Noora Ottman

• Doctor of Philosophy
• PostDoc Position at Karolinska Institutet

It is well established that different sites in healthy human skin are colonized by distinct microbial communities due to different physiological conditions. However, few studies have explored microbial heterogeneity between skin sites in diseased skin, such as atopic dermatitis (AD) lesions. To address this issue, we carried out deep analysis of th...

Akkermansia muciniphila is a well-studied anaerobic bacterium specialized in mucus degradation and associated with human health. Because of the structural resemblance of mucus glycans and free human milk oligosaccharides (HMOs), we studied the ability of A. muciniphila to utilize human milk oligosaccharides. We found that A. muciniphila was able to...

Background After the Second World War, the populations living in the Karelia area were strictly divided by the border between Finland and Russia. This resulted in the development of starkly different lifestyles, standard of living and exposure to the environment. The remarkable allergy disparity, both in children and adults, calls for immunological...

Background: Sufficient exposure to natural environments, in particular soil and its microbes, has been suggested to be protective against allergies. Objective: We aim at gaining more direct evidence of the environment-microbiota-health axis by studying the colonization of gut microbiota in mice after exposure to soil and by examining immune stat...

The discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine where it triggers both host metabolic and immune responses. A. muciniphila is...

The composition and activity of the microbiota in the human gastrointestinal tract are primarily shaped by nutrients derived from either food or the host. Bacteria colonizing the mucus layer have evolved to use mucin as a carbon and energy source. One of the members of the mucosa-associated microbiota is Akkermansia muciniphila, which is capable of...

Gut barrier function is key in maintaining a balanced response between the host and its microbiome. The microbiota can modulate changes in gut barrier as well as metabolic and inflammatory responses. This highly complex system involves numerous microbiota-derived factors. The gut symbiont Akkermansia muciniphila is positively correlated with a lean...

Proteomic analysis of A. muciniphila sucrose density-gradient fractions. Results are presented as log10 label-free quantification (LFQ) intensities. Non-existing LFQ intensity values due to not enough quantified peptides were substituted with the value 3.5. (XLSX)

Supporting information. Fig A. TNF- α/IL-10 cytokine induction ratio. Fig B. Silver staining of A. muciniphila LPS. Fig C. TLR2 signaling of acetate and propionate. Fig D. TEER development in purified proteins of A. muciniphila. Table A. PCR-primers used for plasmid construction. Table B. Number of cells seeded for the human HEK-Blue hTLR2/4/5/9/NO...

Obesity and type 2 diabetes are associated with low-grade inflammation and specific changes in gut microbiota composition. We previously demonstrated that administration of Akkermansia muciniphila to mice prevents the development of obesity and associated complications. However, the underlying mechanisms of this protective effect remain unclear. Mo...

Akkermansia muciniphila is a common member of the human gut microbiota and belongs to the Planctomycetes-Verrucomicrobia-Chlamydiae superphylum. Decreased levels of A. muciniphila have been associated with many diseases, and thus it is considered to be a beneficial resident of the intestinal mucus layer. Surface-exposed molecules produced by this o...

Akkermansia muciniphila is a Gram-negative, mucin-degrading bacterium that resides in the gastrointestinal tract of human and animals. A. muciniphila has been linked with intestinal health and improved metabolic status in obese and type 2 diabetic subjects. Specifically, A. muciniphila has been shown to reduce high-fat diet-induced endotoxaemia, wh...

Current meta-omics developments provide a portal into the functional potential and activity of the intestinal microbiota. The comparative and functional meta-omics approaches have made it possible to get a molecular snap shot of microbial function at a certain time and place. To this end, metagenomics is a DNA-based approach, metatranscriptomics st...

Synbiotics are used to manipulate the endogenous microbiota, but whether they are more effective than the constituting pro- and prebiotics alone remains to be determined. The objective of this work was to evaluate galacto-oligosaccharide (GOS), polydextrose (PDX) and Bifidobacterium lactis Bi-07 alone and in combinations in a simulated human colon...