Norimasa Nakamura

Norimasa Nakamura
Osaka Health Science University | ohsu

MD, PhD, FRCS

About

291
Publications
40,612
Reads
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7,455
Citations
Citations since 2016
99 Research Items
3801 Citations
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
Additional affiliations
April 2009 - November 2016
Osaka Health Science University
Position
  • Professor

Publications

Publications (291)
Article
Background Patellar height, which decreases after open wedge high tibial osteotomy (OWHTO), has conventionally been assessed by tibial references using lateral radiographs of the knee; however, changes in the proximal tibia shape after OWHTO may affect this method. We aimed to evaluate the changes in patellar height position relative to the transep...
Article
Background There are currently no disease-modifying treatments available for knee osteoarthritis (OA), although cultured adipose-derived stromal cells (ASCs) have shown promise in experimental models. However, given the regulatory limits on the use of cultured cells in humans, previous trials have focused primarily on the stromal vascular fraction...
Article
Background There are still few reports on factors associated with postoperative knee joint line obliquity (KJLO). Purpose The purpose was to determine preoperative radiographic factors that are associated with KJLO postoperatively after open wedge high tibial osteotomy (OWHTO) using multivariable linear regression analysis and multivariable logist...
Chapter
Synovial-derived mesenchymal stem cells (SDMSCs) have been shown to have superior proliferative and differentiation capacity when compared to other cell sources. A new tissue-engineered construct (TEC) has been developed using SDMSCs which is natural and scaffold-free. Early results of TEC in chondral repair strategies have been encouraging; demons...
Chapter
Lateral patellar dislocation is a relatively common knee injury in children and adolescents (Nietosvaara et al., J Pediatr Orthop 14(4):513–5, 1994; Fithian et al., Am J Sports Med 32(5):1114–21, 2004), and it may lead to recurrent patellar instability and functional disability (Macnab, J Bone Joint Surg Am 34:957–67, 1952; Hawkins et al., Am J Spo...
Chapter
Osteoarthritis (OA) is the most common joint disorder due to poor regenerative properties of cartilage. Existing approaches leave a treatment gap for patients with moderate OA. The intra-articular administration of a biological agent derived from adipose tissue is one of the novel therapies currently in development to address the limitations of sta...
Chapter
With the advancement of cell-based technologies for cartilage regeneration, many tissue engineering approaches have taken advantage of scaffolds made of either synthetic polymer or natural materials, providing an appropriate three-dimensional environment for cells to optimize their proliferation and chondrogenic differentiation and effectively deli...
Chapter
Symptomatic cartilage lesions and early osteoarthritis (OA) are musculoskeletal issues with both significant clinical and large economic burdens. Despite regenerative techniques, such as the use of autologous chondrocytes, the complete healing of damaged cartilage with consistent reproduction of normal hyaline cartilage has not yet been achieved. A...
Chapter
Meniscal injuries are the most common injury of the knee regardless of age, but effective treatments for such injuries remain challenging due to the meniscus limited healing potential owing to its hypocellularity and hypovascularity, as well as its complex structure. The damaged meniscus is recognized to lose function in the absence of adequate tre...
Article
Full-text available
Anterior cruciate ligament reconstruction (ACLR) has become a popular surgery in orthopedic practice today, and the technique has evolved significantly over time. Surgical procedure, graft choice, and fixation systems have varied over the years. Nonetheless, several challenges like insufficient graft ligamentization, tunnel enlargement, and insuffi...
Chapter
Meniscal injuries are a frequently encountered clinical scenario and at present in patients of all age groups and activity levels. They have been known to occur as a result of trauma as well as joint degeneration, and whether they are a cause or consequence of osteoarthritis remains unclear. It is now known that a meniscal injury has both a biochem...
Chapter
The use of mesenchymal stem cells (MSCs) for the treatment of osteoarthritis has been explored extensively over the last two decades, and newer techniques, as well as evaluation of newer cell sources, have been further studied. Cartilage degeneration has been a major obstacle to overcome in orthopaedic surgery, and stem cell therapy has shown reaso...
Chapter
Chondral regeneration and repair is a field of orthopaedics that has had exponential growth in the last decade. The use of various cells, stem cells and repair techniques have shown encouraging results for addressing chondral joint pathologies. The biomechanics of cartilage has been further researched to understand the requirements of the regenerat...
Chapter
A detailed understanding of biomechanical characteristics of healthy articular cartilage and the effect of mechanobiology on cartilage is needed to prevent joint degeneration with biological-based treatment strategies. In vitro and in vivo experiments of cartilage repair enhanced by mechanical stress have been able to guide rehabilitation protocols...
Article
Full-text available
Interest and research in biologic approaches for tissue healing are exponentially growing for a variety of musculoskeletal conditions. The recent hype concerning musculoskeletal biological therapies (including viscosupplementation, platelet-rich plasma, and cellular therapies, or “stem cells”) is driven by several factors, including demand by patie...
Article
Objectives Several studies have reported negative effects of open wedge high tibial osteotomy (OWHTO) on patellofemoral joints with cartilage degeneration and recommended performing other procedures. However, if chondral resurfacing surgery could promote improvement of cartilage degeneration in the patellofemoral joint, OWHTO would be an acceptable...
Article
Objective The aim of this study was to elucidate the efficacy of T2-mapping MRI and correlation with histology for the evaluation of tissue repair quality following the first-in-human implantation of an autologous tissue engineered construct. Design We directly compared the results of T2-mapping MRI of cartilage repair tissue with the histology of...
Article
Full-text available
Purpose: Chondrocyte -based tissue engineering has been a promising option for the treatment of cartilage lesions. In previous literature, TD198946 has been shown to promote chondrogenic differentiation which could prove useful in cartilage regeneration therapies. Our study aimed to investigate the effects of TD198946 in generating engineered cart...
Article
Full-text available
It is well studied that preparations of decellularized extracellular matrix (ECM) obtained from mesenchymal tissues can function as biological scaffolds to regenerate injured musculoskeletal tissues. Previously, we reported that soluble decellularized ECMs derived from meniscal tissue demonstrated excellent biocompatibility and produced meniscal re...
Article
Human synovium‐derived stem cells (hSSCs) are an attractive source of cells for cartilage repair. At present, the quality of tissue and techniques used for cartilage regeneration have scope for improvement. A small compound, TD‐198946, was reported to enhance chondrogenic induction from hSSCs; however, other applications of TD‐198946, such as primi...
Article
Full-text available
Osteochondral lesions (OL) are a common clinical problem for orthopedic surgeons worldwide and are associated with multiple clinical scenarios ranging from trauma to osteonecrosis. OL vary from chondral lesions in that they involve the subchondral bone and chondral surface, making their management more complex than an isolated chondral injury. Subc...
Article
While the capacity to regenerate tissues or limbs is limited in mammals, including humans, axolotls are able to regrow entire limbs and major organs after incurring a wound. The wound blastema has been extensively studied in limb regeneration. However, due to the inadequate characterization of ECM and cell subpopulations involved in the regeneratio...
Article
Full-text available
Purpose: The rapidly growing and emerging nature of biologics have made indications for regenerative and reparative hip therapies ever changing, with at times only early-stage evidence for their use. The purpose of this study was to review and summarize the currently available data on the management of hip cartilage injuries and osteoarthritis. M...
Article
Introduction Platelet rich plasma (PRP) is able to modulate the joint environment by reducing the inflammatory distress and promoting tissue anabolism. Therefore, it has gained increasing popularity among clinicians in the treatment of osteoarthritis (OA), and it is currently proposed beside consolidated options such as viscosupplementation. Areas...
Article
Historically, anterior cruciate ligament (ACL) suture repair mostly resulted in failure because of intra-articular hypovascularity and poor intrinsic healing capacity of ACL. ACL reconstruction was therefore deemed the gold standard with a high success rate because of more evolved surgical technique. There are, however, clinical and subclinical dis...
Article
Meniscus tears range from acute tears during physical activity to chronic degenerative tears. The role of the meniscus in knee stability, load distribution, knee proprioception and arthritis prevention has been well established, and successful repair of meniscus tears has better clinical outcomes and protection from increased degenerative changes....
Article
Objective To develop patient-focused consensus guidelines on the indications for the use of scaffolds to address chondral and osteochondral femoral condyle lesions. Design The RAND/UCLA Appropriateness Method (RAM) was used to develop patient-specific recommendations by combining the best available scientific evidence with the collective judgement...
Article
Full-text available
Meniscal injuries have posed a challenging problem for many years, especially considering that historically the meniscus was considered to be a structure with no important role in the knee joint. This led to earlier treatments aiming at the removal of the entire structure in a procedure known as a meniscectomy. However, with the current understandi...
Article
Objective Trochlear dysplasia is a major predisposing factor of patellar instability (PI). Dysplasia types are generally evaluated using the Dejour classification, but it is unclear whether this classification covers the entire spectrum. The objective of this study was to confirm whether the trochlear types on an axial view categorised according to...
Article
Background Intra-articular injection of adipose-derived stem cells (ASCs) has shown promise for improving symptoms and cartilage quality in the treatment of osteoarthritis (OA). However, while most preclinical studies have been performed with plastic-adherent ASCs, most clinical trials are being conducted with the stromal vascular fraction (SVF), p...
Article
Purpose: To report the rate of radiographic union, patient-reported outcomes, complications, and reoperations after internal fixation of unstable osteochondritis dissecans (OCD) in the skeletally mature knee. Methods: A literature search was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Pat...
Preprint
While the capacity to regenerate tissues or limbs is limited in mammals including humans, unlike us, axolotls are able to regrow entire limbs and major organs. The wound blastema have been extensively studied in limb regeneration. However, due to the inadequate characterization and coordination of cell subpopulations involved in the regeneration pr...
Article
Objective: The purpose of this systematic review is to determine (1) current reported treatment options for isolated tibial plateau (TP) cartilage lesions, (2) patient reported outcomes following various treatments, and (3) complication rate and survivorship following various treatments. Design: A literature search of PubMed, the Cochrane Librar...
Article
BACKGROUND: The lack of a standardized system for describing cell therapies acts as a barrier to advancement in clinical and basic research and practice. The aim of this study was to establish an international expert consensus on strategies to improve standardization and transparency when describing cell therapies. The secondary aim was to develop...
Article
The multiple ligament-injured knee is a complex injury requiring a comprehensive and thorough evaluation prior to tailoring an appropriate treatment plan. Surgical repair and reconstruction of the involved ligaments are frequently discussed in the literature; however, osteotomy to correct limb malalignment may be just as important to obtaining a go...
Article
Low back pain results in more global disabilities than any other condition, and intervertebral disc (IVD) degeneration is commonly involved in the etiology. Supplementation of IVDs with reparative cells is a rational strategy to address such clinical problems. We have previously developed a scaffold-free tissue-engineered construct (TEC) as a novel...
Article
Full-text available
Objectives Recently, adjustable-length loop cortical fixation devices (ALCFDs) have been developed. However, they are not frequently used for bone–patellar tendon–bone (BTB) grafting, mainly because it is uncertain whether an ALCFD enables sufficient integration of the bone plug. Thus, the purpose of this study was to evaluate bone plug–socket inte...
Article
As an alternative to chondrocytes‐based cartilage repair, stem cell‐based therapies have been investigated. Specifically, human synovium‐derived stem cells (hSSCs) are a promising cell source based on their highly capacities for chondrogenesis, but some methodological improvements are still required towards optimal cartilage regeneration. Recently,...
Book
This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of...
Article
Full-text available
Purpose: Autologous osteochondral transplantation (AOT) in the focal cartilage lesion of the patella has been reported with less successful results compared with other sites. The purposes were to investigate the clinical outcomes of AOT for focal patellar chondral lesion without patellofemoral instability. Methods: Between 2001 and 2007, six pat...
Article
Full-text available
Background: Cartilage restoration is a desperately needed bridge for patients with symptomatic cartilage lesions. Chondral lesion is a pathology with high prevalence, reaching as much as 63% of general population and 36% among athletes. Despite autologous chondrocyte implantation versatility, it still fails to fully reproduce hyaline articular cart...
Article
Full-text available
Damage to the meniscal hoop structure results in loss of biomechanical function, which potentially leads to the extrusion of the meniscus from the weight bearing area. However, there have been no established, effective treatments for such injuries. The purpose of this study was to investigate the applicability of cell-seeded nanofibrous scaffolds t...
Article
Objective Patellar instability (PI) represents various underlying pathologies, including patellar malalignment. Continuous patellar alignment develops to patellar tracking and is regarded as the end product of combined predisposing factors. We quantitatively investigated the inhomogeneity of patellar tracking in PI. Methods Sixty knees of 56 patie...
Article
Full-text available
Stem cell-based therapy is a promising approach to treat cartilage lesions and clinical benefits have been reported in a number of studies. However, the efficacy of cell injection procedures may be impaired by cell manipulation and damage as well as by cell dissemination to non-target tissues. To overcome such issues, mesenchymal stromal cell (MSC)...
Article
Full-text available
Purpose Chondral lesion is a pathology with high prevalence, reaching as much as 63% of general population and 36% among athletes. The ability of human Dental Pulp Stem Cells (DPSCs) to differentiate into chondroblasts in vitro suggests that this stem cell type may be useful for tissue bioengineering. However, we have yet to identify a study of lar...
Article
Objective: This retrospective case series describes a hybrid fixation technique and determines the clinical outcomes, knee function, and activity level of patients at short-term follow-up. Design: Seventeen patients (18 knees) with unstable osteochondritis dissecans (OCD) lesions involving the knee were treated with a hybrid fixation technique i...
Article
Full-text available
Background Little is known about early healing of repaired Achilles tendons on imaging, particularly up to 6 months postoperatively, when patients generally return to participation in sports. Purpose To examine changes in repaired Achilles tendon healing with ultrasonography for up to 12 months after surgery. Study Design Case series; Level of ev...
Article
Background: Articular cartilage has limited healing capacity, owing in part to poor vascularity and innervation. Once injured, it cannot be repaired, typically leading to high risk for developing osteoarthritis. Thus, cell-based and/or tissue-engineered approaches have been investigated; however, no approach has yet achieved safety and regenerativ...
Article
The management of meniscal injuries remains difficult and challenging. Although several clinical options exist for the treatment of such injuries, complete regeneration of the damaged meniscus has proved difficult due to the limited healing capacity of the tissue. With the advancements in tissue engineering and cell-based technologies, new therapeu...
Article
Full-text available
Human synovial mesenchymal stem cells (hSMSCs) are a promising cell source for cartilage regeneration because of their superior chondrogenic potential in vitro. This study aimed to further optimize the conditions for inducing chondrogenesis of hSMSCs, focusing on the dose of dexamethasone in combination with transforming growth factor-β3 (TGFβ3) an...
Article
Full-text available
Articular cartilage does not heal spontaneously due to its limited healing capacity, and thus effective treatments for cartilage injuries has remained challenging. Since the first report by Brittberg et al. in 1994, autologous chondrocyte implantation (ACI) has been introduced into the clinic. Recently, as an alternative for chondrocyte-based thera...
Article
Background: The use of mesenchymal stem cells from various tissue sources to repair injured tissues has been explored over the past decade in large preclinical models and is now moving into the clinic. Purpose: To report the case of a patient who exhibited compromised mesenchymal stem cell (MSC) function shortly after use of high-dose steroid to...
Article
Background: Aging is the most prominent risk factor for the development of osteoarthritis (OA), which affects knees and causes major health burdens. Meniscal dysfunction mostly based on degeneration contributes to the development and progression of knee OA. Meniscal degeneration is caused by various extrinsic factors, such as repetitive trauma or...
Article
Background: The concepts of lateral deviation and lateral inclination of the patella, characterized as shift and tilt, have been applied in combination to evaluate patellar malalignment in patients with patellar dislocation. It is not reasonable, however, to describe the 3-dimensional (3D) positional relation between the patella and the femur acco...
Article
Full-text available
Mesenchymal stem cell- (MSC-) based therapy is a promising treatment for cartilage. However, repair tissue in general fails to regenerate an original hyaline-like tissue. In this study, we focused on increasing the expression levels for insulin-like growth factor-1 (IGF-1) to improve repair tissue quality. The IGF-1 gene was introduced into human s...
Article
Background: To assess responsiveness of the Japanese Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Oxford Knee Score (OKS) in patients undergoing open-wedge HTO to treat knee osteoarthritis and/or osteonecrosis. Methods: Patients completed a set of questionnaires before HTO surgery (baseline) and 1 year after surgery. The questionn...
Chapter
Articular cartilage injuries occur frequently and are quite common in clinical practice [1]. However, articular cartilage does not usually heal spontaneously due to its avascular and aneural surroundings, and it has a relatively unique matrix organization. Therefore, a variety of approaches have been tested to improve cartilage healing over the pas...
Chapter
Autologous cellular therapies have been introduced in the treatment of articular cartilage defects in 1994 by Brittberg et al. [1] Indeed, autologous chondrocyte implantation (ACI) has been proven to restore hyaline-like articular surface, which is mechanically and functionally stable even in athletes at long-term follow-up. However, despite the br...
Chapter
Osteoarthritis (OA) is a common disease, which could potentially affect the quality of life of both young and elderly populations worldwide. The management of OA remains challenging and controversial. Although there are several clinical options for the treatment of OA, it has proven difficult to restore the damaged articular cartilage due to the li...
Article
Full-text available
Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. Our aim was to investigate the...