Nizar Asadi

Nizar Asadi
Royal Brompton and Harefield NHS Foundation Trust · Thoracic Surgery

Doctor of Medicine

About

47
Publications
2,132
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158
Citations
Introduction

Publications

Publications (47)
Article
Aim Optimization of diabetic medications around the time of operation is critical to avoid complications, hence we aimed to conduct an audit to review perioperative diabetic medication prescribing. Method Drug charts for peri-operative cardiac and thoracic patients were reviewed retrospectively on Medchart, a local electronic system used for presc...
Article
Full-text available
Introduction The type of lung cancer surgery impacts on tumour manipulation during surgery and may drive dissemination of cancer cells into the vasculature, thus facilitating metastatic spread. The aim of this study was to investigate the impact of surgically induced trauma using peripheral blood from preoperative and postoperative patients with no...
Article
Background: Pulmonary carcinoids are rare tumors originating from neuroendocrine cells in the lungs. Because of their potentially infiltrative nature, surgical resection remains the treatment of choice. However, not all patients with technically resectable disease will be able to undergo surgery, primarily because of poor lung function or medical...
Article
Introduction Airway complications following lung transplantation are associated with significant morbidity and mortality; they can result to significant functional impairment, poor quality of life and frequent hospitalizations. Anastomotic stenosis remains the commonest post-transplant airway complication with an estimated incidence between 1.6-32%...
Conference Paper
Introduction and Objectives The impact of COVID-19 on the UK National Health Service (NHS) has been dramatic. Reconfiguration of medical facilities, redeployment of staff and implementation of COVID-19 hospital pathways became daily practice overnight. On the 17th of March, additional measures to reduce the nationwide spread of COVID-19 were introd...
Article
Objective: To evaluate and optimize surgical approaches to the management of retrosternal goiter. Material and methods: A cohort retrospective single-center study included 56 patients aged 68.3±9.8 years with retrosternal goiter who underwent surgery between 2004 and 2019. Right-sided goiter was diagnosed in 16 cases, left-sided goiter in 21 pat...
Article
Full-text available
Aims Nuclear grade has been recently validated as a powerful prognostic tool in epithelioid malignant pleural mesothelioma (E‐MPM). In other studies histological parameters including pleomorphic features and growth patterns were also shown to exert prognostic impact. The primary aims of our study are (1) externally validate the prognostic role of p...
Article
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition comprised of a group of disorders with shared clinicopathologic features. Manifestations of IgG4-RD are increasingly recognized in multiple organs, but tracheal involvement remains rare. Patients may present with a mass in the affected organ and most will respond to glucoco...
Conference Paper
Introduction There is limited evidence regarding the optimal number of sampling sites and specimen dimension in histological diagnosis of malignant pleural mesothelioma (MPM). Previously we have validated 2-tier nuclear grade as an independent predictor of survival in epithelioid MPM. This study evaluates the association between sampling parameters...
Article
Nuclear grading systems for epithelioid malignant pleural mesothelioma (MPM) have been proposed but it remains uncertain if they could be applied in a biopsy-heavy setting. Using the proposed system, we conducted an independent, external validation study using 563 consecutive cases of epithelioid MPM diagnosed at our institution between 2003 and 20...
Article
Full-text available
Introduction Lung cancer survival remains poor in the western world due to late presentation in most cases, leading to difficulty of treatment in these advanced and metastatic patients. Therefore, the development of a robust biomarker for prognosis and to monitor treatment response and relapse would be of great benefit. The use of Alu repeats and D...
Article
The role of surgery in malignant pleural mesothelioma (MPM) remains debatable; nonetheless the relative advantages of different surgical approaches are frequently reassessed and reconsidered. While extensive operations and longer recovery periods can be justified for a group of carefully selected patients, many will present at an advanced stage of...
Conference Paper
Full-text available
Introduction Post drain removal pneumothorax is common in thoracic surgery and the complication strongly influences length of stay. Currently, no consensus exists on the acceptable frequency nor have any drain removal protocol been validated. The aim of this audit is to determine the expected standard to which nursing staff would consider acceptab...
Poster
For patients undergoing thoracic surgery at our institution, we aimed to evaluate surgeon decision versus protocol management of chest drain in terms of length of hospital stay and drain related complications.
Article
Background: The ability to sub-stratify survival within stage I is an important consideration as it is assumed that survival is heterogeneous within this sub-group. Liang et al. recently published a nomogram to predict post-operative survival in patients undergoing lung cancer surgery. The aim of our study is external validation of their published...
Article
We wanted to determine the accuracy of transthoracic ultrasound in the prediction of chest wall infiltration by lung cancer or lung infiltration by chest wall tumours. Patients having preoperative CT-scan suspect for lung/chest wall infiltration were prospectively enrolled. Inclusion criteria for lung cancer were: obliteration of extrapleural fat,...
Article
A 75 year-old man with a lesion in the middle lobe of the lung was discovered to also have, during the follow-up period, a mass in the mediastinum, diagnosed as a multi-thymic cyst. Both pathologies were successfully treated with a single surgical approach by video-assisted thoracoscopy. We performed a middle VATS lobectomy with complete lymphadene...
Article
Full-text available
Oncological surgery of the chest wall should be performed to achieve free margins of at least 2 cm for metastasis or 4 cm for primary tumours. When the lesion is not visible or palpable, difficulty in identification may lead to a larger incision and a resection wider than is necessary. We report three cases of non-palpable metastatic chest wall les...
Article
Patients with end-stage renal disease on hemodialysis undergoing surgery for lung cancer represent a high-risk group because of electrolyte imbalance, anemia, hemodynamic instability, bleeding tendency, and immunocompromised state. We describe a patient on hemodialysis with three lung adenocarcinoma of the right lower lobe as an incidental finding...
Article
Full-text available
Parathyroid cysts are a rare situation, unusually in the mediastinum. The preoperative diagnosis could be more difficult in some atypical topographies and imaging characteristics in particular in case of huge mediastinal cyst. In the following years traditionally, in case of intrathoracic parathyroid cysts, sternotomy or thoracotomy have been the p...
Article
Primary malignant cardiac tumors are very rare. Among malignant tumors, sarcomas occupy first place. In particular, primary cardiac osteosarcoma is extremely rare. To the best of our knowledge, only 42 cases have been reported worldwide. Cardiac malignant tumors usually require complex operations due to the difficulty in completely removing the tum...
Article
Thymic carcinomas are very rare and heterogeneous groups of anterior mediastinum neoformations with an extremely aggressive behavior. Often, the diagnosis is made in the advanced stages. Paraneoplastic syndromes associated with thymic carcinoma are extremely rare. We report a case of a 64-year-old man presenting with early stage thymic carcinoma wh...
Article
Sternal involvement in patients with breast cancer is relatively rare and its treatment is still controversial. Surgery is usually indicated in cases of single metastases in a multimodality protocol. Partial or complete sternectomy associated or not with the resection of surrounding tissues is the technique of choice to obtain safety margins and ra...
Article
Objective: The systemic or topical use of antifibrinolytic agents is effective in reducing postoperative bleeding and blood product transfusion in cardiac surgery. We sought to study the effect of the topical application of tranexamic acid into the pleural space to reduce postoperative bleeding after lung surgery. Methods: This was a prospective...
Article
Desmoid tumours have a strong tendency for local invasion and recurrence. A 70 year-old male presented with cervical and left shoulder pain associated with a supraclavicular mass. The computed-tomography showed an expansive lesion measuring 10cm×6cm×5.5cm in the left supraclavicular space. At magnetic resonance imaging the subclavian vessels and th...
Article
Pandemic influenza A H1N1 virus is likely to cause severe disease in patients who have received solid organs transplants. In these patients pneumonia is the most frequent clinical feature. Parapneumonic empyema (PPE) may represent the evolution of secondary bacterial respiratory infections. To our knowledge this is the first reported case of PPE du...

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