Nurdjannah Niode

Sam Ratulangi University | unsrat · Department of Dermatology and Venereology

Atopic dermatitis is a prevalent and persistent chronic inflammatory skin disorder that poses significant challenges when it comes to accurately assessing its severity. The aim of this study was to evaluate deep learning models for automated atopic dermatitis severity scoring using a dataset of Aceh ethnicity individuals in Indonesia. The dataset o...

Background and Objective: The emergence of methicillin-resistant community-acquired Staphylococcus aureus and antibiotic-resistant Neisseria gonorrhoeae has raised significant concerns. Efforts to combat resistance involve the exploration of novel alternative therapies, particularly those derived from insect components. Rhynchophorus sp., a coconut...

Syphilis, a sexually transmitted disease caused by Treponema pallidum, poses a significant global health threat, with an annual incidence of around 12 million cases, predominantly affecting individuals aged 15-49. Reinfection occurs in 11 out of 120 patients, underscoring the importance of effective management. If untreated, 4-9% of cases may progr...

The exploration of the immunomodulatory potential of pineapple metabolites holds promise for substantial implications across several fields, encompassing medicine, pharmacology, nutrition, and public health. This study explores potential immune-regulating properties of secondary pineapple metabolites beyond bromelain, using computational techniques...

This study investigates the application of the Gradient Boosting machine learning technique to enhance the classification of Atopic Dermatitis (AD) skin disease images, reducing the potential for manual classification errors. AD, also known as eczema, is a common and chronic inflammatory skin condition characterized by pruritus (itching), erythema...

Organic waste, particularly from fruits, remains an environmental issue if not properly managed. These wastes have the potential to be reprocessed into products, one of which is beneficial for human health. The trend of recycling fruit scraps into ecoenzyme (EE), a fermented product, has increased in recent years. Several health advantages of EE ha...

Bromelain is a glycoprotein that contains a single carbohydrate moiety group and displays proteolytic activity. Bromelain has long been known to act as an immunomodulator; however, the immunomodulatory activity of its carbohydrate moiety has been very rarely studied and is not well understood. This study aimed to predict the immunomodulatory activi...

Drug-resistant pathogens have become a serious public health concern worldwide considering the rapid emergence and distribution of new strains, which outpace the development of antimicrobial drugs. It is a complex and serious clinical problem that can cause an epidemic of a disease; consequently, numerous research studies are conducted to determine...

Background: Malassezia folliculitis (MF) is a humid-favored fungal skin disease caused by Malassezia species. Inaccurate treatments, changes in skin flora, and disease exacerbation are often occurred due to oversights in the diagnosis. Several diagnostic methods are established for MF. Objective: To identify clinico-laboratory findings of Malass...

Crusted scabies is a rare form of scabies that presents with more severe symptoms than those of classic scabies. It is characterized by large crusted lesions, extensive scales, thick hyperkeratosis, and contains a large number of highly contagious itch mites. Crusted scabies is more prevalent in immunocompromised, malnourished, and disabled individ...

In tropical and subtropical areas, invertebrates that threaten human health are often found inter alia arthropods. Arthropod bites and stings can cause pain and discomfort, severe tissue damage, and even death. This study aimed to determine the skin manifestations caused by arthropod bites and stings. This was a literature review study using two da...

Pineapple [Ananas comosus (L.) Merr.] has long been recognized as a source of bioactive compounds that are frequently used in health and wellness products. The benefits of pineapple, among others, include immunomodulatory and anti-inflammatory properties. This study aimed at evaluating the potential of phytochemical compounds in pineapple peel as i...

Before entering the cell, the SARS-CoV-2 spike glycoprotein receptor-binding domain (RBD) binds to the human angiotensin-converting enzyme 2 (hACE2) receptor. Hence, this RBD is a critical target for the development of antiviral agents. Recent studies have discovered that SARS-CoV-2 variants with mutations in the RBD have spread globally. The purpo...

Green tea is produced from Camellia sinensis (L.) buds and leaves that have not gone through the oxidation and withering processes used to produce black and oolong teas. It was originated in China, but its cultivation and production have expanded to other Eastern Asian countries. Several polyphenolic compounds, including flavandiols, flavonols, fla...

Antimicrobial resistance is a major public health and development concern on a global scale. The increasing resistance of the pathogenic bacteria Neisseria gonorrhoeae to antibiotics necessitates efforts to identify potential alternative antibiotics from nature, including insects, which are already recognized as a source of natural antibiotics by t...

The house dust mite, Dermatophagoides pteronyssinus, is a major source of the inhaled allergen Der p 1, which causes immunoglobulin E (IgE)-mediated hypersensitivity reactions manifesting in allergic diseases. To date, no drugs or vaccines effectively treat or prevent Der p 1 sensitization. We applied in silico immunoinformatics to design T-cell an...

Niode NJ, Adji A, Rimbing J, Tulung M, Tallei TE. 2021. Composition and diversity of bacteria from giant Asian honeybee Apis dorsata gut. Biodiversitas 22: 906-912. As a social insect, honeybee possesses a unique gut bacteria community. Therefore, we need to understand the composition and diversity of bacteria in Apis dorsata gut, the largest honey...

High prevalence of syphilis can be reduced by doing screening. Tests used for screening and diagnosis of syphilis are serological tests of syphilis consisting of nontreponemal tests and treponemal tests. Nontreponemal tests consist of Rapid Plasma Reagin (RPR) and Venereal Disease Research Laboratory (VDRL) meanwhile Treponemal tests consist of Tre...

Pityriasis versicolor is a chronic mild superficial fungal infection of the skin due to lipophilic fungi Malassezia. It commonly affects the face, neck, abdomen, proximal extremities, axilla, groin, and genitalia. The occurrence of this disease is not influenced by sex, albeit, age influences its incidence since it is more common in adolescents and...

Der p 1 gene sequence polymorphism in house dust mite Dermatophagoides pteronyssinus. Biodiversitas 22: 72-78. Gene polymorphisms in Dermatophagoides pteronyssinus (DP) mite can affect the immune response that plays a role in atopic disease. This study aimed to determine the polymorphisms of Der p 1 gene from DP. House dust containing DP was used a...

The leaf of Pangi (Pangium edule) is used as food in North Sulawesi. According to a study conducted in vitro, Pangi leaf extract suppressed the replication of the human immunodeficiency virus (HIV) inside CD4+ helper T cells. The current study aimed to determine the compounds extracted from Pangi leaves and investigate the potential of the targeted...

Since the outbreak of the COVID-19 (coronavirus disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants using...

Since the outbreak of the COVID-19 (Coronavirus Disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants by us...

Since the outbreak of the COVID-19 (Coronavirus Disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). The present study aimed to evaluate bioactive compounds found in plants by us...

Background: Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the cause of COVID-19. The search for plant-based antivirals ag...

Pediculosis capitis is an infection of the skin and hair caused by Pediculus humanus var capitis. This disease mainly attacks young children and spreads quickly in a crowded environment and poor hygiene condition. Transmission are mainly through direct contact head-to-head or indirectly such as combs, hair accessories, pillows, veils, etc. Transmis...

Pediculosis capitis is an infection of the skin and hair caused by Pediculus humanus var capitis. This disease mainly attacks young children and spreads quickly in a crowded environment and poor hygiene condition. Transmission are mainly through direct contact head-to-head or indirectly such as combs, hair accessories, pillows, veils, etc. Transmis...

Buku ajar merupakan salah satu sarana/alat pembelajaran dalam pelaksanaan proses pendidikan, sebagai penunjang kurikulum yang disusun oleh dosen/tim dosen pada satu mata kuliah, berisikan antara lain materi pembelajaran, metode, dan batasan-batasan secara sistimatis dalam rangka mencapai tujuan yang diharapkan yaitu tercapainya kompetensi sesuai ke...

Infeksi human immunodeficiency virus (HIV) menyebabkan penurunan jumlah sel T CD4, sehingga terjadi defisiensi imunitas selular. Selain itu dapat menimbulkan berbagai gangguan termasuk kelainan mukokutan berupa penyakit infeksi dan non-infeksi serta proses neoplastik baik bentuk atipikal maupun tipikal yang berat dan rekalsitrans terhadap terapi.Te...

Pityriasis versikolor is a skin fungal infection that is quite common in Indonesia as a tropical country with a hot and humid climate, especially if the personal hygiene is not good enough. This study was aimed to evaluate the relationship between personal hygiene and the incidence of pityriasis versicolor among male students of the Faculty of Medi...

Pityriasis versikolor is a skin fungal infection that is quite common in Indonesia as a tropical country with a hot and humid climate, especially if the personal hygiene is not good enough. This study was aimed to evaluate the relationship between personal hygiene and the incidence of pityriasis versicolor among male students of the Faculty of Medi...

Aims: This study investigated the seroprevalence and sexual risk behavior factors associated with syphilis and herpes simplex virus type 2 (HSV-2) among men who have sex with men (MSM), in Manado, Indonesia. Methods: Serum samples and questionnaires regarding their socio-demographic and sexual behaviour were collected from 60 MSM in Manado. Sample...

Acute generalised exanthematous pustulosis (AGEP) is a variant of severe drug allergic eruption that usually occurs very acutely (one day after antibiotic consumption, with a mean of 11 days in other cases), associated with fever. Early lesions are edematous and erythemaous patches followed by nonfollicular pustules. Laboratory examination showed l...

Sexually transmitted infections are diseases that are commonly transmitted through sexual contact. Sexually transmitted infections are a major problem in communities that represent a huge economic burden for health care systems. The incidence of sexually transmitted infections in adolescents is still relatively high. This is due to the knowledge an...

Toxic epidermal necrolysis (TEN) is an acute life-threatening muco-cutaneous reaction, characterized by extensive necrosis and detachment of the epidermis (>30% BSA). Drugs are often suspected as the main cause, one of which is trimethoprim- sulfamethoxazole (TMP-SMX). Management includes immediate termination of alleged drugs, supportive treatment...

Pityriasis versicolor is a chronic superficial fungal disease caused by Malasezzia furfur. Pityriasis versicolor can infect the face, neck, trunk, upper arms, underarms, and groin. Pityriasis versicolor is characterized by scaly patches of fine white or dark, irregular to regular shapes, and clear to diffuse limits. However, pityriasis versicolor i...

Bacterial vaginosis (BV) is an abnormal situation in the vaginal ecosystem characterized by Lactobacillus as normal vaginal flora was replaced by a high concentration of anaerobic bacteria, especially Bacteroides sp., Mobilluncus sp., Gardnerella vaginalis, and Mycoplasma hominis. This study was aimed to obtain the profile of bacterial vaginosis in...

Molluscum contagiosum is an infection disease of the skin caused by Molluscipox virus. This disease is transmitted through direct and indirect contact, such as the use of personal goods together. This disease primarily affects children and actively sexual adult. The world highest prevalence of mollucum contagiosum was reported in East Afrika, as mu...

Gonococcal urethritis (GU) is a sexually transmitted infection (STI) which is caused by Neisseria Gonorrhoeae bacteria. In GU, there is an urethral inflammation caused by negative Gram diplococcus ( its natural reservoir is human) and the symptoms are purulent discharge from external urethral orificium, burning sensation during urination, distal ur...

Verruca vulgaris (common warts) is a benign proliferation of squamous epithelium caused by Human papillomavirus (HPV) infection, especially type 2 and 1. Verruca vulgaris can occur at any age, but more often among children and young adults. Warts are spread by direct or indirect contact. The lesions appear most commonly in areas affected by trauma...

Herpes zoster is a reactivation of varicella zoster virus (VZV) that affects the skin and mucosa. The incidence of herpes zoster increases with age. There are three main goals of treatment: overcoming the acute viral infection, relief from acute pain, and prevention of post-herpetic neuralgia. This study aimed to determine the profile of herpes zos...

Lupus vulgaris (LV) is a chronic progressive form of paucibacillary cutaneous tuberculosis. Lesion is usually solitary in the form of nodes or erythematous plaques with an apple-jelly sign on diascopy. Disseminated LV is a rare form of cutanoeus tuberculosis with multiple lesions in several body areas. We reported a male of 40 years old with a supp...

Verruca vulgaris is a benign proliferation of the skin caused by human papilloma virus (HPV). Verruca vulgaris is found in all ages, especially in children. The HPVs are spread by direct contact. The predilection sites are mainly in the extensor part of the limb and sites with frequent trauma such as hands, fingers, and knees. This study aimed to d...

Pityriasis versicolor is a superficial fungal infection of the epidermal layer caused by Malassezia furfur or Pityrosporum orbiculare. This infection is chronic, mild, and usually without inflammation. Pityriasis versicolor infects the face, neck, torso, upper arms, underarms, thighs, andgroin. Skin disorders are very superficial and pityriasis ver...

Condyloma acuminata, also known as genital warts, is a vegetation of certain types of Human Papilloma Virus(HPV), stalky with bumpy surface. This disease is a sexually transmitted disease, most HPV infections in anogenital area are acquired during sex. This was a descriptive retrospective study, where the data were collected from medical records an...