
Nuntiya SomparnThammasat University · Department of Pharmacology
Nuntiya Somparn
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Publications (30)
Elaeagnus latifolia fruit extract (EE) has been reported to contain antioxidant and anti-inflammatory phyto-chemicals. The present study aimed to examine the anti-hepatotoxic effects of EE in acetaminophen (APAP)-injected mice. Pretreatment with EE for 7 days in APAP mice showed significant reductions in the levels of AST and ALT and necrotic area,...
Taurine supplementation is recommended during perinatal life to provide sufficient taurine for fetuses and newborns. Furthermore, perinatal taurine supplementation affects cardiovascular and metabolic functions in adult life. In adults, taurine supplementation is reported to improve exercise training. The present study explored the effects of perin...
Insulin resistance is a salient player in the pathogenesis of obesity and its related abnormal glucose-insulin homeostasis. Red rice bran extract (RRBE) demonstrates several bioactive phytochemicals with anti-diabetic properties. However, little is known about its molecular mechanisms. Therefore, the present study was designed to investigate the an...
Objective: To evaluate the renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats.
Methods: We established a streptozotocin-induced type 2 diabetic model in male Wistar rats. The rats were fed with high-fat diet (45 kcal% lard fat) and injected with 35 mg/kg streptozotocin. Diabetic rats were treated wit...
Oxidative stress caused as a result of iron overload is implicated in clinical manifestation of beta-thalassemia/hemoglobin E (β-Thal/HbE). In the present study, we investigated the cellular adaptation against oxidative stress in β-Thal/HbE patients. Twenty-four pediatric β-Thal/HbE patients and 22 healthy controls were recruited in the study. Bloo...
Rice bran water extract (RBE) has been reported to have cardiovascular protective
effects including lipid-lowering and antioxidant effects. The present study aims to investigate the effects of RBE and its possible protective mechanisms against lipid accumulation and oxidative damage to the heart of male Sprague-Dawley rats induced by a high-fat die...
Maternal dyslipidemia induces metabolic and cardiovascular disorders in adult offspring. This study tests the hypothesis that perinatal taurine supplementation prevents the adverse effects of maternal dyslipidemia on growth and cardiovascular function in adult rat offspring. Female Wistar rats were fed normal rat chow and water with (Dyslipidemia)...
Maternal obesity predisposes metabolic and cardiovascular disorders in adult offspring. This study tests the hypothesis that perinatal taurine supplementation prevents dyslipidemia and hypertension in adult offspring of dyslipidemic rat mothers. Female Wistar rats were fed normal rat chow and water with (Dyslipidemia group) or without dyslipidemic...
Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found...
Purpose: To evaluate the antiproliferative and apoptotic effects of high-dose vitamin C in cholangiocarcinoma cell line (CCA). Methods: Sulforhodamine B colorimetric assay was used to determine cell proliferation in human K100-CCA cell lines. The expression of anti-apoptotic Bcl-2 protein/ pro-apoptotic Bax protein was evaluated by Western blot ana...
This study tests the hypothesis that perinatal taurine supplementation prevents diabetes mellitus and hypertension in adult offspring of maternal diabetic rats. Female Wistar rats were fed normal rat chow and tap water with (Diabetes group) or without diabetic induction by intraperitoneal streptozotocin injection (Control group) before pregnancy. T...
Purpose: To investigate the protective potential of rice bran water extract (RBE) from Khao Dawk Mali
105 on pancreatic abnormalities in high-fat diet (HFD)-induced obese rats.
Methods: Male Sprague-Dawley rats were divided into 4 groups: control group, HFD group, and HFD
group treated with RBE at 2,205 or 4,410 mg/kg/day. After 4 weeks, body weigh...
Purpose: To investigate the protective effect of Cymbopogon citrates Stapf. (CS, lemongrass) extract on paracetamol (PCM)-induced hepatotoxicity in rats.
Methods: The rats were orally administered CS extract (1000 mg/kg/day) for 30 days prior to induction of hepatotoxicity by a single oral administration of PCM (3 g/kg). Hepatoprotection was asses...
Objective: To examine the effect of Pandanus amaryllifolius (P. amaryllifolius) leaf extract on the insulin resistance state in obese ICR mice.
Methods: Obesity was induced in mice fed with high-fat diet (45% fat) for 12 weeks. After the first six weeks on the diet, the obese mice were administered with the water extract of P. amaryllifolius leaf a...
Umbelliferone (UMB) is a natural product that has several pharmacological effects including antihyperglycemic activity in diabetic rats. Thus, the objective of this study was to investigate the effect of UMB on insulin resistance and on the regulation of glucose and lipid metabolism in type 2 diabetic rats. Type 2 diabetes was induced in rats by fe...
Purpose: To investigate the cytoprotective effect of tetrahydrocurcumin, (THC) and curcumin (CUR) on cytotoxicity induced by doxorubicin and cadmium in Chang liver cells. Methods: Cytotoxicity was determined by sulforhodamine B assay. The expression of nuclear factorerythroid- 2-related factor 2 (Nrf2) Nrf2 regulated cytoprotecetive enzymes, glutam...
Tetrahydrocurcumin (THC), an active metabolite of curcumin, possesses potent antioxidant activity and is more stable in vivo than curcumin. We investigated the protective effect of THC on doxorubicin (DOX)-induced apoptotic cell death in association with the dissipation of the mitochondrial membrane potential using cholangiocyte MMNK-1 cell lines....
The pharmacological properties of Allium ascalonicum Linn., commonly called shallot, have been reported as including those that are antibacterial and antioxidant.
The present study aimed to evaluate the antimicrobial effect and wound-healing activity ofthe ethanolic extracts of Allium ascalonicum Linn. (AAE).
The antimicrobial activity of AAE was t...
Hemoglobin E/β-thalassemia (HbE/β-thalassemia) is the most important type of thalassemia in northeastern Thailand. Serious complications of the disease are associated with iron overload and the consequences of oxidative damage to various organs, especially the cardiovascular system. Endothelial dysfunction is an important predictor for the long-ter...
Cymbopogon citratus, Stapf(CCS) is commonly known as lemon grass. Previous studies showed that it has a strong antioxidant property and have been traditionally used as analgesic, antipyretic, antiseptic in SoutheastAsia. However, the effect of CCS on antioxidant defense system has not been demonstrated.
The present study was conducted to investigat...
The ethanolic extract of Boesenbergia rotunda (L.) Mansf was studied for its wound-healing potential. Since wound healing is interrelated with microbial infection and reactive oxygen species (ROS), this study was conducted to evaluate the antimicrobial and antioxidant activity of B. rotunda. The antimicrobial activity of B. rotunda was studied agai...
This study aims to investigate the protective effect of the Polygonum odoratum L. on acetaminophen-induced liver injury in rats. 30 male Spraque Dawley rats were divided into 5 groups. Group I, II and III were given 5%Tween 80 whereas group IV and V were given 500 and 1000mg/kg body weight/day of the plant extract, respectively for 7 days. On day 8...
Thalassemia major is characterized by anemia, iron overload, and oxidant damage to major organs, especially the cardiovascular system. Oxidative stress is ultimately involved in endothelial dysfunction, a condition which is evident in adults suffering from various cardiovascular diseases including thalassemia. We investigated endothelial function i...
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a major pungent ingredient of red pepper, is reported to have antimutagenic and anticarcinogenic properties. However, the mechanisms underlying its chemoprotective effects remain largely unresolved. In the present study, we found that capsaicin induced expression of heme oxygenase-1 (HO-1) in HepG...
Thalassemia disease is a genetic haemoglobinopathy usually associated with an iron overload and some degree of organ impairment. The impact of the disease on the drug metabolising enzyme cytochrome P450 (CYP) is not known. CYP2E1 and CYP3A4 are responsible for the metabolism of a large number of drugs and changes in their activities may have clinic...