Nora BourbiaUKHSA · Neurobiology
PhD in neurophysiology
Group Leader of the Neurobiology group at UKHSA (UK)
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
Citations since 2017
7 Research Items
Throughout my academic journey I was interested by the field of neuroepigenetics. How and why adult on-set of neurological/neuropsychiatric disorders/diseases start? At which moment and how the brain cells trigger a succession of events that cascade to the development and the maintenance of these disorders/diseases? To address these questions, my team and I at PHE (UK) is using animal behaviour, electrophy and genetic tools to investigate the neuroepigenetics of nervous disorders/diseases.
November 2014 - November 2015
- Problem-based learning teacher
- Problem-based learning teacher to master’s degree Transmed student at University of Helsinki. Topic : Urinary physiology ; year : 2014 ans 2015.
January 2010 - August 2015
- Doctoral student in neurophysiology of pain
- Title : Central nucleus of the amygdala in descending control of pain-related behavior.
Ochratoxin A (OTA) is a common mycotoxin and known contaminant of crops, foods and drinks. As OTA crosses the blood-brain barrier, this study investigated the role of OTA, as an environmental hazard, on neuronal survival and viability. The impact of a range of OTA concentrations on the expression of MAPT, BAX, P53, BDNF and TPPP genes was investiga...
Shift work (work outside of standard daylight hours) is common throughout the Western world. However, there are notable health consequences to shift work, including increased prevalence of mental health and sleep disorders in shift worker populations. Therefore, the health and wellbeing of shift workers is a public health concern that needs to be a...
Spermatogenesis-associated protein 13 (Spata13) is a guanine nucleotide exchange factor (GEF) enriched in discrete brain regions in the adult, with pronounced expression in the extended central amygdala (CeA). Loss of Spata13, also known as the adenomatous polyposis coli exchange factor Asef2, has no identifiable phenotype although it has been show...
Here we studied whether descending control of mechanical nociception by glutamate in the central nucleus of the amygdala (CeA) of healthy control animals is induced by amygdaloid NMDA receptors and relayed through the midbrain periaqueductal gray (PAG). Mechanical nociception in the hind paws was assessed in rats with chronic guide cannulae for glu...
Unlabelled: The central nucleus of the amygdala (CeA) is involved in processing and regulation of pain. We determined whether amygdaloid corticotropin-releasing factor (CRF) contributes to pain modulation in the neuropathic rat. Emotional aspect of pain was assessed by an aversive place-conditioning test and sensory aspect of pain by determining m...
A protein altering variant in the gene encoding zinc finger homeobox-3 (ZFHX3) has recently been associated with lower BMI in a human genome-wide association study. We investigated metabolic parameters in mice harbouring a missense mutation in Zfhx3 (Zfhx3Sci/+) and looked for altered in situ expression of transcripts that are associated with energ...
Switches between global sleep and wakefulness states are believed to be dictated by top-down influences arising from subcortical nuclei. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterized by a substantially reduced propensity to transition between wake and sleep states with an especially...
Sleep-wake transitions are modulated through extensive subcortical networks although the precise roles of their individual components remain elusive. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mutant line characterised by a reduced propensity to transition between all sleep states while a profound loss in...
Clinical studies have demonstrated comorbidity between painand depression or anxiety [1,2]. The prevalence of depression inpatientswithchronicpainreaches5–100%,theprevalenceofanxi-etydisorderreaches11–60%,andtheprevalenceofpaininpatientswithdepressiondisorderreaches15–100%dependingonthestudyand type of pain [3,4]. These comorbidities affect negativ...
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in...