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Citations since 2016
8 Research Items
February 2016 - May 2019
- PhD Student
- Involved in research activities related to structural bioinformatics especially on the protein structure analyses and development of computational pipelines using various algorithms and programming languages.
The GrAfSS (Graph theoretical Applications for Substructure Searching) webserver is a platform to search for three-dimensional substructures of: (i) amino acid side chains in protein structures; and (ii) base arrangements in RNA structures. The webserver interfaces the functions of five different graph theoretical algorithms - ASSAM, SPRITE, IMAAAG...
Nepenthes is a genus comprising carnivorous tropical pitcher plants that have evolved trapping organs at the tip of their leaves for nutrient acquisition from insect trapping. Recent studies have applied proteomics approaches to identify proteins in the pitcher fluids for better understanding the carnivory mechanism, but protein identification is h...
Structures of protein-drug-complexes provide an atomic level profile of drug-target interactions. In this work, the three-dimensional arrangements of amino acid side chains in known drug binding sites (substructures) were used to search for similarly arranged sites in SARS-CoV-2 protein structures in the Protein Data Bank for the potential repositi...
A common drug repositioning strategy is the re-application of an existing drug to address alternative targets. A crucial aspect to enable such repurposing is that the drug's binding site on the original target is similar to that on the alternative target. Based on the assumption that proteins with similar binding sites may bind to similar drugs, th...
Abstrak: Burkholderia pseudomallei berkebolehan untuk hidup dalam keadaan dorman dalam badan manusia dan berupaya menyebabkan penyakit melioidosis yang laten. Dalam penyelidikan ini, struktur alfa-kristallin B. pseudomallei telah dimodelkan menggunakan tiga kaedah ramalan i) secara perbandingan homologi ii) secara threading atau pengecaman lipatan...
The three-dimensional structure of a protein can provide insights regarding its function. Functional relationship between proteins can be inferred from fold and sequence similarities. In certain cases, sequence or fold comparison fails to conclude homology between proteins with similar mechanism. Since the structure is more conserved than the seque...