Noraidatulakma Abdullah

Noraidatulakma Abdullah
Hospital Universiti Kebangsaan Malaysia (HUKM) | HUKM · UKM Medical Molecular Biology Institute

PhD in Medical Genetics

About

42
Publications
8,893
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
319
Citations
Citations since 2016
35 Research Items
288 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction

Publications

Publications (42)
Article
Full-text available
To characterize the association with Type 2 diabetes of known Type 2 diabetes risk variants in people in Malaysia of Malay, Chinese and Indian ancestry who participated in the Malaysian Cohort project. Using the MetaboChip array, 1604 people of Malay ancestry (722 cases, 882 controls), 1654 of Chinese ancestry (819 cases, 835 controls) and 1728 of...
Article
Full-text available
CYP2E1 encodes an enzyme that participates in the activation of several carcinogenic substances. Thus, numerous studies have investigated the association between CYP2E1 polymorphisms and colorectal cancer (CRC) risk, but inconclusive results have been obtained. We performed a meta-analysis to precisely evaluate the relationship of CYP2E1 rs2031920,...
Article
Full-text available
Genome-wide association studies (GWAS) have discovered 163 loci related to coronary heart disease (CHD). Most GWAS have emphasized pathways related to single-nucleotide polymorphisms (SNPs) that reached genome-wide significance in their reports, while identification of CHD pathways based on the combination of all published GWAS involving various et...
Article
Full-text available
Asians are more susceptible to type 2 diabetes mellitus (T2D) and its coronary heart disease (CHD) complications than the Western populations, possibly due to genetic factors, higher degrees of obesity, insulin resistance, and endothelial dysfunction that could occur even in healthy individuals. The genetic factors and their mechanisms, along with...
Article
Full-text available
Objective: In this present study, we aim to evaluate the accuracy of the HbA1c relative to fasting plasma glucose (FPG) in the diagnosis of diabetes and pre-diabetes among The Malaysian Cohort (TMC) participants. Methodology: FPG and HbA1c were taken from 40,667 eligible TMC participants that have no previous history of diabetes, aged between 35...
Article
B-cell precursor acute lymphoblastic leukemia (B-ALL) is the commonest cancer in children, comprising over 80% of the entire childhood leukemia. However, the etiology of childhood B-ALL remains poorly understood and genetic susceptibility is a major risk factor for this disease. ARID5B appeared as one of the most promising genetic markers with near...
Article
Full-text available
The attrition rate of longitudinal study participation remains a challenge. To date, the Malaysian Cohort (TMC) study follow-up rate was only 42.7%. This study objective is to identify the cause of attrition among TMC participants and the measures to curb it. A total of 19,343 TMC participants from Kuala Lumpur and Selangor that was due for follow-...
Article
Full-text available
Measuring dietary intakes in a multi-ethnic and multicultural setting, such as Malaysia, remains a challenge due to its diversity. This study aims to develop and evaluate the relative validity of an interviewer-administered food frequency questionnaire (FFQ) in assessing the habitual dietary exposure of The Malaysian Cohort (TMC) participants. We d...
Article
Full-text available
The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will develop cardiovascular disease (CVD) complications, an...
Article
Full-text available
Malaysia is a country with an intermediate endemicity for hepatitis B. As the country moves toward hepatitis B and C elimination, population-based estimates are necessary to understand the burden of hepatitis B and C for evidence-based policy-making. Hence, this study aims to estimate the prevalence of hepatitis B and C in Malaysia. A total of 1458...
Article
Full-text available
Medication non-adherence remains a significant barrier in achieving better health outcomes for patients with chronic diseases. Previous self-reported medication adherence tools were not developed in the context of the Malaysia population. The most commonly used tool, MMAS-8, is no longer economical because it requires a license and currently every...
Article
Full-text available
This study was aimed at determining the prevalence of anaemia amongst the Malaysian Cohort participants and the associated risk factors. This was a cross-sectional study that involved 102,388 participants from The Malaysian Cohort (TMC) aged between 35 and 70 years old recruited from April 2006 to September 2012. Venous blood was taken for the full...
Article
Full-text available
p>Cardiovascular disease (CVD) is the leading cause of deaths worldwide. In 2017, CVD contributed to 13,503 deaths in Malaysia. The current approaches for CVD prediction are usually invasive and costly. Machine learning (ML) techniques allow an accurate prediction by utilizing the complex interactions among relevant risk factors. This study present...
Article
Full-text available
Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potentially can be used as biomarkers and therapeutic tar...
Preprint
Full-text available
Background: Cardiovascular disease (CVD) is the leading cause of deaths worldwide. In 2017, CVD contributed to 13,503 deaths in Malaysia. The current approaches for CVD prediction are usually invasive and costly. Machine learning (ML) techniques allow an accurate prediction by utilizing the complex interactions among relevant risk factors. Results:...
Article
Background: There has been a rapid increase in colorectal cancer (CRC) cases in Asian countries, including Malaysia. CRC is usually diagnosed at a late stage, and early detection of CRC is vital in improving survival. This study was conducted to determine the uptake rate of the immunochemical faecal occult blood test (iFOBT), the response rate to...
Article
Full-text available
Background: Validation of self-reported questionnaire is very crucial in ensuring the quality and reliability of data collection. Objective: The aim of this study were i) to validate the questionnaire on tobacco smoke intake and second-hand smoke exposure among The Malaysian Cohort (TMC) subjects through the determination of urinary cotinine leve...
Article
Full-text available
The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity...
Article
Full-text available
The purpose of this meta-analysis was to compare the ability of the qSOFA in predicting short- (≤30 days or in-hospital mortality) and long-term (>30 days) mortality among patients outside the intensive care unit setting. Studies reporting on the qSOFA and mortality were searched using MEDLINE and SCOPUS. Studies were included if they involved pati...
Article
Background: The phenotypic severity of β-thalassemia is highly modulated by three genetic modifiers: β-globin (HBB) mutations, co-inheritance of α-thalassemia and polymorphisms in the genes associated with fetal haemoglobin (HbF) production. This study was aimed to evaluate the effect of HbF related polymorphisms mainly in the HBB cluster, BCL11A...
Article
Full-text available
Cardiovascular disease (CVD) leads to high morbidity and mortality rate worldwide. Therefore, it is important to determine the risk of CVD across the sociodemographic factors to strategize preventive measures. The current study consisted of 53,122 adults between the ages of 35 and 65 years from The Malaysian Cohort project during recruitment phase...
Article
Full-text available
Background Human gut microbiota-are normal flora living freely in the human gastrointestinal systems and this symbiotic bond begins at birth, and there are associations between human microbiota and skin allergens. Methods This systematic review provides an insight into the role and condition of human microbiota that affects skin der-matitis and ecz...
Conference Paper
Background Mucinous cancer (MC) is a distinctive subtype of colorectal cancer (CRC) identified in 10%–15% of patients. It has long been associated with poor response to treatment, low survival rates, worse prognosis and present at more advanced stage than non-mucinous adenocarcinoma. Yet, the knowledge on the molecular mechanisms associated with th...
Article
Full-text available
Background: This study aimed to identify the factors of CAM usage for general health and to determine the factors associated with the usage of different types of CAM after the diagnosis of chronic diseases among The Malaysian Cohort participants. Methods: This was a cross-sectional study derived from The Malaysian Cohort (TMC) project, a prospec...
Data
Supplemental Material, Supplemental_Material_765945 - Utilization of Complementary and Alternative Medicine in Multiethnic Population: The Malaysian Cohort Study
Article
Full-text available
Objective: In year 2016, quick Sepsis-Related Organ Failure Assessment (qSOFA) was introduced as a better sepsis screening tool compared to systemic inflammatory response syndrome (SIRS). The purpose of this systematic review and meta-analysis is to evaluate the ability of the qSOFA in predicting short- and long-term mortality among patients outsid...
Conference Paper
Full-text available
Colorectal cancer (CRC) is the 3rd most common cancer diagnosed in males and second in females, with approximately around 1.4 million cases of CRC were diagnosed and over 690, 000 deaths were reported in 2012. The majority of CRC are classified as adenocarcinoma (AC) and approximately 10-15% of CRC patients are presented with mucinous carcinoma (MC...
Article
Systemic lupus erythematous (SLE) patients are a high-risk population for suicide. Glutamatergic neurosystem genes have been implicated in the neurobiology of depression in SLE and suicidal behaviour in general. However, the role of glutamate receptor gene polymorphisms in suicidal behaviour among SLE patients remains unclear in the context of esta...
Article
Background and objective Although the multi‐ethnic European Respiratory Society/Global Lung Initiative (ERS/GLI) 2012 reference values have been developed, the Taskforce has called for further validation specifically on subpopulations that were under represented such as the Malays, Chinese and Indians, in which the two latter ethnic groups represen...
Article
Full-text available
Objective: Malaysia has a high and rising prevalence of type 2 diabetes (T2D). While environmental (non-genetic) risk factors for the disease are well established, the role of genetic variations and gene-environment interactions remain understudied in this population. This study aimed to estimate the relative contributions of environmental and gen...
Article
Full-text available
The Malaysian Cohort study was initiated in 2005 by the Malaysian government. The top-down approach to this population-based cohort study ensured the allocation of sufficient funding for the project which aimed to recruit 100 000 individuals aged 35–70 years. Participants were recruited from rural and urban areas as well as from various socioeconom...
Article
Full-text available
The prevalence of Type 2 diabetes is rising rapidly in both developed and developing countries. Asia is developing as the epicentre of the escalating pandemic, reflecting rapid transitions in demography, migration, diet, and lifestyle patterns. The effective management of Type 2 diabetes in Asia may be complicated by differences in prevalence, risk...
Article
Full-text available
(b/a ratio) was found to be a good measure of high-risk of atherosclerosis in parallel with CIMT measurement. In addition, pulse pressure (PP) which is an indicator of arterial stiffness, was found to be positively correlated to CIMT. PP, b/a index and subject’s height (H) were used to predict a high-risk of atherosclerosis by means of a logistic r...
Article
Full-text available
Objective: Radiological investigations that use ionising radiation pose well-established risks to patients. Doses per patient from computed tomographic examinations constitute large radiation burdens, particularly with recurrent imaging and multidetector machines. Yet, referring doctors often have a poor understanding of these risks. The objective...
Article
Objective: Food handlers play an important role in ensuring food safety throughout the chain of production, processing, storage and preparation. This study was aimed to determine knowledge, attitude and practice of food handlers towards food-borne diseases and food safety and to evaluate the effectiveness of the health education program Materials a...
Article
Objective: Diseases spread through food still remain common and persistent problems resulting in appreciable morbidity and occasional mortality. This study was conducted to test the reliability of a newly developed structured questionnaire on knowledge, attitude and practice of food handlers towards food-borne diseases and food safety. Materials an...

Network

Cited By