Nora Eisemann

• Dr rer hum biol
• Statistician at University of Lübeck

Zusammenfassung Hintergrund In Deutschland wurde 2008 ein flächendeckendes Hautkrebsscreening eingeführt. Welche nachfolgend beobachteten Veränderungen in der Epidemiologie des malignen Melanoms (MM), Plattenepithelkarzinoms (SCC) und Basalzellkarzinoms (BCC) auf das Screening zurückzuführen sind, ist unklar. Mit Simulationsmodellen werden verschi...

Artificial intelligence (AI) in mammography screening has shown promise in retrospective evaluations, but few prospective studies exist. PRAIM is an observational, multicenter, real-world, noninferiority, implementation study comparing the performance of AI-supported double reading to standard double reading (without AI) among women (50–69 years ol...

Background Comprehensive skin cancer screening was introduced in Germany in 2008. It is unclear whether subsequently observed changes in the epidemiology of malignant melanoma (MM), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are due to the screening. Simulation models are used to compare different screening scenarios with each oth...

Background: Infection with human papillomavirus (HPV) is one of the more common sexually transmitted diseases in Germany. Vaccination against HPV was introduced in Germany in 2007. In this study, we sought to detect a population-based decline in the incidence of cervical cancer in women under age 30 who were eligible for vaccination in the first 1...

Simple Summary An important component in the study of survival in breast cancer patients is how the tumor is detected. This involves examining whether and to what extent survival differs when the tumor is detected, for example, by screening or by symptoms. In such an analysis, it is important to note that survival times are influenced by several bi...

Background: New treatment options for cutaneous melanomas with a poor prognosis have been available since 2011, including immune therapies and targeted drugs. Randomized controlled trials have demonstrated that these treatments improve survival, but no population-level studies have been available to date. Methods: All patients in the database of...

Background And Aims The evidence for the benefit of the skin cancer screening introduced in Germany in 2008 is weak. We investigate to what extent data from the German epidemiological cancer registries are suitable to contribute to the evaluation of skin cancer screening and report these evaluation results. Material And Methods Skin cancer‐related...

Background There are regional differences in skin cancer screening uptake in Germany. So far, it is unclear whether a high uptake of screening services leads to a reduction in mortality. This article presents study results on the investigation of spatiotemporal associations between skin cancer screening and mortality. The methods used are discussed...

Background Germany‐wide skin cancer screening was introduced in 2008 to reduce skin cancer mortality and morbidity. However, the effectiveness of the program is still unclear. We explore the relationship between early‐stage melanoma incidence and melanoma mortality in subsequent years, using early‐stage melanoma incidence as surrogate for screening...

Zusammenfassung Hintergrund und Ziele Die Evidenz für einen Nutzen des 2008 in Deutschland eingeführten Hautkrebsscreenings ist schwach. Wir untersuchen, inwieweit Daten der deutschen epidemiologischen Krebsregister geeignet sind zur Evaluation des Hautkrebsscreenings beizutragen, und berichten diese Evaluationsergebnisse. Material und Methodik D...

Zusammenfassung Hintergrund und Ziele Die steigende Hautkrebshäufigkeit in Deutschland hat den Bedarf an sekundärpräventiven Maßnahmen erhöht. Hierfür wurde zum 01.07.2008 ein gesetzliches Hautkrebsscreening für Versicherte ab 35 Jahren eingeführt. Ziel dieses Arbeitspakets im Innovationsfonds‐Projekt „Perspektiven einer multimodalen Evaluation de...

Background and goals The rising incidence of skin cancer in Germany has increased the need for secondary prevention measures. For this purpose, a statutory skin cancer screening for insured persons aged 35 and older was introduced on 1 June 2008. The aim of this work package in the Innovation Fund project “Perspectives of a multimodal evaluation of...

Zusammenfassung Hintergrund In Deutschland wurde 2008 ein flächendeckendes Hautkrebsscreening eingeführt, um die Hautkrebsmortalität und ‐morbidität zu senken. Noch unklar ist jedoch die Wirksamkeit des Programms. Wir untersuchen den Zusammenhang zwischen der Inzidenz von Melanom‐Frühstadien und Melanom‐Mortalität in den Folgejahren, wobei die Inz...

Zusammenfassung Hintergrund Es bestehen regionale Unterschiede in der Hautkrebsfrüherkennungsinanspruchnahme in Deutschland. Bislang ist ungeklärt, ob eine hohe Inanspruchnahme von Früherkennungsleistungen zu einer Senkung der Mortalität führt. Dieser Beitrag präsentiert Studienergebnisse zur Untersuchung raumzeitlicher Assoziationen von Hautkrebs...

Background In the present study, we investigated the dynamics of immunity over time by measuring anti SARS-CoV-2 IgG antibodies and SARS-CoV-2 specific T-cell responses (interferon-gamma release assay) after two doses of vaccines in residents and health care workers (HCW). Mostly, 224 (98%) residents and 244 (89%) HCW received two doses of mRNA vac...

Purpose Psychosocial health (PH) and quality of life (QoL) are important health outcomes. We compared PH and QoL of adolescents conceived with intrazytoplasmatic sperm injection (ICSI) and of naturally conceived controls. The impact of disclosure of ICSI-conception on QoL and PH was quantified. Methods The cross-sectional sample consisted of 545 I...

Background. Several retrospective studies have illustrated the potential clinical benefit of artificial intelligence (AI) systems for breast cancer screening. Some systems optimize normal mammography examination triaging, while others aim to improve cancer detection. However, no AI system has shown specificity high enough to replace human radiologi...

Background Scientists, physicians, and the general public legitimately expect scholarly publications to give true answers to study questions raised. We investigated whether findings from studies published in journals with higher Journal Impact Factors (JIFs) are closer to truth than findings from studies in less-cited journals via a meta-epidemiolo...

Background Survival is a key metric of the effectiveness of a health system in managing cancer. We set out to provide a comprehensive examination of worldwide variation and trends in survival from brain tumors in adults, by histology. Methods We analyzed individual data for adults (15–99 years) diagnosed with a brain tumor (ICD-O-3 topography code...

Background In Germany, CRT devices with defibrillator capability (CRT-D) have become the predominant treatment strategy for patients with heart failure and cardiac dyssynchrony. However, according to current guidelines, most patients would also be eligible for the less expensive CRT pacemaker (CRT-P). We conducted a cost-effectiveness analysis for...

Background Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults (aged 15–99 years) diagnosed with a haematological malignancy during 2000–14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and morphology, in yo...

Background: CONCORD-3 highlighted wide disparities in population-based 5-year net survival during 2000-2014. Clinical evidence suggests marked international differences in the proportion of lethal acral and nodular subtypes. Objectives: We aim to assess whether the differences in morphology may explain global variation in survival. Methods: We...

In the present study, we were interested in the decline over time of anti SARS-CoV-2 antibodies and SARS-CoV-2 specific T-cell responses after two doses of mRNA vaccines in total and by age group and comorbidity. The second goal was to suggest an immunological correlate for protection on an individual basis and to describe the probability of protec...

Aims The Virtual Diabetes Outpatient Clinic for Children and Adolescents (VIDIKI) study was a 6-month quasi-randomized, multicentre study followed by an extension phase to evaluate the effects of monthly video consultations in addition to regular care. A health economic analysis was conducted to assess the direct costs. Methods The cost data of 240...

Background: Scientists, physicians, and the general public legitimately expect scholarly publications to give true answers to study questions raised. We investigated whether findings from studies published in journals with higher Journal Impact Factors (JIFs) are more accurate than findings from studies in less-cited journals via a meta-epidemiolog...

In Germany, approximately 3% of all newborns are born after infertility treatment. The most common method of assisted reproduction (ART) is intracytoplasmic sperm injection (ICSI). Whether there are health disadvantages in children and adolescents born after ICSI treatment remains controversial. The German ICSI long-term study includes a cohort of...

Zusammenfassung Ziel der Studie Die Berücksichtigung psychosozialer Problemfelder zählt zu den Merkmalen einer guten Versorgung, auch von Patienten mit Morbus Crohn (MC) oder Colitis ulcerosa (CU). Seit 2014 wird Betroffenen mit chronisch entzündlicher Darmerkrankung (CED) online ein kostenfreies fragebogengestütztes Problemfeld-Assessment mit Vers...

IntroductionCurrent health care data reveal suboptimal prevention in patients with coronary artery disease and an unmet need to develop effective preventive strategies. The New Technologies for Intensive Prevention Programs (NET-IPP) Trial will investigate if a long-term web-based prevention program after myocardial infarction (MI) will reduce clin...

Objective To explore the outcomes of monthly video consultations for children with diabetes. Methods The Virtual Outpatient Diabetes Clinic for Children and Youth (VIDIKI) was a 6‐month multicenter controlled clinical trial followed by an extension phase. The 240 participants (1‐16 years), all using a CGM, were quasi‐randomized by residence locati...

The use of assisted reproductive therapies for the treatment of subfertile couples has been increasing significantly worldwide for several decades. As offspring grow up, their general and health development as well as knowledge about the fertility of the following generation also gain in importance. To date, only limited data are available to compa...

Research Question Are there differences in the cardio-metabolic health of ICSI-conceived adolescents compared to a control group, taking parental risk factors into account? Design ICSI-conceived adolescents (n=272), their mothers (n=271) and naturally conceived control adolescents (n=273) and their mothers (n=273) provided a blood test and answere...

Study question: Are there any differences in the pubertal development and reproductive hormone status during adolescence between singletons following ICSI therapy or spontaneous conception (SC)? Summary answer: Pubertal development and reproductive hormone levels are largely similar between ICSI and SC adolescents, except for a tendency towards...

Background Cardiac resynchronisation therapy (CRT) is a well-established form of treatment for patients with heart failure and cardiac dyssynchrony. There are two different types of CRT devices: the biventricular pacemaker (CRT-P) and the biventricular defibrillator (CRT-D). The latter is more complex but also more expensive. For the majority of pa...

Effective population‐based mammography screening should impact breast cancer (BC) incidence, age and stage‐specific incidence and BC mortality. We aim to investigate such effects in a time period of 10 years after implementation of the German mammography screening program. Data on 323,719 breast cancer patients from 2003 to 2014 for defined regions...

Background The introduction of continuous glucose monitoring (CGM) implies new challenges for diabetes care. As CGM systems are often directly linked to a web-based software solution, structured telemedicine care using a video-consultation may be a new option for families who care for children with type 1 diabetes mellitus (T1DM). Methods “ViDiKi”...

Purpose Screening for colorectal cancer (CRC) by colonoscopy was implemented in Germany in 2002. Although the procedure has proven to be effective in reducing disease-specific mortality in numerous clinical studies, its effect at the population level is unclear. We performed an ecological study at the level of 358 German districts, testing the hypo...

For frequent pediatric chronic conditions, especially less common chronic conditions patient education programs are missing. A recently developed modular patient education approach (ModuS) combines disease-specific modules with generic psychosocial topics. ModuS was associated with increased disease-specific knowledge and improvements in families'...

Das 2008 in Deutschland eingeführte Hautkrebsscreening (HKS) zielt darauf ab, die hautkrebsspezifische Sterblichkeit und Krankheitslast zu reduzieren. Inwieweit das gelingt, ist Gegenstand einer kontroversen Debatte. Dieser Beitrag gibt auf Basis einer selektiven Daten- und Literaturrecherche einen Überblick zur Epidemiologie des malignen Melanoms...

Background: Differences in melanoma relative survival (RS) between histologies were discussed to be mainly caused by tumor thickness. Objective: To investigate RS from melanoma, stratified by tumor thickness for each histological subtype, and identify survival trends. Methods: Using cancer registry data on melanoma cases (ICD-10: C43.0-C43.9)...

Up-to-date melanoma relative survival (RS) estimates and trend analysis facilitate close monitoring of melanoma patients' prognosis. This study aimed to provide recent 5-year and 10-year RS from melanoma, stratified by prognostic factors, and identify latest survival trends. Data from 12 German cancer registries were analysed. We included patients...

In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. Methods CONCORD-3 includes individual records for 37·5 million patients diagn...

Background: In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. Methods: CONCORD-3 includes individual records for 37·5 millio...

Background: Patients with dementia (PwD) are a vulnerable group and caring for these patients in acute care hospitals is challenging. Structural conditions and standardized treatment procedures in hospitals often do not correspond to the needs of this patient group. Physicians may not be well prepared for caring for PwD. Objective: This study ai...

Objective The main purpose of skin cancer screening is melanoma mortality reduction. Before the implementation of nationwide German skin cancer screening, the pilot project SCREEN was conducted in Schleswig-Holstein in 2003–2004. We aimed to determine whether the pilot project had achieved a mortality reduction. Methods Using an incidence-based ap...

The cancer registry in Germany collects area-wide small-area data that can be presented in themes (disease mapping). Because of the occurrence of random extreme values of rates, mapping without prior spatial-statistical data analysis is problematic from a methodological and risk-communicative viewpoint - the extreme values easily mislead the card r...

Introduction: Population-level survival has improved for common haematologic malignancies in the early 21st century. However, relatively few population-level data are available for rare haematologic malignancies. Methods: Data were extracted from 12 cancer registries in Germany and the Surveillance, Epidemiology and End Results database in the U...

Early detection is considered to improve the prognosis of cutaneous melanoma. The value of population-based screening for melanoma, however, is still controversial. The aim of this study was to evaluate the predictive power of established risk factors in the setting of a population-based screening and to provide empirical evidence for potential ris...

Background: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia....

Aim: Parent-reporting is needed to examine Quality of Life (QoL) of children with cerebral palsy (CP) across all severities. This study examines whether QoL changes between childhood and adolescence, and what predicts adolescent QoL. Method: SPARCLE is a European cohort study of children with CP, randomly sampled from population databases. Of 81...

Objective: To support families with a chronically ill child, a modular curriculum and new healthcare structures (trainer education, quality management) for a group self-management program (ModuS) were developed. ModuS focuses on common psychosocial aspects of chronic conditions and comprises generic and disease-specific modules. A pilot test was c...

Background: The rate of interval cancers is an established indicator for the performance of a cancer-screening programme. Methods: We examined the incidence, tumour characteristics and risk factors of melanoma interval cancers that occurred in participants of the SCREEN project, which was carried out 2003/2004 in Schleswig-Holstein, Germany. Dat...

Linked Article: Trautmann et al. Br J Dermatol 2016; 175:912–919.

Background Little is known about the psychosocial development and health-related quality of life (HRQOL) of extremely preterm infants once they are adolescents. Methods The regional population-based study cohort included 90 extremely premature infants (< 27⁺⁰ gestational weeks) born between January 1997 and December 1999 in the German state of Schl...

Background: Benefits of skin cancer screening remain controversial. Objective: We sought to update evidence on the impact of skin cancer screening and secondary prevention campaigns on skin cancer incidence, mortality, stage-specific incidence, and interval cancers after negative screening. Methods: We searched MEDLINE and EMBASE for studies p...

Hintergrund: CED-Patienten sind häufig mit komplexen krankheitsbedingten Belastungen konfrontiert. Ihnen bietet die medizinische Rehabilitation eine multidisziplinäre und multimodale Behandlungsoption an. Unklar ist, wer dieses Angebot nutzt und welche Effekte zu erwarten sind. Methodik: Verglichen wurden Befunde aus 2 zeitlich parallel durchgeführ...

Im Rahmen der Gesundheitsberichterstattung will das Krebsregister Schleswig-Holstein der Beschreibung des Krebsgeschehens im Lande eine weitere Facette hinzufügen. Üblicherweise werden Daten zu Krebs für größere administrative Einheiten präsentiert - auf Ebene der Kreise und kreisfreien Städte oder gar auf Landesebene. Eine solche grobe räumliche A...

Zusammenfassung Selektierte klinische Kohorten sind gekennzeichnet durch ein häufiges Vorkommen von ungewöhnlichen Expositionen und hoher Inzidenz der untersuchten Endpunkte. Sie erlauben damit Analysen, die auf der Basis von bevölkerungsbezogenen Kohorten nicht möglich sind. Die Daten aus dem German Neonatal Network (GNN) sind eine gute Ausgangsla...

Background: Non-melanoma skin cancer (NMSC) is the most common cancer in Germany, but detailed information on survival is lacking. Objectives: To provide survival estimates for female and male patients with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), sarcoma, adenocarcinoma, and Merkel cell carcinoma. Further subgroup analyses wer...

Zehn Jahre sind seit der Einführung des Mammographie-Screenings (MSP) in Deutschland vergangen, eine Gesamtschau auf Teilnahme und Befunde fehlt bislang.

Emergency department (ED) management of the German STEC O104:H4 outbreak in 2011 was not limited to patients being truly infected with STEC. In parallel to spread of alarming news in public media, patients suffering from diarrhea due to other reasons fearfully presented, equally. We retrospectively characterized these two cohorts for anamnestic, cl...

This is the protocol for a review and there is no abstract. The objectives are as follows: To identify, appraise and summarise the best evidence for the efficacy of non-pharmacological interventions for sleep disturbances in people with dementia. To describe the components and processes of any complex intervention used.

Background: Nationwide skin cancer screening was introduced in Germany in 2008. The positive results of a pilot project carried out in 2003-4 in the federal state of Schleswig-Holstein had implied that screening would lower the mortality from melanoma. Methods: Data on the incidence of invasive malignant melanoma of the skin (MM; ICD-10: C43) we...

Nicht-melanozytärer Hautkrebs (NMSC = nonmelanoma skin cancer) ist die häufigste Krebserkrankung in Deutschland. Allerdings herrscht weitgehende Unklarheit über Inzidenztrends des NMSC und dessen häufigste Untertypen, Basalzellkarzinom (BCC) und Plattenepithelkarzinom (SCC), in Deutschland. Die Daten aus Krebsregistern von 14 deutschen Bundesländer...

Nonmelanoma skin cancer (NMSC) is the most common malignant neoplasm in Germany. However, little is known about incidence trends of NMSC and its main subtypes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in Germany. Cancer registry data from fourteen German federal states was used to estimate age-standardized incidence rates by hist...

We aimed at investigating the distribution and risk of all second discordant primary cancers (SDPCs) after a specific first primary cancer in Germany and Sweden to provide etiological understanding of SDPCs and insight into their incidence rates and recording practices. Among 1,537,004 survivors of first primary cancers in Germany and 588,103 in Sw...

Background Shiga toxin-producing, enteroaggregative Escherichia coli was responsible for the 2011 outbreak of haemolytic uraemic syndrome (HUS). The present single-centre, observational study describes the 1-year course of the disease with an emphasis on kidney function. Outcome data after 1 year are associated with treatment and patient characteri...

Background: The final exam grade is the main selection criterion for medical school application in Germany. For academic success, it seems to be a reliable predictor. Its use as the only selection criterion is, however, criticised. At some universities, personal interviews are part of the selection process. However, these are very time consuming an...

We analysed at what age parents start complementary food in very low birth weight infants, determined risk factors for early introduction of complementary food (post-term age) and analysed whether the age at introduction of complementary food influences height or weight at 2 years of age. Parents of premature infants born in 2009-2011 answered ques...

This study describes and compares health-related quality of life (HRQOL) of prostate cancer patients who received either radical prostatectomy (nerve-sparing, nsRP, or non-nerve-sparing, nnsRP) or radiotherapy (external RT, brachytherapy, or both combined) for treatment of localised prostate cancer. The prospective, multicenter cohort study include...

Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. Individual tumour records were submitted by 279 population-based cancer registries in...

Chronic lymphocytic leukaemia (CLL) patients often remain asymptomatic for several years after diagnosis. When the disease becomes symptomatic or progressive, chemotherapy with fludarabine in combination with an anti-CD20 antibody (FCR) is recommended as standard therapy, except for patients with relevant comorbidity or with del(17p13) oder TP53 mu...

Although many activities depend on intact fine motor skills no standardized assessment has been broadly established. The 20 cents test (20-C-T) was developed in 2009 and takes less than 5 mins. The quality criteria were investigated within the framework of this study. A total of 300 geriatric patients participated in the study. The classification o...

Oral and pharyngeal cancer is still a serious health problem with an annual incidence of about 13,000 in Germany. This study aimed at describing trends of incidence and mortality in Germany by age, sex, and sub-site as a baseline for an oral cancer prevention campaign. Using data from the National Association of Population-based Cancer Registries,...

In Schleswig-Holstein wurde von Juli 2003 bis Juni 2004 ein Pilotprojekt zum Hautkrebsscreening (SCREEN) durchgeführt. Der Einfluss dieses Screenings auf die stadienspezifische Inzidenz des malignen Melanoms ist bislang unbekannt, aber für die Bewertung des Screenings von großer Bedeutung. Hypothetisch sollte ein effektives Hautkrebsscreening mitte...

Background Children with cerebral palsy who can self-report have similar quality of life (QoL) to their able-bodied peers. Is this similarity also found in adolescence? We examined how self-reported QoL of adolescents with cerebral palsy varies with impairment and compares with the general population, and how factors in childhood predict adolescent...

Background: A nationwide skin cancer screening (SCS) was implemented in Germany in 2008. It aims at improving early detection of melanoma in order to reduce melanoma mortality. While the idea of early detection is compelling, demonstrating the effectiveness of melanoma screening is crucial. Since it is not feasible to conduct epidemiological studi...

The patient reported outcome in interventional studies is often measured with questionnaires at baseline and after the intervention. A person whose difference in outcome exceeds a critical threshold (the minimal important difference, MID) is classified as a responder, otherwise as a non-responder. The generally low reliability of differences causes...

Background In 2008 Germany was the first country to introduce a nationwide population-based skin cancer screening after a pilot project in Schleswig-Holstein had shown promising results. Objectives This article gives an overview of the current evidence for the effectiveness of a German skin cancer screening program. Material and methods The number...

A pilot project in skin cancer screening (SCREEN) was conducted in Schleswig-Holstein from July 2003 to June 2004. Although the impact of this screening on the stage-specific incidence of melanoma is of great importance for screening evaluation, it remains unknown. In theory, an effective skin cancer screening program should result in a medium-term...

The diagnosis of prostate cancer and the following treatment does not only affect the patient, but also his partner. Partners often suffer even more severely from psychological distress than the patients themselves. This analysis aims to describe the quality of life (QoL) after the cancer diagnosis over time and to identify the effects of possible...

The advent of tyrosine kinase inhibitors has produced 5-year survival of 90 + % for chronic myelocytic leukemia (CML) patients in clinical trials. However, population level survival has been lower, especially in older patients. Here, we examine survival of patients with CML in Germany and compare it to survival of patients in the United States (US)...

Non-melanoma skin cancer (NMSC) is the most common malignancy, whose public health significance is often unrecognized. This analysis has two objectives: First, to provide up-to-date incidence estimates by sex, age-group, histological type, and body site; second, to study the impact of skin cancer screening. The impact of screening on NMSC incidence...