Nobutaka Hattori

Nobutaka Hattori
Juntendo University · Department of Neurology

MD, PhD

About

1,009
Publications
72,783
Reads
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45,959
Citations
Citations since 2017
70 Research Items
15372 Citations
201720182019202020212022202305001,0001,5002,0002,500
201720182019202020212022202305001,0001,5002,0002,500
201720182019202020212022202305001,0001,5002,0002,500
201720182019202020212022202305001,0001,5002,0002,500
Additional affiliations
August 1990 - August 1993
Juntendo University
Position
  • Professor (Full)

Publications

Publications (1,009)
Article
Full-text available
Guanosine triphosphate cyclohydrolase I (GCH1) mutations are associated with increased risk for dopa-responsive dystonia (DRD) and Parkinson’s disease (PD). Herein, we investigated the frequency of GCH1 mutations and clinical symptoms in patients with clinically diagnosed PD and DRD. We used the Sanger method to screen entire exons in 268 patients...
Article
Full-text available
Background: Physical exercise has been considered as an effective non-pharmaceutical measure for the treatment of Alzheimer’s disease (AD). In this report, we described the effect of long-term forced and voluntary exercise on tau protein modification using tauopathy model mice, Tg601. Methods: 12-month-old non-transgenic and Tg601 mice were subject...
Article
Full-text available
Increasing evidence shows that metabolic abnormalities in body fluids are distinguishing features of the pathophysiology of Parkinson’s disease. However, a non-invasive approach has not been established in the earliest or pre-symptomatic phases. Here, we report comprehensive double-cohort analyses of the metabolome using capillary electrophoresis/l...
Article
Full-text available
Both the subthalamic nucleus (STN) and the globus pallidus pars interna (GPi) are major targets for neuromodulation therapy for movement disorders. An example of such a therapy is deep brain stimulation (DBS). The striatum is the primary target for pharmacological treatment of these disorders. To further our understanding of both the functional rel...
Article
Full-text available
Objectives To investigate the impact of sleep disturbances on Parkinson’s disease (PD) clinical motor subtypes and disease-related disability in a multicentre setting. Methods We report a cross-sectional relationship between sleep-related symptoms and clinical motor subtypes (tremor dominant (TD); intermediate; postural instability and gait distur...
Article
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We herein report the case of a 47-year-old female with the colony-stimulating factor 1 receptor (CSF1R) mutation p.G589R, which is related to hereditary leukoencephalopathy with axonal spheroid (HDLS). The patient presented with an early-onset cognitive decline and progressive aphasia. Brain magnetic resonance imaging revealed HDLS-related alterati...
Chapter
Parkinson’s disease (PD) is a common neurodegenerative disorder, with ageing being a major risk factor. Accordingly, estimates predict an increasing number of PD patients due to our expanding life span. Consequently, developing a true disease-modifying therapy is necessary. In this regard, monogenic PD offers a suitable means for determining pathog...
Article
Full-text available
Objective Parkinson's disease (PD) is a common, progressive, neurodegenerative disorder. With progression of PD, the wearing-off phenomenon occurs more frequently as a motor complication, decreasing the patient's quality of life. The aim of this study was to investigate the risk factors for the wearing-off phenomenon in Japanese PD patients. Method...
Article
Full-text available
Background: Early neurological worsening is associated with increased mortality and long-term functional disability. We developed the WORSEN score for predicting whether patients with stroke will deteriorate during the week after stroke onset and investigated its usefulness. Patients and methods: We retrospectively investigated the cases of 478...
Article
Background: We investigated the prevalence and impact of restless legs syndrome (RLS) and leg motor restlessness (LMR) in patients with Parkinson's disease (PD) in a multicenter study. Methods: A total of 436 PD patients and 401 age- and sex-matched controls were included in this study. RLS was diagnosed based on four essential features. LMR was...
Article
Background The relationship between hippocampal and amygdaloid volumes and depression in patients with Parkinson’s disease (PD) is a controversial issue. Purpose To investigate the correlation between the 15-item shortened version of the Geriatric Depression Scale (GDS-15) and gray matter volume in PD. Material and Methods In the present study, 4...
Article
Full-text available
We report a case of limb-shaking transient ischemic attack (TIA) caused by a dissection of the middle cerebral artery (MCA) following lung surgery under general anesthesia. An 81-year-old male patient who underwent lobectomy for lung cancer suddenly developed transient shaking movements of the neck and the left upper distal limb on postoperative da...
Article
Full-text available
Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium bovis (BCG) have been associated to several human autoimmune diseases such as multiple sclerosis (MS), but there are conflicting evidence on the issue. The objective of this study is to evaluate their role in Japanese patients affected by inflammatory demyelinating disorders of the...
Data
Movement of DCVs in a control axon.
Data
Movement of DCVs in a TBPH+/−; p150G50R axon.
Data
Movement of DCVs in a TBPH+/− axon.
Data
Movement of DCVs in a p150G50R axon.
Data
Consecutive FIB-SEM imaging of mitochondrial cristae in a dCHCHD2+/+ fly. Mitochondria of the indirect flight muscles in a 14-day-old adult fly. Scale bar = 500 nm.
Data
Supplementary Figures and Supplementary References
Data
Consecutive FIB-SEM imaging of mitochondrial cristae in a dCHCHD2-/- fly. Mitochondria of the indirect flight muscles in a 14-day-old adult fly. Scale bar = 500 nm.
Article
Peripheral nerve hyperexcitability (PNH) syndromes are caused by spontaneous discharges originating from motor axons. Antibodies against voltage-gated potassium channels (VGKC) are detected in some patients with PNH syndrome, but the cause in the remaining patients has not yet been clarified. The index patient was a 46-year-old female with recurred...
Article
Full-text available
Highlights • Fly model of Perry syndrome exhibits motor disturbance and impaired dopamine release. • Perry mutation in dynactin produces aggregation of dense core vesicles (DCVs) in axons and disrupts axonal flux of DCVs. • Removal of a copy of the TDP-43 gene improves retrograde flux of DCVs. Parkinsonian Perry syndrome (PS), caused by mutations...
Article
Background Unilateral spatial neglect (USN) is frequently found in ischemic stroke patients. Because USN is related to poor functional outcomes, evaluating recovery from USN after stroke is critical. Methods Patients with acute ischemic stroke with lesions in the right cerebral hemisphere on MRI and exhibiting left USN were administered the Behavi...
Article
We have assessed the frequency of alpha-synuclein (SNCA) mutations in Japanese patients with familial or sporadic Parkinson's disease (PD) and surveyed their associated clinical manifestations. We screened SNCA exon 3 in 988 patients without SNCA multiplications (430 with autosomal dominant PD and 558 with sporadic PD). We detected 1 patient harbor...
Article
A 49-year-old man with Parkinson's disease developed wearing-off and levodopa-induced dyskinesia with a dystonic component in the left upper limb. He decided to undergo deep brain stimulation. Asymmetric targets were chosen; for the right side, globus pallidus interna was selected to improve the dystonia in his left upper extremity, and for the lef...
Article
The ubiquitin (Ub) kinase PINK1 and the E3 Ub ligase Parkin, two gene products associated with young-onset Parkinson's disease (PD), participate in mitochondrial quality control. The phosphorylation of mitochondrial polyUb by PINK1, which is activated in a mitochondrial membrane potential (ΔΨm)-dependent manner, facilitates the mitochondrial transl...
Article
Full-text available
Mycobacterium is a genus of aerobic and acid-fast bacteria, which include several pathogenic organisms that cause serious diseases in mammals. Previous studies have associated the immune response against mycobacteria with multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system with unknown etiology. The role of mycoba...
Article
Full-text available
Spinocerebellar ataxia type 10 (SCA10) is an autosomal-dominant cerebellar ataxia that is variably accompanied by epilepsy and other neurological disorders. It is caused by an expansion of the ATTCT pentanucleotide repeat in intron 9 of the ATXN10 gene. Until now, SCA10 was almost exclusively found in the American continents, while no cases had bee...
Data
Fluorescent repeat-primed PCR analysis to assess C9orf72 mutation in an SCA10 family. Fluorescent repeat-primed PCR analysis of the C9orf72 gene revealed the presence of repeat expansion in the positive control but not in the proband (IV-1) or in her mother (III-3). (TIF)
Article
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensitive brain imaging techniques is essential to facilitate early diagnosis and assessment of disease severity. GM microstructure was assessed with GM-based spatial statistics applied to diffusion kurtosis imaging (DKI) and n...
Article
Full-text available
Background: Istradefylline is a selective adenosine A2A receptor antagonist approved for Parkinson's disease (PD) patients with wearing-off symptoms. The Japanese phase III trial showed that 20 mg of orally administrated istra-defylline decreased the Off-time. However, istradefylline showed prominent effects in some patients and no benefits in othe...
Article
Acute akinesia (AA) is an unusual motor complication in Parkinson's disease (PD). Reported risk factors for AA include infection, trauma, surgical intervention, and the withdrawal of antiparkinsonian medication. Recently, patients with genetic PD were reported to have a three-fold risk of AA than patients with non-genetic PD. We describe a patient...
Article
A 64-year-old woman with Parkinson's disease who developed motor fluctuations and both levodopa-induced and stimulation-induced dyskinesia, after long term treatment of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS), she underwent implantation of additional globus pallidus internus (GPi) DBS leads. Although an appropriate DBS targ...
Article
Full-text available
Heat shock protein 27 (HSP27) is a multidimensional protein that acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in protective roles in various disease states. The current review presents HSP27 in multiple disease...
Article
Introduction: There has been no clinical data on Japanese patients with Parkinson's disease with which to examine whether motor symptoms improve and to assess the safety profile after the dose of ropinirole was increased in those who had not achieved an optimal response to the ropinirole immediate-release formulation 15 mg/day or the controlled-re...
Article
Full-text available
Objective: Dopamine transporter (DAT) imaging with [(123)I]FP-CIT (DaTSCAN) is a widely used diagnostic tool for Parkinsonism and dementia. Since it was approved by the Japanese Ministry of Health, Labor, and Welfare in 2013, there have been no articles focusing on a Japanese normal population. The aim of this study was to examine the effect of ag...
Article
Full-text available
A recessive mutation in PLA2G6, which is known to cause infantile neuroaxonal dystrophy (INAD) and neurodegeneration associated with brain iron accumulation (NBIA), has recently been shown to be responsible for PARK14-linked dystonia-parkinsonism. To study the frequency of PLA2G6 mutations, including those caused by gene rearrangement in patients w...
Article
Full-text available
Parkinson’s disease (PD) is caused by the loss of dopaminergic neurons. Recently, specific T1-weighted magnetic resonance imaging (MRI) at 3 Tesla was reported to visualize neuromelanin (NM)-related contrast of dopaminergic neurons. Using NM-MRI, we analyzed whether disease severity and motor complications (MC) are associated with the degree of dop...
Article
Full-text available
Objectives: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder that may be caused in part by oxidative stress. Uric acid (UA) protects neurons in neurodegenerative disorders via antioxidative effects. The aim of this study was to investigate the relationship between the serum UA concentration and disease progression in MSA p...
Article
Both PINK1 and parkin are the responsible genes (PARK6 and PARK2, respectively) for familial early-onset Parkinson's disease (PD). Several lines of evidences have suggested that mitochondrial dysfunction would be associated with PD pathogenesis. Lewy body, one of PD pathological hallmarks, contains alpha-synuclein, a familial PD (PARK1/4)-gene prod...
Article
We report a case of bilateral hearing loss caused by decreased vascular flow in the anterior inferior cerebellar artery (AICA) territory. A 74-year-old man who experienced right hearing loss 5 months ago presented with bilateral deafness and right cerebellar ataxia; however, no ischemic lesion was detected in the bilateral AICA area. After stroke t...
Chapter
Mitochondrial quality control is a key process in tissues with high energy demands, such as the brain and muscles. Recent studies using Drosophila have revealed that the genes responsible for familial forms of juvenile Parkinson’s disease (PD), PINK1 and Parkin regulate mitochondrial function and motility. Cell biological analysis using mammalian c...
Article
Full-text available
After publication of the original article [1], it came to the authors' attention that there was an error in the number of male and female participants. The correct number is 90 male and 88 female, not 89 male and 89 female as originally reported. This error was present in the Methods section of the abstract and in Table 1.
Article
Cryptogenic stroke is not uncommon, and there is etiological heterogeneity of cryptogenic stroke regarding the underlying embolic source. So far, several potential embolic sources demonstrated on transesophageal echocardiography (TEE) including patent foramen ovale (PFO), and aortic arch plaques (AAPs) have been associated with the pathogenesis of...
Article
Behavioral and psychological symptoms of dementia (BPSD) occur in up to 80% of AD patients and represent one of the largest factors contributing to caregiver burden. To analyze the effect of galantamine on BPSD and caregiver burden, we treated a total of 50 patients with mild AD for 12 weeks and evaluated them using the Neuropsychiatric Inventory (...
Article
Full-text available
The role of metabolic diseases in ischemic stroke has become a primary concern in both research and clinical practice. Increasing evidence suggests that dysbiosis is associated with metabolic diseases. The aim of this study was to investigate whether the gut microbiota, as well as concentrations of organic acids, the major products of dietary fiber...
Data
Scatter plots of concentrations of fecal organic acids in ischemic stroke patients and control subjects. Means and standard deviations are indicated. (TIFF)
Data
Demographic profiles of subjects with and without bacteremia. (DOCX)
Data
16S and 23S rRNA gene-targeted primers used in this study. (DOCX)
Data
Scatter plots of fecal bacterial counts in ischemic stroke patients and control subjects. (A) Obligate anaerobes; (B) facultative anaerobes and aerobes; (C) Lactobacillus. Means and standard deviations are indicated. (TIFF)
Data
Comparisons of fecal Lactobacillus counts between ischemic stroke patients and control subjects. (DOCX)
Article
MAP route of exposure and MS. Japanese and Sardinian with certain HLA genotype are more likely to develop MS when exposed to MAP contaminated products.
Article
Full-text available
Introduction: We aimed to investigate the prevalence and severity of nonmotor symptoms (NMSs) and to identify factors affecting NMSs and the health-related quality of life of Japanese patients with Parkinson's disease (PD). Methods: A total of 1021 patients with PD who had one or more NMS and showed wearing-off under anti-parkinsonian treatment...
Article
Deep brain stimulation (DBS) is a surgical option for advanced Parkinson's disease. Although DBS is used to treat motor fluctuation, DBS may affect non-motor symptoms including mood disorders, cognitive dysfunction, and behavior problems. Impulse control disorders (ICDs) are abnormal behaviors with various manifestations such as pathological gambli...
Article
Patient-specific induced pluripotent stem cells (iPSCs) show promise for use as tools for in vitro modeling of Parkinson's disease. We sought to improve the efficiency of dopaminergic (DA) neuron induction from iPSCs by the using surface markers expressed in DA progenitors to increase the significance of the phenotypic analysis. By sorting for a CD...
Article
Full-text available
Renal cell carcinoma (RCC) patients who develop a paraneoplastic syndrome may present with neuromuscular disorders. We herein report the case of a 50-year-old man who suffered from progressive gait disturbance and muscle weakness. The results of a nerve conduction study fulfilled the criteria of chronic inflammatory demyelinating polyneuropathy. An...
Article
A 42-year-old man presented with coma from methanol intoxication (178 mg/dL; its metabolite, formic acid, 860 μg/mL). Continuous hemodiafiltration improved his disturbance of consciousness, but he subsequently developed cognitive dysfunction and parkinsonism, which were finally alleviated by rehabilitation and amantadine therapy. Brain MRI revealed...
Article
Full-text available
Background: Patients presenting with the classical idiopathic normal pressure hydrocephalus (iNPH) triad often show additional parkinsonian spectrum signs. Accurate differential diagnosis strongly influences the long-term outcome of cerebrospinal fluid (CSF) shunting. Objective: The aim of this study was to find potential CSF microRNA (miRNA) bioma...
Article
Full-text available
Background It is clinically rare to find cytomegalovirus (CMV)-associated encephalomyelitis in immunocompetent adults. Here, we present the case of an adult patient who developed acute transverse myelitis that was followed by immune-mediated disseminated encephalomyelitis. Case presentationA 38-year-old man developed acute paraplegia with paresthes...
Article
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by cerebral infarction related to mutations in the notch homolog protein 3 (NOTCH3). We enrolled 10 patients whose brain magnetic resonance imaging (MRI) fluid-attenuated inversion recovery images showed hyperintensities (HI) in the...
Article
Full-text available
FUS/TLS is an RNA/DNA-binding protein associated with neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Previously, we found that a prion-like domain in the N-terminus of FUS/TLS mediates co-aggregation between FUS/TLS and mutant huntingtin, the gene product of Huntington’s disease (HD). Here,...