Norihiro Koizumi

Norihiro Koizumi
The University of Electro-Communications | UEC · Department of Mechanical Engineering and Intelligent Systems

Dr. Eng.
" Medical and Bio are New DigITals (Me-DigIT) ! " " Let's get A Whole New Me-DigIT Era & World ! "

About

137
Publications
9,658
Reads
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579
Citations
Additional affiliations
October 2015 - present
The University of Electro-Communications
Position
  • Professor (Associate)
November 2007 - September 2015
The University of Tokyo
Position
  • Lecturer (Assistant professor)
April 2004 - November 2007
The University of Tokyo
Position
  • Professor (Assistant)

Publications

Publications (137)
Article
Full-text available
High-intensity focused ultrasound (HIFU) was experimentally used for focal therapy for anti-cancer effects in prostate cancer (PC). Focal therapy is a diagnosis-based investigational treatment option for localized PC that cures clinically significant PC (csPC) while preserving the anatomical structures related to urinary and sexual function based o...
Article
PurposeNoise-free ultrasound images are essential for organ monitoring during regional ultrasound-guided therapy. When the affected area is located under the ribs, however, acoustic shadow is caused by the reflection of sound from hard tissues such as bone, and the image is output with missing information in this region. Therefore, in the present s...
Article
Full-text available
PurposeDiagnosis of liver fibrosis is important for establishing treatment and assessing the risk of carcinogenesis. Ultrasound imaging is an excellent diagnostic method as a screening test in terms of non-invasiveness and simplicity. The purpose of this study was to automatically diagnose liver fibrosis using ultrasound images to reduce the burden...
Article
Full-text available
Purpose To estimate the role of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced MRI (EOB-MRI) in predicting hypervascularization outcome of non-hypervascular hypointense hepatic lesions in high-risk patients for hepatocellular carcinoma (HCC). Methods Under the premise of non-hyperenhance in arterial phase (AP) and hypointensi...
Article
Full-text available
Aim: To clarify the utility of contrast-enhanced ultrasonography (CEUS) for interim evaluation of response to chemotherapy in lymphoma treatment. Materials and methods: CEUS was performed both before (day 0) and after the treatment (7 and/or 14 days), and a time-intensity curve was obtained. The patients were divided into two groups (complete re...
Article
In recent years, the development of medical image diagnostic devices has made it possible to perform diagnosis using a large amount of medical data, but the increased burden on physicians has become a problem. Therefore, in this study, we applied deep learning to the ultrasound B-mode images of the liver to diagnose the presence or absence of disea...
Article
The main purpose of this study is to construct a tumor trucking method for ultrasound-guided radiofrequency ablation (RFA) treatment. During RFA, tissues other than the liver and hyperechoic region generated by ablation hide the tumor. In this paper, estimate the three-dimensional (3D) movement of the liver to solve these problems. In the proposed...
Article
Liver fibrosis is important information for diagnosing the prognosis of fatty liver. Diagnosis of the degree of fibrosis by ultrasound is non-invasive and cost-effective. However, it is difficult to evaluate the effect of fat on interpretation and mild fibrosis. In this report, we propose a novel method utilizing deep learning to improve the accura...
Article
In this research, we developed a mechanism that has vertical axis rotation in the tip of a bed-type ultrasound robot that can follow three-dimensional movement of abdominal organs with higher accuracy, which is impossible with a conventional bed-type ultrasound robot. As a preparation stage for position and orientation tracking, a new method for es...
Article
The purpose of this study is to develop a novel algorithm that can automatically acquire an ultrasound image using the newly developed bed-type ultrasound diagnostic robot. We confirmed the effectiveness of our novel proposed method by comparing tracking accuracy with the conventional template matching method and simulated a basic algorithm for con...
Article
It is difficult to perform proper ultrasound diagnosis when the respiratory organs are moving, so it is necessary for the patient to stop breathing. However, stopping breathing puts a burden on the patient, so it is necessary to acquire a still image while breathing, that is, even when the organ is moving. We developed a bed-type ultrasound robot a...
Article
In this research, we proposed a robotic motion control framework that can detect kidney in real-time by utilizing deep learning, and evaluate the accuracy of automatically acquiring and maintaining ultrasound diagnostic images of kidney. Furthermore, we performed object detection experiments using a model that was generated by a kidney phantom, est...
Article
Purpose: The main purpose of this study is to construct a system to track the tumor position during radiofrequency ablation (RFA) treatment. Existing tumor tracking systems are designed to track a tumor in a two-dimensional (2D) ultrasound (US) image. As a result, the three-dimensional (3D) motion of the organs cannot be accommodated and the ablat...
Article
Full-text available
Purpose This paper examines the feasibility of automated alignment in sagittal direction in MR-TRUS fusion biopsy of the prostate by comparing the prostate contour in axial images between different modalities. In the treatment of prostate cancer, an important factor affecting the prognosis of patients is focal therapy of cancer within the prostate....
Article
Full-text available
Purpose: This study evaluated the usefulness of intraprocedural contrast-enhanced ultrasound (CEUS)/ultrasound (US) fusion imaging using a perflubutane-based contrast agent combined with preprocedural auto sweep three-dimensional US to obtain volume data for guidance and evaluation of the therapeutic efficacy of radiofrequency ablation (RFA). Metho...
Article
Full-text available
Background & aims: To explore the ability of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging (EOB-MRI)/ultrasound (US) fusion imaging (FI) to improve the prognosis of radiofrequency ablation (RFA) by ablating the characteristic findings of hepatocellular carcinoma (HCC) in hepatobiliary phase (HBP) imaging....
Article
We are developing a system to treat kidney, liver and other organs, as well as stones and cancer in these organs using high-power focused ultrasound (HIFU) while tracking lesions that move by breathing and body movements. The system estimates organ movement by analyzing ultrasound images obtained from the probe and compensates for this movement wit...
Article
This paper examines the feasibility of automated alignment in prostate targeted biopsy by comparing the prostate contour between different modalities. The prostate targeted biopsy that is attracting attention in the treatment of prostate cancer largely depends on the doctor who operates surgery, so it can be expected to reduce the variation in the...
Article
Hepatic hemangioma is lesion frequently found in ultrasonography. Although hepatic hemangioma is benign tumor, other tumors are subject to detailed examination by judging hepatic hemangioma. Therefore, in this study, we proposed a new discrimination method aimed at improving accuracy by using deep learning to classify hepatic hemangioma and blood v...
Article
Full-text available
Robotic medical ultrasound can support diagnostics and alleviate fatigues. However, state-of-the-art ultrasound devices are too large and complex for home healthcare. Moreover, organs move in accordance with respiration. This movement changes the ultrasound image pattern and it is difficult for the operator to diagnose easily and accurately. To cop...
Article
Ultrasound has a lot of advantages in observing diseased organ areas compared with other imaging diagnostic modalities. Nevertheless, the presence of acoustic shadows in ultrasound images can impede observation of the diseased area, and although the ultrasound probe can be moved to scan for obtaining ultrasound images that avoid the bones, this lim...
Article
In this report, we proposed a method of classification of fascia and other tissue using Histograms of Oriented Gradients (HOG) and Support Vector Machine (SVM) in ultrasound images. The muscle layer can be determined by detecting the fascia. The decline of muscle and bone density due to aging is increased the likelihood of injury. So it is consider...
Article
In this report we propose a novel method for shape extraction and modeling of MRI prostate contours. Transperineal targeted biopsy with real-time fusion image of multiparametric magnetic resonance image and transrectal ultrasound image have a problem that the diagnostic ability is uneven in accordance with the skill of the medical professionals. To...
Article
Full-text available
The expectation that intersections of various science and engineering technologies such as mathematics, information, control, artificial intelligence, and robot technology with medicine and biology have enormous potential is rapidly growing day by day. Bill Gates said, “If I were a student, I would learn biology,” and Nicolas Negroponte said, “Bio...
Article
An obtained image by ultrasound diagnostic device depends on the skill of the operator. In addition, it is difficult to observe an image easily and precisely due to organ motions and deformations in accordance with the breathing and pulsation. To cope with this problem, we have developed the physiological motion compensation device to track and fol...
Article
In recent years, HIFU (High Intensity Focused Ultrasound) therapy, which is one of the non-invasive therapies utilizing focused ultrasound, have attracted a great attention as a novel treatment method for a focal lesion, such as a tumor and a stone. However, the focal lesion moves in accordance with respiration, which may cause the damage for the s...
Article
In this report we propose a novel robust tumor tracking method for ultrasound guided RFA treatments. RFA (radiofrequency ablation) treatments have a serious problem to hide a tumor to be treated due to the hyperechoic region, which is generated by vapors during RFA. Moreover, organ deformations seriously deteriorate the tracking performance. To cop...
Article
Full-text available
An obtained image by ultrasound diagnostic device depends on the skill of the operator. In addition, it is difficult to observe the image due to the organ motions and deformations in accordance with the breathing and pulsation. For this research, we have developed the physiological motion compensation device to track and follow the moving and defor...
Article
Acoustic shadows, which are generated by rib bones, make it difficult to obtain proper diagnostic images from the proper viewpoints for medical professionals. To cope with this, we combined separate parts of organ images together by utilizing the contours of the kidney. The contours are extracted by the algorithms which are Snake and Partial Active...
Article
Full-text available
Objectives To evaluate the abdominal visceral fat area (VFA), we developed novel ultrasonographic (US) methods for estimating. Methods 100 male volunteers were recruited, and their VFA was calculated by two novel US methods, the triangle method and the ellipse method. The VFA calculated by these methods was compared with the VFA calculated by CT....
Article
Full-text available
Purpose: Radiofrequency ablation for liver tumors (liver RFA) is widely performed under ultrasound guidance. However, discriminating between the tumor and the needle is often difficult because of cavitation caused by RFA-induced coagulation. An unclear ultrasound image can lead to complications and tumor residue. Therefore, image-guided navigation...
Article
Full-text available
High intensity focused ultrasound (HIFU) is potentially useful for treating stones and/or tumors. With respect to HIFU therapy, it is difficult to focus HIFU on the focal lesion due to respiratory organ motion, and this increases the risk of damaging the surrounding healthy tissues around the target focal lesion. Thus, this study proposes a method...
Conference Paper
We have been studying the Non-Invasive Ultrasound Theragnostic System (NIUTS), which tracks and follows the affected area while irradiating High Intensity Focused Ultrasound (HIFU). In this report, we propose a phantom model that includes rib bones and respiratory motion.
Conference Paper
It has been reported that MRgFUS has pain palliative effects on the local pain in patients with bone metastasis. In general, a severity of pain has been evaluated using only subjective method with numerical rating scale (NRS) or visual analogue scale (VAS). It is important to evaluate local pain-palliative effects of MRgFUS treatment with objective...
Data
Supplementary Figure: We designed a belt-shaped ultrasound probe-compatible device for the triangle method. The belt-shaped device has three holes, a center basal point and each 5 cm distant right and left side, for applying US probe. The angles between the line from the aorta to the basal point and the lines from the aorta to the bilateral holes w...
Article
Full-text available
Background: Although high intensity focused ultrasound (HIFU) is a promising technology for tumor treatment, a moving abdominal target is still a challenge in current HIFU systems. In particular, respiratory-induced organ motion can reduce the treatment efficiency and negatively influence the treatment result. In this research, we present: (1) a m...
Article
Monitoring and evaluating the therapeutic effects, in ultrasound images during HIFU (High Intensity Focused Ultrasound) and RFA (Radio Frequency Ablation) therapies, are important. However, the common problem is the difficulty to monitor the progress and identify the positions of the focal lesion precisely in accordance with the progress of the tre...
Article
In accordance with the progress of the HIFU (High Intensity Focused Ultrasound) and RFA (Radio Frequency Ablation) treatments, the intensity of the focal lesion and the surrounding marginal area changes little by little. Here, it should be noted that the human eyes are very weak when the image takes a long time to change even if the image change fr...
Article
We propose a noninvasive ultrasound theragnostic system (NIUTS) that compensates for movement by tracking and following the area to be treated by using stereo ultrasound imaging while irradiating the focal lesion with HIFU. Theragnostics involves therapeutics and diagnostics. Our proposed system uses focused ultrasound to destroy tumors and stones...
Article
The main problem on HIFU (High Intensity Focused Ultrasound) therapy is the difficulty to locate HIFU focus precisely onto the focal lesion, which is located in the moving organ such as livers/kidneys, due to the deformation and rotation, which is caused by respiration. Furthermore, rib bones frequently block the acoustic path to the lesion. The ac...
Article
Shock wave lithotripsy has generally been a fi rst choice for kidney stone removal. The shock wave lithotripter uses an order of microsecond pulse durations and up to a 100 MPa pressure spike triggered at approximately 0.5-2 Hz to fragment kidney stones through mechanical mechanisms. One important mechanism is cavitation. We proposed an alternative...
Article
High intensity focused ultrasound (HIFU) has a great potential for the treatments of stones and/or tumors. In HIFU therapy, respiratory organ motions make it difficult to locate the HIFU focus onto the focal lesions and the risk for damaging the surrounding healthy tissues could be increased. Therefore, we have developed the ultrasound guided motio...
Article
Full-text available
One of the reasons for the long treatment time of FUS for HCC compared with RFA is that we have to adjust the target lesion which has a respiratory movement. In this study, we evaluated the usefulness of respiratory tracking system for the FUS monitoring images of hepatocellular carcinoma (HCC).
Article
High intensity focused ultrasound (HIFU) has a potential for a treatment of stones or tumors. In HIFU therapy, respiratory organ motion makes it difficult to focus HIFU on an affected area, and increases the risk of damaging healthy tissues around the target. In this paper, we proposed the method for tracking a respiratory organ motion, in which we...
Conference Paper
Full-text available
The authors have developed a non-invasive ultrasound theragnostic system (NIUTS) with a focal lesion servo (FLS) function based on stereo ultrasound imaging in order to compensate for movement while irradiating high-intensity focused ultrasound (HIFU) onto a focal lesion. In the present paper, we propose a redundant motion control mechanism of the...
Conference Paper
Full-text available
The authors have developed a bed-type non-invasive ultrasound theragnostic system (NIUTS) that compen-sates for movement by tracking and following the area to be treated by stereo ultrasound imaging while irradiating high-intensity focused ultrasound (HIFU) onto the affected area. In this paper, we propose a novel robust template matching method to...
Article
We have studied technologizing and digitalizing methodologies for medical professional skills based on the mechanism, control, and image processing technologies. In this paper, we analyzed the probe manipulation task between rib bones and propose probe manipulation mechanisms to acquire ultrasound images avoiding the effects of rib bones.
Article
Full-text available
In this paper, we propose a method for identifying systems incorporating a mechanical oscillation part for a non-invasive ultrasound theragnostic system(NIUTS). The NIUTS tracks and follows movement in an area requiring treatment (renal stones, in this study) by irradiating the area with high intensity focused ultrasound (HIFU). Blur noise caused b...
Article
Full-text available
We have developed a non-invasive ultrasound theragnostic system (NIUTS) that tracks and follows the movement of an affected area (kidney stone / tumor, in this study) while irradiating it with high-intensity focused ultrasound (HIFU). In this paper, we propose a method to simplify extracting, tracking and following, monitoring the affected area by...
Article
Full-text available
In this paper, we propose a mechanical system identification method for the Non-Invasive Ultrasound Theragnostic System (NIUTS). NIUTS tracks and follows the movement in an affected area (kidney stones, in the present study) by irradiating the area with high-intensity focused ultrasound (HIFU). Blur noise caused by oscillation of the mechanical sys...
Article
Full-text available
Unwanted motion is a serious problem in enhancing servoing performance in an affected area, which incorporates stones/tumours in non-invasive ultrasound theragnostic systems (NIUTS). To solve this problem, we proposed a new method for restricting the motion of the affected area ventrodorsally in the region of interest (ROI) in ultrasound imaging. T...