Noopur Verma

Introduction: Artificial intelligence (AI) has the potential to revolutionize drug design and discovery by significantly reducing the time and costs involved in developing new drugs. This literature review aims to explore the use of AI in drug design, focusing on virtual screening, de novo drug design, and prediction of ADME properties. Objective:...

Purpose/Objective(s) Oligometastatic disease (OMD) is typically defined by a threshold number of metastases. Local ablative treatment of oligometastases is intended in part to prevent the development of new metastases elsewhere. It is unclear whether the size of metastases is associated with the risk of developing new metastasis. We hypothesized th...

Purpose/Objective(s) While a prescribed biologically effective dose (BED) of 100 Gy optimizes local control in early-stage non-small cell lung cancer (NSCLC), pulmonary oligometastases from radioresistant primary tumors such as colorectal cancer are associated with higher local failure rates despite similar radiotherapy (RT) regimens. We hypothesiz...

Purpose/Objective(s) While comprehensive local treatment of non-small cell lung cancer (NSCLC) oligometastatic disease (OMD) has thus far yielded promising results, challenges remain in selecting patients with a more localized oligometastatic phenotype, as opposed to those with a large subclinical systemic disease burden. We sought to identify clin...

Purpose/Objective(s) Stereotactic body raiation therapy (SBRT) is increasingly used to treat oligometastatic tumors. To account for internal motion, 4D-CT is commonly used for lung SBRT. Biology-guided radiotherapy (BgRT) is an emerging concept that may allow for reduction of treatment volumes using positron emission tomography (PET) signal guidanc...

Background: Tinea corporis and cruris is said to be recurrent when there is relapse of sign and symptoms after 6 weeks of cure. Recently, there has been increase in cases of recurrent tinea corporis and cruris, with atypical lesions. This study was done to establish efficacy and safety of different terbinafine regimens against recurrent tinea corpo...

Nanofluids that directly absorb solar radiation have been proposed as an alternative to selectively coated metallic receivers in solar thermal collectors. Given the expense of characterising a potential nanofluid experimentally methods for comparing nanofluids virtually are needed. This paper develops a computational wave optics model using COMSOL...

In 2011, UK’s low temperature heat (<500 °C) demand accounted for 41% of total industrial heat demand, which resulted into 70% of greenhouse gas emissions from the sector. India’s low temperature (80-250 °C) industrial heat demand accounted for 31% of its total energy consumption in 2006-2007. Theoretically concentrating solar thermal technologies...

Sophisticated modern research tools for evaluation of medicinal plants are available but microscopic methods are one of the simplest and cheapest methods to establish the identity of the source materials. Pharmacognostical investigation of the dried, powdered and anatomical sections of the fruits of Trachyspermum roxburghianum (DC) Craib was carrie...

Chrysanthemum stunt viroid (CSVd) belonging to Pospiviroidae was found prevailing in some of the chrysanthemum plant samples collected from various geographical regions of India. In this study 70% cultivars of chrysanthemum were tested positive for CSVd by reverse transcription polymerase chain reaction (RT-PCR) and DNA-RNA hybridisation. The viroi...

The study was undertaken to investigate the folkloric claim of Cressa cretica (CC) (Family: convolvulaceae) for antidiabetic effect of single oral administration of ethanolic extract to alloxan induced diabetic rats. The maximum glucose lowering effect of 11.86% was observed at 12 hour after the administration of 300mg/Kg. Repeated oral treatment w...

Tomato aspermy virus (TAV), along with Cucumber mosaic (CMV), Chrysanthemum B viruses (CVB) found infecting chrysanthemum cv. Regol Time either alone or in mixed conditions were eradicated from the plants using in vitro techniques combined with meristem tip culture, chemotherapy and thermotherapy. The plants were indexed by bioassay, enzyme linked...

The hepatoprotective activity of the ethanolic extract of the rhizomes of Costus speciosus (Koenig) Sm. was studied on carbon tetrachloride treated rats. The extract registered a significant fall in the levels of serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), serum bilir...

Tomato aspermy virus (TAV), an important viral pathogen of chrysanthemums, was detected by double antibody sandwich-enzyme linked immunosorbent assay (DAS-ELISA) from chrysanthemums exhibiting mottling and deformed inflorescence grown in various states of India. Out of 15 cultivars (cvs.) tested, 11 (73.3%) were found to be positive for TAV. On sap...

Antioxidant activity of defatted ethanolic extract of fruits of Ficus bengalensis was studied for its free radical scavenging property in different in vitro models as 1, 1-Diphenyl-2-picryl hydrazyl (DPPH), nitric oxide, superoxide, hydroxyl radical and lipid peroxide radical model. The extract showed significant dose-dependent free radical scaveng...

Screening of chrysanthemum cultivars was carried out using enzyme linked immunosorbent assay (ELISA), northern hybridization and reverse transcription polymerase chain reaction (RT-PCR) for Chrysanthemum B (CVB), Cucumber mosaic (CMV), Tomato aspermy (TAV), tospo- and potyviruses. By hybridization and RT-PCR, 48.7%, 42.5%, 26.2%, 12.5% and 6.25% cu...

A survey of sixty one carnation cultivars growing in the state of Himachal Pradesh, India showing varied symptoms on the leaves and flowers, were screened through bioassay and ELISA which revealed the widespread presence of Carnation vein mottle virus (CVMoV) and Carnation ringspot virus (CRSV). Out of sixty-one cultivars tested forty-seven were fo...

Tomato aspermy virus (TAV), an important viral pathogen of chrysanthemums, was detected by Double antibody sandwich enzyme linked immunosorbent assay (DAS-ELISA) from chrysanthemums exhibiting mottling and deformed inflorescence grown in various states of India. Out of 15 cvs tested, 11 (73.3%) were found to be positive for TAV. On sap inoculation...

Rose geraniums (Pelargonium spp.) are important essential oil bearing plants of great demand in national and international markets. Geraniums are susceptible to several viruses; however, the incidence of Prunus necrotic ring spot virus (PNRSV) was not reported until recently. During the survey of geranium plantations in experimental fields of the I...

In a survey of lily growing fields in various parts of Himachal Pradesh, India, three viruses, Cucumber mosaic (CMV), Lily symptomless (LSV) and Lily mottle virus (LMoV) lily strain, were found quite prevalent in Asiatic (12 cultivars) and Oriental hybrids (4 cultivars) of lily, Lilium longiflorum and L. tigrinum. Apart from these viruses, Strawber...

In a survey of rose and lily plantations in experimental fields of the Institute of Himalayan Bioresource Technology, Palampur, a number of symptoms characteristic of nepoviruses were observed. Symptomatic rose and lily leaves were tested for the presence of nepoviruses. Strawberry latent ringspot virus (SLRSV) and Arabis mosaic virus (ArMV) were d...

Chrysanthemum morifolium cv. Regol Time plants were found to be infected with Chrysanthemum B carlavirus (CVB). They were made CVB-free by using meristem tip culture, chemotherapy and thermotherapy. The plants were indexed by biological assay, double antibody sandwitch enzyme linked immunosorbent assay (DAS-ELISA) and reverse transcriptase polymera...

Infection of Alstroemeria hybrids in India with a subgroup 1 strain ofCucumber mosaic virus (CMV) is reported for the first time. The virus was identified on the basis of host range, transmission byAphis gossypii andMyzus persicae in the non-persistent manner, ELISA, electron microscopy and RT-PCR using CMV-specific primers. CMV was detected in nin...

Gerbera jamesonii (family Asteraceae) is a popular perennial ornamental cut flower and potted plant with considerable economic importance. In a survey of gerbera grown in floriculture fields at the Institute of Himalayan Bioresource Technology (IHBT), Palampur and nearby nurseries, color break symptoms on the petals, asymmetrical ray florets, and d...

Chrysanthemum cv. Regol Time was found infected with a viral disease showing characteristic chlorotic spots on leaves and stunting of plants. The virus was identified as Cucumber mosaic cucumovirus (CMV) on the basis of mechanical inoculation on Chenopodium amaranticolor and Cucumis sativus, DAS-ELISA and RT-PCR. CMV was eliminated from chrysanthem...

A study was conducted to examine the impact of the perspiration of the fading behavior of dichlorotriazine reactive dyes. Scoured cotton fabric was dyed in 1.0% shade on laboratory model semi-automatic Jigger. The dye solution was prepared comprising above mentioned chemicals. For the application of dye, fabric was padded as per experimental design...

750 × 11 nm) were observedin both the leaf epidermis of infected plants and purifiedpreparations. In ultrathin sections of the leaves, character-istic potyvirus-like cylindrical inclusions were observed.In double-diffusion tests and DAS-ELISA, the purifiedpreparations reacted with DsMV-specific antibodies (Agdia,USA). These observations lead to the co...

During a survey of chrysanthemum cvs. grown in Himachal Pradesh. (India) a variety of symptoms were seen. The disease incidence ranged between 40.62% and 94.66%. Out of 36cvs. surveyed 7 were found to be negative for CBV in DAS-ELISA. The virus has a very narrow host range infecting only N. clevelandii, N. glutinosa, N. rustica, Petunia hybrida and...

The need for environmentally friendly chemicals and processing techniques in the textile industry has become much more pressing, and the use of enzymes has revolutionized textile processing as they are safer, more efficient and very specific in nature. The structure and nature of enzymes are explained, and seven important properties listed. Factors...

Following a general introduction to these dyes, the materials used in the present study are specified - fabric, pretreatment of the fabric, chemicals and water. The methods describe the determination of exhaustion and fixation noting experimental conditions, and the determination of fixation efficiency. Dye exhaustion and fixation are significantly...

Hepatic artery infusion (HAI) chemotherapy has been used to treat patients with unresectable liver tumours. We report a preclinical study of the pharmacokinetics of HAI combined with hepatic venous drug extraction (HVDE) for regional administration of doxorubicin. HVDE was aided by a double balloon catheter inserted via femoral vein cutdown into th...

A swine model was developed to study quantitatively the pharmacokinetics of hepatic extraction and clearance of doxorubicin (DOX). Systemic and hepatic artery infusions of DOX (0.5-9 mg kg-1) were administered to 34 pigs. Pharmacokinetic analysis was simplified by use of a double-balloon catheter in the inferior vena cava to collect hepatic venous...

Hepatic artery infusion (HAI) has been used to take advantage of the steep dose-response relationship characteristic of chemotherapeutic agents. Systemic toxicity, however, remains the dose limiting factor for HAI of low hepatic extraction drugs. This investigation compared the pharmacokinetics of doxorubicin administered using a system that combin...

Ausgehend vom Oxazolin (I) wird auf dem im Formelschema skizzierten Weg das Bromid (IIIc) hergestellt, aus dem durch Umsetzung mit (IV) und anschließende Reduktion das Pyrrolidinon (VI) erhalten wird.