Norhayati Mohamed NoorUniversity of Technology Malaysia | UTM · UTM Innovation and Commercialisation Centre
Norhayati Mohamed Noor
PhD in Pharmaceutics
About
30
Publications
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Introduction
As a researcher and formulator at IBD, UTM since 2004, I have been actively conducting research on the lipid nanoparticles for topical/transfollicular delivery and has developed cosmeceutical products for other companies focussing on aromatherapy, perfume, cosmetic and personal care products. My studies involve in nanoparticle formulation, characterisation, production, in vitro cytotoxicity and evaluation of their potential for the skin and hair.
Additional affiliations
April 2014 - October 2017
July 2004 - present
Education
April 2014 - October 2017
July 2007 - March 2013
July 1999 - July 2004
Publications
Publications (30)
Dutasteride, used for treating benign prostate hyperplasia (BPH), promotes hair growth. To enhance delivery to the hair follicles and reduce systemic effects, in this study dutasteride has been formulated for topical application, in a nanostructured lipid carrier (NLC) coated with chitosan oligomer-stearic acid (CSO-SA). CSO-SA has been successfull...
Dutasteride, licensed as an oral medicine for the treatment of benign prostatic hypoplasia, has been investigated as a treatment for androgenic alopecia. In this study, the potential for dustasteride to be delivered topically in order to reduce systemic exposure, irritation of the skin, and also cytotoxicity was explored. Chitosan oligomer (CSO) wa...
Fatty acid such as lauric and oleic acid have been used extensively either in cosmeceutical or pharmaceutical products as an emollient or moisturiser. In this study, fatty acids which combine lauric and oleic acids have been formulated into nanostructured lipid carriers (FA-NLCs) system in order to improve its physical stability hence, enhancing th...
Male pattern baldness (MPB) is a common condition that has a negative impact on the psycho-social health of many men. This study aims to engineer an alcohol-free formulation to cater for individuals who may have had allergic reactions to alcohol-based preparations. A lipid-based nanoparticle system composed of stearic and oleic acid (solid and liqu...
UTM's successful commercialisation efforts through its ICCubeX Incubator Program, which has facilitated the commercialisation of 18 innovations in 2022 and 17 in 2023, generated RM 12.84 million in revenue. This program bridges the gap between academic research and market needs by providing IP management, seed funding, training, shared facilities,...
The unscientific disposal of the most abundant crustacean wastes, especially those derived from marine sources, affects both the economy and the environment. Strategic waste collection and management are in need of the hour. Sustainable valorization approaches are played a crucial role in solving those issues as well as generating wealth from waste...
The rise in health awareness raises the demand on safe, cheaper, convenience, and health-related products. Breadfruit is packed with nutrients, high in resistant starch, low glycemic, as well as possesses promising functional properties. In addition, it contains abundance of phytochemicals extract containing bioactive compounds which offer therapeu...
The moisturising cream is commonly formulated in an emulsion system either oil-in-water (O/W) or water-in-oil (W/O). Due to instability of the system, it is crucial to ensure emulsions are physically and mechanically stable in the development of topical applications.Virgin coconut oil (VCO) has been proven clinically to possess anti-inflammatory ch...
Renewable, natural and biocompatible characteristic of lignin portray a huge milestone in cosmeceutical applications. The wide availability of lignin which exist in abundance in nature and from low-cost biowaste has put this polymer as one of the highly promising elements to be explored for replacing the common chemical-based ingredients in cosmeti...
Ananas comosus peels (AcP) are among the agro-industrial biomasses contributing to a significant volume of waste in Malaysia. Thus, the AcP extract (AcPE) may prove useful for other applications, such as an ingredient in a nanocream for controlled delivery for dermal application. Therefore, this study aimed to develop an oil-in-water (O/W) nanocrea...
The rise in health awareness raises the demand on safe, cheaper, convenience, and health-related products. Breadfruit is packed with nutrients, high in resistant starch, low glycemic, as well as possesses promising functional properties. In addition, it contains abundance of phytochemicals extract containing bioactive compounds which offer therapeu...
The world market has been introduced with cannabis industry since long ago before the start of the Common Era. Since a century ago, this industry has been overwhelmed with controversial legal battles and debates. However, recently, the legitimate cannabis market has been growing rapidly and is highly potential to significantly boost the world's eco...
Results:
The virgin coconut oil nanoparticles are solid lipid nanoparticles form and were stable for a reasonable length of time at room temperature, using probe sonicator and lab homogenizer to form two-phase emulsion.
The average particle size inside the emulsion was obtained at a fixed period of time repeatedly. Overall, average particle sizes...
Lemongrass with scientific name Cymbopogon citratrus was widely found in tropical country. The aroma scent released by the lemongrass able to relieve anxiety and rejuvenate us. Lemongrass oil is suitable to use as one of the car freshener ingredient. However, the oil is easily evaporating when expose to high temperature environment. In order to pre...
Ananas comosus (A. comosus) is one of the many commercial crops in Asian countries well-known for its medicinal characteristics, and widely popular in the food industry. Nonetheless, large quantities of the antioxidant rich pineapple peels (PP) are discarded or used as animal fodder, thus the full potential of the PP for nanocosmeceutical applicati...
Hair loss or alopecia is a common dermatological issue that can affect millions of human population of all ages and both gender, male and female. Frequently, alopecia has been found to be associated with significant adverse effects or reduction of psychological and self-esteem. Consequently, this may lead to psychological problems such as depressio...
INTRODUCTION: Androgenic alopecia (AA) patients usually have high levels of dihydrotestosterone on their balding scalp area. Currently, dutasteride (DST) is given orally and has systemic adverse effects; diminished sexual desire, increased depression and ejaculation disorder. Topical administration of DST is an appropriate drug-delivery strategy wi...
Abstract:
Virgin coconut oil (VCO) is the finest grade of coconut oil, rich in phenolic content, antioxidant activity and
contains medium chain triglycerides (MCTs). In this work formulation, characterisation and penetration of VCO-solid lipid particles (VCO-SLP) have been studied. VCO-SLP were prepared using ultrasonication of molten stearic acid...
Asia is a region rich in plant sources that can be harnessed for efficacious cosmeceutical products. With the increase in consumer demands for cosmeceutical products that are natural, safe, efficacious and ethical, it is befitting that research work related to cosmetics conducted on the plants from this region be on the rise. Five plants, Garcinia...
Nanostructured lipid carrier (NLC) is the blend of solid lipid, liquid lipid and suitable surfactant for the purpose of encapsulated poorly water soluble drugs. [6]-gingerol is the main bioactive compound in Zingiber officinale, widely known as ginger in Malaysia. Zingiber officinale extract has been discovered to have anti-oxidant, anti-inflammato...
Virgin Coconut Oil is oil extracted from well matured and fresh coconut through specialized processes without damaging its natural nutrition. In this work virgin coconut oil is loaded into solid lipid microparticles to be used in a moisturizer formulation. The virgin coconut oil loaded solid lipid microparticles were prepared using ultrasonificatio...
Virgin Coconut Oil is usually extracted from well matured and fresh coconut through specialized processes without damaging its natural nutrition. In this work, formulation, characterization and efficacy of VCO-SLPs have been studied. VCO-SLPs were prepared using ultrasonification of molten stearic acid and virgin coconut oil in an aqueous solution...
The health promoting capacity of natural antioxidant from phytochemicals has increase attention from researchers and public. However, processing is affecting the activity and the bioavailability of bioactive compounds. Therefore, the optimization of extraction condition of antioxidant activity from Zingiber zerumbet oleoresin was investigated. A Bo...
Questions
Questions (3)
Let say if you want to compare mean of release profile at time 12th for 4 different types of formulation and each of formulation you make it at least 4 measurements, can we say it is parametric and use one-way ANOVA?
Thanks a lot!
We're preparing NPs for the topical delivery (to avoid systemic effect). How can we determine the permeation parameters if the drug doesn't pass to the receptor chamber? What we have only the amount of drug extracted from the full thickness skin. Do we need to use only epidermis layer for this study? One more question, how can we separate the epidermis and dermis of the pig ear skin? We've tried use heat separation method (immerse the skin into 60 deg C water for 120s) but still couldn't separate it.
Thanksing you in advance.
I've prepared nanoemulsion and need to measure the release and permeation of that formulation using franz diffuiosn cell. I've found some of the researchers added SDS (sodium dodecyl sulphate, 2%) or ethanol in PBS 7.4? Which one is the best? Is there any guideline that I can follow for this experiment? My drug is very hydrophobic (0.039 ng/ml - solubility in water) and high solubility in methanol and ethanol. Thanks a lot.
