Nur Atik

Nur Atik
Universitas Padjadjaran | UNPAD · Anatomy and cell biology

MD., PhD

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76
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336
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Publications

Publications (76)
Article
Full-text available
Background and aim: Food safety is an important aspect to be evaluated in preventing any potentially harmful side effects of food product such as yogurt. The purple sweet potato yogurt product was developed to combine the benefits of probiotic activities in yogurt and the bioactive effects of anthocyanin in purple sweet potato. This study was perf...
Article
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Introduction: The study on guava fruit ethanol extract from Dukuhwaluh Village, Purwokerto, Central Java, Indonesia showed increased megakaryocytes and platelet numbers in thrombocytopenic mice model. The study of acute oral toxicity of the extract did not show toxic effects in the kidney and liver at doses of 2000 and 5000 mg/kg b.w. The aim of th...
Article
Background: Sepsis causes several immunological and metabolic alterations that induce oxidative stress. The modulation of fatty acid-binding protein 4 (FABP4) has been shown to worsen this condition. Extract of cogon grass root (ECGR) contains flavonoids and isoeugenol compounds that exhibit anti-inflammatory and antioxidant properties. This study...
Article
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Rosacea is a common chronic inflammatory skin disease characterized by flushing, transient erythema, persistent erythema, telangiectasia, papules, pustules, phymata, edema, pain, stinging, or burning, and its treatment is still being developed. Rosacea is known to be regulated by excessive activation of Kallikrein-5 (KLK5). This research aimed to d...
Article
Background: Sepsis causes several immunological and metabolic alterations that induce oxidative stress. The modulation of fatty acid-binding protein 4 (FABP4) has been shown to worsen this condition. Extract of cogon grass root (ECGR) contains flavonoids and isoeugenol compounds that exhibit anti-inflammatory and antioxidant properties. This study...
Article
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Background & Aims: This study evaluated the construct validity of the Indonesian version of WHODAS 2.0 among persons with physical impairment. Methods: WHODAS 2.0 was self-administered to 212 participants with physical impairment in Bandung, Indonesia. The Rasch model was used to analyse the instrument’s construct validity. Results: Data of 212 par...
Article
Aim: This study was aimed to compare the maternal and neonatal outcomes among teenage and reproductive-age pregnancies. Patients and methods: This was a cross-sectional study of pregnant mothers in Hasan Sadikin General Hospital, the tertiary referral hospital in West Java, Indonesia. Patients who gave birth during January 2015-December 2018 were i...
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Patients suffering from skin wounds often have their life heavily affected economically and socially. In general, wound healing consists of four different sequentially and overlapping phases. Interrupting those phases results in extending the healing time. Turmeric (Curcuma longa) is widely used by Indonesians to treat wounds, with curcumin as an a...
Article
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Background and aim: Brown adipose tissue's (BAT) ability to increase energy expenditure has become a new focus in obesity research. The amount and activity of BAT are inversely correlated with body-mass index and body fat percentage. Bone morphogenetic protein 7 (BMP7) plays a role in the differentiation and development of BAT, which can be increa...
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Purpose: Inflammation plays an important role and is involved in all stages of acute ischemic stroke. One of these stages involves the recruitment of leukocytes from the peripheral circulation into the ischemic tissue. Lymphocytes as a subtype of leukocytes are important mediators and can become a predictor of neurological outcome. Several studies...
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Background: Probiotics have numerous health benefits to the digestive system, one of them being clinically able to prevent and treat diarrhea. The growing scientific evidence of probiotic benefits has led to increased production of probiotic products. Health science students, as future healthcare professionals (HCPs), should have more knowledge ab...
Article
Wound prevalence is still high, both nationally and globally, having a negative impact on patients' physical, psychological and financial wellbeing. The wound healing process involves hemostasis, inflammation, proliferation and remodeling, with angiogenesis being one aspect of the proliferation phase. Curcuma longa has long been used for the therap...
Article
Objective To assess serum FABP4 and other metabolic-related parameters in Systemic Lupus Erythematosus (SLE) active and non-active episode. Methods Fifty-four SLE patients in Hasan Sadikin General Hospital, Bandung, Indonesia in 2018–2019 were recruited and serum samples were collected in their active and non-active episode status. Serum was analy...
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Background: Intracerebral hemorrhage (ICH) stroke contributes to a considerable number of deaths, ranging between 30% and 40% of the overall stroke mortality. The incidence of stroke increases with higher blood pressure. High blood pressure at the onset of ICH stroke is a strong predictor for mortality and morbidity. This study aimed to explore the...
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Corneal stromal wound healing is slower than other connective tissues, which is thought to be partly controlled by various matrix metalloproteinases. Transforming Growth Factors-βeta 1 (TGF-β1) appears in the three main phases of the wound healing process as a mediator and plays a role in the final matrix formation phase. Aloe vera has a glucomanna...
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Context: Diabetes is a chronic health condition with insulin disturbance. Hibiscus surattensis L. is a medicinal plant and plays a pivotal role in diabetes. Aims: To evaluate the effect of H. surattensis leaves extract to increase insulin secretion and repair pancreatic tissue damage in streptozotocin (STZ)-induced diabetic mice. Methods: This rese...
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Context: Diabetes is a chronic health condition with insulin disturbance. Hibiscus surattensis L. is a medicinal plant and plays a pivotal role in diabetes. Aims: To evaluate the effect of H. surattensis leaves extract to increase insulin secretion and repair pancreatic tissue damage in streptozotocin (STZ)-induced diabetic mice. Methods: This rese...
Article
BACKGROUND: Cardiovascular disease is a leading cause of death globally with the 287,000 deaths per years, characterized by declining of heart function caused by the reduction of heart capacity and lead to heart failure. Cell therapy using endothelial progenitor cells (EPCs) has a big potential for cardiovascular regeneration. EPCs are cells that h...
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While M1 macrophages initiate wound healing by inducing the inflammation phase, M2 macrophages are crucial in the proliferation phase by producing growth factors that accelerate new tissue formation. Turmeric (Curcuma longa L.) is known to accelerate wound closure; however, mechanisms underlying the wound healing properties of C. longa L. remain to...
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The nosocomial infection could be acquired through airborne disease in the hospital. However, only a particular health center in Indonesia carried out a complete, cautious prevention procedure by utilizing air purifiers due to cost problems. Thus, to minimize the number of nosocomial infections related to bacterial air pollutants, excellent tools w...
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In the developing brain, the polarity of neural progenitor cells, termed radial glial cells (RGCs), is important for neurogenesis. Intercellular adhesions, termed apical junctional complexes (AJCs), at the apical surface between RGCs are necessary for cell polarization. However, the mechanism by which AJCs are established remains unclear. Here, we...
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Purpose: D-dimer is one of the main coagulation factors that plays a role in some diseases. Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease with various clinical presentations, and the D-dimer might contribute to its clinical progress. Our study's objective was to explore the association between D-dimer level and focal neurologi...
Article
Antibiotic growth promoter (AGP) telah digunakan pada hewan produksi untuk meningkatkan pertumbuhan dan efisiensi konversi pakan. Namun, beberapa penelitian menunjukkan bahwa aktivitas utama beberapa AGP dapat disebabkan oleh efek antiinflamasinya yang menyebabkan penurunan katabolisme otot dan pencegahan anoreksia. Hal tersebut membuat energi bany...
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Titanium-based material or commonly known as "titanium plate" is a type of implant that is widely used for maxillofacial trauma treatment. The use of titanium plate has shown a great impact on osteo-conductivity but it is still lacking an impact on osteo-stimulation promotion. Mud crab shell has components that are very similar to human bone. Thus,...
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Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that belongs to the coronavirus family. The first case was reported in December 2019, and the disease has become a pandemic. Impaired immune regulation is one of the factors that play a role in its pathogenesis and...
Article
Anthocyanins, natural pigments belonging in the flavonoid group that can be found in different types of plants, are popular bioactive compounds with various beneficial properties. In the topic of skeletal muscle, overtraining, or pathological conditions can cause excessive ROS production and chronic inflammation, leading to degradation in function,...
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Objective: Flare in Systemic Lupus Erythematosus (SLE) is an exacerbation of SLE clinical features that were earlier quiescent. The disease activity changes from inactive to active with an increase of several immunological profiles; the rise of immune activity induces a metabolic shift in SLE patients. The previous study aimed to investigate the lo...
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Purpose: Highly active systemic lupus erythematosus (SLE) causes a high risk of tuberculosis (TB) infection in SLE patients in Indonesia, a country in which the disease, especially extrapulmonary TB, is endemic. Interferon (IFN)-γ releasing assay (IGRA) can detect latent or previous TB infection. This study sought to determine latent TB infection...
Article
Our study examined factors associated with the utilization of health services in children younger than 5 years with acute respiratory infections (ARIs) symptoms in Indonesia. Data were derived from the 2012 and 2017 Indonesia Demographic and Health Survey. Information from 1408 children younger than 5 years showing ARI symptoms in the past 2 weeks...
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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and...
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Introduction: Prolonged obstruction in UPJO would lead to kidney destruction. It is important to find a non-invasive biomarker for early detection of renal impairment before definitive treatment for UPJO. In this study, we aim to evaluate the role of urinary cytochrome c and caspase-3 as a novel biomarker to predict renal function impairment in a...
Article
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Systemic Lupus Erythematosus (SLE) is a complex and multifactorial autoimmune disease characterized by various cellular and molecular aberration resulting in different phenotypes in each individual. SLE occurs worldwide, with the incidence and prevalence varies by country and geographically. Many components of the immune system contribute to the pa...
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Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with high mortality and morbidity rates, one of the causes of which is cardiovascular events. Dyslipidaemia is known to be one of the main risk factors for cardiovascular disorders and can be induced by steroid therapy, which is commonly administered to SLE patients. This study a...
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The study aims of this research are to observe organosomatic indices comprising liver and kidney with acute oral toxicity study-up and down procedure on extract Psidium guajava Linn. fruit in mice. Twelve swiss webster mice were in different groups which were control: distilled water, group I: dose of 2000 mg/kg b.w. p.o., group II: dose of 5000 mg...
Article
Smoking epidemic remains to be one of the biggest public health issues the world has ever faced. Cigarette smoke can stimulate peroxidation of lipid and oxidation of proteins and become a risk factor for atherosclerosis and cardiovascular disease. Aloe vera has been used for medicinal purposes for centuries and reported to have potent antioxidant c...
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Depression is one of the major problems, and the prevalence is higher among the elderly. The underlying mechanism of depression among this set of the population is multifactorial, and one of the most important factors in the pathophysiology of depression is the level of brain serotonin. Protein deficiency is linked to tryptophan deficiency that is...
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Characteristics of obesity as dysfunction of adipose tissue and chronic low-grade inflammation can have impacts to haematological parameters. The Moringa oleifera leaves have been used empirically to treat metabolic and blood-related diseases. However, it is still unknown whether Moringa oleifera leaves can influence haematological parameters in hi...
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Penile metastasis of adenocarcinoma of prostate is an extremely rare clinical entity and even less of such cases presenting with malignant priapism. Management of priapism with penile shunting is recommended in this case. No consensus beyond personal recommendation from other studies found in this case due to the relative rarity of the disease and...
Article
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Stroke iskemik merupakan salah satu penyebab stroke tersering, disebabkan oleh oklusi pembuluh darah serebral dan penyebab kematian ketiga. Saat awitan stroke iskemik terjadi, area otak yang diperdarahi oleh pembuluh darah akan kekurangan oksigen dan nutrisi sehingga sel otak terutama neuron berada dalam risiko, neuron ini masih dapat berfungsi yan...
Article
Currently, the trends of alternative and complementary medicine are highly developed. In the last few decades, the National Health Statistics Report (NHSR) in America has shown a substantial increase in the use of alternative and complementary drugs. The use of herbs as medications or supplementations should result from a right decision between pat...
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Studies in neuroscience can be performed in vitro and in vivo. In vivo studies will show significant results, but it is difficult to do and time-consuming. Primary hippocampal cell culture widely has used in neurobiological studies such as identifying the cellular mechanism of proteins, neuronal activity, and characteristics. The results of studies...
Article
Objective: The main objectives of the research are to investigate the phytochemical screening, histology appearance, and safety of acute oral toxicity study on the extract of the fruit of Psidium guajava Linn. in mice. Methods: Mice that were administered by oral feeding with different and controlled dose were divided into three groups, with dose l...
Article
Full-text available
Objective: The main objectives of the research are to investigate the phytochemical screening, histology appearance, and safety of acute oral toxicity study on the extract of the fruit of Psidium guajava Linn. in mice.Methods: Mice that were administered by oral feeding with different and controlled dose were divided into three groups, with dose li...
Article
Full-text available
Psidium guajava Linn. is a cultivated and herbal medicines from tropical and subtropical areas that extensively consume around the world as a food and folk medicine. Recent study showed that extract of P. guajava increased the number platelets in thrombocytopenia mice model. The purpose of this research is to know the profile of liver function afte...
Article
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Background Dengue virus infection that most frequently occur in tropical and subtropical regions can cause many symptoms, one of which is a decrease in thrombocyte count. Recent studies showed that guava leaf extract can increase the thrombocyte count in rats. The present study aimed to determine the effect of guava leaf juice in increasing the num...
Article
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Objective: The purpose of this study was to determine the mechanism through which guava extract increases platelet count.Methods: Twenty male Swiss webster mice were divided into 4 group. Group I received 2.8 mg/20 g body weight of quinine and 1 ml of distilled water. Group II received 2.8 mg/20 grBW of quinine and 0.785 mg/20 grBW of guava extract...
Article
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Most of the case of patient with hemoglobin disorder genes need routine blood transfusion throughout their life. It leads to increase iron accumulation with liver as the main organ for iron storage. Liver is the main organ for metabolic process, including triglyceride and cholesterol. However, correlation between metabolism of triglyceride and chol...
Conference Paper
In the past decade, Indonesia’s Government through the Ministry of Health has issued the guideline book for health research ethics. This guideline organizes all ethical aspects of research including archived biological materials. At the same time, there have been some considerable changes in the research environment. The changes include the develop...
Article
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Hemangioendothelioma is a vascular tumor that commonly found in soft tissue, lungs, heart, liver, and bones, but it is very rare in bladder. We report a case of pediatric hemangioendothelioma of the bladder in a 2 years 7 months-old boy that treated with total excision of the bladder and bilateral ureterocutaneoustomy. This case is the second case...
Article
The incidence of heart disease related with cigarette smoking has been increasing over the years due to numerous factors, includes smoke cardiomyopathy. Modern medicine is costly and have many side effects. Thus, many people are turning to traditional or herbal medicine instead. Hence, this study was done to evaluate the effect of Aloe vera (A. ver...
Article
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Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with primary manifestation in the joints. Early management of RA will prevent further joint damage. The joint damages, result of uncontrolled disease activity, will decrease patient’s quality of life. RA should be diagnosed earlier and followed by early treatment initiation, in...
Article
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BIG1, an activator protein of the small GTPase, Arf, and encoded by the Arfgef1 gene, is one of candidate genes for epileptic encephalopathy. To know the involvement of BIG1 in epileptic encephalopathy, we analyzed BIG1-deficient mice and found that BIG1 regulates neurite outgrowth and brain development in vitro and in vivo. The loss of BIG1 decrea...
Data
Loss of BIG1 does not affect commissural axon projection. (A) The CC width relative to the brain height (**p = 0.001) or width (***p = 0.0008) is smaller in Arfgef1geo/geo brains based on the results in Fig 6Axii-xiii. n = 4 per group. (B) At E17.5, dye tracing showed the commissural axons (yellow arrowheads) in Arfgef1geo/geo brains can reach cont...
Data
Loss of BIG1 does not affect survival or migration of interneurons. (A-B) In Arfgef1geo/geo brains, activated Caspase-3 does not colocalize with Prox1 at E15.5 (A) or with Calbindin at E17.5 (B). White arrowheads show the Prox1+ or Calbindin+ cells that migrated into the neocortex and hippocampus. Scale bars, 200 μm; *insets, 50 μm. n = 3 per group...
Data
Caspase-3 colocalized with Ctip2. (A-C), Activated Caspase-3 colocalized with Ctip2 (white arrowheads) at (A) E13.5, (B) E15.5 and (C) E17.5 in Arfgef1geo/geo brains. Scale bars, 200 μm; *insets, 20 μm. n = 3 per group. Max, maximum apoptosis area. (TIF)
Data
Loss of BIG1 does not affect axonal extension at E15.5. (A) The axon extending pattern, visualized by axonal markers Map1b and Tau-1, in the E15.5 Arfgef1geo/geo brains were similar to the controls. Scale bars, 500 μm. n = 3 per group. (TIF)
Data
Loss of BIG1 does not affect various parameters of stage III neurons. Various parameters at DIV 2 such as (A) the longest axon length (p = 0.16), (B) the total axon length (p = 0.12), (C) the amount of axon branch (p = 0.36), (D) the longest dendrite length (p = 0.18), (E) the total dendrite length (p = 0.47), (F) the amount of dendrite branch (p =...
Conference Paper
Sistem kekebalan tubuh merupakan hasil sinergi yang rumit antara elemen seluler dan molekuler yang telah melewati proses perkembangan dan pematangan guna menjaga tubuh terhadap serangan. Pada kondisi normal, sistem kekebalan tubuh menunjukkan toleransi (ketidakmampuan untuk bereaksi) ke molekul yang diakui sebagai ''diri sendiri'' sehingga tidak be...