Nizami Duran

Mustafa Kemal University, Medical Faculty · Microbiology and Clinical Microbiology

SARS CoV-2, which is the cause of Covid-19 disease, has become the only and most important agenda of the world due to its mortality and morbidity that globally affects the whole world. The virus has profoundly affected life all over the world. The lifestyles of people have changed due to the virus. This study is planned to understand how important...

Today, the treatment of infectious diseases is getting more difficult every day due to increasing drug resistance against microorganisms. In order to overcome the increasing drug resistance globally, a wide variety of studies are carried out on probiotic microorganisms. In this study, we aimed to investigate the synergistic activities of the bioact...

The increasing drug resistance in herpes viruses in recent years brings with it new treatment approaches. In recent years, it has been tried to overcome drug resistance, especially with the use of herbal products in combination with existing drugs. In this study, we aimed to investigate the effectiveness of eucalyptol in combination with acyclovir....

People apply a wide variety of over-the-counter treatments as food supplements against respiratory tract infections. In this study, we investigated the antiviral efficacy of piperine, capsaicin, and glycyrrhetinic acid (GA) against coronaviruses (SARS-CoV-2) and Influenza viruses (H1N1), which are associated with acute respiratory infections. TCID5...

Oleic acid is a naturally occurring fatty acid in animal and vegetable oils and has been shown to have a wide variety of pharmacological effects. It aimed to investigate the efficacy of oleic acid on the adhesion and invasion of S. aureus to the host cell and biofilm production. The standard S. aureus strain (ATCC 25923) was used in the experiments...

Streptococcus pyogenes, Streptococcus mutans, and Candida albicans are important human pathogens and their infections in the mouth, mouth, and throat are important. Prophylaxis against oral and respiratory tract infections is of great importance in terms of both reducing the use of antibiotics and lowering the infection frequency. This study invest...

Objectives The aim of this study was to evaluate the levels of salivary and serum interleukin (IL)-1β, visfatin, and omentin-1 in the relationship between periodontal disease and overweight/obesity as well as to reveal the possible role of periodontal inflamed surface area (PISA) in this association. Materials and methods Ninety-six individuals (6...

Obesity is a rapidly growing public health concern that can create a family-wise burden. This study was aimed to investigate behavioral, cognitive, neuroinflammatory, and neuromodulatory consequences of the diet and parental obesity. Female and male Wistar albino rats were fed on either an obesogenic or standard diet for 12 weeks, beginning with w...

The aim of study was to investigate the anti-proliferative and inflammatory effects of atorvastatin, rosuvastatin, and simvastatin in lung cancer. The effects of statins were investigated in Vero, BEAS-2B, and A549 cell lines. In addition to expressions of BAX, BCL-2, TNFα, IL-10, IL-6, protein levels of TNFα, IL-10, IL-6 were determined. Cell viab...

In the present work, a series of bisbenzazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Bisbenzazole derivatives showed significant antiproliferative activity against all the four tested cancer cell lines. Among the various bisbenzazole...

Aims In this study, it was aimed to determine the isolation frequency and species distribution of Candida species isolated from asthmatic patients using long-term inhaled steroids. It was also aimed to determine the drug resistance patterns and the frequency of erg11, HWP1, ALS1, INT1, SAP1 PLB1 genes in isolates. Methods Genotyping of Candida str...

Aims Flavonoids and related compounds, such as quercetin-based antiviral drug Gene-Eden-VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus (SARS-CoV-2). The alkylated chalcones isolated from Angelica keiskei inhibit SARS-CoV proteases. In this study, we aimed to compare the anti-SARS CoV-2 activities of both newly sy...

In the present work, a series of fluoro-substituted benzimidazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Fluoro-substituted benzimidazole derivatives showed significant antiproliferative activity against all the tested cancer cell lin...

Flavonoids and related compounds, such as quercetin-based antiviral drug Gene-Eden-VIR/Novirin, inhibit the protease of severe acute respiratory syndrome coronavirus (SARS-CoV-2). The alkylated chalcones isolated from Angelica keiskei inhibit SARS-CoV proteases. Hydroxychloroquine and Favipiravir have been used in many countries since the beginning...

Background : Malassezia species are reported to play a role in the etiology of Psoriasis vulgaris. Objective : The aim of this study was to determine the presence, frequency, distribution, and genotyping of skin colonization of Malassezia species in Psoriasis vulgaris and to compare with healthy individuals and to investigate its relationship with...

A series of new chalcones containing fluoro atom at B ring have been designed, synthesized, and evaluated to be antiproliferative activity against a panel of human tumor cell lines. Some of the analogs (8, 9, 12, 45, 46 and 48) displayed powerful antiproliferative effects to certain human tumor cells, but all of them were devoid of any cytotoxicity...

Hypericum perforatum is a useful plant because of its biological features, such as bactericidal, virucidal, and fungicidal effects. Elimination of periodontal pathogens, including Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, from the oral environment, is important for the stability of periodontal health. Therefore, we aimed t...

Aim: Oral streptococci were found to be associated with Early Childhood Caries. The aim of this study was to evaluate the 6 different bacteria in the streptococcus group in the saliva of children with severe early childhood caries (S-ECC) by polymerase chain reaction (PCR). Materials and methods: A total of 60 children between 3 and 6 years of a...

Background: Multidrug-resistant bacteria such as extended-spectrum beta-lactamase (ESBL), Enterobacteriaceae, and methicillin-resistant Staphylococcus aureus (MRSA) pose a challenge to the human health care system. MRSA is among the major causes of hospital-acquired and community infections. Methods: Therefore, in the present study, we evaluated...

Introduction : Previous studies have indicated that acute bouts of strenuous, long duration exercise induce significant increases in the inflammatory profile and cardiovascular risk markers. Although recreational soccer (RS) is a widespread activity, there are no data on this topic. Thus, the aim of this study was to examine RS-induced changes in i...

Aim: Hepatitis B is an important public health problem and many groups, including health workers, are at risk for hepatitis B. We aimed to determine the hepatitis B surface antibody levels and frequency of needlestick injury among health occupations students. Method: The study population and sample were 973 students in Mustafa Kemal University, Med...

Objective: The aim of this study was to investigate the protective effects of the combined use of probiotic strains on the development of bacterial translocation in addition to liver and intestinal tissue damage due to biliary obstruction in rats. Materials and methods: Here, 3 groups each consisting of 10 rats were created:group 1 (sham group),...

Aims: The aim of this in vitro study was to investigate the antimicrobial effects, nanohardness, and cytotoxicity of different glass-ionomer restorative materials in dentistry. Materials and methods: The following glass-ionomer restorative materials were used in our study: Argion (VOCO, Germany), Zirconomer (Shofu Inc., Japan), EQUIA Forte (GC,...

Aim : The aim of this study was to investigate the in-vitro efficacy of Glycyrrhetinic acid against Helicobacter pylori (H. pylori) strains, as compared with conventional antibacterial agents. Methods : A total of 41 H. pylori isolates were used, 6 of which were of standard strains (NCTC 1637), 8 of which were drug-sensitive, and 27 were resistant...

In the present study, the response of Japanese Quails to dietary Thymbra spicata L. essential oil was investigated. A total of 192 Japanese quail chicks, 1-day old and of mixed sexes, were used in the feeding trial. Birds were randomly allocated to four dietary treatments comprising three experimental groups and one control group (basal diet). Each...

Aim: The aim of the present study was to determine the frequency of shiga-like toxin (stx1 and stx2) and drug resistance profiles food-borne Escherichia coli O157:H7 in Hatay province, Turkey. Methods: The presence of the virulence genes (stx1, stx2, hlyA) in a total of 150 E.coli isolates were studied with multiplex PCR. Results: A total of 327 sa...

Aim: We aimed to identify the distribution of species in candidal strains isolated from clinical samples and restriction fragment length polymorphism (RFLP) method based on Msp I and Bln I restrictive enzyme cuts of polymerase chain reaction (PCR) products after the amplification of ITS1 and ITS2 regions of rDNA genotypically. Materials and metho...

Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disorder characterized by recurrent fever, serositis, abdominal pain, arthritis, arthralgia and erysipelas like erythema. Fas and Fas ligand molecules play a central role in the apoptosis signaling of various cell types including neutrophils. Neutrophils are the major cel...

Objective: The purpose of this study was to evaluate the presence of an association between the CRP +1059 G/C and ACE I/D gene polymorphisms and patients who were diagnosed to have acute coronary syndrome and underwent coronary angiography. Methods: A total of 126 patients (mean age: 60.0±12.9) and 144 healthy individuals (mean age: 52.1±13.0) were...

The aim of the study was to investigate vancomycin and high-level aminoglycoside resistance (HLAR) in Enterococcus species by phenotypic and genotypic methods. A hundred Enterococcus strains were included in the study. Antimicrobial susceptibilities of strains were investigated by automated system, betalactamase production was investigated by nitro...

A series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Mos...

Pseudomonas aeruginosa strains may develop the resistance to antibiotics via different mechanisms such as, alteration of protein binders of penicillin, porin mutations, DNA-gyrase mutation and active expulsion pumps. Especially, multi-drug resistant P.aeruginosa strains, are known to be most important cause of mortality in the intensive care units....

Levofloxacin (LV) is a hydrophilic broad-spectrum antibiotic commonly used in pulmonary treatment against recurrent infections of Pseudomonas aeruginosa, and particularly in cystic fibrosis (CF) disease. In order to study feasible carriers for LV, solid lipid nanoparticles (SLN) of myristyl myristate were prepared by the ultrasonication method in t...

Aim This study aimed to investigate the rate of Panton-Valentine Leukocidin producing Staphylococcus aureus and methicillin (mecA) and slime (icaA/icaD) genes in staphylococcal strains isolated from nasal cavities of footballers. Materials and Methods Nasal swab samples were taken from each footballers and a healthy control group for the isolation...

BACKGROUND: Staphylococci are the primary causes of external and internal auditory canal infections among other bacterial agents. The ability of disease in staphylococci depend on various virulence factors. The aim of this study was to investigate the frequency of mecA genes and slime production in staphylococci isolated from the external auditory...

Background Propolis is a bee product widely used in folk medicine and possessing many pharmacological properties. In this study we aimed to investigate: i) the antiviral activities of Hatay propolis samples against HSV-1 and HSV-2 in HEp-2 cell line, and ii) the presence of the synergistic effects of propolis with acyclovir against these viruses....

Introduction: Acinetobacter and Pseudomonas strains lead to serious and nosocomial infections in intensive care units (ICUs) and the other clinics. Resistance of these bacteria against to antibiotics, in particular is emerging as a very significant in intensive care units. The factors which affect the increase in resistance to antimicrobial drugs a...

Objective: It was aimed to investigate the presence of metallo-β-lactamase (MBL) production and blaIMP-1, blaIMP-2, blaVIM-1 and blaVIM-2 genes in Acinetobacter strains isolated from clinical samples. Methods: 150 Acinetobacter strains isolated from clinical samples which were sent to microbiology laboratory from March 2009 to June 2012 were includ...

Silver nanoparticles are one of the most important materials in the nanotechnology industry. Additionally, the protein corona is emerging as a key entity at the nanobiointerface; thus, a comprehensive understanding of the interactions between proteins and silver nanoparticles is imperative. Therefore, literature reporting studies involving both sin...

The interaction of promising nanoparticles with red blood cells (RBCs) is a critical point to be addressed in nanomedicine and nanotoxicology, and the hemolytic assay is a classical and common test used to evaluate such interactions and the consequent nanoparticle toxicity. In addition, the protein corona is an emergent concept in bionanoscience as...

The graphene sample GO:Single-layer graphene oxide, purity 99%, thickness 0.7-1.2 nm (AFM); ~300-800nm X&Y dimensions is the standard size <450 nm & 1-20 μm lateral dimensions. Cheap Tubes Inc., Bratleboro, USA was selected for our study. Exhaustive characterization of GO was afforded. It exhibited thermal stability over 60oC and it was suspended i...

Nanotechnology is an emerging cutting-edge technology, which involves interdisciplinary subjects, such as physics, chemistry, biology, material science and medicine. Different methods for the synthesis of nanoparticles have been discussed here. Although physical and chemical methods have been successfully used to synthesize nanoparticles, the use o...

Objectives: In this study, the production of extended spectrum beta-lactamase (ESBL), metallo-beta-lacatamase (MBL) and AmpC beta-lactamase enzymes of Pseudomonas aeruginosa (P aeruginosa) strains which were isolated from clinical samples were investigated. AmpC gene was also detected by the polymerase chain reaction (PCR) analysis. Methods: A h...

The present study describes the role of the ubiquitin ligase Siah-2 and corepressor N-CoR in controlling androgen receptor (AR) and estrogen receptors (ERα and ERβ) signaling in an appropriate animal model (Fischer 344 female rats) of non-muscle invasive bladder cancer (NMIBC), especially under conditions of anti-androgen therapy with flutamide. Fu...

This review discusses recent advances in the synthesis, characterization and toxicity of metal oxide nanoparticles obtained mainly through biogenic (green) processes. The in vitro and in vivo toxicities of these oxides are discussed including a consideration of the factors important for safe use of these nanomaterials. The toxicities of different m...

Because of high occurrence of side effects of conventional anticancer drugs, new therapies have been widely studied, such as the use of non-usual molecules and the association with nanomaterials. In this context, sildenafil is a molecule that has been lately considered as a co-adjuvant in cancer therapy because it inhibits an enzyme with a potentia...

One of the major problems in cancer therapies is the high occurrence of side effects intrinsic of anticancer drugs. Doxorrubicin is a conventional anticancer molecule used to treat a wide range of cancer, such as breast, ovarian and prostate. However, its use is associated with a number of side effects like multidrug resistance and cardiotoxicity....

Natural medical, pharmaceutical and cosmetic products and their ingredients have attracted increasing attention during the last decades. Due to their properties, natural ingredients with functional and biological activity are continuously researched. In the recent years the interest in using essential oils in pharmaceuticals and medicine increased....

The aim of this study was to determine the ESBL with phenotypic tests and investigate the blaCTX-M genes with the PCR method in Escherichia coli strains. The presence of ESBL in E. coli strains was determined with the Vitek 2 automated system. ESBL-positive 100 and ESBL-negative 50 E. coli strains were included in the study. The ESBL disk diffusion...

The white-rot fungus Stereum hirsutum was studied to evaluate its applicability for use in the biosynthesis of copper/copper oxide nanoparticles under different pH conditions and in the presence of three different copper salts (CuCl2, CuSO4, and Cu(NO3)2). The nanoparticle formation was evaluated by UV-visible spectroscopy, electron microscopy (TEM...

Introduction: The study was designed to investigate the epidemiology, risk factors, and clonal relationships in extended-spectrum beta lactamase (ESBL)-positive and quinolone resistant Escherichia coli strains isolated from urinary tract infections. Materials and methods: The study included 96 E. coli strains isolated from urine samples and identif...

The endogenously found free radical nitric oxide (NO) has important roles in several aspects related to plant defense and growth. NO is a signaling messenger in animals and plants due to its particular chemistry, as uncharged and small molecule, relatively lipophilic. In recent year, important papers have been describing the advantages of using NO...

The production of transgenic plants is considered as a valuable tool in plant research and the technology is comprehensively useful in agricultural research. Gene transfer in plants is generally carried out by Agrobacterium sp., application of some chemicals, and physical techniques (electroporation, microprojectile, etc.). Now-a-days with better e...

Nanobiotechnology as an application of Science and Engineering on biomolecules at the nanometer scale toward many different uses providing novel devices with a wide variety of uses that will expand the opportunities in different areas and large benefits to the society. The design, characterization, production, and application of biostructures, biod...

Background The supratrochlear foramen (STF) is an important and relatively common anatomic variation in the lower end of the humerus in humans. Its structure has received increased attention in recent years. Anatomical knowledge of STF is useful for anatomists, anthropologists, orthopedic surgeons, and radiologists. This aperture is of great intere...

For many years, cisplatin has been used to treat many types of cancer, including urogenital, skin and lung cancers. Unfortunately, treatment with this drug causes serious side effects, such as severe toxicity; that include nephrotoxicity, neurotoxicity, gastrointestinal toxicity, peripheral neuropathy, ototoxicity, asthenia and hematological toxici...

Background: Tuberculin skin test (TST) has been used for years as an aid in diagnosing latent tuberculosis infection (LTBI) but it suffers from a number of well-documented performance and logistic problems. Quantiferon-TB Gold In Tube test (QFT-GIT) has been reported to have better sensitivity and specifity than TST. In this study, it was aimed to...

Nanomedicine, environmental sciences, waste water and soil technologies intensively use many carbon nanostructures, such as carbon nanotubes, graphenes, and fullerenes. Possibly, due to the several perspectives of use of these nanomaterials, approaches on toxicology and safety management have become the focus of intense interest, as the industrial...

Background We aimed to investigate the prevalence of disinfectant resistance genes (qacA/qacB,qacC) and the aminoglycosides resistance genes [(aac(6′)aph(2″),aph(3′)-IIIa,ant(4′)-Ia)] in both S. aureus and coagulase-negative staphylococcal strains (CoNS) isolated from surgical site infections. Material/Methods Totally, 130 staphylococcal strains i...

Nanotechnology involves the study and use of materials at the nanometric scale, exploiting the different physiochemical properties exhibited by these materials at the nanoscale. This technology is becoming increasingly important for the agricultural sector. Promising applications are already in development in the areas of drug delivery systems usin...