Noureddine Djebli

Abdelhamid Ibn Badis University Mostaganem-ALGERIA- · Biology

For many years, medicinal plants have been used to treat diabetes because they cause less undesirable effects than synthetic drugs. This research aimed to study the in vivo antidiabetic activity of Algerian date pulp of the Deglet Noor variety in streptozotocin (STZ)-induced experimental diabetes. The polyphenol composition was established by RP-HP...

Figs are the edible fruits of the fig tree, Ficus carica L., that have been used for centuries for human consumption and in traditional medicine, to treat skin problems, inflammation, and gastrointestinal disorders. Our previous study investigated the presence of phenolic compounds in aqueous extracts of two Algerian popular fig varieties, azendjar...

Background The components of kretek cigarettes include tobacco as the main part, clove, and sauce. Filtered kretek cigarettes are kretek cigarettes that have one end filtered. Cigarette smoke contributes to the disruption of the respiratory system, so it is necessary to know the effect of low doses of cigarette smoke on changes in the histometric o...

The primary purpose of this research is to investigate, both in vitro and in vivo studies, whether Chestnut 'Castanea sativa Mill.' Honey consumption, can counteract the neurodegeneration occurring in Alzheimer's model mice brains caused by aluminium chloride combined with D-galactose. Within the scope of in vitro studies. The antioxidant activity...

The conference was held on November 26-28, 2023 in Abdelhamid Ibn Badis University, Mostaganem, Algeria, which will be organized by pharmacognosy &Api phytotherapy laboratory. The scientific program covered all related aspects of medicinal plants in the following main topics: Using medicinal plants and their extracts in the pharmacological activiti...

Several pharmacological properties have been reported for the flowers of Punica granatum (Punicaceae), which contain diverse bioactive compounds such as gallic acid, ursolic acid, maslinic acid, daucosterol, and anthocyanins. The aim of this research is to assess the antioxidant impact of a pomegranate flower-derived anthocyanin extract. Phytochemi...

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of s...

The stilbene-rich acetone fraction in high yield (6.6%, PEAS) of Passiflora edulis Sims was prepared and evaluated for neuroprotective activity in murine Alzheimer's disease model induced by aluminum chloride and D-galactose. The phytochemical and HPLC-DAD-MS analysis of the polyphenolic stilbene-rich acetone fraction showed that it contained diffe...

In this study, for the first time, the anti-inflammatory, antioxidant, anti-tyrosinase and antimicrobial property of P. atlantica Desf. subsp. atlantica leaf-bud extract have been investigated. The anti-inflammatory activity was determined in vivo by reducing carrageenan-induced hind paw edema in mice, while the antiradical function was evaluated u...

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of s...

Highlights ➢ Crude extracts and fractions from three algal species Sargassum vulgare, Cladostephus hirsutus and Rissoella verruculosa were prepared. ➢ Total phenolic, flavonoid, flavonol and total condensed tannin contents were determined. ➢ The antioxidant activity of crude extracts and all fractions, using three assays, were evaluated. ➢ In vivo...

El objetivo fue evaluar la actividad antidiabética de hojas de Atriplex halimus en ratas diabéticas modelo. Para evaluar se utilizó la glicemia, pérdida de peso, volumen de consumo de agua, parámetros bioquímicos. estudio histológico. Las investigaciones fitoquímicas indican la presencia de flavonoides, taninos, saponinas, mucílagos, glucósidos. pr...

Ficus carica L., commonly known as the fig tree, is a plant belonging to the Moraceae family whose fruits are traditionally used for edible and therapeutic purposes. The study aimed to investigate the lyophilized aqueous extracts of two native Algerian fig varieties, azendjar (Az) and taamriouth (Ta), as a potential source of antiox-idant compounds...

The present study aims at studying the phytochemical compounds and evaluating in vivo the anti-inflammatory effect of aqueous and ethanolic extracts of Ficus carica L. fruit. The total contents of phenolics, flavonoids, and condensed tannins were determined spectrophotometrically using Folin-Ciocalteu, aluminum trichloride and vanillin reagents res...

Date fruit (Phoenix dactylifera L.) is not only known for its nutritional properties but also its therapeutic virtues. The objective was to investigate the phenolic compounds and evaluate the antioxidant and anti-inflammatory activities of pulp, seed, and whole fruit of Algerian dates. The total phenolic and flavonoid contents of ethanolic pulp (EP...

Carthamus caeruleus L belongs to the family Asteraceae and is reported to have anti-inflammatory, anti-burns and wound healing properties. The aim of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Carthamus caeruleus L rhizome in mice. Carrageenan was used to induce inflammation in mice; the percentage inhibi...

Symptoms of neurodegenerative diseases acquired through neurologic disorder in behavior and memory are sometimes associated with severe aggression. Differences in terminology have resulted in varying estimates, but behavior disorders and memory loss appear to be characteristic of Alzheimer's disease. This work provides a brief neurologic comparison...

The aim of the current study is to analyze the phytochemical, antioxidant and antimicrobial activities of 34 extracts prepared from Pistacia atlantica Desf. subsp. atlantica, according to gender, organ type (roots, buds and fruits), geographical location and stage of ripening. Bud extracts exhibited the highest phenolic content (565.74 ± 9.84 mg GA...

Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficiency and biological effectin Alzheimer’s model mice. Materials and Methods: Alzheimer’s disease was induced in mice and treated in...

Free radicals, oxidative stress or antioxidants is more and more often used to explain different pathological disorders and their therapeutic approach. The aim of this study was to evaluate the protective effect of anthocyanin extract obtained by maceration of the flowers of Lavandula dentata in 0.1 % HCl/methanol (v/v) solution on oxidative stress...

Aim and Objective: This study aimed at investigating the gastro-protective effects of Algerian Sahara (Sidr) honey from Apis mellifera intermissa against HCl/Ethanol-induced gastric ulcers in rats. Material and Methods: Total phenolic content, antioxidant activity and phenolic compounds were determined. Than, Three groups of rats (control, HCl/ Et...

Aim: The aim of this study was to evaluate the neuroprotective effect of oral administration of acomplex of curcumin with 1,3-β-glucan extracted from Vietnamese mushrooms named Bioglucur to increase drug delivery efficiency and biological effectin Alzheimer’s model mice. Materials and Methods: Alzheimer’s disease was induced in mice and treated in...

The purpose of this study was to determine the neuroprotective potential of pomegranate peel methanolic extract (500 mg kg-1) on lead acetate (1000 ppm) induced neurotoxicity. After 12 weeks, the mice were subjected to behavioral tests. Brain injuries were determined with hematoxylin and eosin staining and lead accumulation was measured by graphite...

The study investigated whether ethanolic propolis extract would exhibit an antidiabetic effect in rats. The animals were divided into four groups of five rats each. Diabetic rats received 30% or 15% propolis extract at a dosage of 0.5 ml/100 g for 4 weeks. Data for the diabetic groups treated with 30% and 15% propolis showed a decrease in blood sug...

Nowadays, because of the industrialization, a lot of contaminant were available ; the consequences of this availability are apparition of diseases including neurodegeneration. Neurodegenerative diseases of the human brain comprise a variety of disorders that affect an increasing percentage of the population. This study is based on the effect of the...

Hepato-Protective Effect of Curcuma longa against Paracetamol-Induced Chronic Hepatotoxicity in Swiss Mice Salima Douichene, Wahiba Rached* and Noureddine Djebli Laboratory of Pharmacognosy ApiPhytotherapy, Faculty of Life and Natural Sciences, University ofMostaganem, 27000, Algeria. Abstract Curcuma longaL. (Zingiberaceae),is a natural spice, has...

Antimicrobial activity of hydroalcoholic extracts (30/70) from leaves and stems of three halophytes (Tamarix africana, Arthrocnemum macrostachyum and Suaeda fruticose) was investigated. In vivo toxicological study and anti-inflammatory activity of leaf extract of T. africana were tested on carrageenan-induced inflammatory paw edema. T. africana pos...

Argan oil is thought to be the most expensive edible oil worldwide. It is difficult to produce and the argan tree only grows in a limited geographical area, notably Morocco and Algeria. Because it is produced by mechanical means, argan oil contains “minor” components that might be endowed with healthful effects. We investigated in vivo the anti-inf...

The study investigated the antibacterial effect of honey against uropathogenic bacteria isolated from clinical samples (Escherichia coli, Morganella morgani, Enterobacter cloacae, Klebsiella pneumoniae, Serratia fonticola, Proteus mirabilis and Pseudomonas aeruginosa). A total of four natural Algerian honeys (NAHs) were investigated for their antib...

Inflammation is a process used to eliminate the pathogen and repair tissue damage. Many plants and herbs have been shown to exhibit potent anti-inflammatory effects. The present research aims to study the anti-inflammatory effects of a mixture of two medicinal plants: mushroom and curcumin (bioglucumine). The experiments were performed on the model...

Context: Populus nigra L., is a species of cottonwood poplar that belongs to the Salicaceae family, is cultivated in multiple areas in Algeria, with an Algerian name of Safsaf. Aims: To evaluate the Populus nigra flower buds extract for its effects on brain modifications against aluminum-induced neurotoxicity in mice. The hypouricemic action of the...

In incidents of emergency, our hospitals routinely record poisonings or intoxications related to the misuse (or not) of products or foods used by the individual. These intoxications result in symptoms which vary according to the nature of the poisons. The symptoms can be neurological, cardiovascular, respiratory, digestive or renal. Consequences of...

Context: Populus nigra L., is a species of cottonwood poplar that belongs to the Salicaceae family, is cultivated in multiple areas in Algeria, with an Algerian name of Safsaf. Aims: To evaluate the Populus nigra flower buds extract for its effects on brain modifications against aluminum-induced neurotoxicity in mice. The hypouricemic action of the...

Diabetes mellitus is a common and widespread disease that affects citizens in developed and developing countries. Diabetes is a disease that combines inherited and environmental causes that cause high blood sugar levels known as hyperglycemia.Phytotherapy has achieved good clinical practice and shows a bright future in the treatment of diabetes mel...

Aluminum (Al) is an element with ubiquitous presence on the earth crust that may cause neuropathological, neurobehavioral, neurophysical, and neurochemical changes linked to its bioavailability. The purpose of the present study was to determine the neuroprotective potential of pomegranate juice on Al induced neurotoxicity. Three groups of 7 female...

Les métaux lourds sont des contaminants environnementaux. Ils provoquent de nombreuses incidences pathologiques suite à des dysfonctionnements physiologiques, biochimiques et comportementaux variés dans le système nerveux. Dans le cerveau, l'hippocampe joue un rôle crucial dans la consolidation de la mémoire et toute atteinte de ce dernier par les...

Background: Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The characteristic features of diabetic dyslipidemia are a high plasma triglyceride concentration, low HDL cholesterol concentration and increased concentration of small dense LDL-cholesterol particles. The objective of this work was to define...

Punica granatum L. is a plant widely used in traditional Algerian medicine to treat digestive, inflammatory and painful diseases. The objective of the present study was to determine the phenolic, flavonoids, anthocyanin, hydrolyzable & condensed tannins, proanthocyanidin contents and to evaluate in vivo the anti-inflammatory activity of the methano...

This work represent a part of the valorization of the hydro-methanolic extract of the leaves of Olea europeae L. and flowering tops of Erythreae centaurium L. by the evaluation of antioxidant and antidiabetic activities of polyphenols.The antioxidant power of these extracts was evaluated in vitro by the DPPH test, after having quantified the total...

Osteoarthritis is a very common rheumatic disease associated with a couple of disabilities and chronic pains. Although, curative treatments are not available,, more and more patients are currently using complementary medicines and particularly phytotherapy. The aim of the present study was to determine the frequency of phytotherapy in patients with...

This study was carried out in order to set up an inventory list of medicinal plants used in traditional medicine to treat diabetes for which an ethnobo-tanical test was carried out on 670 diabetic subjects in the Western region of Algeria (Chlef, Mostaganem, Mascara, Oran, Sidi-bel-Abbes, Saida and Tiaret) using a survey. 24 antihyperglycemic medic...

Resumen Context: Populus nigra L., is a species of cottonwood poplar that belongs to the Salicaceae family, is cultivated in multiple areas in Algeria, with an Algerian name of Safsaf. Aims: To evaluate the Populus nigra flower buds extract for its effects on brain modifications against aluminum-induced neurotoxicity in mice. The hypouricemic actio...

Resumen Context: Populus nigra L., is a species of cottonwood poplar that belongs to the Salicaceae family, is cultivated in multiple areas in Algeria, with an Algerian name of Safsaf. Aims: To evaluate the Populus nigra flower buds extract for its effects on brain modifications against aluminum-induced neurotoxicity in mice. The hypouricemic actio...

Résumé: Introduction. Punica granatum (Punicacées) est un arbre prometteur connu pour ses activités biologiques; antioxydantes, anti-inflammatoires et neuroprotéctrices. Objectif. L'intérêt du présent travail est d'évaluer l'effet préventif du jus de grenade contre la maladie de Parkinson induite par l'halopéridol. Matériel et méthodes. 28 souris a...

Objective: The present study was carried out to determine the phenolic and flavonoid contents of pomegranate juice and determine its effect against carbon tetrachloride (CCl4) induced hepatoxicity in rats. Material and methods: Animals were divided into four groups (n=5): group I: control, group II: CCl4 (1ml/kg), group III: CCl4 + pomegranate jui...

Citation: Boudjelthia K, Hammadi K, Kouidri M, Djebli N (2017) Evaluation of Antidiabetic Activity of Two Plants Berberis vulgaris and Zygophyllum geslini. J Phys Chem Biophys 7: 236. Abstract This work is part of the valorisation of the methanolic extract and aqueous solutions of Berberis vulgaris and Zygophyllum geslini as antidiabetic plants; wi...

Objective: To evaluate the antibacterial effect of Sahara honeys (SHs) against bacterial biofilms formed on urinary catheters in combination with propolis-Sahara honeys (P-SHs). Methods: Three clinical isolates were subjected to biofilm detection methods. The antibacterial and anti-biofilm activity for SHs and P-SHs were determined using agar well...

Objective: To investigate the antibacterial effect of Peganum harmala (P. harmala) extracts against urinary tract infection pathogens isolated from infected patients. Methods: Agar diffusion technique was used for detecting the antibacterial activity. The minimum inhibitory concentration was tested by serial dilution methods. Alkaloids extract of s...

The effect of Aluminum chloride was investigated to describe the associated behavioral and brain modifications. We don’t know enough about the biological chemistry of chronic and sub- acute exposure to Aluminium to be able to predict its impact on human health. Although the hypothesis of a link between Aluminium and Alzheimer’s disease (AD) has bee...

Objective: The aim of this study, we based on protective and antioxidant efficiency of Hypericum perforatum that shows a wide range of beneficial effect in vitro and in vivo. Methods: The in vitro antioxidant activity of the extract was assessed by using several antioxidant tests. The cytotoxic activity of Hypericum perforatum was also determined b...

The objective of this research work was to evaluate the effect of heat processing on antibacterial capacity of Sahara honey (SH). Various thermal treatments were carried out at 25°C, 50°C, 75°C and 100°C for 15 min, 30 min, and 60 min, and the parameters were determined: colour intensity, phenolic contents and antibacterial activity of two species...

Objective: To investigate the effect of unheated and heat-treated of Sahara honey. Methods: A total of 24 Swiss albino mice weighing 25–35 g were divided into four groups (n = 6). Anti-inflammatory effect was assessed at 1, 2, 3, 4, 5 and 6 h after subplantar injection of carrageenan (0.5 mL of a 1% solution in normal saline). In addition, total ph...

The present study was conducted to explore the antioxidant, antiulcer, hepatoprotective and vasodilatory effects of Ulmus campestris (Ulmaceae) ethanol bark extract at different doses, using several experimental methods. The extract was evaluated for its antioxidant activity different model systems, including hydroxyl and 2,2-diphenyl-1-picrylhydra...

The present study reviewed the literature about heavy metals including lead (pb) from various points of view including chemistry of these heavy metals and their interactions with neurons. We also introduced the concept of neurotoxicity with heavy metals. The role of heavy metals in induction of Parkinson Disease was also discussed, particularly the...

Objective: To search for further synergistic combinations of gentamicin and raw honey that might have potential in treating wounds. Methods: The antibacterial activity and synergistic interaction of raw honey and gentamicin was assessed by using agar well diffusion method. Two Gram-negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa AT...

Objective: To search for further synergistic combinations of gentamicin and raw honey that might have potential in treating wounds. Methods: The antibacterial activity and synergistic interaction of raw honey and gentamicin was assessed by using agar well diffusion method. Two Gram-negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa AT...

Objective: To evaluate the influence of the temperature on honey colour, polyphenol contents and antimycotic capacity and to evaluate the correlation between these parameters. Methods: Sahara honey were heated up to 25, 50, 75 and 100 °C for 15, 30 and 60 min, and their colour intensity, polyphenol contents and antimycotic capacity. The Folin-Cio...

Objective: To evaluate the methanolic extracts of aerial parts of Hypericum scabroides (HSM) (200 mg/kg, p.o.) for in vivo anti-inflammatory activity. Methods: The anti-inflammatory activity of HSM was tested in mice weighting (25±5) g. Either vehicle (control group), the methanolic extracts (200 mg/kg) or diclofenac (50 mg/kg), was administered...

Parkinson disease is a common neurodegenerative disease. Deficiency of dopamine is thought to be responsible for development of Parkinson Disease. Exercise training has been associated with improvements in patients with Parkinson Disease. The objective of the present study is to explore the effect of exercise training on the expression of HSP70 in...

Alternative therapy for Klebsiella pneumoniae eradication from natural products is gaining much attention. The aim of the present study was to determine the physico-chemical parameters and the synergistic effects of six natural honeys in combination with potato starch against pathogenic Klebsiella pneumoniae. Physico-chemical parameters, such as fr...

To evaluate the in vitro activity and synergism of the combinations of natural honey and curcuma starch against Rhodotorula mucilaginosa in correlation with total phenolic, flavonoid contents, and diastase activity. The Folin-Ciocalteu test was used to determine the total polyphenols content and the flavonoid content was analyzed using by the alumi...

To evaluate antioxidant, anti-inflammatory, hepatoprotective and vasorelaxant activities of Populus nigra flower buds ethanolic extract. Antioxidant and anti-inflammatory activities of the extract were assessed using respectively the ABTS test and the animal model of carrageenan-induced paw edema. Protection from hepatic toxicity caused by aluminum...

The aim of this study was to determine the anti-Candia albicans activity of 6 varieties of honey and their combination with Curcuma starch in correlation with diastase number (α-amylase) andphenolic compounds. The quality parameters (principally, diastase number and hydroxymethyl furfural levels (HMF) of honey were investigated. The total flavonoid...

The objective of this study is to clarify the positive effect of Sideritis breavibracteata used as a moderated treatment against neurodegenerative diseases including Alzheimer's caused by aluminum chloride AlCl3. The mice were randomly divided into four groups; each group containing seven mice (for each experience: neurotoxicity (AD): control group...

Sahara honey samples from Algeria were screened for total phenolic contents by Folin Ciocalteau method and colour characteristics.Two different assays were performed to evaluate the antibacterial capacity of the honey samples: agar-well diffusion and Growth inhibition %.Total phenolic content varied from 0.620 to 1.044 mg/100 g honey as gallic acid...