Noham Wolpe

Noham Wolpe
University of Cambridge | Cam · Department of Clinical Neurosciences

MD PhD
http://noham-wolpe.org/

About

35
Publications
6,246
Reads
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599
Citations
Introduction
Carrying out any action requires a stream of intricate computations in the brain, which can be influenced by many neurological and psychiatric disorders, and even by healthy ageing. My research interests lie in understanding the mechanism and the neural bases of these changes that occur across the lifespan and in cases of disease. To study this, I combine psychophysical, computational and neuroimaging methods.
Additional affiliations
October 2014 - December 2018
Hebrew University of Jerusalem
Position
  • MD in Clinical Medicine
October 2013 - September 2014
University of Cambridge
Position
  • PostDoc Position
October 2010 - September 2013
University of Cambridge
Position
  • PhD Student

Publications

Publications (35)
Article
Full-text available
Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial. Degeneration of the locus coeruleus-noradrenaline system is known to contribute to motivational deficits,...
Article
The pre-supplementary motor area (pre-SMA) is central for the initiation and inhibition of voluntary action. For the execution of action, the pre-SMA optimises the decision of which action to choose by adjusting the thresholds for the required evidence for each choice. However, it remains unclear how the pre-SMA contributes to action inhibition. He...
Article
Response inhibition is a core executive function enabling adaptive behavior in dynamic environments. Human and animal models indicate that inhibitory control and control networks are modulated by noradrenaline, arising from the locus coeruleus. The integrity (i.e., cellular density) of the locus coeruleus noradrenergic system can be estimated from...
Preprint
Vascular, cardiovascular and neurovascular ageing processes contribute to cognitive impairment. However, the unique and synergistic contributions of cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation of each other. We hypothesized that vascular risk fac...
Preprint
Full-text available
A bstract Apathy is a debilitating feature of many diseases, including Parkinson’s disease. We tested the hypothesis that degeneration of the locus coeruleus-noradrenaline system contributes to apathy by modulating the relative weighting of prior beliefs about action outcomes. Participants with mild-to-moderate idiopathic Parkinson’s disease ( N =1...
Preprint
Full-text available
Response inhibition is a core executive function enabling adaptive behaviour in dynamic 1 environments. Human and animal models indicate that inhibitory control and control networks 2 are modulated by noradrenaline, arising from the locus coeruleus. The integrity (i.e., cellular 3 density) of the locus coeruleus noradrenergic system can be estimate...
Article
Full-text available
Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory systems represents an important therapeutic strategy. Among these, the locus coeruleus-noradrenaline system has been extensively implicated in response inhibition defi...
Preprint
Full-text available
Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory systems represents an important therapeutic strategy. Among these, the locus coeruleus-noradrenaline system has been extensively implicated in response inhibition defi...
Article
Full-text available
Alien limb refers to movements that seem purposeful but are independent of patients’ reported intentions. Alien limb often co-occurs with apraxia in the corticobasal syndrome, and anatomical and phenomenological comparisons have led to the suggestion that alien limb and apraxia may be causally related as failures of goal-directed movements. Here, w...
Article
Full-text available
Apathy is a debilitating syndrome that is associated with reduced goal-directed behavior. Although apathy is common and detrimental to prognosis in many neuropsychiatric diseases, its underlying mechanisms remain controversial. We propose a new model of apathy, in the context of Bayesian theories of brain function, whereby actions require predictio...
Article
Full-text available
An alien limb is a debilitating disorder of volitional control. The core feature of alien limb is the performance of simple or complex semi-purposeful movements which the patient reports to be unintentional or unwanted, or occasionally in opposition to their intentions. Theories of the mechanism of alien limb phenomena have emphasised the role of d...
Article
Full-text available
The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 322, aged 18-89 years) using a v...
Preprint
Full-text available
Alien limb refers to movements that seem purposeful but are independent of patients' reported intentions. Alien limb often co-occurs with apraxia in the corticobasal syndrome, and anatomical and phenomenological comparisons have led to the suggestion that alien limb and apraxia may be causally related as failures of goal-directed movements. Here, w...
Preprint
Full-text available
Apathy is a debilitating syndrome that is associated with reduced goal-directed behaviour. Although apathy is common and detrimental to prognosis in many neuropsychiatric diseases, its underlying mechanisms remain controversial. We propose a new model of apathy, in the context of Bayesian theories of brain function, whereby actions require predicti...
Article
Full-text available
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Article
Full-text available
Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson’s disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted conse...
Article
Full-text available
Inhibitory control requires precise regulation of activity and connectivity within multiple brain networks. Previous studies have typically evaluated age-related changes in regional activity or changes in interregional interactions. Instead, we test the hypothesis that activity and connectivity make distinct, complementary contributions to performa...
Preprint
Full-text available
The ability to adapt one’s movements to changes in the environment is fundamental in everyday life, but this ability changes across the lifespan. Although often regarded as an ‘implicit’ process, recent research has also linked motor adaptation with ‘explicit’ learning processes. To understand how these processes contribute to differences in motor...
Article
Full-text available
Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson's disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted conse...
Code
For any researcher who is interested in using the intentional binding task, I am happy to share this code I wrote some years ago in Matlab with Psychtoolbox. Please contact me to receive the files.
Article
Full-text available
The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to sensorimotor attenuation - a reduction in the perceived intensity of sensations from self-generated compa...
Article
Full-text available
Parkinson’s disease (PD) can cause impulsivity with premature responses, but there are several potential mechanisms. We proposed a distinction between poor decision-making and the distortion of temporal perception. Both effects may be present and interact, but with different clinical and pharmacological correlates. Objectives. This study assessed...
Article
Full-text available
Parkinson's disease (PD) impairs the control of movement and cognition, including the planning of action and its consequences. This provides the opportunity to study the dopaminergic influences on the perception and awareness of action. Here we examined the perception of the outcome of a goal-directed action made by medicated patients with PD. A vi...
Article
Full-text available
People perceive the consequences of their own actions differently to how they perceive other sensory events. A large body of psychology research has shown that people also consistently overrate their own performance relative to others, yet little is known about how these "illusions of superiority" are normally maintained. Here we examined the visua...
Article
Full-text available
The investigation of human volition is a longstanding endeavor from both philosophers and researchers. Yet because of the major challenges associated with capturing voluntary movements in an ecologically relevant state in the research environment, it is only in recent years that human agency has grown as a field of cognitive neuroscience. In partic...
Article
Full-text available
The volitional impairments of alien limb and apraxia are a defining feature of the corticobasal syndrome, but a limited understanding of their neurocognitive aetiology has hampered progress towards effective treatments. Here we combined several key methods to investigate the mechanism of impairments in voluntary action in corticobasal syndrome. We...
Article
Full-text available
'Intentional binding' describes the perceived temporal attraction between a voluntary action and its sensory consequence. Binding has been used in health and disease as an indirect measure of awareness of action or agency, that is, the sense that one controls one's own actions. It has been proposed that binding results from cue integration, in whic...
Article
Full-text available
Women and men differ in the way they experience emotional events. Previous work has indicated that the impact of an emotional event depends on how it is anticipated. Separately, it has been shown that anticipation affects memory formation. Here, we assessed whether anticipatory brain activity influences the encoding of emotional events into long-te...

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Projects

Projects (2)
Project
The ability to act voluntarily is fundamental to humans, yet it has proved difficult to study experimentally. Only in recent decades has neuroscience research begun to rigorously tackle questions surrounding normal and impaired awareness and control of voluntary action. However, there remains a paucity of mechanistic accounts for disorders of movement. Such accounts are essential not only to better explain these disorders, but also to develop the theory concerning normal motor control. The aim of this project is to extend these mechanistic accounts through the use of experimental paradigms that probe distinct mechanisms in sensorimotor control.
Project
1) To determine the factors that contribute to healthy ageing of the motor system, as well as those that put elderly people at risk of experiencing problems with movement. 2) To establish a link between the mechanism of healthy ageing in the motor system and that in other cognitive domains, such as learning and memory.