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Citations since 2017
Publications
Publications (16)
In actual work we clearly highlight in the first time the experimental factors (dominantly the concentration of the macromolecule components) influencing the formation of human serum albumin/hyaluronic acid (HSA/HyA) complex carrier particles which is not available in the literature despite the several published articles. We have shown that the cha...
In this review, we clearly highlight the importance of the detailed study of the interactions between noble metal colloids (nanoparticles (NPs) and nanoclusters (NCs)) with serum albumins (SAs) due to their rapidly growing presence in biomedical research. Besides the changes in the structure and optical property of SA, we demonstrate that the chara...
While numerous papers have been published according to the binary surfactant mixtures, only a few articles provide deeper information on the composition dependence of the micellization, and even less work attempts to apply the enhanced feature of the mixed micelles. The most important parameter of the self-assembled surfactants is the critical mice...
In this work, we firstly presented a simple encapsulation method to prepare thiamine hydrochloride (vitamin B1)-loaded asolectin-based liposomes with average hydrodynamic diameter of ca. 225 and 245 nm under physiological and acidic conditions, respectively. In addition to the optimization of the sonication and magnetic stirring times used for size...
A protein-polysaccharide-based potential nanocarrier system have been developed via a simple, one-step preparation protocol without the use of long-term heating and the utilization of hardly removable crosslinking agents, surfactants, and toxic organic solvents. To the best of our knowledge, this article is the first which summarizes in detail the...
We first demonstrate a simple and rapid fabrication protocol of bovine serum albumin (BSA) nanoparticles (NPs), as potential drug carriers using a microchannel flow technique with the successful encapsulation of a water-soluble kynurenic acid (KYNA) having neuroactive property has also been performed. By comparison, the preparation of a hydrophobic...
Fabrication possibilities, detailed size and structural characterization of biodegradable chitosan (Chit) polysaccharide-modified hyaluronic acid (HyA)-based colloidal carriers are demonstrated. The negatively charged and highly hydrophilic HyA polymer chains have been ionically modified by positively charged pure Chit and crosslinked Chit macromol...
The (±)-α-Tocopherol (TP) with vitamin E activity has been encapsulated into biocompatible poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) carriers, which results in the formation of well-defined nanosized (d ~200–220 nm) core-shell structured particles (NPs) with 15–19% of drug loading (DL%). The optimal ratios of the polymer carrier...
Three drugs with different hydrophilicity are encapsulated in poly-lactide (PLA) and Poly(lactide-co-glycolide) (PLGA) drug delivery systems prepared by ring-opening polymerization (ROP). Formation of well-defined core-shell type nanoparticles (NPs) is observed for α-tocopherol (TP) and by systematically altering the hydrophilicity of the drug carr...
This paper presents some findings from the rheological and drug dissolution characterizations of hyaluronic acid (HyA)-based colloidal drug delivery systems. During this investigations the widely applied, non-steroidal, anti-inflammatory ketoprofen (KP) has been used as model drug. For the moderation of the hydrophilic character of HyA and encapsul...
The experiments in the present work describe, the synthesis and preparation, rheological, conductometric and titration calorimetry based characterization, and drug dissolution of different hyaluronic acid (HyA)-based colloidal drug delivery systems. During this investigations the hydrophobic ketoprofen (KP), one of the most used non-steroidal anti-...
This paper presents the preparation of a multifunctional coating with triplet photoreactive, superhydrophobic and intelligent self-healing properties. Beside the structural and morphological behaviors of the hybrid thin films consist of fluoropolymer matrix and Ag-TiO2 photocatalyst particles, the wetting properties were also studied by static (Θ)...
This work demonstrates the preparation, characterization, and drug dissolution of different hyaluronic acid (HyA)-based colloidal drug delivery systems containing hydrophobic ketoprofen (KP), a non-steroidal anti-inflammatory drug (NSAID), as the model drug molecule. Because of the highly hydrophilic character of HyA the cross-linked derivatives at...
This work demonstrates the preparation, structural characterization, and the kinetics of the drug release of hyaluronic acid (HyA)-based colloidal drug delivery systems which contain hydrophobic ketoprofen (KP) as model molecule. Because of the highly hydrophilic character of HyA the cross-linked derivatives at different cross-linking ratio have be...
The complex formation between Nd(III) and D-gluconate (Gluc–) is of relevance in modelling the chemical equilibria of radioactive waste repositories. In the present work, the formation of NdpGlucqH–r complexes at 25 °C and pH = 2–8 was studied via spectrophotometry, potentiometry, freezing point depression, conductometry and NMR spectroscopy. In ad...
The complex formation equilibria between Ca(2+) ions and six carbohydrate derivatives related to d-glucose was quantitatively characterized by potentiometry, freezing point depression and polarimetry. Complexation could not be observed for d-glucose, while weak association was deduced for d-sorbitol and d-mannitol. Stronger complexes are formed wit...
Projects
Projects (2)
The use of colloidal delivery systems, such as nanoparticles and associated colloids, has drawn a particular attention in the clinical therapy. These nanosized carriers can also be manipulated to guide the drugs toward desired cells and improve the biodistribution. Formulation and physicochemical properties of these solid and semi-solid particles play an important role in bioavailability and targeting efficiency of drugs.
The aim of this project is to create new biopolymer based drug delivery systems. These systems are mainly nanoparticles and nanocomposites, and they will be used for encapsulating new pharmaceuticals and investigating their release capabilities.
