Nuray Yazihan

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• Prof. Dr.
• Professor at Ankara University

Cancer incidence and mortality rates have been increasing in Turkey as most of the developing countries. Besides socioeconomic factors, one of the most prominent attributes of developing countries is the dissimilarity of their age-dependent demographic structure. In Turkey, cancer incidence rates rise due to individual and environmental risk factor...

Gastrointestinal sistem (GIS) insan vücudunun ihtiyaç duyduğu çeşitli besin maddeleri, vitaminler, mineraller ve sıvı gıdaların vücuda alımını sağlayan giriş kapısıdır. Alınan protein, yağ ve karbohidratlar mide ve barsakta sindirilerek emilebileceği yapı taşlarına ayrışırlar. Daha sonra bu partiküller kana veya lenfatik dolaşıma alınırlar. Sindiri...

The prevalence of obesity and metabolic syndrome continue to increase by years and now obesity is a growing public health problem. World Health Organization (WHO) reports that more than 1.9 billion adults were overweight in 2016, 39% of them obese and 8.5–12.2% of adults aged 18 years and older had diabetes. Nutritional imbalance (over- or under-nu...

Background Fetal growth restriction (FGR) is characterized by the fetus’s inability to reach its growth potential and affecting approximately 10% of the population. The etiology of late-onset FGR, which occurs after 32 weeks, is unclear but may be influenced by maternal weight. A proinflammatory diet can cause chronic inflammation and, Dietary Infl...

ÖZET Kolajenler memelilerde en çok bulunan proteinlerdir. Kolajen;özellikle deri, kas, tendon, ligament ve kemik yapısındaki başlıca proteindir ve tüm proteinlerin yaklaşık %30'unu oluşturur. Kolajen yapı derinin yaklaşık %70'ini; kemik dokunun organik kısmının %90'ını oluşturur. İnsanlarda kollajeni kodlayan 40'dan fazla gen tanımlanmıştır ve 28'd...

Background Parkinson’s disease (PD) is characterized by the inability of dopamine production from amino acids. Therefore, changes in amino acid profile in PD patients are very critical for understanding disease development. Determination of amino acid levels in PD patients with a cumulative approach may enlighten the disease pathophysiology. Metho...

Parkinson’s Disease (PD), a neurodegenerative disorder, is associated with substantial morbidity. α-Klotho, an anti-aging protein known for its neuroprotective properties, has gained attention. This study aims to assess serum levels of α-Klotho in PD patients. This study is a cross-sectional case-control study. PD was diagnosed according to UK Park...

Purpose To assess the potential influencing effects of Dexmedetomidine on impaired lacrimal glands after high-dose radioiodine treatment (RAI). Methods Thirty-six rats were arbitrarily separated into 3 groups: Sham, RAI, and Dexmedetomidine. Dexmedetomidine group was given Dexmedetomidine and RAI, the Sham group was given the same millimeters of s...

Background & Aims: Non-alcoholic Fatty Liver Disease (NAFLD) is both cause and consequence of metabolic disturbances. Therefore, the disease term was recently changed to metabolic dysfunction-associated steatotic liver disease (MASLD). Turkey is one of the leading countries with a high incidence of diseases such as diabetes, obesity, metabolic synd...

Introduction: Imbalance in copper (Cu) and zinc (Zn) homeostasis is a frequent finding in patients undergoing dialysis. These patients have higher serum Cu and lower serum Zn levels compared to controls. This study is designed to investigate the relationship between blood Cu and Zn levels and Cu/Zn ratio and, ESA (erythropoietin stimulating agent)...

Aim: To investigate midkine levels in women diagnosed with intrahepatic cholestasis of pregnancy (ICP). Materials and Method: This study was conducted with 112 pregnant women, 40 of whom had ICP (study group) and 72 were in the control group. The two groups were compared regarding demographic characteristics, obstetric data, laboratory parameters,...

We aimed to examine the relationship between serum midkine levels and placental invasion in pregnant women with placenta previa. The study group consisted of 43 pregnant women diagnosed with placenta previa, whereas the control group consisted of 60 healthy pregnant women. Serum midkine levels were compared between pregnant women with placenta prev...

Objective This study aimed to investigate maternal serum vascular endothelial growth factor (VEGF) C and D levels in patients with intrahepatic cholestasis of pregnancy (ICP). Methods A total of 83 patients, including 41 patients with ICP and 42 healthy pregnant women, were included in the study. We first compared the maternal serum VEGF‐C and VEG...

Introduction: To estimate the possible role of VEGF-A in predicting poor early pregnancy outcomes including threatened abortion and early pregnancy loss. Methods: We conducted a prospective case-control study with three groups of pregnant women diagnosed with threatened abortion, early pregnancy loss, and uncomplicated healthy pregnancies betwee...

Purpose To assess the potential influencing effects of Dexmedetomidine (DEX) at impaired lacrimal glands after high-dose radioiodine treatment (RAI). Materials and methods Thirty-six rats were arbitrarily seperated into 3 groups; Sham, RAI and DEX group. DEX group were given DEX and RAI, Sham group were given same millimeters of saline and RAI gro...

The present study investigated the suitability of combinations one Streptococcus thermophilus and five Lactobacillus delbrueckii subsp. bulgaricus isolates for industrial yogurt productions. The isolates were selected after a detailed pre-screening procedure based on acidification performances, production of volatile aroma compounds, texture develo...

The parathyroid glands are localized at the back of the thyroid glands in the cervical region and are responsible for regulation of the calcium level in the blood, through specialized cells that sense Ca2+ and secrete parathyroid hormone (PTH) in response to a decline in its serum level. PTH stimulates the skeleton, kidneys and intestines and contr...

Sometimes it can be difficult to chorionicity determination in twin pregnancies. This study aimed to compare maternal serum midkine levels between twin and singleton pregnancies. We also evaluated the relationship between chorionicity and maternal serum midkine level in twin pregnancies. The present prospective cohort study included 16 patients wit...

Objective: To assess midkine (MK) levels in pregnant women with preterm premature rupture of membranes (PPROM) and compare them to healthy pregnant women. We also assessed the performance of the maternal serum MK level in predicting neonatal intensive care unit (NICU) requirement in the PPROM group. Methods: Forty pregnant women who presented to...

Objective To evaluate changes in maternal serum midkine levels in pre‐eclampsia. Methods This study included 40 pregnant women with pre‐eclampsia and 66 healthy pregnant women in the control group. Demographic data, laboratory results, and midkine levels were compared between the groups. Results The pre‐eclampsia and control groups were similar i...

Objective To compare umbilical cord blood pro‐B‐type natriuretic peptide (BNP) levels in newborns of severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) positive pregnancies to those of SARS‐COV‐2 negative pregnancies. Methods Prospectively cord blood samples from newborns of 42 SARS‐COV‐2 positive women, and 42 negative pregnant were col...

Injury to the skin begins a series of complex events related to inflammatory cell infiltration, cell proliferation, new tissue formation, matrix and tissue remodeling. So it causes partial regeneration of the injured area. During the wound healing process are responsible various mediators (growth factors, chemotactic factors, vasoactive amines), pa...

Amaç: Bu çalışmanın amacı Nerium oleander distilatının hiperkolesterolemik sıçanların serum biyokimyasal parametreleri üzerindeki etkisini değerlendirmektir. Gereç ve Yöntem: 30 erkek Sprague-Dawley rattan oluşan üç eşit grup oluşturuldu. Kontrol grubu için herhangi bir uygulama yapılmadı. İkinci gruba yüksek kolesterol diyeti verilirken, üçüncü gr...

Objectives To compare maternal serum midkine (MK) level in pregnant women with idiopathic fetal growth restriction (FGR) and healthy. In addition, we assessed the value of maternal serum MK level in predicting neonatal intensive care unit (NICU) admission. Methods A total of 144 pregnant women were included, 72 with idiopathic FGR and 72 healthy i...

Musculoskeletal injuries as a kind of traumas that the human body is exposed to, adversely affect the quality of life and workforce of individuals due to restriction of movement function. This study was aimed to evaluate the effects of dose-dependent ascorbic acid administration on the repair process after gastrocnemius muscle injury in rats. In th...

Objective: We aimed to compare maternal serum midkine level in pregnant women with different types of diabetes mellitus (DM) and healthy pregnant women. We also assessed maternal serum midkine level performance to predict adverse neonatal outcomes in the DM group. Methods: The study included 57 pregnant women diagnosed with gestational diabetes...

Purpose: To evaluate the radioprotective effect of spirulina (SP) on the lacrimal glands after RAI treatment. Methods: A total of 30 rats were separated into control, RAI and SP group. The radioprotective effect of SP on lacrimal glands was evaluated with histopathological and cytopathological analysis. Lacrimal glands were analyzed for tumor ne...

The objective of this study was to evaluate the utility of first trimester maternal serum afamin levels together with vitamin E and various elements (zinc, copper, selenium, and magnesium) for the prediction of gestational diabetes mellitus (GDM). All pregnant women between 11th and 14th weeks of gestation admitted for combined test were asked to p...

ÖZET Koronavirüs hastalığı-2019 (COVID19) salgını yaklaşık bir yılı aşkın süredir ülkemizde ve dünyada pandemi boyutunda görülen ve ağır akut solunum yetmezliği de dahil olmak üzere birçok sağlık sorununa yol açan bir hastalıktır. 'Severe acute respiratory syndrome coronavirus' (SARS-Cov) ailesinden olan SARS-CoV-2 virüsünün sebep olduğu bu hastalı...

Introduction. It is known that nutrition and trace elements are important in critically ill patients and trace element levels change during infammation[1]. Since zinc and copper are included in the structure of superoxide dismutase enzyme, which is involved in antioxidant defense systems, it may be crucial to consider serum zinc and copper levels d...

Background: SARS CoV-2 is a novel coronavirus which cause recent pandemia and many deaths. This study aimed to determine zinc, copper and magnesium status on pregnant women with COVID-19. Methods: Totally 200 pregnants were included in the study, 100(34/33/33) were pregnants with COVID-19 infection and 100(33/32/35) were healthy pregnants and each...

Background New biomarkers for diagnosis and monitoring the COVID-19 disease are the most important topics to be studied recently. We aimed to investigate the association between midkine levels and disease severity in pregnant women with COVID-19. Methods Totally 186 pregnant women were participated in this study. 96 of them were healthy pregnant w...

Purpose Developing a vaccine with improved immunogenicity is still a growing priority for many diseases. Different types of adjuvants may be beneficial to initiate and maintain the long-lasting immunogenicity of vaccines. Evidence has shown that polysaccharide adjuvants are efficient in improving immunological mechanisms with their biocompatibility...

Throughout history new types of food, food ingredients or ways of producing food have been developed all corners of the globe. Increasing globalization, growing ethnic diversity and the search for new sources of nutrients are the key drivers for the development of novel foods and functional foods. Undoubtedly, novel foods and functional foods are d...

Aim We compared maternal serum and fetal cord blood proBNP levels in healthy pregnancies to those with intrauterine growth restriction (IUGR). Methods: Prospectively, maternal and cord blood samples at childbirth of 40 pregnant women with isolated IUGR and 40 healthy pregnant women were evaluated for ProBNP levels. Results: The mean serum ProBNP le...

The active form of vitamin D (Vit D), 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), is important for cell functions and immunity, as well as its role in bone metabolism. Monocytes/macrophages initiate innate immune response, and is considered to be the cell that first comes into contact with the pathogen. They play effective roles in innate immune and i...

Background: Cardiovascular diseases (CVDs) are one of the most important causes of mortality all around the world. Studies have been shown that vitamin D is closely related CVDs, including heart failure (HF). We aim to assess the serum vitamin D levels in patients with HF in this meta-analysis. Methods: A systematic research was performed in Pubmed...

Objectives Lung injury is one of the most important risk factor for morbidity and mortality, especially in older people. There are several reasons causing acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) such as pneumonia, sepsis, viruses, oxidants, and trauma. Evidence has shown that carnosine has many properties, such as sup...

Background This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT). Method 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinata...

Growth patterns and some technological performances of five Streptococcus thermophilus and seven Lactobacillus delbrueckii subsp. bulgaricus strains isolated from yogurt samples which were collected from remote rural areas of Anatolia, Turkey were assessed. The single isolates were screened for milk acidification performances, production of volatil...

Aim: Adequate maternal selenium level is essential for immune response and healthy pregnancy. This study aimed to enlighten selenium status of pregnant women with COVID-19 and the effects of potential deficiency in serum selenium levels. Methods: Totally 141 pregnant women, 71 of them was COVID-19 patients, in different trimesters were included...

Purpose To evaluate the usability of first-trimester maternal serum ProBNP levels in the prediction of intrauterine growth restriction (IUGR). Methods In this prospective study, blood samples taken from 500 women who applied to our polyclinic for routine serum aneuploidy screening between the 11–14th gestational weeks were centrifuged. The obtained...

Zinc is known for anti-inflammatory and antioxidant roles. In this meta-analysis, we aim to evaluate the impact of zinc supplementation on inflammatory markers, acute-phase reactants, and serum zinc level during inflammatory and infectious diseases. PubMed, Scopus, and Web of Science databases were screened systematically with the terms "zinc suppl...

Bone-related diseases are very common problems, especially in the elderly population. Zinc takes part in the growth and maintenance of healthy bones. This meta-analysis aims to evaluate the effects of zinc supplementation or dietary zinc intake on serum zinc levels and bone turnover markers. A systematical research was performed with 2899 articles...

The objective of this study was to evaluate the utility of first trimester maternal serum afamin levels together with vitamin E and various elements (zinc, copper, selenium, and magnesium) for the prediction of gestational diabetes mellitus (GDM). All pregnant women between 11th and 14th weeks of gestation admitted for combined test were asked to p...

Objective To compare the levels of various cytokines between pregnant women with confirmed coronavirus disease (COVID-19) infection and pregnant women without any defined risk factor. Materials and Methods Pregnant women with confirmed COVID-19 infection (study group)(n=90) were prospectively compared to a gestational age-matched control group of...

Background and objectives: Epithelial cells and macrophages play major roles in modulating the state of inlammatory response regulated by intracellular signaling pathways. The aim of this study was to characterize changes in cell proliferation, apoptosis and inflammation related intracellular signalling pathways MAPKs and NF-κB in Caco-2 epithelial...

Background and aim Zinc and copper are essential trace elements for cell growth and proliferation. Their deficiency may contribute to intrauterine growth restriction (IUGR). We aimed to determine the zinc and copper status of maternal serum and placenta samples of pregnant women with fetal IUGR and age-matched pregnant women without IUGR. Method S...

Objective: To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID-19) and to investigate their association with composite adverse perinatal outcomes. Methods: This prospective, case-control study consisted of 60 pregnant women with COVID-19 infection and 36 age-matched pregnant women witho...

Objective To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID‐19) and to investigate their association with composite adverse perinatal outcomes. Methods This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age‐matched pregnant women without...

Insulin resistance, impaired glucose regulation, dyslipidemia, low-grade inflammation, and elevated blood pressure are main components of the metabolic syndrome (MetS). Trace elements, especially zinc (Zn) and copper (Cu) and cytokines, have physiological importance due to their presence in inflammatory processes and glucose metabolism. Therefore,...

The aim is to compare VEGF‐A values between pregnant women with coronavirus disease 2019 (COVID‐19) and healthy controls. Furthermore, the association of inflammation parameters, disease severity, and obstetric complications with VEGF‐A was investigated. This prospective case‐control study was conducted on pregnant women who were admitted to Ankara...

Objective: To compare VEGF-A values between pregnant women with Coronavirus disease 2019 (COVID-19) and healthy controls. Furthermore, the association of inflammation parameters, disease severity and obstetric complications with VEGF-A was investigated. Methods: This prospective case-control study was conducted on pregnant women who were admitted...

Background: SARS CoV-2 is a novel coronavirus which cause recent pandemia and many deaths. This study aimed to determine zinc, copper and magnesium status on pregnant women with COVID-19. Methods: Totally 200 pregnants were included in the study, 100(34/33/33) were pregnants with COVID-19 infection and 100(33/32/35) were healthy pregnants and each...

Diabetes is mainly defined as disturbances of glucose and lipid metabolism, and characterized by hyperglycemia. The progress of diabetes affects most of the tissues and organs such as endothelium, retina, heart, kidney, and brain. Glycolysis and metabolism are controlled by oxygen (O2) which is essential for the maintenance of life of all aerobic o...

Objective: The present study aimed to investigate the protective effect of nebivolol in the bladder isolated from rats exposed to ischemia-reperfusion (IR) injury. Methods: Sprague-Dawley rats were divided into control, IR, and nebivolol+IR groups. In the nebivolol+IR group, nebivolol was administered (0.4 mg/kg, subcutaneous) in rats prior to IR...

Background Frailty is a medical syndrome resulting in loss of endurance, strength and physiological function. There is insufficient data to understand the process of frailty formation at the gene level, however the Klotho gene is known as an anti-aging gene with many functions that prolong lifespan. We aimed to investigate the relationship between...

Objective The present study aimed to investigate the protective effect of nebivolol in the bladder isolated from rats exposed to ischemia‐reperfusion (IR) injury. Methods Sprague‐Dawley rats were divided into control, IR, and nebivolol+IR groups. In the nebivolol+IR group, nebivolol was administered (0.4 mg/kg, subcutaneous) in rats prior to IR in...

The effects of homogenisation, heat treatment and their order on in vitro gastric/pancreatic digestions, and in vitro absorption of milk lipids, expressed as free fatty acids, were investigated. Milk, cream or mixture of homogenised/heat‐treated cream and skim milk were subjected to gastric digestion at pH 2 or 6, followed by pancreatic digestion a...

Purpose We have evaluated the potential radioprotective, antioxidant and anti-apoptotic effects of resveratrol (RSV) against high-dose radioactive iodine (RAI) therapy associated damage of the lacrimal glands by biochemical, histopathological and immunohistochemical methods. Materials and Methods Thirty Wistar-albino rats were randomly divided int...

Background and aim: Non-alcoholic fatty liver disease (NAFLD) is a common health problem related to diet and a sedentary lifestyle. Zinc has essential roles in diabetes, insulin resistance and inflammation. This meta-analysis aims to evaluate the relationship between NAFLD and dietary zinc intake/serum zinc levels. Materials and methods: A syste...

The balanced presence of polyunsaturated fatty acids and specific bioactive components of high-polyphenol extra virgin olive oil (HP-EVOO)result in the presumed health benefit. Enrichment of its principal polyphenols is shown to be protective in oxidative damage and improves mitochondrial dysfunction. We investigated the effect of different concent...

The prevalence of obesity and metabolic syndrome continue to increase by years and now obesity is a growing public health problem. World Health Organization (WHO) reports that more than 1.9 billion adults were overweight in 2016, 39% of them obese and 8.5–12.2% of adults aged 18 years and older had diabetes. Nutritional imbalance (over- or under-nu...

There are many studies examining the effect of olive oil consumption and its bioactive components on health. Experimental mod-els and studies on volunteers, epidemiological studies, systemic reviews and metaanalyses show that olive oil consumption has a positive effect on the formation, prevention and treatment processes of many chronic diseases, m...

OBJECTIVE: The mechanism of the leiomyoma formation process is still unknown. However, the menstrual cycle is associated with hypoxia, and ongoing hypoxia is associated with cellular events leading to the conversion of myometrial cells into uterine fibroids. After the hypoxic environment, the balance of cellular cytokines and growth factors changes...

Protein kinase C (PKC) and aldose reductase (AR) enzyme activities are increased in diabetes and complications are include retinopathy, nephropathy, and neuropathy. However, the relationship between PKC and AR and the underlying molecular mechanisms is still unclear. We aimed to evaluate the relationship between these two enzymes and clarify the un...

Erythropoietin (EPO) in its recombinant form is mainly used clinically for anaemia associated with diseases including chronic kidney disease due to its primary role in the induction of erythropoiesis. Accumulating evidence has also indicated that erythropoietin provides protection against ischaemia reperfusion injury in several organs and tissues i...

The aim of the study is to provide some strategies for women in academia to improve innovative health entrepreneurship. Empowering women’ participation in science and increasing women’s inclusion in the market, social/cultural development are very important. A survey will be conducted to analyze the perceptions of university, society, private and p...

ABSTRACT Background: The association between maternal and cord blood zinc level and pregnancy outcomes remains uncertain. The present study aims to assess whether maternal blood zinc level represents cord blood zinc level correctly. Methods: In this meta-analysis, systematic search was performed in PubMed, Web of Science and Scopus databases for...

Süte uygulanan ısıl işlem süresince şiddetine bağlı olarak, serum proteinlerinin denatürasyonu, κ-kazein/β-laktoglobulin kompleks oluşumu, kalsiyum fosfat presipitasyonu, Maillard reaksiyonu gibi fizikokimyasal değişimler meydana gelmektedir. Bu çalışmanın amacı farklı sıcaklık uygulanan sütlerde sıcaklığın proteinlere etkisinin vibrasyonel olarak...

Bu çalışmada homojenizasyon ve ısıl işlem uygulamalarının süt yağının sindirim ve emilim düzeyleri üzerindeki olası etkilerinin belirlenmesi amaçlanmıştır. Çalışma iki aşamalı olarak yürütülmüştür. Birinci aşamada süt yağının sindirim ve emilim etkinliğinin homojenizasyon basıncına ve ısıl işlemin homojenizasyondan önce ya da sonra uygulanmasına ba...

BACKGROUND In this study, hyaluronic acid (HA) was produced using Streptococcus equi ssp. equi via an optimized Central Composite Design process, with purification by an alternative extraction method. Determinations of molecular weight, cytotoxicity, viscosity; proton nuclear magnetic resonance (H‐NMR) and Fourier transform infrared‐attenuated tota...

Purpose: To evaluate antioxidant effects of active vitamin D (calcitriol) against high-dose radioiodine (RAI) therapy-associated damage of lacrimal gland. Materials and Methods: Wistar albino rats were used and divided into three groups randomly (n = 12/group). The first group was appointed as the negative control group and received no RAI or medic...

In the present study, culture conditions of Streptococcus equi was optimized through Box–Behnken experimental design for hyaluronic acid production. About 0.87 gL⁻¹ of hyaluronic acid was produced under the determined conditions and optimal conditions were found as 38.42 °C, 24 hr and 250 rpm. The validity and practicability of this statistical opt...

Background and Objectives: Magnesium (Mg) plays a key role in regulation of body heat, synthesis of nucleic acids and proteins, electrical potentials in nerves and muscle membranes, calcium homeostasis and together with calcium plays an important role in insulin secretion and in the process of glucose uptake by cells and providing the oxygen requir...

Macrophages are accepted as cells that initially contact with the pathogens and initiate the innate immune response. They play effective roles in innate immune and inflammatory responses by intercellular relations and inflammatory mediator secretion. Human THP-1 leukemia cells are frequently used for the in vitro determination of the signal pathway...

Obesity is the most common nutritional disorder and associated with an increased risk of developing insulin resistance and type 2 diabetes. There have been several reports related with inflammation in diabetes and obesity, but the relationship between inflammatory status, lipid profile and aldose reductase (AR) enzyme activity in diabetic and high-...

Purpose: To evaluate protective effect of coenzyme Q10 (CoQ10) in lacrimal glands against high-dose radioactive iodine (RAI)-associated oxidative damage. Materials and Methods: Thirty Wistar albino rats were randomly divided into three groups. Group 1 was the control group. Group 2 received 3 mCi/kg RAI via gastric gavage but no medication. Group 3...

Süt ve süt ürünleri, insanların büyüme, gelişme ve yaşlanma sürecinde ideal dengeli beslenme kaynaklarıdır. Özellikle anne sütü yenidoğan ve ilk altı ayda bebekler için vazgeçilmez temel besindir. Bununla beraber anne sütü dışında diğer kaynaklardan elde edilen sütler insanların diyetlerinin bir parçası haline gelmiştir. Süt ve süt ürünleri; prote...

Wound healing is important for longevity. Midkine is a cytokine involved in controlling tissue repair and new tissue development, and in regulating inflammation. We investigated the effect of midkine on wound healing in rats. In total, 108 Wistar albino rats were used: 12 as healthy and diabetic controls; 96 were split into 4 groups: healthy, salin...

Obesity is a complex disorder which also predisposes subjects to other diseases including type 2 diabetes. Inflammation is the common key feature in both diseases. Evidence exists that the inflammation could be induced by hypoxia or vice versa. A hypoxic and inflammatory phenotype has been reported in adipose tissue during obesity. The cellular res...