma is one of the unequivocal contraindications to work in the highlands, however, in light of recent successes in achieving asthma cont...

Background Despite knowing that health systems with strong primary care improve overall health outcomes within a population, many countries are facing a global trend of declining interest and shortage of family doctors. This is the case of the Kyrgyz Republic, in which rural areas are struggling to attract and retain family medicine (FM) doctors. T...

Background Asthma control, patients’ awareness level and adherence to treatment in Kazakhstan have never been studied. The aim of this study was to verify the prevalence of controlled, poorly controlled and uncontrolled asthma in a large sample of three largest cities of Kazakhstan. Methods We recruited 600 (median age 54 (interquartile range (IQR...

The article discusses the necessity to strengthen action to achieve universal health coverage (UHC), which has been slowed down by the COVID-19 pandemic, considering policy concepts. The dynamics of the UHC index in Kazakhstan and Kyrgyzstan for 2000-2019 is regarded. Several global activities for the development of primary health care and UHC in K...

Background Despite knowing that health systems with a strong primary care basis improve overall health outcomes within a population, many countries are facing a global trend of declining interest and shortage of family doctors. This is the case of the Kyrgyz Republic, in which rural areas are struggling to attract and retain family medicine (FM) do...

In light of the COVID-19 pandemic, the article provides a literature review on the development of the concept of universal health coverage (UHC), starting with the Alma-Ata Declaration on PHC of 1978, including the Astana Declaration of 2018 and the UN Political Declaration on UHC of 2019. The development of primary health care in the CIS countries...

On December 10, 2021, an International conference dedicated to the Universal Health Coverage (UHC) Day was held at the Al Farabi Kazakh National University. The purpose of the conference was to support and develop the main ideas of the UHC. The conference was attended by more than 100 representatives of universities and the medical community from K...

The article presents the goals, principles and results of the implementation of the Almaty Declaration of the World Health Organization (WHO) on primary health care (PHC) of 1978; the background and main provisions of the Astana Declaration of WHO on PHC 2018. The article presents the stages of PHC development in the USSR, which was characterized b...

The article highlights the problems of the relationship between the general practitioners and specialists-pulmonologists, which were discussed in the framework of the XXVIII National Congress on Respiratory Diseases, held in Moscow on October 16–19, 2018. Outlines the main provisions of the reports of the School “Problems of pulmonology in the work...

РЕЗЮМЕ В статье приводится качественный и количественный анализ отдельных показателей эффективности предварительного и периодического медосмотра для сотрудников высокогорной горнодобывающей компании. В сравнении с государственными учреждениями по месту жительства, специально созданная частная медклиника обеспечивает более высокое качество медосмотр...

Brimkulov, Nurlan, Louis Louton, Salima Sydykova, Denis Vinnikov, and Farida Imanalieva. Morbidity in the mountainous Province of Kyrgyzstan: results from a population-based cross-sectional study. High Alt Med Biol 00:000-000, 2017.-The aim of this study was to identify the main causes of using primary care facilities in the mountainous Naryn Provi...

Background Medical students are the first line active force to combat tobacco epidemic, but they may suffer from high smoking prevalence and wrong attitude themselves. The aim of the study was to assess the effect of current curriculum on smoking behavior of medical students in Kyrgyzstan. Methods 20% random sample of all 6 years of the School of...

Background: Patient education in chronic obstructive pulmonary disease (COPD) combined with essential hypertension (EH) is pivotal in disease management, however, the effect of combined telephone patient education (TPE) remains questionable. Aim: To assess the effect of TPE on self-reported disease management, functional capacity and quality of lif...

Background. High-altitude climate therapy (HACT) is a long-standing environmental intervention in childhood and adult asthma. Nonetheless, objective improvement following HACT has not been subjected to systematic analysis. Aim. To systematically analyze lung function changes following HACT. Methods. We used meta-analysis to analyze the effect of HA...

We used meta-analysis to measure the effect of high-altitude climate therapy (HACT) on lung function outcomes in asthma, and systematically searched PubMed, Embase and www.elibrary.ru for publications appearing from 1970 to mid-2015. We included studies carried out with children or adults with an exposure of up to 12 weeks at an altitude of ≥1500 m...

Materials and methods: Data from pre-employment and annual screening of high-altitude mining company (elevation 4000 meters above sea level) were obtained for 472 workers aged 34.1 ± 7.8 years, working 2-week shifts, followed by 2 weeks of rest at low altitude (cumulative exposure 6 months). Overall systolic, diastolic BP change (ΔBP) were calcula...

Bronchial asthma (BA) at high altitude (HA) has been studied for decades, but studies were limited to relatively low altitudes (below 3000 meters above sea level (MASL). Very scarce scientific evidence is available whether BA subjects can proceed to HA for recreational purposes and for work, and if they can, how well they will do. This paper summar...

Aim: Acute mountain sickness (AMS) is a common condition with potentially severe morbidity. Studies of the association between cigarette smoking and AMS have reached contradictory conclusions showing it to both carry risk and be a protective factor. We used meta-analysis to better delineate the true relationship between smoking and AMS. Materials...

We aimed to ascertain risk factors for acute mountain sickness (AMS) in miners exposed to chronic intermittent high altitude conditions. All new hires (2009-2012) for mine employment (4000 m above sea level) were followed up for 12 months after first ascent. Demographics, physiologic data, and cigarette smoking were assessed at preemployment screen...

Background: Studies of occupational acute mountain sickness (AMS) have not focused on the more severe end of the spectrum to date. Aims: To examine risk factors associated with the development of occupational AMS severe enough to receive treatment in a compression chamber. Methods: A nested case referent study in a cohort of high-altitude (400...

To assess the annual lung function decline associated with the reduction of secondhand smoke exposure in a high-altitude industrial workforce. We performed pulmonary function tests annually among 109 high-altitude gold-mine workers over 5 years of follow-up. The first 3 years included greater likelihood of exposure to secondhand smoke exposure befo...

AIM The aim of this study was to assess annual lung function change in 109 newly employed healthy subjects (age 31.8 ± 6.7 years) exposed to chronic intermittent hypoxia during six years of continuous employment at a gold mine. METHODS џWe tested pulmonary function annually among 109 high-altitude gold mine workers over five years of follow-up. џOn...

Представлен обзор о внедрении стратегии PAL ВОЗ в Кыргызстане. Показана эффективность внедрения стратегии PAL.

The aim of this study was to determine if work at high altitude is associated with accelerated lung function decline and if smoking could further accelerate this decline. Subjects working at high altitude (3800 to 4500 m) in a gold mine on shift-rotation basis were included, and 7320 spirometry reports were obtained throughout a 4-yr observation pe...

The aim of this study was to assess how exhaled nitric oxide (NO) levels in healthy subjects changed upon exposure to intermittent hypoxia at high altitude. Eighty-one healthy subjects with a mean age of 31.8±6.7 years, well acclimatized at altitudes of 3800-4000m above sea level, and employed by a gold-mining company were recruited for the study....

Results Conclusions assess the levels of secondhand smoke (SHS) exposure of men and women in public places in Kyrgyzstan and relate it to respiratory health џ Cross-sectional study in 10 bars and restaurants in Bishkek in 2008. џ џ Owners were interviewed about the capacity of their facilities, customers' preferences, smoking regulation in the venu...

The aim of this study was to assess the levels of secondhand smoke (SHS) exposure of men and women in public places in Kyrgyzstan. This cross-sectional study involved 10 bars and restaurants in Bishkek the capital city of Kyrgyzstan. Smoking was allowed in all establishments. Median (interquartile range) air nicotine concentrations were 6.82 (2.89,...

BackgroundIn Kyrgyz Republic, some, but not all, workplaces and public places have been designated smoke-free, but the extent of support for this is unknown. The aim of this study was to determine how big if any this support is.MethodsA cross-sectional sample of employees at the biggest mining company in Kyrgyzstan was interviewed during their annu...

Ambulatory health centres in Bishkek, Kyrgyzstan. To assess the results of training family doctors in Practical Approach to Lung Health (PAL) techniques. Comparison of the results of two surveys, before (baseline) and after (impact) training on PAL guidelines. Both surveys were carried out according to the same protocol. A total of 86 family physic...

The Practical Approach to Lung Health (PAL) strategy was adopted by the Ministry of Health of Kyrgyzstan to improve the quality of case management of priority respiratory illnesses, including tuberculosis (TB). The process of development and implementation of the strategy is described in the present study. The World Health Organization stepwise fra...

Among many studies on cytisine only a few have been controlled trials, and the aim of this study was to assess the efficacy of cytisine in a randomized controlled double-blind trial compared to placebo in medium-dependent smoking men working in mining industry. Materials and methods: 171 middle-aged smokers were randomised to either cytisine (25-da...

A cross-sectional analysis of management of asthma patients before and after short-term training of 78 physicians in Bishkek was performed. At baseline, diagnosis of asthma was made in 37 patients (4.1 % of all respiratory diseases). Just after training, in 1 year and in 2 years, asthma was diagnosed in 26, 45 and 26 patients, respectively. At base...

Study objective: To determine the current prevalence of smoking among medical students and to ascertain their readiness for counseling on smoking cessation. Methods: Cross-sectional randomized study, in which 297 medical students (146 males and 151 females) completed a questionnaire and exhaled carbon monoxide (CO). Setting: Kyrgyz State Medical Ac...

To study nicotine dependence (ND) basing on special questionnaires and measurement of CO concentrations in the exhaled air. 350 smokers (318 males and 32 females) aged 20-57 years (mean age 37.1 +/- 7.3 years) were studied. ND was assessed by Fagerstrom test (FT), motivation to smoke and to quit tests, smoking history and exhaled CO measurement. In...

Aim. To study nicotine dependence (ND) basing on special questionnaires and measurement of CO concentrations in the exhaled air. Material and methods. 350 smokers (318 males and 32 females) aged 20-57 years (mean age 37.1 ± 7.3 years) were studied. ND was assessed by Fagerstrom test (FT), motivation to smoke and to quit tests, smoking history and e...

Earlier we found that asthmatic patients treated at a high altitude sanatorium (3.200 m) had numerous episodes of arterial blood desaturation during the night. To investigate if periodic breathing (PB) was responsible for those episode we studied 5 asthmatics (A) (mean age 34 yrs) and 3 healthy controls (C) (mean age 28 yrs) using MESAM 4, a simple...

24 patients exposed to low-dose radiation after the Chernobyl accident were examined before and after 24-day treatment of chronic bronchitis in the high-altitude rehabilitation center (3200 m above the sea level) in Tien Shan. Sanogenic alpine climate improved the patients' general condition, physical performance and lung ventilation, corrected com...

The aim of our study was to investigate the severity of overnight arterial blood desaturations in patients with asthma at the altitude of 3200 meters above sea level. 12 asthmatics and 12 healthy controls were investigated. Three overnight pulsoximetries were performed in all subjects, one at the lowland and on the 1st and 5th night at the altitude...

24 patients exposed to low-dose radiation after the Chernobyl accident were examined before and after 24-day treatment of chronic bronchitis in the high-altitude rehabilitation center (3200 in above the sea level) in Tien Shan. Sanogenic alpine climate improved the patients' general condition, physical performance and lung ventilation, corrected co...

The aim of the study was to assess effects of acetazolamide in prevention of acute mountain sickness (AMS) and on overnight oxygenation, in patients with asthma treated at the altitude of 3,200 m. Sixteen patients with asthma, 6 males and 10 females, mean age 32 yrs, were first investigated at low altitude (760 m). They presented with mild airways...

As many as 132 patients with bronchial asthma were examined for the clinical, functional and laboratory parameters before and during alpine climatotherapy at a height of 3200 m above the sea level (the Tyuya-Ashu pass, the northern Tien Shan). In addition to the improvement of the general status, the patients manifested amelioration of ventilation...

132 bronchial asthma patients living in Frunze (760 m above the sea level) and those on adaptation days 3-5 and 25-30 to the climate of North Tien Shan (3200 m above the sea level) underwent clinical and functional examination involving assessment of ACTH, cortisol and aldosterone levels. The patients showed clinical response and improvement of bro...

The superficial activity and cytological composition of bronchoalveolar washes off (BAW) were investigated in 55 patients with bronchial asthma. As compared to the control group the patients with bronchial asthma in remission demonstrated a moderate decrease in the superficial BAW activity which grew in the phase of exacerbation, a degree of variat...

The effect of i. v. verapamil administration on some indices of the hemodynamics of the greater and lesser circulation was studied in 19 patients with bronchial asthma by a multiple approach using noninvasive methods (rheopulmonography, polycardiography, tetrapolar chest rheography). A decrease in the systemic as well as pulmonary arterial pressure...

The effect of beta-adrenergic block on the circulatory reactions of a human being induced by high altitude hypoxia was studied by multi-channel rheography and indirect determination of systolic pulmonary arterial pressure. In healthy people not subjected to a pharmacological effect, 25-day stay at an altitude of 3,200 m was marked by an increase in...