Nozomu Matsumoto

Kyushu University | Kyudai · Department of Otorhinolaryngology

High-risk human papillomavirus (HPV) is a risk factor for the development of several head and neck squamous cell carcinomas (SCCs). However, there have been few reports of high-risk HPV infection in temporal bone squamous cell carcinomas (TBSCCs), and thus the prevalence and clinicopathologic significance of high-risk HPV in TBSCCs are still unclea...

We measured and determined the standard values of the auditory processing test battery (APT), the test that is used to evaluate patients suffering from (central) auditory processing disorder (APD). A total of 21 subjects with normal hearing who were 20 to 37 years old were enrolled in the study. Pure tone audiometry, Fisher's auditory problems chec...

Background: There is no guideline for hearing compensation after temporal bone resection. This study aimed to retrospectively analyze surgical cases with reconstruction for hearing preservation after temporal bone malignancy resection and propose a new alternative to compensate for hearing loss. Methods: We retrospectively reviewed the medical r...

Objectives To obtain new insights into research questions on how executive function and social interaction would be observed to change after the introduction of hearing aids (HAs) in older people with hearing impairment. Design Multi-institutional prospective single-arm observational study. Setting and Participants Outpatients with complaints of...

Although negative pressure wound therapy (NPWT) is widely used, its application to the head and neck region remains challenging due to anatomical complexities. This report presents the case of a female patient presenting with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes, uncontrolled diabetes and severe bilateral se...

External auditory canal squamous cell carcinoma (EACSCC) is an extremely rare and aggressive malignancy. Due to its rarity, the molecular and genetic characteristics of EACSCC have not yet been elucidated. To reveal the genetic alterations of EACSCC, we performed whole exome sequencing (WES) on 11 primary tumors, one relapsed tumor and 10 noncancer...

Objective The immune checkpoint inhibitor Nivolumab was approved for the treatment of platinum-refractory head and neck squamous cell carcinoma (SCC), expanding the treatment options for recurrent or advanced head and neck SCC. However, since temporal bone squamous cell carcinoma (TB-SCC) is very rare cancer, the effectiveness of Nivolumab remains...

Objectives/Hypothesis The extreme rarity of temporal bone squamous cell carcinoma (TB‐SCC) has delayed the accumulation of high‐quality clinical evidence. For the purposes of retrospective meta‐analysis in the future, a large dataset with information from various institutions would be ideal. Our objective here was to retrospectively review cases of...

Objective: To develop a registration procedure to achieve a higher degree of registration accuracy in image-guided otological surgery, paying particular attention to the registration centroid. Methods: A head phantom was used to measure the target registration error (TRE) at measurement points at various depth from the surface of the head. The s...

Background: Perivascular epithelioid cell tumors (PEComas) of the skull base are extremely rare. Here we report the first description of a malignant PEComa mimicking jugular foramen schwannoma and presenting as Collet-Sicard syndrome, and we review the previous literature on PEComas of the head, neck and skull base. Case description: A 29-year-o...

We herein introduce our recent research on an image-guided surgery (IGS) interface for otological procedures. We designed the IGS screen to show selected information that is considered to be most important for the surgeon. Since the “importance” of this information changes during a surgical procedure, the information on the screen is selected and u...

Computed DWI (cDWI) is a mathematical technique that calculates arbitrary higher b value images from at least two different lower b values. In addition, the removal of high intensity noise with image processing on cDWI could improve cholesteatoma-background contrast-to-noise ratio (CNR). In the present study, noise reduction was performed by the cu...

Objectives: To evaluate the effects of chronic kidney disease (CKD) and hemodialysis (HD) on the inner ear using the G width (the width between the bimodal peaks of the conductance (G) tympanogram at 2,000 Hz), which reflects the inner ear pressure and/or the existence of endolymphatic hydrops. Materials and methods: We selected five patients (1...

Objective: Ultrahigh-resolution CT (U-HRCT) provides better spatial resolution than conventional multi-detector row CT (ConvCT) and could be expected to identify microstructures with its 0.25-mm collimation, 1792 channels and 160 detector rows, 0.4 × 0.5 mm focus size, and a 1024 matrix. The aim of the study was to evaluate key anatomic structures...

“UD talk” is a software program aimed at supporting communication between people with and without hearing disability, using automatic speech recognition. However, its speech recognition accuracy is still not perfect. We performed a Japanese hearing test battery for cochlear implant recipients (CI2004 test) using the “UD talk” software program. The...

We herein report a case in which extensive preparation changed a difficult-to-treat patient into an easy one. We performed a revision cochlear implantation on a patient whose first procedure had been aborted due to unidentified difficulties. During a series of thorough three-dimensional simulations, we found that the patient in question had a norma...

Objective: Voice-aligned compression (VAC) is a method used in Oticon's hearing aids to provide more comfortable hearing without sacrificing speech discrimination. The complex, non-linear compression curve for the VAC strategy is designed based on the frequency profile of certain spoken Western languages. We hypothesized that hearing aids could be...

Objective This study aimed to verify cutoff values for G width (the width of bimodal peaks for the waveform obtained when measuring conductance at 2000 Hz) in Japanese individuals diagnosed with Ménière’s disease (MD) using multifrequency tympanometry (MFT) and to determine the relationship between the G width and ability to hear low-pitched sounds...

Purpose Image-guided surgery (IGS) for otological procedures requires minimal invasiveness and a high degree of accuracy. We have recently developed a noninvasive registration method, the Surface Template-Assisted Marker Positioning (STAMP) method, which uses a rigid template of the surface of the temporal bone. However, the STAMP method is not app...

Objectives/hypothesis: Image-guided optical tracking systems are being used with increased frequency in lateral skull base surgery. Recently, electromagnetic tracking systems have become available for use in this region. However, the clinical accuracy of the electromagnetic tracking system has not been examined in lateral skull base surgery. This...

Objective: To develop an otological robot that can protect important organs from being injured. Methods: We developed a five degree-of-freedom robot for otological surgery. Unlike the other robots that were reported previously, our robot does not replace surgeon's procedures, but instead utilizes human-robot collaborative control. The robot basi...

Objective: To investigate the characteristic physical properties of the oscillating system in the intact middle ear using a high-speed camera. Design: We analysed the oscillation of the guinea pig stapes using a high-speed camera. The specimens were prepared so that the middle-ear structures were intact. Tones of various frequencies were deliver...

Objective: We investigated the ossicular movement in the near-intact middle ear in response to acoustic stimulation using a high-speed video camera and video analysis software program. Design: We have designed a good visual access to the middle ear of the guinea pig by opening the ventral wall of the otic capsule, without injuring the sound-cond...

Background: Bone contouring is currently the best treatment for fibro-osseous lesions after bone growth arrest. Navigation systems available for this surgery allow intra-operative visualisation with improved cosmetic outcomes. However, conventional navigation systems using superficial skin registration cannot prevent subtle discrepancies. Method:...

The surgical procedure for Bonebridge implantation cannot be done in some cases without exposing the dura mater or sigmoid sinus. Surgical simulation technol ogy can help to identify such difficulties prior to surgery and be used to clarify the optimal location and orientation of the device to be implanted. However, there has not been a simple stra...

We herein report a case of posterior semicircular canal dehiscence (SCD) syndrome who had been audiologically followed up for eight years. The patient originally had sensorineural hearing loss. The audiogram had gradually transformed to pure conductive hearing loss. The posterior SCD was identified in CT scan. The reported case showed the possibili...

We introduce our reference antenna for image-guided temporal bone surgery. Our reference antenna was fixed to the tailor-made splint for each patient. The splint secured the accuracy as well as stability throughout the surgery for at least 4 hours. The splint-fixed reference frame was a useful in image-guided temporal bone surgery where invasive he...

We introduce our IGS reference frame for easy and rapid registration. we produced dentally affixed reference frame tailored for each patient. This reference frame is detachable and has both fiducial markers and reference markers. So, by taking patient's CT scans with this reference frame, we can finish the registration without patient, before surge...

Conclusion The surface template-assisted marker positioning (STAMP) method is useful for successful Bonebridge™ (BB) implantation on a planned site while avoiding dangerous positions. Objectives To confirm the usefulness of the STAMP method for the safe operation of BB. Methods From a patient’s temporal bone CT data, a guide plate and confirmatio...

In cochlear implantation (CI), the insertion of the electrode array into the appropriate compartment of the cochlea, the scala tympani, is important for an optimal hearing outcome. The current surgical technique for CI depends primarily on the surgeon's skills and experience level to achieve the correct placement of the electrode array, and the sur...

A navigation system that generating tones according to the relative distance to multiple targets. The surgeon is focusing on the microscopic image (inset) but is able to receive the relative proximity to the different scalae of the cochlea by hearing the different tones.

鼻副鼻腔領域に比べ, 側頭骨領域のナビゲーション手術はあまり普及していない. これは必ずしも当該領域においてコンピュータやナビゲーション技術の必要性が低いと判断されているためではなく, 側頭骨領域のナビゲーション手術特有の使いにくさ, 侵襲性などの問題点によりナビゲーションの利点を実感しにくかったためと考えられる. 九州大学では耳鼻咽喉科と先端医工学診療部とが連携し, 側頭骨領域の手術ナビゲーションで問題と考えられた精度, 侵襲性, インターフェースの3点について解決を試みた. 開発された新技術によりこれまで侵襲性の高い方法でのみ可能であった高精度の位置合わせ (レジストレーション), 長時間手術で安定して使用できるリファレンスが可能になった. レジストレーションの時間も1分以内と短縮された...

Most of the current Bonebridge surgeries undergo preoperative simulation planning in a computer. However, surgeons usually use the landmarks on the bone surface to determine the location where to implant the device, using the simulation image in the computer only as a reference (conventional method). We developed an image-guided method for precisel...

PURPOSE To assess the feasibility of high–resolution three dimensional diffusion–weighted images (HR3D–DWI) / multi–detector row CT (MDCT) images data fusion for surgical planning for cholesteatoma. METHOD AND MATERIALS A total of 14 patients (M/F= 7/7, age 11 to 72 years, mean 42.5 years) with acquired cholesteatoma underwent preoperative MRI usi...

A cochlear implant is an artificial sensory organ for patients with severe to profound hearing loss who have little benefit from hearing aids. The fact that more patients with previous temporal bone surgery or cranial malformations are receiving cochlear implants implies that the number of atypical cochlear implantation will continue to grow. Surgi...

Image-guided otological surgeries require minimal invasiveness and high accuracy, and these two factors usually compete with each other. Our recently developed registration method, called the STAMP method, showed minimal invasiveness with accuracy comparable to that of the current more invasive registration methods used in image-guided temporal bon...

Objective: To prospectively evaluate the usefulness of a newly developed high-resolution three-dimensional diffusion-weighted imaging method, turbo field-echo with diffusion-sensitized driven-equilibrium (TFE-DSDE) in diagnosing middle-ear cholesteatoma by comparing it to conventional single-shot echo-planar diffusion-weighted imaging (SS-EP DWI)....

Purpose: We developed a surgical navigation system that warns the surgeon with auditory and visual feedback to protect the facial nerve with real-time monitoring of the safe region during drilling. Methods: Warning navigation modules were developed and integrated into a free open source software platform. To obtain high registration accuracy, we...

We recently developed a new noninvasive registration method for image-guided otologic surgery (STAMP method). We investigated the benefit and potential drawback of our new method in clinical application and tested the feasibility of routine image-guided surgery. Retrospective case review. Tertiary referral university hospital. Forty-six cases (45 p...

We recently reported a noninvasive registration method, namely STAMP, for accurate image-guided temporal bone surgery. In this study, we modified our STAMP method to make the procedure as simple as possible in the operating room. We attached a pole with optical markers on the STAMP template and finished most of the registration process pre-operativ...

Osteoblastoma is categorized as a benign bone-forming tumor, which occurs rarely in the craniofacial region. We report a case of osteoblastoma developed in the nasal cavity and ethmoid sinus in a 14-year-old girl whose chief symptom was nasal obstruction and exophthalmos on the right side. CT revealed the lesion having the same density as bone and...

Precise assessment of the risk of aspiration is critical in older patients with a history of pneumonia. However, the currently popular videofluoroscopic and videoendoscopic examinations of swallowing only evaluate volitional swallowing. A method for quantitative analysis of reflexive swallowing is not yet available. We evaluated volitional swallowi...

Otosclerosis, which is characterized by disordered bone remodeling, occurs exclusively in the human temporal bone. The etiology of the disease is unknown, but a popular hypothesis is that it is caused by persistent measles virus (MV) infection. Paramyxovirus-like filamentous structures were found in otosclerotic lesions of stapes footplates from pa...

Since otologic surgery is generally minimally invasive, it has not been easy to employ conventional surgical navigation that necessitates invasive procedures. We introduce our 21 consecutive navigated cochlear implantation using newly developed method for noninvasive navigation.

We performed cochlear implantation for a deaf patient induced by eosinophilic otitis media. The patient has showed constant and good hearing abilities for 2 years after the surgery without any difficulties. Eosinophilic otitis media is characterized by persistent glue like otorrhea, and is known to be an intractable disease. It is rare but sudden,...

This work proposes an image-guided robotic Mastoidectomy. A surgical navigation software was developed to guide the robot without damaging the critical area. A forbidden- region virtual fixture is implemented for safety. A human-robot collaboration control mode is used to allow the human intervention during surgery, to compensate tremor by operator...

To obtain additional depth and visual information in endoscopic surgery, a dual surgical navigation system using virtual reality (VR) and augmented reality (AR) techniques complementarily was developed. A VR environment was constructed in the default 3-D view of the navigation software and an AR environment was developed as a plug-in module. The sp...

Williams syndrome (a.k.a. Williams-Beuren Syndrome) is a multisystem disorder caused by the hemizygous deletion of a 1.6 Mb region at 7q11.23 encompassing about 26 genes, including that encoding LIM kinase 1 (LIMK1). Individuals with Williams Syndrome manifest hyperacusis and progressive hearing loss, and hyperacusis early onset suggests that it co...

Cochlear outer hair cells undergo reversible changes in shape when externally stimulated. This response, known as OHC motility, is a central component of the cochlear amplifier, the mechanism responsible for the high sensitivity of mammalian hearing. We report that actin depolymerization, as regulated by activation/inhibition of LIMK/cofilin-mediat...

Robotic surgery in the head and neck areas can help in keeping the safety margin to critical organs and performing minimally invasive surgery. This work proposes an ear surgery robot to perform an automatic mastoidectomy. Using the temporal bone model based on a patient's CT image, the best position and orientation of a drill hand piece are determi...

We investigated whether the general belief is true that image-guided surgery improves surgical safety but increases the surgical time. We compared intraoperative complications and surgical time in our cochlear implant and acoustic tumor removal surgeries with or without the assistance of image guidance. No comparison was possible in complications w...

聴力正常の聴覚過敏患者24名 (男性8名, 女性16名) に対してSISI検査, MCL・UCL検査, 自記オージオメトリー検査, Metz検査を行い, リクルートメント現象の陽性率を検討した。17名 (71%) が, 聴力が正常であるにもかかわらず何らかの内耳機能検査で陽性であった。それぞれの検査の陽性率はSISI検査で27%, MCL・UCL検査で38%, 自記オージオメトリー検査で38%, Metz検査で33%であった。片側のみの聴覚過敏は9名 (37.5%), 両側の聴覚過敏は15名 (62.5%) であった。片側聴覚過敏の場合, 症状と陽性を示した検査側は必ずしも一致しなかった。

The ganglioside GM3 synthase (SAT-I), encoded by a single-copy gene, is a primary glycosyltransferase for the synthesis of complex gangliosides. In SAT-I null mice, hearing ability, assessed by brainstem auditory-evoked potentials (BAEP), was impaired at the onset of hearing and had been completely lost by 17 days after birth (P17), showing a defor...

An image-guided surgical system for otologic surgery was developed and clinically evaluated. With reliable hybrid registration, real-time patient movement compensation and virtual intraoperative computed tomography imaging have been originally proposed. In contrast to the commercially available systems that mainly use 2-D images for pointing probes...

A new, minimally invasive registration method was developed for image-guided otologic surgery. We utilized laser-sintered template of the patient's bone surface to transfer the virtual markers to the patient's bone intraoperatively and eliminated the necessity for preoperative marker positioning or additional CT scan. Simulation surgeries and clini...

Based on open source software, an image guided surgical system for Ear-Nose-Throat (ENT) surgery was developed and evaluated. Real-time patient movement compensation and virtual CT was provided intraoperatively. Real-time updating was accomplished by an alternative display that represents the relative position of surgical instrument against moving...

The registration process determines the overall accuracy of image-guided surgery. Otologic surgery requires submillimetric accuracy, and it is known that invasive registration using bone-anchored fiducial markers acquire less error. We have developed a less-invasive strategy for attaching bone markers by transferring the markers to the patient's bo...

The aim of this study is to investigate the salicylate-induced morphological changes of cochlear inner hair cells (IHCs) and outer hair cells (OHCs). IHCs and OHCs were acutely isolated from the guinea-pig cochlea. Cells were observed under the inverted microscope and 10mmol/L sodium salicylate solutions or 0.01mmol/L dexamethasone-plus-salicylate...

Tetraethylammonium (TEA)-sensitive potassium currents in the cochlear inner hair cells (IHCs) possess the kinetics of fast inactivation. IHCs of guinea-pigs were separately isolated from the apical and basal turns and the tonotopic gradient of inactivation kinetics was investigated. TEA-sensitive potassium currents showed voltage-dependent time con...

We investigated the effects of metabolic inhibition on both the shift in the equilibrium potential for Cl(-) (E(Cl)) and the run down of GABA(A) receptor responses, using nystatin- and gramicidin-perforated patch-clamp recordings from rat hippocampal CA1 neurons. Metabolic inhibition with NaCN decreased outward GABAergic currents while increasing i...

Brain-type fatty acid-binding protein (B-FABP) belongs to a family of intracellular lipid-binding proteins. B-FABP exhibits a binding affinity to long-chain fatty acids (FAs) whose effects on brain functions including development, emotion, learning and memory have been proposed. B-FABP is localized in the ventricular germinal cells in embryonic bra...

We examined 117 ears suffering middle ear cholesteatoma in fresh cases operated on from 1993 to 2003. To evaluate the importance of the attic ventilation route, we compared the occurrence of tympanic membrane retraction and cholesteatoma recurrence in the cases that had undergone tympanoplasty type I and other prodedures, including type III, type I...

Bilirubin is a well-known neurotoxin that can result in multiple neurologic deficits. Previous studies have suggested that bilirubin affects aspects of synaptic transmission; however the acute effects of bilirubin on synaptic transmission have not been examined in real-time. In this study, using whole-cell voltage-clamp recordings, we observed the...

Electromotility of cochlear outer hair cells (OHC) is associated with conformational changes in the integral membrane protein prestin. We have recently reported that electrical stimulation evokes significant prestin-dependent changes in the length, width, and area of the longitudinal section of OHCs, but not in their volume. In contrast, prestin-in...

The motile response of isolated guinea pig outer hair cells (OHCs) was investigated using a combination of whole-cell patch clamp recording and continuous video image analysis. OHC's length, width, and area were measured from video images and the cell volume estimated from these values. Morphological data was then correlated with electrophysiologic...

1Nystatin-perforated patch recordings were made from mechanically dissociated basolateral amygdala neurons with preserved intact native presynaptic nerve terminals to study the mechanism of 5-HT3 receptor-mediated serotonergic modulation of GABAergic inhibition.2The specific 5-HT3 agonist mCPBG (1 μM) rapidly facilitated the frequency of GABAergic...

• Spontaneous miniature outward currents (SMOCs) were observed in mechanically dissociated rat Meynert neurons using nystatin perforated patch recordings under voltage-clamp conditions. • SMOCs were blocked by apamin, a selective blocker of small conductance Ca2+-activated K+ (SK) channels, but not by blockers for other types of Ca2+-activated K+ c...

We investigated P2X purinoceptors in rat dorsomedial hypothalamic (DMH) neurons using nystatin-perforated patch-clamp recordings and fura-2 microfluorometry. Adenosine triphosphate (ATP) concentration-dependently evoked an inward current and increased cytosolic Ca(2+) ([Ca](i)). The rise in [Ca](i) was dependent on external Ca(2+) and Na(+), was bl...

Serotonin (5-HT) is considered to play a significant role in anxiety-related behaviors in animals through actions on the amygdaloid complex. To evaluate this role from the point of neurotransmitter release regulation, nystatin-perforated patch recording was employed on mechanically dissociated basolateral amygdala neurons containing functional syna...

Presynaptic and postsynaptic membrane activities during experimental metabolic inhibition were analysed in mechanically dissociated rat hippocampal neurons using nystatin-perforated and conventional whole-cell patch clamp recordings. NaCN, an inhibitor of mitochondrial ATP synthesis, induced an outward current across the postsynaptic soma membrane....