Nirosha J Murugan

Nirosha J Murugan
Algoma University · Department of Biology

About

48
Publications
12,969
Reads
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372
Citations
Introduction
I am an interdisciplinary scientist who uses a top-down approach, to combine principles and state-of-the-art techniques from neuroscience, regenerative medicine, and cancer biology, to investigate how cancer cell fate can be reprogrammed into healthy cells using regenerative microenvironments, and in turn, how cancer microenvironments can modulate the function of distant organ systems such as the brain to induce cancer-related cognitive impairments.
Additional affiliations
April 2017 - August 2017
Tufts University
Position
  • PostDoc Position
May 2013 - March 2017
Laurentian University
Position
  • Research Associate
Education
June 2013 - September 2016
Laurentian University
Field of study
  • Biomolecular Science
September 2011 - June 2013
Laurentian University
Field of study
  • Biology (conc. Behavioural Neuroscience)
September 2007 - June 2011
Laurentian University
Field of study
  • Behavioural Neurosience

Publications

Publications (48)
Article
Full-text available
Early detection is a critically important factor when successfully diagnosing and treating cancer. Whereas contemporary molecular techniques are capable of identifying biomarkers associated with cancer, surgical interventions are required to biopsy tissue. The common imaging alternative, positron-emission tomography (PET), involves the use of nucle...
Article
Full-text available
The brain’s extracellular matrix (ECM) is a dynamic protein-based scaffold within which neural networks can form, self-maintain, and re-model. When the brain incurs injuries, microscopic tissue tears and active ECM re-modelling give way to abnormal brain structure and function including the presence of ectopic cells. Post-mortem and neuroimaging da...
Article
Bioengineered neural tissues help advance our understanding of neurodevelopment, regeneration, and neural disease; however, it remains unclear whether they can replicate higher-order functions including cognition. Building upon technical achievements in the fields of biomaterials, tissue engineering, and cell biology, investigators have generated a...
Article
Full-text available
The unicellular protist Physarum polycephalum is an important emerging model for understanding how aneural organisms process information toward adaptive behavior. Here, it is revealed that Physarum can use mechanosensation to reliably make decisions about distant objects in its environment, preferentially growing in the direction of heavier, substr...
Article
Limb regeneration is a frontier in biomedical science. Identifying triggers of innate morphogenetic responses in vivo to induce the growth of healthy patterned tissue would address the needs of millions of patients, from diabetics to victims of trauma. Organisms such as Xenopus laevis-whose limited regenerative capacities in adulthood mirror those...
Article
Pancreatic adenocarcinoma is one of the most lethal cancers with rising incidence. Despite progress in its treatment, with the introduction of more effective chemotherapy regimens in the last decade, prognosis of metastatic disease remains inferior to other cancers with long term survival being the exception. Molecular characterization of pancreati...
Chapter
Physarum polycephalum is a protist slime mould that exhibits a high degree of responsiveness to its environment through a complex network of tubes and cytoskeletal components that coordinate behavior across its unicellular, multinucleated body. Physarum has been used to study decision making, problem solving, and mechanosensation in aneural biologi...
Article
Full-text available
Biomechanical Signaling Physarum polycephalum, a slime mold with one cell and no brain, is a remarkable new model for understanding basal cognition. Its living material deforms its own structure to interact with the objects around it. In article number 2008161, Michael Levin and co-workers show that Physarum senses strain in its substrate, using bi...
Article
Full-text available
Early detection of cancer improves treatment options and increases survival. Building upon previous demonstrations that ultraweak photon emissions (UPE) could be measured to detect cancers, we designed an early detection protocol to test malignancy in both in vitro and in vivo systems. Photons were measured for 100 s from plates containing ~1 milli...
Preprint
Full-text available
The unicellular protist Physarum polycephalum is an important emerging model for understanding how aneural organisms process information toward adaptive behavior. Here, we reveal that Physarum can use mechanosensation to reliably make decisions about distant objects its environment, preferentially growing in the direction of heavier, substrate-defo...
Chapter
There have been various definitions of treatment-resistant schizophrenia recommended by practice guidelines and various clinical trials. No clear consensus exists for a single definition, but in general treatment resistance has been defined as an inadequate response to at least two different antipsychotic trials at the maximally tolerated dose. Clo...
Article
Full-text available
Post-mortem human neural tissues fixed in ethanol and aldehyde-based solutions express modulated frequency-dependent microvolt potentials when probed by chemical and electrical stimuli. These observations run contrary to the assumption that basic tissue functions are irreversibly impaired upon fixation, in the absence of nutrients and sufficient co...
Article
Full-text available
The structure of the post-mortem human brain can be preserved by immersing the organ within a fixative solution. Once the brain is perfused, cellular and histological features are maintained over extended periods of time. However, functions of the human brain are not assumed to be preserved beyond death and subsequent chemical fixation. Here we pre...
Data
5-HTP Trials. This file contains data used in the analysis involving post-mortem tissue exposed to injections of 5-HTP. (XLSX)
Data
Nicotine Trials. This file contains data used in the analysis involving post-mortem tissue exposed to injections of nicotine. (XLSX)
Article
Synergisms between a physiologically patterned magnetic field that is known to enhance planarian growth and suppress proliferation of malignant cells in culture and three light emitting diode (LED) generated visible wavelengths (blue, green, red) upon planarian regeneration and melanoma cell numbers were discerned. Five days of hourly exposures to...
Article
Full-text available
Strategic whole body application of physiologically-patterned, weak magnetic fields has been evolving as a third option to treat cancer. Unlike chemical therapies and ionizing radiation physiologically-patterned magnetic fields diminish the growth of only malignant cells but not normal cells. In addition these fields provide some analgesic relief....
Article
Full-text available
         The physical processes by which specific point duration magnetic fields affect aberrant expressions of living matter may involve non-classical mechanisms. The Aharanov-Bohm voltage for a quantum of energy that is convergent with the quotient of the proton’s magnetic moment to its charge multiplied by the viscosity of water at h...
Article
Full-text available
Increasing research into heliobiology and related fields has revealed a myriad of potential relationships between space weather factors and terrestrial biology. Additionally, many studies have indicated cyclicity in incidence of various diseases along with many aspects of cardiovascular function. The current study examined annual mortality associat...
Article
Full-text available
According to the Trushin hypothesis, light emissions between cells and microorganisms could be a major mechanism for "interunit" communication. The capacity for particularly patterned electromagnetic magnetic fields with specific temporal parameters to remain or to be "trapped" within the cell's aqueous environments that facilitate interfacial wate...
Article
Full-text available
Emphasis upon early detection of malignant cellular growths rather than imaging could allow earlier intervention. Photon emissions from malignant cells even when they constitute a very small proportion of the normal organ has been shown to require a technical understanding of the spectral power density profiles that can be predicted by Cosic’s Mole...
Article
Full-text available
A fast, inexpensive, and accurate method for differentiating normal (non-malignant) cells from malignant cells could facilitate diagnosis and subsequently treatment. Although blood constituents are the current dominant indicators, we have found that Spectral Power Densities (SPD) obtained from only 100 s of measurements of spontaneous ultra-weak ph...
Article
Full-text available
Muir-Torre syndrome (MTS) is a rare autosomal dominant inherited genodermatosis that is considered to be a phenotypic subtype of hereditary nonpolyposis colorectal cancer (HNPCC), commonly referred to as Lynch syndrome. We describe the clinical course of a 57-year-old female patient with MTS. She has a confirmed HMSH2 mutation. Recently she present...
Article
Full-text available
Changes in pH in spring water placed in the center of specific temporal parameters of rotating magnetic fields with changing angular velocities separated by 10 meters displayed conspicuous evidence of excess correlation. Serial microinjections of a proton donor into one (increased acidity) of the two volumes were associated with small increased shi...
Article
Full-text available
Sudden deaths in groups of animals have been observed by field and laboratory biologists. We have measured mortalities in large group-housed planarian during the infrequent periods of very intense geomagnetic activity. In 13 separate episodes over the last 5 y we have observed the sudden death in our laboratory of hundreds of planarian if their den...
Article
Full-text available
Quantitative electroencephalographic (QEEG) measurements were completed for a 35 year old of paramedic following two to five days of shift change and rest periods. The most conspicuous and reliable change was a marked increase (factor of 5) in power within the alpha band over the left prefrontal region and, to a lesser degree, increased power withi...
Article
Full-text available
The quantitative relationship between local changes in magnetic fields and photon emissions within ∼2 mm of aggregates of 10(5)-10(6) cells was explored experimentally. The vertical component of the earth's magnetic field as measured by different magnetometers was ∼15 nT higher when plates of cells removed from incubation were measured compared to...
Article
Full-text available
Cosic discovered that spectral analyses of a protein sequence after each constituent amino acid had been transformed into an appropriate pseudopotential predicted a resonant energy between interacting molecules. Several experimental studies have verified the predicted peak wavelength of photons within the visible or near-visible light band for spec...
Article
Full-text available
Previous studies have shown that exposure to extremely low-frequency electromagnetic fields (ELF-EMFs) have negative effects on the rate of growth of bacteria. In the present study, two Gram-positive and two Gram-negative species were exposed to six magnetic field conditions in broth cultures. Three variations of the 'Thomas' pulsed frequency-modul...
Article
Full-text available
The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or minimal numbers of human fatalities. The results clearly differentiated highly lethal and non-lethal strains. Solutions for the two leth...
Article
Full-text available
Spring water but not double-distilled water was exposed, in darkness, to a temporally patterned weak magnetic field that has been shown to affect planarian behavior and slow the rate of cancer cell proliferation. Exposure to the magnetic field caused a reliable shift in the peak (longer) wave-length of ~10 nm for fluorescence emissions and a ~20% i...
Article
Full-text available
The duality of matter-energy as particle-waves was applied to the classic ERK-MAP signaling pathways between the plasma cell membrane and the nucleus and was tested with Cosic’s Resonance Recognition Method. Spectral analyses of sequences of pseudopotentials that reflect de-localized electrons of amino acids for the 11 proteins in the pathway were...
Article
Full-text available
There has been a substantial history of correlative associations between subtle changes in geomagnetic intensity and the prevalence of multiple sclerosis. Several experiments have shown that rats in which experimental allergic encephalomyelitis had been induced respond to naturally-patterned weak magnetic fields. Exposures of only 6 min once per ho...
Article
Full-text available
Purpose: The behavioral responses of planaria to the exposures of a range of concentrations of morphine (μM to attoM) or the μ-opiate antagonist naloxone or to either of these compounds and a burst-firing magnetic field (5 μT) were studied. Material and methods: The locomotor velocity (LMV) of planaria was measured after individual worms were ex...
Article
Full-text available
Hailey-Hailey disease (HHD) is a chronic familial bullous disease characterized by recurrent blisters and erosions typically at friction-prone areas of the body accompanied by acantholysis upon histologic examination. There are a number of therapies used in the management of HHD. Its symptoms have been effectively treated with antimicrobial therapi...
Article
Full-text available
During the first 24 h after removal from incubation, melanoma cells in culture displayed reliable increases in emissions of photons of specific wavelengths during discrete portions of this interval. Applications of specific filters revealed marked and protracted increases in infrared (950 nm) photons about 7 h after removal followed 3 h later by ma...
Article
Full-text available
Cultured mouse melanoma cells were removed from incubation to room temperature and injected with either 1 μM of morphine or its mu-receptor antagonist naloxone, or, not treated. Photon emissions were counted measured by a photomultiplier unit for 24 hr. Cells injected with morphine exhibited conspicuous bursts of photon emissions whose amplitudes w...
Article
Full-text available
Both four-dimensional (space-time) models and Casimir-like processes predict that the representations of stimulusresponse pairing remain in altered or virtual states that can be potentially retrieved. Over a six month period we demonstrated "excess correlations" between mild acidification in quantities (50 ml) of spring water in a local space and t...
Article
Full-text available
A tandem sequence composed of weak temporally-patterned magnetic fields was discovered that produced 100% dissolution of planarian in their home environment. After five consecutive days of 6.5 hr exposure to a frequency-modulated magnetic field (0.1 to 2 µT), immediately followed by an additional 6.5 hr exposure on the fifth day, to another complex...
Data
A time-lapsed film of the activity of the planarian after initiation of the GM field can be found at the specified address. (WMV)
Article
Full-text available
The principles of neuroscience assume and predict that all experiences are generated by brain activity as a consequence of structural patterns. A convergence of methodologies and measurements indicate that religious/mystical experiences and beliefs associated with them are predictable phenomena. The central roles of the right hemisphere, specifical...

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Projects

Projects (2)
Project
Investigating regeneration and patterning using electroceuticals in viv
Project
Information processing and transfer in non-neural systems