Nirmal Mazumder

Nirmal Mazumder
Manipal Academy of Higher Education | MAHE · department of biophysics

PhD

About

117
Publications
15,428
Reads
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677
Citations
Introduction
Biophysics, Biophotonics. I am working on integration of adaptive optics with nonlinear optical microscopy such as 2p-FLIM, SHG,CARS microscopy. My PhD thesis was on the development of Stokes vector based SHG microscopy to investigate the molecular orientation and polarization properties of non-centrosymmetric biomolecules such as collagen, skeletal muscle, starch etc.
Additional affiliations
November 2013 - November 2014
University of viriginia, United States
Position
  • Research Associate
September 2009 - September 2013
National Yang Ming University
Position
  • PhD
July 2007 - June 2009
Tezpur University
Position
  • Master’s Degree

Publications

Publications (117)
Chapter
Chirality has always been an interesting topic in science. At present, chiral nanoparticles are in increased demand because of their unique chiroptical properties. Collective oscillations of free electrons in nanostructures result in plasmonic effects. Plasmonic has enabled the confinement of light to the nanoscales resulting in increased chiroptic...
Chapter
Remarkable photothermal properties of plasmonic nanostructures, led to the evolution of a new branch of nanoscience termed thermo-plasmonics, based on plasmonic heating of structures in nanoscale by external electromagnetic illumination. This heating generally occurs in noble metallic nanostructures, when localized surface plasmonic resonance (LSPR...
Book
This book gives a comprehensive overview of recent advancements in both theory and practical implementation of plasmonic probes. Encompassing multiple disciplines, the field of plasmonics provides a versatile and flexible platform for nanoscale sensing and imaging. Despite being a relatively young field, plasmonic probes have come a long way, with...
Article
Full-text available
Native starch is subjected to various forms of modification to improve its structural, mechanical, and thermal properties for wider applications in the food industry. Physical, chemical, and dual modifications have a substantial effect on the gelatinization properties of starch. Consequently, this review explores and compares the different methods...
Chapter
Plasmonic nanoparticles are metal-based nanoparticles with the efficient ability to absorb and scattering of light. These are extremely strong absorbers and scatters of light and used in diagnostics, imaging, surface-enhanced spectroscopy, labeling, and color changing sensors. In this chapter, we discuss the applications and benefits of using vario...
Chapter
Plasmonic nanoparticles, particularly gold and silver, are significant for various biomedical applications as they have unique plasmonic properties due to their interactions with light and functions as excellent and stable bioimaging agents. The plasmonic properties of nanoparticles have kindled researches and applications in in vitro and in vivo i...
Article
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Zinc alumino borosilicate (ZABS) glasses incorporated with Dy 3+ ions are prepared through melt-quenching technique. Non-crystallinity behaviour of the glasses are confirmed through XRD studies. The presence of functional and vibrational groups in the glass network are witnessed through FTIR studies. From the differential thermal analysis (DTA), th...
Chapter
Full-text available
A group of microalgae known as diatoms that are widely distributed among almost all the water bodies including freshwater, oceans, lakes, rivers, waterways and moist soil, contributes about 50% of the atmosphere's oxygen are of interest due to their extensive applications in biomedicine, pharmaceuticals, toxicity testing, diagnostic procedures, nan...
Chapter
For centuries, unicellular diatoms have fascinated scientists because of their intricate nanoporous cell wall architectures, known as frustules, made of amorphous silica. Siliceous frustules, with their highly symmetric nanopatterns, possess unique mechanical, optical, and photocatalytic properties. In particular, when excited by using sufficient e...
Chapter
Diatoms are microscopic, unicellular, autotrophic, and ubiquitous. They are the main organisms in the marine ecosystem which have photosynthetic as well as photoprotective and antioxidant properties. All of these properties facilitate the effective production of biomass and oxygen. Chlorophyll a/c and fucoxanthin (Fx) are the core light‐harvesting...
Book
Diatoms are microscopic photosynthetic algae with siliceous frustule usually bound to aquatic environments. Atomic force microscopy (AFM) is widely applied to study and comprehend the morphology, topography, and structure of diatoms. The most common application of AFM is to study the biomineral formation in diatoms. Further, AFM is very useful in v...
Chapter
Wounds and infections are extremely common cases that are dealt with in the medical field. Their effective and timely treatment ensures the overall well-being of patients in general. Current treatments include the use of collagen scaffolds and other biomaterials for tissue regeneration. Although the use of collagenous biomaterials has been tested,...
Chapter
Diatoms are the common eukaryotic microalga present in most water bodies. They differ in their three‐dimensional structure, functional as well as mechanical properties. Diatoms also remain the most habitual phytoplankton available for aquatic animals. X‐ray‐based techniques are the common techniques used to analyse the properties of marine frustule...
Chapter
Diatoms are single‐celled eukaryotic microalgae with silica‐based cell walls of various shapes and sizes, and with a hierarchical pore structure leading to a very high surface area which can be useful in nanotechnology, drug delivery, biomimetics,molecular biology, and especially in biosensing. Diatom frustules are gaining popularity as biosensors...
Article
The suitability of deep-UV-LEDs (285 nm) as an excitation source to induce autofluorescence in nonenzymatically glycated proteins has been reported for the first time in this study. Non-enzymatically glycated proteins show high autofluorescence when excited with deep-UV light, i.e., deep-UV-induced autofluorescence (deep-UV-IAF). Multiple autofluor...
Article
Microfluidics is revolutionizing the way research on cellular biology has been traditionally conducted. The ability to control the cell physicochemical environment by adjusting flow conditions, while performing cellular analysis at single-cell resolution and high-throughput, has made microfluidics the ideal choice to replace traditional in vitro mo...
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Optical microscopy has emerged as a key driver of fundamental research since it provides the ability to probe into imperceptible structures in the biomedical world. For the detailed investigation of samples, a high-resolution image with enhanced contrast and minimal damage is preferred. To achieve this, an automated image analysis method is prefera...
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Sanitization of inanimate objects or body surfaces using disinfectant is essential for eliminating disease-causing pathogens and maintaining personal hygiene. With the advent of health emergencies, the importance and high demand for hand sanitizers (HS) are observed in everyday life. It is also important to know the constituent added to formulate H...
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Nosocomial infections, termed hospital-acquired infections (HAIs), are acquired from a healthcare or hospital setting. HAI is mainly caused by bacteria, such as Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Enterococci spp., Methicillin-resistant Staphylococcus aureus (MRSA), and many more. Due to growing antibacterial resistanc...
Article
Cellulose obtained from plants is a bio-polysaccharide and the most abundant organic polymer on earth that has immense household and industrial applications. Hence, the characterization of cellulose is important for determining its appropriate applications. In this article, we review the characterization of cellulose morphology, surface topography...
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Full-text available
Starch is one of the most common and abundantly found carbohydrates in cereals, roots, legumes, and some fruits. It is a tasteless, colorless, and odorless source of energy that is present in the amyloplasts of plants. Native starch comprises amylose, a linear α-glucan having α-1,4-linkage and amylopectin, a branched polysaccharide with both α-1,4-...
Article
The interaction between starch and lipid gives rise to complexes that have various applications in the food industry. These complexes are known to be useful in food technology, where they influence the texture and quality of the food product, along with various other characteristics. For example, they can be used as fat replacements in different fo...
Article
Sm3+ containing BaO-ZnO-LiF-B2O3 glass system by a melt-quenching procedure was synthesized and the structural, thermal, dielectric, optical, and radiative properties were studied. The creation of Non-Bridging Oxygens (NBOs) with Sm3+ doping was manifested from Fourier Transform Infrared (FTIR) spectroscopy by the decrement of the relative area of...
Article
Citrus species possess essential nutritional elements. Being rich in vitamin C, they provide considerable health benefits. Likewise, essential oils of citrus peel vary in quantity as well as quality. This concept note outlines the use ofusing a novel electrochemical biosensor for easy and fast detection of citrus metabolites which is going to, whic...
Article
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Regretfully, because of her sudden demise, Assoc. Prof. Ekaterina Borisova is no longer amongst us. COVID-19 pulled away a brilliant scientist during the peak of her scientific career (see Fig. 1). All authors would like to express deepest condolences and sincere support to her family, friends, relatives and colleagues! We, therefore, rightfully co...
Article
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Starchy food items such as rice and potato with high carbohydrate content raise blood sugar. Hence, consuming low glycaemic foods is one tool to keep diabetes under control. In this study, potato and brown rice (Njavara rice) starches were subjected to hydrothermal treatments: heat moisture treatment (HMT) and annealing (ANN) to develop starch-base...
Article
Starch is one of the most abundantly found carbohydrates in cereals, roots, legumes and fruits located in amyloplasts of plants. Native starch comprises of amylose, a linear α-glucan with α-1,4-linkage and amylopectin, a branched polysaccharide with both α-1,4-linkage and α-1,6-linkage. In food industries, the native starch is modified to manufactu...
Article
To reduce dependence on fossil fuels and boost sustainability, bioplastics offer an exceptional replacement for petroleum-based environmentally harmful plastics. The present work describes the preparation and characterization of starch-based bioplastic composites reinforced with 10%, 30%, and 50% citric acid for crosslinking. Comprehensive morpholo...
Article
Over recent decades, three-dimensional (3D) bioprinting has been studied, improved, and extensively applied to various areas such as medicine, healthcare, food, etc. Although several applications have been identified, the field still requires extensive study to enhance and broaden the application sensitivity. The review provides a comprehensive ove...
Article
Full-text available
Understanding the mechanism of the brain via optical microscopy is one of the challenges in neuroimaging, considering the complex structures. Advanced neuroimaging techniques provide a more comprehensive insight into patho-mechanisms of brain disorders, which is useful in the early diagnosis of the pathological and physiological changes associated...
Article
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The complete polarization state of second harmonic (SH) light was measured and characterized by collagen type I and skeletal muscle fiber using a Stokes vector-based SHG microscope. The polarization states of the SH signal are analyzed in a pixel-by-pixel manner and displayed through two dimensional (2D) Stokes vector images. Various polarization p...
Article
Starch from a given botanical source can vary considerably in terms of physicochemical properties in its native and hydrolyzed forms. The current study investigated the structural and functional characteristics of starch from ten indigenous rice varieties endemic to Northeast India. In vitro enzymatic hydrolysis was used to reveal the dextrose equi...
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The present work focuses on Dy³⁺ doped 20SiO2-(20-x) B2O3–10Al2O3–10ZnO–30NaF–10ZnF2 glass ceramics (GCs), a white light emitting material prepared by conventional melt-quenching technique and thermal treatment. The glass ceramics exhibited good morphological evolution of α-Na3AlF6 crystals at elevated temperatures. Bandgap values are obtained lowe...
Article
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This paper addresses the application of multimodal nonlinear optical (MNLO) microscopy to clinical research within the context of label-free non-invasive molecular imaging. Here, a compact MNLO microscope based on a laser scanning microscope, a femtosecond laser, a time-correlated single-photon counting system, and a photonic crystal fiber are intr...
Article
Engineered biomaterials provide unique functions to overcome the bottlenecks seen in biomedicine. Hence, a technique for rapid and routine tests of collagen is required, in which the test items commonly include molecular weight, crosslinking degree, purity, and sterilization induced structural change. Among them, the crosslinking degree mainly infl...
Article
Full-text available
Exosomes are the smallest extracellular vesicles present in most of the biological fluids. They are found to play an important role in cell signaling, immune response, tumor metastasis, etc. Studies have shown that these vesicles also have diagnostic and therapeutic roles for which their accurate detection and quantification is essential. Due to th...
Article
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With the recent developments in optical imaging tools and techniques, scientists are now able to image deeper regions of the tissue with greater resolution and accuracy. However, light scattering while imaging deeper regions of a biological tissue remains a fundamental issue. Presence of lipids, proteins and nucleic acids in the tissue makes it inh...
Article
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The use of polarized light for biomedical diagnostics of skin and mucosa has already a long history. Prior studies have shown a contrast enhancement of the polarimetric values and in images of cancerous and healthy zones tissues. In the present study, reflectance-geometry polarization measurements were made with gastrointestinal tissue (GIT) sample...
Article
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The microstructural analysis of tissues plays a crucial role in the early detection of abnormal tissue morphology. Polarization microscopy, an optical tool for studying the anisotropic properties of biomolecules, can distinguish normal and malignant tissue features even in the absence of exogenous labelling. To facilitate the quantitative analysis,...
Article
Full-text available
Smartphone-based imaging devices (SIDs) have shown to be versatile and have a wide range of biomedical applications. With the increasing demand for high-quality medical services, technological interventions such as portable devices that can be used in remote and resource-less conditions and have an impact on quantity and quality of care. Additional...
Article
Full-text available
Smartphone-based imaging platforms have shown great prospects as compared to traditional optical microscopes. With their continuous development, they seem to have a wide variety of biomedical applications. In this work, a smartphone-based imaging platform was designed, developed, and fabricated using an electroluminescence display panel (EDP) as th...
Article
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic coronavirus disease 2019 (Covid-19) has claimed more than a million lives. Various in silico, in vitro, and in vivo studies are being conducted to understand the effect of SARS-CoV-2 on the cellular metabolism of humans and the various drugs and drug-t...
Conference Paper
Oxidation of oils produces many harmful chemicals with unpleasant odour and taste and can severely effect on human health. In this study, various spectroscopic methods were employed to understand how the storage condition and time affects the oxidation of oil.
Conference Paper
Alpha, microcrystalline and nanocrystalline cellulose were sequentially extracted from stems and leaves of Saccharum spontaneum and were subjected to morphological and structural characterization using advanced microscopy techniques, including Scanning electron microscopy and nonlinear optical microscopy.
Conference Paper
Novel elastomers are synthesized from corn and potato starch with potential application in the fabrication of biodegradable microfluidic devices. The developed elastomers were subjected to morphological and thermal characterization.
Article
Full-text available
Neurological diseases are a category of disease that deals with any damageable changes in the nervous system. Neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and a few others also come under this category. Detection of the cause of such diseases can be mainly studied by diggin...
Article
A multi-omics-based approach targeting the plant-based natural products from Thumbai (Leucas aspera), an important yet untapped potential source of many therapeutic agents for myriads of immunological conditions and genetic disorders, was conceptualized to reconnoiter its potential biomedical application. A library of 79 compounds from this plant w...
Article
Microorganisms thrive in well-organized biofilm ecosystems. Biofilm-associated cells typically show increased resistance to antibiotics and contribute significantly to treatment failure. This has prompted investigations aimed at developing advanced and novel antimicrobial approaches that could effectively overcome the shortcomings associated with c...
Article
Starch is an abundant plant polysaccharide that occurs naturally and the main source of carbohydrate and fuel in the human diet. Several biochemical and physicochemical studies have been performed to understand the molecular structure of starch of which microscopy, spectroscopy, and thermal analysis are the most popular. The ultrastructure and bire...
Article
Full-text available
Identification and classification of microbes are vital for maintenance of normal and altered state of human health and have applications in pharmaceutical industries, food processing, clinical analysis, and treatment. Development of methods aimed towards achieving these goals must be rapid and reliable. Conventional physiochemical and morphology-b...
Article
Full-text available
Potatoes are highly consumed food around the world, usually following processing of some kind. Apart from its noteworthy presence in diets, potato starch has a multitude of industrial applications as a food additive and recently in novel domains such as nanotechnology and bioengineering. This review examines the microscopic and spectroscopic method...
Article
Full-text available
Severe Acute Respiratory Syndrome Coronaviruses (SARS‐CoVs), causative of major outbreaks in the past two decades, has claimed many lives all over the world. The virus effectively spreads through saliva aerosols or nasal discharge from an infected person. Currently, no specific vaccines or treatments exist for coronavirus; however, several attempts...
Article
A series of Dy³⁺ doped aluminoborosilicate glasses with general formula 20SiO2-(40-x) B2O3–10Al2O3–20NaF2–10ZnO-xDy2O3 (x = 0, 0.1, 0.5, 1.0. 1.5, 2.0 and 2.5 mol %) were prepared by melt-quenching method. The FTIR analysis confirms the presence of stretching and bending vibrations of BO4, BO3 and SiO4 units in the prepared glasses. DTA results sho...
Article
Many diseases in rural areas and developing countries are detected late at an advanced stage when treatment might involve complications and higher cost, resulting in a greater number of fatalities. This study aims to make early disease detection simpler and affordable for people living in remote areas and developing countries. A new age optical mic...
Article
Full-text available
Deep tissue imaging using two-photon fluorescence (TPF) techniques have revolutionized the optical imaging community by providing in depth molecular information at the single-cell level. These techniques provide structural and functional aspects of mammalian brain at unprecedented depth and resolution. However, wavefront distortions introduced by t...
Article
Full-text available
Starch is a major source of our daily diet and it is important to understand the molecular structure that plays a significant role in its wide number of applications. In this review article, microscopic structures of starch granules from potato, corn, rice canna, tania, wheat, sweet potato, and cassava are revealed using advanced microscopic techni...
Article
Starch granules from rice and corn were isolated, and their molecular mechanism on interaction with α‐amylase was characterized through biochemical test, microscopic imaging, and spectroscopic measurements. The micro‐scale structure of starch granules were observed under an optical microscope and their average size was in the range 1–100 μm. The su...
Article
Since time immemorial, tuberculosis (TB) has intimidated the human race owing to its severity. Its socio-economic burden has led to it being a major cause of concern. It is one of the world's major causes of death from a single agent. Since most of the middle- and low-income countries are burdened with TB, sputum smear examination using conventiona...
Conference Paper
We have developed a four-channel Stokes-Mueller polarization microscope in transmission geometry, employed with an image classification algorithm for quantitative analysis of microstructural properties of the tissue specimens.
Conference Paper
Starch is an important plant polysaccharide that is a widespread food supply for mankind. It has semicrystalline nature and the amount of crystalline structures in starch affects important parameters like digestion kinetics. Several methods have used to study starch crystallinity. However, Second Harmonic generation microscopy technique is the most...
Conference Paper
We have developed elastomers using potato and corn starch with various concentration and characterised them using microscopic and spectroscopic techniques.