Nurgül Örnek

Nurgül Örnek
Kirikkale University · Department of Ophthalmology

Professor FEBO

About

80
Publications
6,719
Reads
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493
Citations
Additional affiliations
February 2022 - present
Kirikkale University
Position
  • Professor
October 2015 - January 2022
Kirikkale University
Position
  • Professor (Associate)
May 2012 - October 2015
Kirikkale University
Position
  • Professor (Assistant)

Publications

Publications (80)
Article
In vivo confocal microscopy was performed on the central cornea of both eyes of a patient with megalocornea and central mosaic dystrophy. In the stroma, starting just below Bowman's membrane, polygonal, moderately reflective areas of opacification separated by diagonal hyporeflective striations were observed. The opaque areas appeared smaller in th...
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To determine the effect of intravitreal bevacizumab on retrobulbar blood flow of patients with diabetic macular edema. Peak systolic velocity, end-diastolic velocity, resistance, and pulsatility indices of central retinal artery (CRA), nasal posterior ciliary artery (NPCA), temporal posterior ciliary artery (TPCA), and ophthalmic artery (OA) were a...
Article
ÖZ Siliopatiler, silia organeli taşıyan hücreleri etkileyen bir grup hastalıktır. Retina tutulumu sık görülür. Retina fotoreseptörlerinin dış parçaları silialardan oluşmaktadır. Leber doğumsal amarozisi ve retinitis pigmentoza gibi özellikle fotoreseptörlerdeki siliaları etkileyen fonksiyonel bozukluklar sendrom olmayan siliopatiler olarak sınıflan...
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Significance: Vitamin D has antiangiogenic, anti-inflammatory, and antifibrotic properties, which may play an inhibitory role on pterygium formation. Vitamin D concentration was measured in few studies, and contradictory results have been reported. There is no study investigating tear fluid concentration of vitamin D in pterygium patients. Purpos...
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Purpose Presentation of a case with ocular hypertension who developed cystoid macular edema (CME) following selective laser trabeculoplasty (SLT). Case report A 62-year-old male patient who had undergone phacoemulsification surgery for traumatic cataract 9 years ago was on ocular hypertension treatment for the last 5 years. Due to uncontrolled int...
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PurposeTo compare the repeatability and agreement of central corneal thickness (CCT) measurements by spectral-domain optical coherence tomography (OCT), corneal topography (CT) with a combined Scheimpflug–Placido system, optical biometry (OB), specular microscopy (SM), and ultrasound pachymetry (UP). MethodsA single observer measured CCT twice in 1...
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Purpose To evaluate the analgesic effect of topical 0.1% nepafenac solution during intravitreal Ozurdex injection. Methods This prospective, randomized, double-blind placebo-controlled study included 59 patients who were diagnosed with retinal vein occlusion or pseudophakic cystoid macular edema and were selected to receive intravitreal Ozurdex in...
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ABSTRACT A 27-year-old multigravid patient was admitted with bilateral blurring of vision after caesarean delivery. She had history of oxytocin infusion for labor stimulation. Visual acuities were 1/10 in both eyes. Fundus examination showed bilateral serous retinal detachments affecting predominantly the posterior pole and the peripapillary area....
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Objective: To report a female patient with bilateral limbal stem cell deficiency (LSCD) due to primary adrenocortical insufficiency (PAI). Methods: Case report Results: A 40-year-old female patient had blurry vision, foreign body sensation, tearing, and photophobia for several years. On examination, corneal epithelial haze, surface irregularity, an...
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Purpose: To evaluate corneal endothelial cell parameters after a single session of selective laser trabeculoplasty (SLT) in pseudoexfoliative glaucoma (PEG) patients. Methods: Corneal endothelial cell parameters of 18 PEG patients were compared with 18 healthy subjects following SLT treatment. All patients underwent SLT treatment to 180 degrees...
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Background: To assess corneal endothelial cell changes after intravitreal dexamethasone (DEX) implant (Ozurdex®) injection in patients with macular edema secondary to retinal vein occlusion (RVO). Methods: Twenty-two eyes of 22 patients were assessed prospectively after intravitreal 0.7 mg DEX implant injection. Twenty-two eyes of 22 healthy vol...
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Introduction: Selective laser trabeculoplasty (SLT) is used successfully for management of early to advanced glaucoma and ocular hypertension (OHT). Primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PXFG), pigmentary glaucoma (PG), normal-tension glaucoma (NTG), primary angle-closure glaucoma (PACG), steroid-induced glaucoma, silicone...
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Amaç: İntravitreal deksametazon enjeksiyonunun göz içi basıncı (GİB) ve ön kamara açısı (ÖKA) üzerine etkisini incelemek. Gereç ve Yöntem: Otuz sekiz hastanın 40 gözü incelendi. Hastaların yaş ortalaması 61.39 yıl (aralık: 36-83) olup, %63.2'i kadın, %36.8'i erkekti. %70'i retina ven tıkanıklığı, %20'i diabet, %7.5'i arka üveit ve %2.5'i psödofakik...
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Diabetic retinopathy (DR) is a complication of diabetes mellitus (DM) that may causes blindness. The vitreous is an extracellular matrix and it may have changes through liquefaction and syneresis in patients with DM, even in those without apparent DR. Diffusion-weighted imaging (DWI) is a new technique provide tissue contrast relying on difference...
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Purpose: To describe a full-thickness macular hole (MH) opening to macular intrachoroidal cavitation in a patient with pathologic myopia. Methods: Full ophthalmologic examination, fundus camera (Topcon TRC; Topcon Co, Tokyo, Japan), optical coherence tomography (RetinaScan Advanced RS-3000; NIDEK, Gamagori, Japan) imaging, and cataract surgery....
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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To evaluate corneal endothelial cell density and morphology in patients with polycystic ovary syndrome (PCOS). M Ma at te er ri ia al ls s a an nd d M Me et th ho od ds s: : This prospective study included 46 (46 eyes) PCOS patients. An age-matched group of 46 (46 eyes) volunteers served as c...
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Objectives: To evaluate corneal endothelial cell density (CD) and morphology in different trimesters of pregnancy. Methods: This prospective study included 66 (66 eyes) pregnant women. The patient group was divided into three subgroups comprised of 22 women in the first, second, and third trimesters of pregnancy. An age-matched group of 22 (22 e...
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A 31 year old female patient had decreased vision in her left eye for several months. Visual acuity was 20/20 in right eye and counting fingers from 2 m in left eye. Examination of left eye demonstrated massive macular exudation with grayish discoloration of central macula and, aneurysmal and telangiectatic vessels with surrounding exudation in tem...
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The aim of this study was to evaluate plasma adropin levels in patients with pseudoexfoliation (PEX). This retrospective case-control study included 35 patients with PEX and 35 individuals without PEX who served as controls. Plasma adropin levels with triglycerides, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), a...
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Macular edema (ME) in retinitis pigmentosa (RP) often impairs central vision dramatically. A 41-year-old woman diagnosed with RP was referred to our outpatient clinic due to severe visual deterioration in both eyes. The patient was treated with topical carbonic anhydrase inhibitors, topical corticosteroids and intravitreal triamcinolone acetonide i...
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ABSTRACT Objective: To evaluate the effect of a single dose of ranibizumab in patients with diabetic macular edema who discontinued treatment. Methods: One eye of 85 patients with diabetic macular edema who discontinued treatment after a single injection of ranibizumab was studied. Best corrected visual acuity (BCVA), intraocular pressure (IOP), ce...
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Aim: To investigate the serum levels of vascular endothelial growth factor receptor-2 (VEGFR-2) and adropin in age-related macular degeneration (AMD) patients. Methods: Ninety-eight AMD patients were included in the study. Seventy-eight age- and sex-matched healthy volunteers were recruited as the control group. Fundus florescein angiography and...
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Objective: To investigate the retinal nerve fiber layer (RNFL) thickness in essential tremor (ET). Methods: Twenty-seven eyes of 27 patients with essential tremor were included in this study. Twentyseven eyes of 27 healthy volunteers served as controls. All eyes were examined with spectral domain optical coherence tomography (OCT) (Retinascan Advan...
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Purpose: To assess corneal and conjunctival sensitivity in rosacea patients. Methods: A total of 55 patients with rosacea and 37 control subjects participated in the study. Corneal and conjunctival sensitivity was determined by Cochet-Bonnet esthesiometer. Subjective symptoms of ocular dryness were evaluated using Ocular Surface Disease Index (O...
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To evaluate the early effect of sildenafil on the retinal nerve fiber layer (RNFL) thickness. Sixty eyes of 60 patients were enrolled in the study. The patients underwent RNFL analysis by scanning laser polarimetry (Nerve Fiber Analyzer, GDx VCC:5.3.3; Laser Diagnostic Technologies, San Diego, CA, USA) before and after a single 100 mg dose of silde...
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The aim of this study was to evaluate whether the presence of polycystic ovary syndrome (PCOS) alters ocular blood flow parameters. Color Doppler imaging of the orbital vessels was performed in 41 eyes of 41 patients with PCOS. Forty-eight eyes of 48 age-matched volunteers served as controls. The ophthalmic artery (OA), the central retinal artery a...
Article
Objective: To evaluate the relationship between serum homocysteine levels and the presence of nonproliferative diabetic retinopathy (NPDR) in type 2 Diabetes Mellitus (T2DM) patients Methods: One-hundred patients with a diagnosis of T2DM and 30 healthy control subjects whose age and sex were similar were included in this study. In diabetic patients...
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Aim. To describe a case of branch retinal artery occlusion following dental extraction and to point out the ophthalmic complications of dental procedures to ophthalmologists and dentists. Case. A 51-year-old woman was referred to our clinic with painless sudden visual loss in her left eye after tooth extraction two days ago. In her left eye the bes...
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Objective: The exact pathogenic mechanism underlying the thrombotic tendency in retinal vein occlusion (RVO) is still not fully established. We investigated relationship between platelet indices including mean platelet volume (MPV) and platelet count in RVO patients compared to control group. Patients and methods: Forty six patients (19 female,...
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Objective: To compare the ability of the MMSE and MoCA to identify cognitive dysfunction in patients with age-related macular degeneration (AMD). Patients and methods: The study included 81 (29 female, 52 male) AMD patients who were recruited from the Ophthalmology Department of Kırıkkale University during 2012. Participants were screened for co...
Article
Abstract Purpose: To evaluate corneal and conjunctival sensitivity changes following intravitreal ranibizumab (IVR) injection in eyes with diabetic retinopathy. Methods: Forty-six eyes of 46 patients with diabetic macular edema who underwent intravitreal injection of ranibizumab were included in this prospective study. Fifty eyes of 50 type 2 diabe...
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Purpose: To measure corneal sensitivity and tear function in neurodegenerative diseases (NDs) and to compare them with age and sex-matched controls. Methods: Twenty patients with Alzheimer's disease (AD), 20 patients with multiple sclerosis (MS), 30 patients with Parkinson's disease (PD), 10 patients with Friedreich's ataxia (FA) and 21 patients...
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Purpose: To conduct an in vitro experimental study comparing the effectiveness of conventional silicone oil and heavy silicone oil against endophthalmitis-causing agents. Materials and Methods: The antimicrobial activity of conventional silicone oil (RS OIL 5000) and heavy silicone oil (heavySil 1500) was tested. The antimicrobial effects of both...
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Background and Purpose: Today no method of topical anesthesia for intravitreal injection administration has been proven to make the patient comfortable yet. We compared the efficacy of topical levobupivacaine 0.75% and proparacaine 0.5% in patients undergoing intravitreal injections. Materials and Methods: A prospective, randomized study comparing...
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Abstract Rieger syndrome (RS) is a multiple malformation syndrome characterized by ocular manifestations and extraocular defects. Herein, we report a 9-year-old boy who exhibited Rieger Syndrome phenotype as well as congenital hypothyroidism which may be an underappreciated feature of RS.
Article
We report a case of bilateral optic neuropathy presenting with psychiatric symptoms. A 50-year-old woman was admitted with blurry vision in both eyes. She had a 3 months' history of depressed mood. Both optic discs had mild temporal pallor with visible spontaneous venous pulsations. Magnetic resonance imaging of the brain showed a large frontal mas...
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The purpose of this work is to study the effectiveness of silicone oil, heavy silicone oil and perfluorodecaline against Bacillus cereus. For this we tested the antimicrobial activities of three intraocularly used liquids-silicone oil (Siluron 1000), heavy silicone oil (Densiron-68) and perfluorodecaline (F-Decalin)-against B. cereus (NCTC 9946). T...
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To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure (IOP) after cataract surgery. The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens implantation. Patients scheduled for phacoemulsification were assigned to 1 of 2 groups. The treatment group received 1 drop of brinzolam...
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To investigate the optical coherence tomography (OCT) and visual field findings in Friedreich ataxia (FRDA). Ten eyes of 10 patients with genetically confirmed FRDA were included in this study. Twenty-two eyes of 22 age- and sex-matched volunteers served as controls. All eyes were examined with spectral domain OCT (Retinascan Advanced RS-3000; NIDE...
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A 39-year-old man was admitted with a sudden visual loss in the left eye. Visual acuities were 10/10 on the right and 1/10 on the left. Fundus examination did not show any abnormalities. Visual acuity improved to 10/10 and visual field defect regressed in the following 2 weeks. Three years later, the patient returned with acute visual loss in the r...
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A 55-year-old man was admitted with a 2-year history of pseudoexfoliation glaucoma. The best-corrected visual acuities were 10/10 in both eyes. Pseudoexfoliation material was noted on the iris and the lens capsule. Fundus examination evidenced cup-to-disc ratio of 0.7 OD and 0.9 OS with peripapillary atrophy. Gonioscopy revealed open angles. Optica...
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This study was designed to investigate the effect of vitiligo on the retinal nerve fiber layer (RNFL) thickness. This prospective study was conducted in the Department of Ophthalmology at Kırıkkale University during 2010 and 2011. Sixty eight eyes of 34 vitiligo patients were included in the study. Eighty four eyes were served as control. RNFL thic...
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The left eye of a 65-year-old male was blind due to optic atrophy and only seeing eye had also dry type age-related macular degeneration. An anterior ischemic optic neuropathy developed in the better seeing eye. Vision recovered in the blind eye in a short time after losing the better eye. Gaining some vision in a blind eye may be an adaptation of...
Article
The left eye of a 65-year-old male was blind due to optic atrophy and only seeing eye had also dry type age-related macular degeneration. An anterior ischemic optic neuropathy developed in the better seeing eye. Vision recovered in the blind eye in a short time after losing the better eye. Gaining some vision in a blind eye may be an adaptation of...
Article
The aim of this study was to report the short-term clinical and angiographic outcomes after an intravitreal injection of bevacizumab in eyes with refractory diabetic macular edema. Patients who had been treated with both grid-laser photocoagulation and intravitreal trimacinolone acetonide injections for diabetic macular edema received intravitreal...
Article
: To evaluate corneal structure in eyes with keratoconus by using in vivo confocal microscopy. : In a prospective institutional study, 48 eyes of 24 consecutive patients with keratoconus were examined by in vivo confocal microscopy. Forty-four eyes of 22 healthy subjects served as the control. The main outcome measures were qualitative and quantita...
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To evaluate the corneal sensitivity and nerve morphology in dry eyes. A total of 32 eyes of 16 patients (10 Sjogren's syndrome and six non-Sjogren's syndrome) and 19 eyes of 10 age-matched controls were studied. Sensitivity of the central cornea was measured by the Cochet-Bonnet aesthesiometer. The morphology of corneal nerves was studied by in viv...
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To evaluate the characteristics and evolution of corneal morphologic changes induced by systemic amiodarone treatment by using in vivo slit scanning confocal microscopy in an attempt to understand the pathogenesis of corneal and other systemic side effects of this drug. Forty-nine eyes of 25 consecutive subjects receiving amiodarone therapy (group...
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To report a patient with Behcet disease presenting with acute optic neuropathy. A 47-year-old man was admitted to the authors' clinic owing to sudden visual loss in the left eye. Ophthalmologic and systemic examinations were performed. Visual acuity was 4/10 in the left eye. Fundus examination demonstrated swollen optic disc with blurred margins. T...
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We report a case of unilateral congenital ptosis which is associated with ocular and systemic congenital malformations including mild microphthalmia, microcornea, cataract, iris and chorioretinal coloboma, ectopic kidney, and ventricular septal defect. An inciting factor, acting during the second month of gestation, may affect the development of th...